Clinical trials: Heparin
Left Sided Heart Failure, Left Ventricular Assist Device
Ventricular Assist Device Anti-Factor Xa (VAD ANTIX) Monitoring Study: a Prospective Randomized Feasibility Trial
This study evaluates two different methods for monitoring a patient's anti-clotting [heparin] therapy after they receive a heart pump implant [left ventricular assist device -LVAD].
- Conditions
- Left Sided Heart Failure, Left Ventricular Assist Device, Anticoagulant Therapy, Gastro Intestinal Bleeding
- Trial name
- VAD-ANTIX (NCT03143569)
- Testing
- aPTT guided heparin management, Anti-factor Xa guided heparin management
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Washington University School of Medicine
Heparin-induced Thrombocytopenia
Immunogenetics of Heparin-Induced Thrombocytopenia: Aim 2
The purpose of this research is to identify genomic markers that can predict heparin-induced thrombocytopenia (HIT), which is a very serious side effect to heparin.
- Trial name
- NCT02526485
- Testing
- Blood Draw
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Vanderbilt University Medical Center
Heparin-Induced Thrombocytopenia
Fondaparinux for the Treatment of Heparin-Induced Thrombocytopenia (HIT)
The purpose of this study is to determine how safe and effective fondaparinux is in treating patients with suspected or confirmed heparin-induced thrombocytopenia (HIT).
- Trial name
- NCT00673439
- Testing
- fondaparinux, warfarin
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Louisville
Heparin
Study With Heparin Sodium in Intravenous Administration
The purpose of this phase I study is to know the pharmacodynamic profile in in intravenous application in humans of the sodium heparin of porcine origin of the company União Química, building from the pharmacodynamic data…
- Trial name
- NCT03125187
- Testing
- Sodium heparin UQ Intravenous drug administration, Sodium heparin FK Intravenous drug administration
- Where
- Brazil
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- União Química Farmacêutica Nacional S/A
Heparin
Study With Heparin Sodium in Subcutaneous Administration
The purpose of this phase I study is to know the pharmacodynamic profile in humans of the sodium heparin of porcine origin of the company União Química, building from the pharmacodynamic data generated its pharmacokinetic…
- Trial name
- NCT03113084
- Testing
- Sodium Heparin UQ subcutaneous drug administration, Sodium Heparin FK subcutaneous drug administration
- Where
- Brazil
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- União Química Farmacêutica Nacional S/A
Unfractionated Heparin, Cardiopulmonary Bypass Surgery
Haemostatic Markers in Cardiopulmonary Bypass
This study is to understand the changes occurring in a blood clotting protein, von Willebrand factor (VWF), in patients undergoing cardiac surgery who receive the blood thinner called Heparin.
- Trial name
- NCT03861286
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Imperial College London
Heparin-Induced Thrombocytopenia
Fondaparinux in Patients With Acute Heparin-Induced Thrombocytopenia (HIT)
The purpose of this study is to test the safety and efficacy of fondaparinux in patients with heparin-induced thrombocytopenia (HIT).
- Trial name
- NCT00603824
- Testing
- fondaparinux, argatroban or lepirudin
- Sponsor
- Methodist Healthcare - Memphis
Heparin-induced Thrombocytopenia
Prognosis Related to Induced Thrombopenia With Heparin Under Venoarterial ECMO in Reanimation
Thrombocytopenia is a frequent and serious adverse event in patients treated with veno-arterial extracorporeal membrane oxygenation (VA-ECMO) for refractory cardiogenic shock.
- Trial name
- TIH ECMO (NCT03979625)
- Testing
- Hospitalization for more than 3 days with high clinical suspicion of HIT and positive anti-PF4/heparin antibodies
- Volunteers
- 39 people
- Sponsor
- Central Hospital, Nancy, France
Gynecologic Neoplasms, Venous Thromboembolism
Thromboprophylaxis After Surgery for Gynecologic Malignancy in China
Venous thromboembolism (VTE) is an important cause of post-operative morbidity and mortality in women undergoing surgery for gynecologic malignancies.
- Conditions
- Gynecologic Neoplasms, Venous Thromboembolism, Low Molecular Weight Heparin, Argatroban
- Trial name
- NCT02935530
- Testing
- s-LMWH, LMWH, Argatroban
- Where
- China
- Volunteers
- 315 people
- Sponsor
- Huazhong University of Science and Technology
Heparin Causing Adverse Effects in Therapeutic Use, Heparin-induced Thrombosis
Study on Continuous Intravenous of Unfractionated Heparin (UFH) to Treat Progressive Cerebral Infarction
A clinical trial to study the effects of dosage, infusion methods and complications of unfractionated heparin (UFH) treating acute progressive cerebral infraction was conducted.
- Conditions
- Heparin Causing Adverse Effects in Therapeutic Use, Heparin-induced Thrombosis, Acute Cerebral Ischemia
- Trial name
- UHPCI (NCT01378000)
- Where
- China
- Volunteers
- 480 people
- Sponsor
- Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine
Heparin-induced Thrombocytopenia
Multi-Center Single Arm Trial to Determine The Effectiveness of Warfarin Therapy Duration For Heparin-Induced Thrombocytopenia (HIT)
Multi-Center Single Arm Trial to Determine The Effectiveness of Warfarin Therapy Duration For Heparin-Induced Thrombocytopenia (HIT)
- Trial name
- HIT (NCT03147638)
- Testing
- Warfarin, NOAC
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Marshall University
Hemodialysis, Citrate
The Effect of Citrate Dialysate on Clot Formation and Anemia in Hemodialysis Patients
Acetate-free citrate containing dialysate is expected to be clinically effective in maintaining hemodynamic stability during hemodialysis (HD).
- Conditions
- Hemodialysis, Citrate, Heparin
- Trial name
- NCT03470727
- Testing
- Citrate dialysate
- Where
- Thailand
- Volunteers
- 60 people
- Sponsor
- Bangkok Metropolitan Administration Medical College and Vajira Hospital
Coronary Artery Bypass Graft Surgery, Presence of Heparin/Platelet Factor 4 Antibody
Significance of Antibodies to Heparin/Platelet Factor 4 Complex in Vein Graft Patency and Potential Role of Argatroban for Prevention of Vein Graft Occlusion
Heparin/Platelet Factor 4 (PF4) antibody testing will be performed in subjects who have just undergone coronary artery bypass grafting (CABG) surgery.
- Trial name
- NCT01246011
- Testing
- Argatroban and warfarin
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Massachusetts General Hospital
Achievement of a Sufficient Thrombosis Prohpylaxis in Clitically Ill Patients With Heparin Resistance
Argatroban in Critically Ill Patients With Heparin Resistance
Critically ill patients with high risk for thrombosis or tromboembolic events with the presence of heparin resistance, treated at the Department for General and Surgical Critical Care Medicine of the Medical University Innsbruck…
- Trial name
- NCT01734252
- Testing
- Argatroban
- Where
- Austria
- Volunteers
- 44 people
- Sponsor
- Medical University Innsbruck
Cardiac Surgery, Bleeding
Adjusted Calculation of Heparin and Protamin Dosing and Correlation With Postoperative Bleeding and Transfusions
The study will compare a novel calculation model (HeProCalc AB) with a standard weight-based and activated clotting time adjusted calculation for the dosing of Heparin and protamine and assess the impact on postoperative bleeding…
- Conditions
- Cardiac Surgery, Bleeding, Transfusion, Protamine Sulfate
- Trial name
- NCT02785575
- Testing
- HeProCalc algorithm
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Karolinska University Hospital
Heparin-Induced Thrombocytopenia, Thrombosis
Thrombotic Biomarkers to Predict Thrombosis in Heparin-induced Thrombocytopenia
Heparin induced thrombocytopenia (HIT) is a kind of catastrophic thrombotic complications after the application of heparin. If HIT without treatment, death rate is as high as 30% to 50%.
- Conditions
- Heparin-Induced Thrombocytopenia, Thrombosis, Biomarkers
- Trial name
- NCT03269019
- Testing
- HIT with thrombosis
- Volunteers
- 200 people
- Sponsor
- Wuhan Asia Heart Hospital
Acute HIT II (Heparin-induced Thrombocytopenia Type II)
Retrospective Registry of Patients With Acute Heparin-induced Thrombocytopenia Type II
The purpose of this retrospective registry is to collect data about patients with acute HIT II (Heparin-induced Thrombocytopenia type II) which were treated with Lepirudin, Danaparoid, Argatroban or Fondaparinux.
- Trial name
- NCT01304238
- Testing
- lepirudin, danaparoid, argatroban
- Volunteers
- 195 people
- Sponsor
- GlaxoSmithKline
Heparin, Heparin Overdose
The Effect of Heparinization Due to LBW
High dose heparin regimens are required in cardiac surgery under cardiopulmonary bypass (CPB) and this may increase postoperative bleeding.
- Conditions
- Heparin, Heparin Overdose, Bleeding
- Trial name
- LBWH (NCT03113708)
- Testing
- Heparin Sodium
- Volunteers
- 50 people
- Sponsor
- Adiyaman University Research Hospital
Cardiopulmonary Bypass, Altered Heparin Response
Understanding "Heparin Resistance" in Cardiac Surgery
This study will explore altered heparin responsiveness (AHR) in cardiac surgical patients undergoing cardiopulmonary bypass (CPB) requiring systemic anticoagulation with heparin.
- Trial name
- NCT01598883
- Testing
- Heparin, ATryn
- Where
- United States
- Volunteers
- 504 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Infertility, Low Molecular Weight Heparin
Weight Adjusted Low Molecular Weight Heparin in Recurrent Implantation Failure: a Randomized Open Labeled Trial
Prospective randomized study of patients with infertility candidates to Assisted ReproductiveTechniques (ART), screened for all inclusion and exclusion criteria, submitted to ART cycle with or without low molecular weight heparin…
- Trial name
- NCT02991950
- Testing
- Parnaparin Sodium
- Volunteers
- 271 people
- Sponsor
- Istituto Clinico Humanitas