Clinical trials: Hemorrhage Gastric
Stress Ulcers, Stress-related Mucosal Disease (SRMD)
China Survey of Stress Ulcer Bleeding in Critically Ill Neurosurgical Patients
Stress ulcers or stress-related mucosal disease (SRMD) is defined as "acute superficial inflammation lesions of the gastric mucosa induced when an individual is subject to abnormally elevated physiologic demands."[1] Studies have…
- Trial name
- SUP (NCT02316990)
- Where
- 11 sites in China
- Volunteers
- 1,416 people
- Sponsor
- AstraZeneca
Stomach Neoplasms
The Efficacy of Esomeprazole Premedication on Intraoperative Bleeding During Gastric ESD
This will be a single-centre, randomised, endoscopist-blind, parallel-group study in patients who are scheduled endoscopic submucosal dissection (ESD) for gastric mucosal lesion.
- Trial name
- NCT02730533
- Testing
- Esomeprazole, No PPI treatment
- Where
- China
- Volunteers
- 74 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Gastrointestinal Hemorrhage, Stomach Ulcer
Pharmacogenetics of Gastrointestinal Bleeding
Gastrointestinal bleeding is a severe adverse effect occurring in subjects secondary to the use of nonsteroidal anti-inflammatory drugs (NSAIDs). The enzyme CYP2C9 is responsible for the elimination of several NSAIDs.
- Conditions
- Gastrointestinal Hemorrhage, Stomach Ulcer, Non-steroidal Anti-inflammatory Drug Sensitivity
- Trial name
- NCT00190255
- Testing
- CY2PC9 genotyping
- Where
- 4 sites in France
- Volunteers
- 200 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Liver Cirrhosis and Hepatoma., Gastric Variceal Bleeding
Endoscopic Cyanoacrylate Obliteration vs. Nadolol Treatment in the Prevention of Gastric Variceal Rebleeding
Gastric variceal bleeding has a very high rebleeding rate even after endoscopic variceal injection of cyanoacrylate (GVO) which is considered the first choice of endoscopic treatment.
- Trial name
- GVO-nadolol (NCT00567216)
- Testing
- Nadolol
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Gastric Variceal Bleeding
Removable Titanium Clip Treatment for Acute Variceal Hemorrhage from the Gastric Fundus
Removable Titanium Clip Treatment for Acute Variceal Hemorrhage from the Gastric Fundus
- Trial name
- NCT06736314
- Testing
- a removable titanium clip
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Shupei Li
Upper GI Bleeding
Metoclopramide for Gastric Visualization in Active Upper GI Bleeding
This study aim to evaluate the efficacy of metoclopramide for gastric visualization in patients with active UGIB. This is a double-blinded, multicenter RCT.
- Trial name
- NCT06167837
- Testing
- Metoclopramide Sulfone, Normal Saline 10 mL Injection
- Where
- 2 sites in Thailand
- Volunteers
- 220 people
- Sponsor
- King Chulalongkorn Memorial Hospital
Gastric Varices Bleeding, Gastric Varix
Combined and Simultaneous Approach for the Treatment of High-risk Gastric Varices Using B-RTO and EVO
The aim of this pilot study is to evaluate the efficacy and safety of combined and simultaneous endoscopic variceal obliteration together with balloon occluded-retrograde transvenous obliteration (B-RTO) for the treatment of…
- Trial name
- BeRTO (NCT03853720)
- Testing
- balloon-occluded retrograde transvenous and endoscopic obliteration of high-risk gastric varices
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Bleeding Peptic Ulcer
The Use of OTSC in LBGDU to Standard Endoscopic Hemostatic Methods
In managing bleeding gastroduodenal ulcers, endoscopic control of bleeding is the first line treatment-further bleeding after endoscopic hemostasis is associated with a 3-fold increase in mortality.
- Trial name
- OTSC-LBGDU (NCT06196710)
- Testing
- Over-the-scope Clips, Hemo-clipping
- Sponsor
- Chinese University of Hong Kong
Calcium Electroporation for Hemostasis in Gastric Neoplasms
Endoscopic Calcium Electroporation in Gastric Tumors
Brief Summary Background Gastric cancer (GC) remains a major global public health challenge, ranking as the fifth most common malignancy worldwide and the third leading cause of cancer-related mortality.
- Trial name
- GASTRIC-CaEP (NCT07647731)
- Testing
- Endoscopy Calcium Electroporation
- Volunteers
- 28 people
- Sponsor
- Hospital del Rio Hortega
Gastrointestinal Bleeding, Stress Ulcers
Stress Ulcer Prophylaxis in the Intensive Care Unit
Stress ulcer prophylaxis (SUP) is standard of care in the intensive care unit (ICU), however the quantity and quality of evidence is low and potential harm has been reported.
- Trial name
- SUP-ICU (NCT02467621)
- Testing
- Pantoprazole, Saline (0.9%)
- Where
- 33 sites in Denmark, Finland and 4 more
- Volunteers
- 3,350 people
- Sponsor
- Dr. Morten Hylander Møller
Supraglottic Airway Efficiency, Airway Complication of Anesthesia
Wei Nasal Jet Tube vs Gastro Laryngeal Tube in Endoscopic Retrograde Cholangiopancreatography
The most common adverse event in endoscopic procedures is hypoxia. Different airway devices have been investigated in the literature to prevent hypoxia.
- Conditions
- Supraglottic Airway Efficiency, Airway Complication of Anesthesia, Airway Aspiration, Complication of Anesthesia
- Trial name
- NCT05360810
- Testing
- Wei Nasal Jet Tube, Gastro Laryngeal Tube
- Where
- Turkey (Türkiye)
- Volunteers
- 114 people
- Sponsor
- Bezmialem Vakif University
Gastric Varix, Cirrhosis
EUS-guided Combined Therapy Versus Beta Blocker Therapy in Primary Prophylaxis o GOV II and IGV I
The EUS-guided combined therapy of coilingand 2-octyl-cyanoacrylate in patients with gastric varices reduced rebleeding and need for reintervention in comparison to EUS-guided coiling alone.The purpose of this study is to…
- Conditions
- Gastric Varix, Cirrhosis, GastroIntestinal Bleeding
- Trial name
- NCT04075760
- Testing
- Coils + Cyanoacrylate Group + beta-blocker, beta blocker therapy
- Where
- Ecuador
- Volunteers
- 26 people
- Sponsor
- Instituto Ecuatoriano de Enfermedades Digestivas
Feeding Intolerance, Abdominal Distention
SAFEstart Feeding Intolerance Study Phase II
Feeding intolerance is a common problem in the NICU. Feeding intolerance complicates the hospitalization, lengthens the hospital stay, and adds substantially to the cost of care.
- Conditions
- Feeding Intolerance, Abdominal Distention, Gastric Residual, Emesis and Diarrhea
- Trial name
- NCT00331201
- Testing
- SAFEstart
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Intermountain Health Care, Inc.
Acute Coronary Syndrome, Myocardial Infarction
Clopidogrel and the Optimization of Gastrointestinal Events (COGENT-1)
The purpose of the COGENT-1 clinical trial is to determine whether CGT-2168 (clopidogrel and omeprazole) compared to clopidogrel is safe and effective in reducing the incidence of gastrointestinal bleeding and symptomatic ulcer…
- Conditions
- Acute Coronary Syndrome, Myocardial Infarction, Coronary Artery Disease, Percutaneous Coronary Intervention
- Trial name
- COGENT-1 (NCT00557921)
- Testing
- CGT-2168 (clopidogrel 75 mg/omeprazole 20 mg) and aspirin, Plavix (clopidogrel 75 mg) and aspirin
- Where
- 491 sites in United States, Australia and 14 more
- Volunteers
- 5,000 people
- Sponsor
- Cogentus Pharmaceuticals
TIPS, Portal Hypertension
TIPS for Complicated Portal Hypertension Related to Porto-Sinusoidal Vascular Disease
Porto-sinusoidal Vascular Disease (PSVD) is characterized by a portal hypertension (PH) without cirrhosis. This can induce PH complications, like digestive hemorrhage from esophageal or gastric varices, ascites, or even portal…
- Conditions
- TIPS, Portal Hypertension, Porto-Sinusoidal Vascular Disease, Refractory Ascite
- Trial name
- TIPS-PSVD (NCT07163689)
- Where
- France
- Volunteers
- 360 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Esophageal and Gastric Varices
Comparison of Endoscopic Band Ligation Plus 24-hour Versus 72-hour Terlipressin Therapy
In the Western world, liver cirrhosis is a significant issue. Acute variceal bleeding (AVB) is a considerable complication of cirrhosis associated with high mortality.
- Trial name
- NCT05331768
- Testing
- banding ligation plus terlipressin infusion
- Where
- Mexico
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Instituto Mexicano del Seguro Social
Surgical Procedures, Operative
A Study Comparing ETHICON™ 4000 Stapler System With Standard of Care Stapling Devices in Adults Undergoing Gastric and Thoracic Procedures
The purpose of this study is to compare how well the ETHICON™ 4000 Stapler works as compared to the standard stapling devices by assessing how often air leaks and bleeding along the staple line occur during lung and stomach…
- Trial name
- NCT07744568
- Testing
- ETHICON™ 4000 Stapler System, Standard of Care Stapler and Reloads
- Volunteers
- 300 people
- Sponsor
- Ethicon Endo-Surgery
Portal Hypertension, Gastric Varices Bleeding
Preemptive TIPS for Gastric Variceal Bleeding in Patients With Cirrhosis
The prevalence of gastric varices is approximately 20%. It is important to note that gastric varices tend to bleed more severely, have a higher morbidity and mortality rate, and have a 35% to 90% risk of rebleeding after the…
- Conditions
- Portal Hypertension, Gastric Varices Bleeding, Portosystemic Shunt
- Trial name
- NCT06122792
- Testing
- preemptive TIPS, standard second prophylaxis
- Volunteers
- 144 people
- Sponsor
- West China Hospital
Peptic Ulcer
PPI vs H2RA in Patients With Helicobacter Pylori-Negative Idiopathic Bleeding Ulcers
The aim of this study is to compare the efficacy of a proton pump inhibitor (lansoprazole) and a histamine-2 receptor antagonist (famotidine) in preventing recurrent ulcer bleeding in patients with a history of H.
- Trial name
- NCT01180179
- Testing
- Lansoprazole, Famotidine
- Where
- China
- Volunteers
- 228 people
- Sponsor
- Chinese University of Hong Kong
Gastro Intestinal Bleeding, Hematemesis
Study of Early Endocapsule (EC) in Clinical Decision Unit Versus Standard of Care Work-up for GI Bleeding
This study will evaluate the use of the Olympus EndoCapsule EC-10 video capsule compared with the standard of care workup for patients in the Clinical Decision Unit who have symptoms of gastrointestinal (GI) bleeding.
- Conditions
- Gastro Intestinal Bleeding, Hematemesis, Melena
- Trial name
- NCT03955055
- Testing
- Video Capsule Endoscopy
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Christopher Marshall