Clinical trials: Hepatic
Mild Hepatic Dysfunction, Moderate Hepatic Dysfunction
Pharmacokinetics Of Orally Administered Fx-1006A In Subjects With Hepatic Dysfunction
This is a Phase I, open-label, single-dose study designed to assess the effects of hepatic dysfunction on the PK of orally administered Fx-1006A 20 mg soft gelatin capsules. An adaptive 2-stage study design will be implemented.
- Trial name
- NCT01358565
- Testing
- Fx-1006A
- Where
- South Africa
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Pfizer
Malignant Biliary Tract Tumors
A Prospective, Open-Label, Randomized Controlled Clinical Study Comparing Hepatic Arterial Infusion Chemotherapy (HAIC) With Capecitabine as Adjuvant Therapy After Radical Surgery for Malignant Biliary Tract Tumors
3. Study Design 3.1.1 Study Site and Overall Population Overview This study is a prospective, open-label, randomized controlled clinical trial designed to observe and evaluate the efficacy and safety of hepatic arterial infusion…
- Trial name
- NCT07790445
- Testing
- Oxaliplatin + 5-Fluorouracil/Leucovorin, Capecitabine
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Zhai Wenlong
Alcohol Related Disorders
Hepatic Function During and Following Three Days of Acetaminophen Dosing in Alcoholics
The study objective was to determine whether liver injury develops in alcoholic patients who ingest therapeutic doses of APAP for three consecutive days.
- Trial name
- NCT00402571
- Testing
- acetaminophen
- Where
- 2 sites in United States
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- Denver Health and Hospital Authority
Portal Vein, Cavernous Transformation Of, Hypertension, Portal
Interventional Radiology for the Treatment of Symptomatic Portal Hypertension in Patients With Cavernous Transformation of Portal Vein
To evaluate the values of portosystemic shunt and other interventional radiology approaches for treatment of symptomatic portal hypertension in patients with cavernous transformation of portal vein.
- Trial name
- NCT02504034
- Testing
- Transhepatic portosystemic shunt, 6-French sheath, 22-gauge chiba needle
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Sun Yat-sen University
HBV, Hepatitis B
Evaluating the Effects of Inarigivir on Immune Response and Viral Markers in Chronic Hepatitis B Patients
A single center, open-label, study to evaluate the intra-hepatic effect of inarigivir dose per day and three times per week on immune response and viral markers in virally suppressed patients with chronic hepatitis B infection
- Conditions
- HBV, Hepatitis B, Hepatitis B, Chronic
- Trial name
- NCT03932513
- Testing
- inarigivir soproxil
- Where
- Singapore
- Volunteers
- 8 people
- Sponsor
- F-star Therapeutics, Inc.
Liver Neoplasms
Clinical Study of Targeted Cryoablation Therapy in the Treatment of Hepatic Carcinoma
The purpose of this study is to evaluate the safety and efficacy of targeted cryoablation therapy for hepatic carcinoma.
- Trial name
- NCT02969096
- Testing
- Targeted Cryoablation Therapy
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shanghai University of Traditional Chinese Medicine
Portal Hypertension Gastropathy, Esophageal Varices
Study on B-blockers to Prevent Decompensation of Cirrhosis With HTPortal
This is a multicenter, randomized, double-blind, placebo-controlled study on the effectiveness of treatment with beta-blockers to prevent decompensation of cirrhosis with portal hypertension.
- Conditions
- Portal Hypertension Gastropathy, Esophageal Varices, Spontaneous Bacterial Peritonitis, Hepatic Encephalopathy
- Trial name
- PREDESCI (NCT01059396)
- Testing
- propranolol, carvedilol
- Where
- 8 sites in Spain
- Volunteers
- 201 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Hepatic Impairment
Study of Single-dose DS-3201b in Participants With Hepatic Impairment
This is a Phase 1, open-label, parallel design, single-dose pharmacokinetic (PK) study to assess the safety, tolerability, and PK of a single dose of 50 mg of DS-3201b in participants with normal and impaired hepatic function.
- Trial name
- NCT04276662
- Testing
- DS-3201b
- Where
- 3 sites in United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Daiichi Sankyo
Ascites Hepatic, Cirrhosis, Liver
SGLT-2 Inhibitors in the Treatment of Ascites
The goal of this observational study is to test the efficacy of glyphozines (SGLT-2 inhibitors) in the control of ascites in patients with liver cirrhosis in class A6-B9, according to the Child-Pugh classification, and type 2…
- Conditions
- Ascites Hepatic, Cirrhosis, Liver, Diabete Type 2
- Trial name
- NCT05999773
- Testing
- SGLT2 inhibitor
- Where
- 2 sites in Italy
- Volunteers
- 40 people
- Sponsor
- University of Palermo
Liver Cirrhoses
Preoperative Portal and Splanchnic Flow Measurement Using MRI
This study aims to assess the alteration of portal and splanchnic flow using MRI after liver transplantation in patients with splenomegaly or splenic varix.
- Trial name
- NCT03868397
- Testing
- Liver MRI
- Where
- South Korea
- Volunteers
- 12 people
- Sponsor
- Seoul National University Hospital
Liver Cirrhosis, Ascites Hepatic
Fresh Frozen Plasma as a Substitute for Albumin in Patients Receiving a Large Volume Paracentesis
Large volume paracentesis with albumin administration is the standard of care for patients with refractory ascites complicating end-stage liver disease.
- Trial name
- NCT03202524
- Testing
- Fresh Frozen Plasma (FFP), Albumin
- Sponsor
- Montefiore Medical Center
Foot Ulcer, Diabetic Foot
EZCast-DFU Study With Portal for Application of Topical Medications
This study is designed to evaluate the ability to modify a contact cast system so that topical medications can be applied daily to an underlying wound in patients with diabetic plantar ulcers.
- Trial name
- EZCast-DFU (NCT02131961)
- Testing
- Collagenase ointment, Modified Contact Cast System
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Miami
Non-alcoholic Fatty-liver Disease
Effects of Dietary Fructose Reduction in Children With Hepatic Steatosis
Primary Objectives: 1. To determine whether a 4 week reduction in dietary fructose intake improves hepatic steatosis in overweight children who have a baseline high fructose consumption and hepatic steatosis. 2.
- Trial name
- Sweet Bev (NCT01188083)
- Testing
- Fructose Drink, Glucose Drink
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Emory University
Hepatocellular Carcinoma
The LC Bead Trial; Transarterial Chemoembolization of Hepatocellular Carcinoma (HCC)With a Drug-eluting Bead
This study involves the combined use of the FDA approved device, LC Bead and the FDA approved drug, Doxorubicin for the treatment of primary hepatocellular carcinoma (HCC).
- Trial name
- NCT01259024
- Testing
- transarterial chemoembolization using a drug-eluting bead
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Healthy
Sallie Life U Feasibility Study
This feasibility trial explored the usability of the patient-driven chiropractic patient portal, Sallie™ Life U. The study aimed to recruit 30 participants to track their daily symptoms, triggers, and habits over 30 days while…
- Trial name
- SLU (NCT06812897)
- Testing
- Sallie (TM) Life U
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Life University
Colorectal Cancer
Postoperative Hepatic Arterial Chemotherapy in High-risk Patients as Adjuvant Treatment After Resection of Colorectal Liver Metastases
Currently, no adjuvant study with hepatic arterial infusion in the adjuvant setting is opened. Recently, the results of a phase II study (NCT00268463, NSABP-C-09) assessing the potential benefit of systemic oxaliplatin and…
- Trial name
- PACHA-01 (NCT02494973)
- Testing
- Oxaliplatin HAI, Oxaliplatin IV, mFOLFOX6
- Where
- France
- Volunteers
- 104 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Thrombosis of Portal Venous System.
Evaluation of Portal Venous System Thrombosis After Blunt Splenic Trauma Utilizing Doppler Ultrasound
The true incidence of thrombosis in the portal venous system after blunt splenic trauma is unknown and has not been elucidated in the medical literature.
- Trial name
- NCT01906983
- Testing
- Doppler Ultrasound
- Where
- Israel
- Volunteers
- 80 people
- Sponsor
- Rambam Health Care Campus
Hepatic Tumor
Multicenter Study to Evaluate a New Robotic Device for Image-guided Percutaneous Needle Placement
This study evaluates the safety and performance of a new robotic device in the treatment of hepatic thermoablation in adults. The new robotic device will be used in all patients.
- Trial name
- NCT04230642
- Testing
- The Quantum Surgical device
- Where
- 2 sites in France
- Volunteers
- 22 people
- Sponsor
- Quantum Surgical
Adult Primary Hepatocellular Carcinoma, Advanced Adult Primary Liver Cancer
Erlotinib in Treating Patients With Unresectable Liver Cancer and Liver Dysfunction
Phase I trial to study the effectiveness of erlotinib in treating patients who have unresectable liver cancer and liver dysfunction.
- Conditions
- Adult Primary Hepatocellular Carcinoma, Advanced Adult Primary Liver Cancer, Localized Unresectable Adult Primary Liver Cancer, Recurrent Adult Primary Liver Cancer
- Trial name
- NCT00047346
- Testing
- erlotinib hydrochloride, pharmacological study, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- National Cancer Institute (NCI)
Lymphoma
Revlimid® Capsules Drug Use-results Surveillance (Relapsed or Refractory ATLL)
To understand the safety and efficacy of Revlimid® Capsules 2.5 mg and 5 mg (hereinafter referred to as Revlimid) under actual conditions of use in patients with relapsed or refractory adult T-cell leukemia lymphoma (hereinafter…
- Trial name
- NCT03098589
- Testing
- Revlimid
- Where
- Japan
- Volunteers
- 1,149 people
- Sponsor
- Celgene