Clinical trials: Hemostasis, Surgical
Hemostasis
Blood Sparing Strategies: Omni-stat Routinary Use in Cardiac Surgery. A Prospective Randomized Study.
The study enrolles all consecutive patients undergoing cardiac surgery at the European Hospital, Rome. The population undergoes randomization to receive usual surgical hemostasis or added topical application of Omni-stat Celox.
- Trial name
- NCT01008436
- Testing
- Omni-stat Celox, Control
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- Cardiochirurgia E.H.
On-pump Cardiac Surgery, High Risk for Bleeding
COmbined pLaTelet and eRythrocyte AutotransfusioN During Cardiac surgEry (COLTRANE) Trial
Despite significant advances in patient blood management, cardiac surgery remains a surgical procedure at high risk for bleeding.
- Conditions
- On-pump Cardiac Surgery, High Risk for Bleeding, Autotransfusion
- Trial name
- COLTRANE (NCT06425614)
- Testing
- Autotransfusion
- Where
- 10 sites in France
- Volunteers
- 570 people
- Sponsor
- University Hospital, Bordeaux
Blood Loss
The Use of FLOSEAL to Reduce Bleeding in Total Knee Replacement Surgery
The purpose of this study is to determine if the agent, Floseal, can decrease the amount of blood patients lose after total knee replacement (TKR) surgery.
- Trial name
- NCT00990288
- Testing
- Hemostatic Matrix
- Where
- United States
- Volunteers
- 196 people
- Sponsor
- Hospital for Special Surgery, New York
Ruptured Abdominal Aortic Aneurism
START - Early Thrombocyte Administration to Patients With Ruptured Abdominal Aortic Aneurism
The purpose of this study is to investigate the effect of platelet infusion prior to transfer to a vascular surgical department in patients with a ruptured abdominal aortic aneurism.
- Trial name
- rAAA (NCT01291290)
- Testing
- Platelet
- Where
- Denmark
- Volunteers
- 420 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Hemorrhoids, Anal Fistula
Hemostatic and Analgesic Effect of Gel Foam and Gauze With Bosmin After Anal Surgery
To evaluate the hemostatic and analgesic effect of using gauze with Bosmin or Gelfoam after anal surgery.
- Trial name
- NCT05605080
- Testing
- Gelfoam, Bosmin gauze
- Where
- Taiwan
- Volunteers
- 292 people
- Sponsor
- Taipei Medical University Shuang Ho Hospital
Coagulopathy, Congenital Heart Disease
FFP Usage in Pediatric CV Surgery
When small children undergo heart surgery with the heart-lung machine, in the past, blood products to help the blood clot such as Fresh Frozen Plasma (FFP) was routinely used in children under 10kg.
- Trial name
- NCT05819788
- Where
- Canada
- Volunteers
- 431 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Postoperative Morbidity, Postoperative Mortality
Hemostasis Evolution During Fluid Loading in Abdominal Surgery. Effects of Fluid Choice: Saline Versus Hydroxyethyl Starch (HAEMO Study)
The primary purpose of the study is to evaluate whether the type of fluid (0.9% saline or 6% Hydroxyethyl starch 130/0.4) in the context of an individualized goal-directed fluid therapy is associated with a difference in…
- Conditions
- Postoperative Morbidity, Postoperative Mortality, Hemostasis Change
- Trial name
- HAEMO (NCT03420261)
- Testing
- 0.9% saline, HES 130/0.4
- Where
- France
- Volunteers
- 56 people
- Sponsor
- University Hospital, Clermont-Ferrand
Head and Neck Cancer, Intraoperative Complications
Coagulation and Vitamin K in Head and Neck Microvascular Free Flap Surgery
For patients with large head and neck tumors the recommended treatment, in many cases, is a combination of extensive surgery and postoperative radiotherapy.
- Conditions
- Head and Neck Cancer, Intraoperative Complications, Coagulation Disorder, Blood, Vitamin K Deficiency
- Trial name
- MVL-COAG (NCT04517461)
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Region Skane
Gastrointestinal Cancer
Endoscopic Nebulizing Device for Surgical Haemostatic-sealant Glubran® 2 Usability Trial in EMR and ESD
The aim of this single-center study is to evaluate the feasibility of the technique, usability and safety of the device ENDONEB.
- Trial name
- NCT06588881
- Testing
- nebulized application of the haemostatic surgical sealant after gastrointestinal endoscopic resection
- Where
- Italy
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- GEM SRL
Congenital Heart Disease
Platelets or Fibrinogen as First-line Treatment for Bleeding During Pedatric Heart Surgery
The study aims to test whether platelet transfusion or fibrinogen concentrate is the most effective treatment of intraoperative bleeding, when performing open heart surgery with cardiopulmonary bypass on children with congenital…
- Trial name
- NCT04807621
- Testing
- Platelet transfusion, Fibrinogen concentrate
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Sahlgrenska University Hospital
Noonan Syndrome
Link Between Abnormal Bleeding and Coagulation Disorders in Noonan Syndromes
Noonan syndrome is a relatively rare genetic disorder, affecting around 1 in every 1,000 to 2,500 children born. Patients often have a tendency to bleed more easily, particularly from the skin or mucocutaneous tissue (such as…
- Trial name
- PlatNoon (NCT07259135)
- Testing
- Reuse of routine clinical and biological data
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Bordeaux
Hip Fractures, Anticoagulants and Bleeding Disorders
Caudal Block & Hip Fracture Surgery in Anticoagulated Patient
Hip fractures are common in elderly patients, and require surgery. Many elderly patients take anticoagulants for vasculopathy treatment.
- Trial name
- NCT05946863
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Salem Anaesthesia Pain Clinic
Endodontic Infection, Periapical Diseases
The Effect of Different Hemostatic Agents on Hemorrhage Control, Pain and Quality of Life After Endodontic Microsurgery.
Background This randomized clinical trial evaluated the effect of two different hemostatic materials for endodontic microsurgery on bleeding control, postoperative pain and patients' quality of life.
- Trial name
- NCT07311291
- Testing
- Hemostatic Agent 1: Surgical glue (IfaBond, Dipromed, Italy), Hemostatic Agent 2: Ferric sulfate
- Where
- Italy
- Volunteers
- 34 people
- Sponsor
- University of Turin, Italy
Seroma
Evaluation of a Hemostatic and Sealing Agent to Prevent Surgical Complications After Axillary Lymphadenectomy
This study was intended to assess the value of a hemostatic and sealing agent, a collagen sponge coated with human coagulation factors (fibrinogen and thrombin) (TachoSil®), for decreasing occurrence of seroma after axillary…
- Trial name
- NCT00852826
- Testing
- Standard axillary lymphadenectomy, Collagen sponge coated with human coagulation factors
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Hospital Universitario Virgen de la Arrixaca
Palate; Wound
Palatal Donor Site Wound Healing Following Periodontal Plastic Surgery Using Amnion-Chorion Membrane
The purpose of this clinical trial is to assess if donor site healing in the palatal area and patient pain perception are similar or different when using amnio-chorion membrane (ACM) on the donor site after surgery compared to a…
- Trial name
- NCT05927714
- Testing
- Amnion-chorion Membrane, ActCel Cellulose Gauze
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Surgery
Effect of Prostacyclin on Haemostasis in Abdominal Surgery
The purpose of this study is to investigate the effect of continuous perioperative infusion of prostacyclin on haemostasis and endothelial functionality in patients undergoing major abdominal surgery.
- Trial name
- NCT01528943
- Testing
- Prostacycline, Isotonic saline
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Hemostasis, Surgical Blood Loss
Hemocoll, Avitene, or Bone Wax for Cancellous Bone Bleeding After Single-Ray Amputation
This is a multicentre, prospective, three-arm, parallel-group randomized controlled superiority trial evaluating fibrillar Type-I collagen haemostat (Hemocoll®) FTC, Avitene™ Microfibrillar Collagen Hemostat (MCH), and…
- Conditions
- Hemostasis, Surgical Blood Loss, Amputation Stump, Hemorrhage
- Trial name
- CANHAEM-Ray (NCT07788846)
- Testing
- Hemocoll® Fibrillar type-I collagen haemostat, Bone wax, Avitene™ Microfibrillar Collagen Hemostat
- Where
- 3 sites in India
- Volunteers
- 135 people
- Sponsor
- Adichunchanagiri Institute of Medical Sciences, B G Nagara
Hemorrhage, Cardiopulmonary Bypass
Management of Bleeding Following Cardiopulmonary Bypass
We believe ongoing bleeding during complex cardiac surgery can be accurately measured and that administration of a specific blood product replacement strategy designed to optimally slow or stop the bleeding can be followed by the…
- Trial name
- NCT00672516
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- University of Minnesota
Knee Replacement Surgery, Osteoarthritis
Efficacy and Safety of FLOSEAL for Hemostasis in Total Knee Arthroplasty
The purpose of this study is to compare the efficacy and safety of FLOSEAL to standard of care for hemostasis in subjects undergoing total knee arthroplasty.
- Trial name
- NCT01410240
- Testing
- Standard of Care, FLOSEAL Hemostatic Matrix + Standard of care
- Where
- 12 sites in United States
- Volunteers
- 137 people
- Sponsor
- Baxter Healthcare Corporation
Postoperative Pain
RADA16 for Adult Tonsillectomy
The purpose of the research is to determine if RADA16 (also known as PuraStat®, PuraGel®, or PuraSinus®) improves patient outcomes following tonsillectomy procedures.
- Trial name
- NCT07060495
- Testing
- RADA16 hydrogel
- Where
- 2 sites in United States
- Volunteers
- 134 people
- Sponsor
- Rutgers, The State University of New Jersey