Clinical trials: Hemorrhage Brain
Hemorrhagic Stroke, Intracerebral Hemorrhage
Mesenchymal Stem Cells Therapy in Patients With Recent Intracerebral Hemorrhage
The overall goal of this study is to develop mesenchymal stem cell therapy for treatment of acute spontaneous hemorrhagic stroke.
- Trial name
- NCT03371329
- Testing
- MSC
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Mayo Clinic
Pituitary Tumor, Blood Loss
Tranexamic Acid for Blood Loss Minimization in Endoscopic Pituitary Surgery
This trial is to determine the effect of Tranexamic Acid (TXA) on blood loss during endoscopic pituitary surgery. The hypothesis of this study is that TXA will reduce blood loss during surgery compared to a placebo.
- Conditions
- Pituitary Tumor, Blood Loss, Surgery
- Trial name
- NCT04863339
- Testing
- Tranexamic acid
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Intracranial Aneurysms, Subarachnoid Hemorrhage, Aneurysmal
Screening in Relatives With Elevated Risk for Unruptured Intracranial Aneurysms
The purpose of this study is to screen first-degree relatives of patients with aneurysmal subarachnoid hemorrhage using magnetic resonance angiography to detect unruptured intracranial aneurysms.
- Trial name
- SIREN (NCT07387575)
- Where
- Serbia
- Volunteers
- 300 people
- Sponsor
- University of Novi Sad
Intracranial Hemorrhage, Hypertensive, Craniotomy Tumor Removal Surgery
Comparison of Post-Craniotomy Blood Pressure Targets
The goal of this pragmatic clinical trial is to learn if a more intensive or more liberal blood pressure target after surgery is more effective in improving patient outcomes for adults undergoing craniotomy for removal of a brain…
- Trial name
- COMPETE (NCT07093151)
- Testing
- Target SBP <160mmHg, Target SBP <140 mmHg
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Vanderbilt University Medical Center
Aneurysmal Subarachnoid Hemorrhage
Cilostazol for Preventing Delayed Cerebral Ischemia in Aneurysmal Subarachnoid Hemorrhage
The investigators propose to conduct a multicenter randomized trial to test whether cilostazol reduces the incidence of delayed cerebral ischemia (DCI) following aneurysmal subarachnoid hemorrhage (aSAH) and improves patients'…
- Trial name
- CAPTAIN (NCT07249853)
- Testing
- Cilostazol 100 mg BID
- Where
- China
- Volunteers
- 380 people
- Sponsor
- Beijing Tiantan Hospital
Intracerebral Hemorrhage
A Study Evaluating the Safety and Efficacy of Neuroprotective Peptide CN-105 Peptide in Patients With Acute Supratentorial Intracerebral Hemorrhage
Intracerebral hemorrhage (ICH) is a devastating form of cerebrovascular disease for which there are no approved therapeutics that improve outcomes.
- Trial name
- NCT06255977
- Testing
- CN-105
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Beijing Tiantan Hospital
LVAD (Left Ventricular Assist Device) Thrombosis, Heart Failure
SWITCH: Apixaban vs Vitamin K in HM3
This study is being done to learn the safety and efficacy of a new anticoagulant therapy with apixaban as compared to warfarin to prevent thrombotic events while protecting from bleeding complications in patients with advanced…
- Conditions
- LVAD (Left Ventricular Assist Device) Thrombosis, Heart Failure, Bleeding, Thrombosis; Artery
- Trial name
- NCT07471139
- Testing
- Warfarin, Apixaban
- Volunteers
- 460 people
- Sponsor
- Columbia University
Traumatic Intracranial Haemorrhage
Timing to Restart Direct Oral Anticoagulants After Traumatic Intracranial Haemorrhage
Older people falling from a standing height is the most common cause of hospital admission for head injury. Up to 1 in 3 patients admitted are taking a tablet medication which thins the blood, known as an oral anticoagulant.
- Trial name
- RESTARTtlCrH (NCT06322953)
- Testing
- Direct-Acting Oral Anticoagulants (used as per local standard practice)
- Where
- 2 sites in United Kingdom
- Volunteers
- 1,084 people
- Sponsor
- Walton Centre NHS Foundation Trust
Preterm Birth, Periventricular Leukomalacia
Neuroprotection by Magnesium Sulfate Given to Women at Risk of Very Preterm Birth
Magnesium is neuroprotective in neonatal animal models of acquired hypoxic-ischemic and/or inflammatory cerebral lesions. It is associated with a significant reduction of perinatal death and cerebral palsy in some observational…
- Conditions
- Preterm Birth, Periventricular Leukomalacia, Brain Ischemia, Intracranial Hemorrhages
- Trial name
- NCT00120588
- Testing
- magnesium
- Where
- France
- Volunteers
- 700 people
- Sponsor
- University Hospital, Rouen
Stroke
The Clinical Trial Research of Stem Cell Transplantation Treats Cerebral
All experimental group patients of 100 patients accept a treatment course stem cell transplantation, including one time stem cell transplantation through intravenous injection way at the 10-21th day of cerebral hemorrhage, and…
- Trial name
- NCT01389453
- Testing
- stem cell transplantation
- Where
- China
- Sponsor
- General Hospital of Chinese Armed Police Forces
Subarachnoid Hemorrhage, Aneurysmal
Safety/Pharmacokinetic Study Comparing Intracisternal EG-1962 to Standard of Care Enteral Nimodipine in Adults With aSAH
Safety and Pharmacokinetic study comparing intracisternal EG-1962 to enternal nimopidine in the treatment of aneurysmal subarachnoid hemorrhage.
- Trial name
- NCT02893826
- Testing
- EG-1962 (nimodipine microparticles), Enteral Nimodipine
- Where
- 4 sites in United States, Canada
- Volunteers
- 6 people
- Sponsor
- Edge Therapeutics Inc
Subarachnoid Hemorrhage
HyperHAES Versus Placebo - Effect on Intracranial Pressure in SAH Patients
The purpose of this study is to determine whether 7.2% NaCl in 6% hydroxyethyl starch will lower intracranial pressure (ICP) in SAH-patients with normal or moderately elevated ICP in a placebo controlled study, and to describe…
- Trial name
- NCT00199706
- Testing
- 7.2% NaCl in 6% hydroxyethyl starch solution
- Volunteers
- 20 people
- Sponsor
- Oslo University Hospital
Subarachnoid Hemorrhage
Antiepileptic Drugs and Vascular Risk Markers
The purpose of this study is to determine if certain seizure medications raise levels of cholesterol and other blood components which could increase the risk of heart attacks and strokes.
- Trial name
- NCT00774306
- Testing
- phenytoin, valproate, levetiracetam
- Volunteers
- 52 people
- Sponsor
- Thomas Jefferson University
Hematoma, Subdural, Chronic
Exhaustive Drainage Versus Fixed-time Drainage for Chronic Subdural Hematoma After One-burr Hole Craniostomy
A prospective, multicenter, randomized controlled trial is designed to compare the recurrence rates and clinical outcomes in patients with chronic subdural hematoma using exhaustive drainage or fixed-time drainage after one-burr…
- Trial name
- ECHO (NCT04573387)
- Testing
- Operation, Fixed-time drainage, Exhaustive drainage
- Where
- 17 sites in China
- Volunteers
- 309 people
- Sponsor
- Beijing Tiantan Hospital
Chronic Thrombocytopenia
Cerebral Dysfunction in Chronic ITPwith High Risk of Serious Bleeding Excluding Intracranial Hemorrhage.
Intracranial hemorrhage despite being rare, several chronic ITP patients experience moderate to severe behavioral problems including learning difficulties, memory affection .These changes could be due to the presence of minute…
- Trial name
- NCT01764971
- Testing
- IQ assessment and visual- motor assessment, EEG,brain imaging
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Ain Shams University
Subarachnoid Haemorrhagic Stroke
Investigation of the Role of Inflammatory Markers in the Early Detection of Cerebral Vasospasm, Delayed Cerebral Ischemia, and Meningitis Associated With External Cerebrospinal Fluid Drainage After Non-Traumatic Subarachnoid Hemorrhage - A Prospective Case-Control Study
Background Non-traumatic subarachnoid haemorrhage (SAH) is frequently complicated by delayed cerebral ischaemia (DCI) and by ventriculitis/meningitis when external CSF drains are used; bedside TCCD has limited accuracy for…
- Trial name
- NCT07129603
- Where
- Hungary
- Volunteers
- 100 people
- Sponsor
- Tamas Vegh, MD
Subarachnoid Aneurysm Hemorrhage
Early Motor-Cognitive Integrative Training on Cognitive and Motor Performance in Aneurysmal Subarachnoid Hemorrhage
Despite its lower incidence rate within the stroke population and tendency to affect younger individuals, SAH carries the highest risk of PSCI.
- Trial name
- NCT06648187
- Testing
- Early motor-cognitive integrative training (e-MCIT)
- Where
- Taiwan
- Volunteers
- 6 people
- Sponsor
- National Taiwan University Hospital
Subarachnoid Hemorrhage, Lymphatic System Disorder
Radiological Changes of Glymphatic-meningeal Lymphatic Drainage System After Subarachnoid Hemorrhage
Subarachnoid hemorrhage (SAH) is a common and extremely critical disease in neurosurgery. The mortality rate within 30 days of the onset of SAH is as high as 50%, and about 15% of SAH patients die without reaching the hospital.
- Conditions
- Subarachnoid Hemorrhage, Lymphatic System Disorder, Meningeal Lymphatic Vessels
- Trial name
- NCT06444438
- Testing
- subarachnoid hemorrhage
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Subarachnoid Hemorrhage
Impact of Herniation on WFNS Grading in Spontaneous Subarachnoid Hemorrhage - a SWISS SOS Observational Trial
All patients (≥18 years) with a spontaneous SAH proven by computed tomography (CT), magnetic resonance imaging (MRI) or lumbar puncture will be considered for this trial.
- Trial name
- hWFNS (NCT02304328)
- Testing
- Clinical assessment
- Where
- 8 sites in Switzerland
- Volunteers
- 250 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Intracerebral Hemorrhage Lobar, Cerebral Amyloid Angiopathy
Remote Ischemic Conditioning for Cerebral Amyloid Angiopathy-related Intracerebral Hemorrhage
Cerebral amyloid angiopathy-related intracerebral (CAAH) hemorrhage is second factor of primary intracerebral hemorrhage. However, no effective prevention and treatment strategies have been established.
- Trial name
- RIC-CAAH (NCT04757597)
- Testing
- Remote ischemic conditioning
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Capital Medical University
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