Clinical trials: Hemorrhage Brain
Subarachnoid Hemorrhage, Aneurysmal
Noninvasive Assessment of Cerebral Oxygenation and Cardiac Function in Patients With Neurovascular Diseases
This prospective observational study will assess the regional cerebral oxygen saturation and cardiac output non-invasively in patients with subarachnoid hemorrhage during nimodipine administration for the prevention/management of…
- Trial name
- NCT02991157
- Testing
- Nimodipine
- Where
- India
- Volunteers
- 25 people
- Sponsor
- National Institute of Mental Health and Neuro Sciences, India
Trauma, Brain, Mass Lesion
Assess the Clinical Effectiveness in AI Prioritising CT Heads
Non-Contrast Computed Tomography (NCCT) of the head is the most common imaging method used to assess patients attending the Emergency Department (ED) with a wide range of significant neurological presentations including trauma…
- Conditions
- Trauma, Brain, Mass Lesion, Skull Fractures, Hemorrhage, Intracranial
- Trial name
- ACCEPT (NCT06027411)
- Testing
- qER (qER EU 2.0)
- Where
- 4 sites in United Kingdom
- Volunteers
- 16,800 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Intracerebral Hemorrhage
Safety of Pioglitazone for Hematoma Resolution In Intracerebral Hemorrhage
Intracerebral hemorrhage (ICH) is a devastating disease with less than 20% of survivors being independent at 6 months. There is currently no approved treatment for ICH which has been shown to improve outcomes.
- Trial name
- SHRINC (NCT00827892)
- Testing
- Pioglitazone
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- The University of Texas Health Science Center, Houston
Aneurysmal Subarachnoid Hemorrhage
Cervical Spinal Cord Stimulation for the Prevention of Cerebral Vasospasm
The study investigates safety, feasibility and effectiveness of cervical spinal cord stimulation (SCS) in prevention of cerebral arterial vasospasm following aneurysmal subarachnoid hemorrhage (aSAH).
- Trial name
- NCT00766844
- Testing
- spinal cord stimulation
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Konstantin V. Slavin
Subarachnoid Hemorrhage, Spontaneous
SFX-01 After Subarachnoid Haemorrhage
This is a Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Study of SFX-01 in Subarachnoid Haemorrhage, with exploratory evaluations of efficacy.
- Trial name
- SAS (NCT02614742)
- Testing
- SFX-01
- Where
- 3 sites in United Kingdom
- Volunteers
- 90 people
- Sponsor
- Evgen Pharma
Intracerebral Hemorrhage
Clinical Diagnosis and Treatment of Intracerebral Hemorrhage Based on Artificial Intelligence
The purpose of this study is to test the reliability and validity of an artificial intelligence system and a related 5-score scale to predict hematoma expansion, and conduct a study cohort of intracerebral hemorrhage to screen…
- Trial name
- CATCH-AI (NCT04951570)
- Where
- China
- Volunteers
- 1,374 people
- Sponsor
- Beijing Tiantan Hospital
Hematoma, Subdural Hematoma
Patient Registry for Patients With Chronic Subdural Hematoma
All admitted patients diagnosed with unilateral or bilateral chronic subdural hematoma are included into this registry after consent.
- Conditions
- Hematoma, Subdural Hematoma, Chronic
- Trial name
- CSDH-R (NCT04170582)
- Where
- Germany
- Volunteers
- 250 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Ruptured Aneurysm of Intracranial Artery, SAH (Subarachnoid Hemorrhage)
Efficacy of Daily IV Administration of Dornase Alfa up to 14 Days Post Subarachnoid Hemorrhage on Functional Independence at 6 Months
Subarachnoid hemorrhage due to aneurysm rupture (SAH) results in high mortality, while survivors frequently suffer reduced quality of life and even loss of autonomy, particularly in the active population.
- Conditions
- Ruptured Aneurysm of Intracranial Artery, SAH (Subarachnoid Hemorrhage), Delayed Cerebral Ischemia
- Trial name
- RESET (NCT06723717)
- Testing
- Daily infusion of dornase alfa
- Where
- 6 sites in France
- Volunteers
- 304 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Post-hemorrhagic Hydrocephalus (PHH)
Ventricular mTOR Inhibition to Prevent Hydrocephalus After Brain Hemorrhage
Hydrocephalus is a serious condition in which fluid builds up inside the brain, often requiring lifelong surgical placement of a shunt to drain excess cerebrospinal fluid (CSF).
- Trial name
- VENTURE-PHH (NCT07662174)
- Testing
- Sirolimus (Rapamune®)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Massachusetts General Hospital
Intracranial Hemorrhages
Validation of Falls Decision Rule to Exclude Intracranial Bleeding in Geriatric Fall Patients
Although falls are the most important cause of intracranial hemorrhage in the population over 65, studies have shown that bleeding occurs in only 5% of geriatric patients who fall.
- Trial name
- NCT06525727
- Testing
- Falls Decision Rule
- Where
- Turkey (Türkiye)
- Volunteers
- 800 people
- Sponsor
- Marmara University
Aneurysmal Subarachnoid Hemorrhage
Erythropoietin Therapy for Subarachnoid Hemorrhage
ABSTRACT: Delayed ischemic deficits (DID) and strokes caused by low cerebral blood flow (CBF) are major sources of poor outcome following aneurysmal subarachnoid hemorrhage (SAH).
- Trial name
- NCT00140010
- Testing
- erythropoietin beta
- Where
- United Kingdom
- Volunteers
- 80 people
- Sponsor
- University of Cambridge
Aneurysmal Subarachnoid Hemorrhage
Prevention of Ischemia in Aneurysmal Subarachnoid Hemorrhage Through Remote Ischemic Preconditioning
Aneurysmal subarachnoid hemorrhage (SAH) is a severe form of stroke caused by bleeding around the brain. Despite early treatment of the initial hemorrhage, many patients develop delayed cerebral ischemia several days later, which…
- Trial name
- HMA (NCT07761520)
- Testing
- Remote Ischemic Preconditioning
- Volunteers
- 140 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Subarachnoid Haemorrhage
Simvastatin in Aneurysmal Subarachnoid Haemorrhage (STASH) a Multicentre Randomised Controlled Clinical Trial
Intracranial bleeding from ruptured blood vessels (called a subarachnoid haemorrhage -SAH) affects 7000 patients each year in the UK and is a source of considerable death and disability, even in young adults.
- Trial name
- STASH (NCT00731627)
- Testing
- simvastatin
- Where
- 2 sites in United States
- Volunteers
- 803 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Traumatic Brain Injury
Interacting Together Everyday: Recovery After Childhood Traumatic Brain Injury (TBI) "I-InTERACT
The purpose of this study is to test an on-line intervention for families of young children who have experienced moderate or severe traumatic brain injury (TBI).
- Trial name
- I-InTERACT (NCT01056146)
- Testing
- Internet-based Interacting Together Everyday: Recovery After Childhood TBI, Internet Resources Comparison
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Chronic Subdural Hematoma
Efficacy of Atorvastatin in Chronic Subdural Haematoma
This prospective, double-blind, randomized, placebo-controlled study aims to evaluate the efficacy and safety of atorvastatin in patients with chronic subdural haematoma.
- Trial name
- REACH (NCT03956368)
- Testing
- Atorvastatin 20mg
- Where
- 7 sites in Hong Kong
- Volunteers
- 690 people
- Sponsor
- Chinese University of Hong Kong
Intracranial Hemorrhage, Ventriculitis
Clearance of Intracranial Blood Products by Continuous Irrigation With the IRRAflow System
The study is a multi-center prospective cohort, controlled, phase 4 post-market registry evaluating the efficacy and radiographic outcomes associated with the use of the IRRAflow® Active Fluid Exchange System compared to standard…
- Conditions
- Intracranial Hemorrhage, Ventriculitis, Intracranial Abscess
- Trial name
- CRYSTAL (NCT06649097)
- Testing
- IRRAflow® CNS (Active Fluid Exchange) System
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Christopher P Kellner
Cerebral Hemorrhage
Human Umbilical Cord Mesenchymal Stem Cell in Cerebral Hemorrhage Sequela
The purpose of this study is to evaluate the safety and efficacy of human umbilical cord mesenchymal stem cell(hUC-MSC) for cerebral hemorrhage sequela.
- Trial name
- NCT02283879
- Testing
- Human umbilical cord mesenchymal stem cells
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Shenzhen Hornetcorn Bio-technology Company, LTD
Brain Death, Brain Injuries
Resting Energy Needs in Brain Dead Patients (reSting EneRgy nEeds iN brAin DEad Patients)
The study will examine the resting energy need (REE) in patients suffering from brain damage. For the measurement of REE will be used a metabolic computer (which with continuous recording of breath-to-breath volume (Vt)…
- Conditions
- Brain Death, Brain Injuries, Brain Edema, Brain Hemorrhage
- Trial name
- SERENADE (NCT05070182)
- Testing
- REE - Resting Energy Expenditure, Transcranial Doppler
- Where
- Greece
- Volunteers
- 66 people
- Sponsor
- Aristotle University Of Thessaloniki
Aneurysmal Subarachnoid Haemorrhage, SAH
Goal Directed Therapy After Aneurysmal Subarachnoid Haemorrhage
The objective of this study is to determine whether a goal-directed therapy can reduce the incidence of delayed cerebral ischaemia after aneurysmal subarachnoid haemorrhage.
- Trial name
- PiSAH (NCT01832389)
- Testing
- PiCCO
- Where
- Germany
- Volunteers
- 108 people
- Sponsor
- Technical University of Munich
Intracerebral Hemorrhage
Efficacy and Safety of Factor VIIa on Rebleeding After Surgery for Spontaneous Intracerebral Hemorrhage (ICH)
Although the role of surgical treatment is still controversial, surgical evacuation of intracerebral hematoma is a frequent practice. Rebleeding is a frequent complication in patients submitted to hematoma evacuation.
- Trial name
- PRE-SICH (NCT00128050)
- Testing
- rFactor VIIa (Eptacog alfa, NovoNordisk), rFVIIa, Sodiun chloride 0.9%
- Where
- 3 sites in Italy
- Volunteers
- 30 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
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