Clinical trials: Hepatic
Liver Blood Supply
3T MR Angiography of the Hepatic Vasculature
This study plans to learn more about the two Magnetic Resonance Angiography (MRA) techniques.
- Trial name
- NCT02299934
- Testing
- Magnetic Resonance Imaging (MRI), Compurtized Tomgraphy (CT)
- Volunteers
- 13 people
- Sponsor
- University of Colorado, Denver
Moderate Hepatic Impairment, Severe Hepatic Impairment
A Study to Learn About the Study Medicine (Called Lorlatinib) in People With Liver Dysfunction
The purpose of this clinical trial is to learn about the safety and effects of the study medicine (called Lorlatinib) in health participants.
- Conditions
- Moderate Hepatic Impairment, Severe Hepatic Impairment, Healthy Volunteers
- Trial name
- NCT05224609
- Testing
- Lorlatinib
- Where
- 3 sites in United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Pfizer
Hepatic Failure
Study To Evaluate The Pharmacokinetics, Safety, And Tolerability Of Dimebon [Pf-01913539] In Subjects With Hepatic Impairment And Normal Hepatic Function
1. To compare the pharmacokinetics of Dimebon in subjects with mild and moderate hepatic impairment to subjects with normal hepatic function. 2.
- Trial name
- NCT00831532
- Testing
- Dimebon
- Where
- 2 sites in United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Pfizer
Surgery--Complications, Congestive Heart Failure
The Clinical Significance of Portal Hypertension After Cardiac Surgery: a Multicenter Prospective Observational Study
Portal flow pulsatility detected by Doppler ultrasound is an echographic marker of cardiogenic portal hypertension from right ventricular failure and is associated with adverse outcomes based on previous studies performed at the…
- Conditions
- Surgery--Complications, Congestive Heart Failure, Right Heart Failure, Anesthesia
- Trial name
- TECHNO-MULTI (NCT03656263)
- Testing
- Doppler assessment of portal vein flow
- Where
- Canada
- Volunteers
- 360 people
- Sponsor
- Montreal Heart Institute
Diabetes Mellitus, Type 2
My Diabetes Care Mobile: A Usability Study
The purpose of this study is to conduct a prospective, longitudinal study on the My Diabetes Care mobile (MDC-m) intervention to assess usage patterns, user experience, and to uncover errors in functionality prior to a larger…
- Trial name
- NCT04894916
- Testing
- My Diabetes Care Mobile (MDC-m)
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Vanderbilt University Medical Center
Hepatobiliary Cancer, Pancreatic Cancer
Impact of Comprehensive Geriatric Management on Morbidity and Quality of Life in Elderly Patients Undergoing Major Hepatectomy and Pancreaticoduodenectomy for Cancer
The worldwide incidence of hepatobiliary and pancreatic (HPB) cancers is dramatically increasing especially for pancreatic cancer. Increasing age is associated with increased cancer risk.
- Trial name
- HPB70+ (NCT06999512)
- Testing
- Comprehensive Geriatric Assessment
- Where
- 12 sites in France
- Volunteers
- 526 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Neuroendocrine Tumors
Pasireotide, Everolimus and Selective Internal Radioembolization Therapy for Unresectable Hepatic Metastases
The purpose of this study is to see the safety and activity of using pasireotide, everolimus and radioembolization (Selective Internal Radioembolization Therapy-SIRT) in the treatment of neuroendocrine tumors (carcinoid) that has…
- Trial name
- NCT01469572
- Testing
- Pasireotide, Sir-sphere Radioembolization, Everolimus
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Emory University
Biliary Tract Cancer
Covered Versus Uncovered Biliary Stents for Biliary Malignancies
Patency duration of covered metal stents as compared with uncovered metal stents in the management of malignant strictures of the extra-hepatic biliary tree.
- Trial name
- NCT02102984
- Testing
- covered biliary stents, uncovered biliary stents
- Where
- Italy
- Volunteers
- 140 people
- Sponsor
- Nuovo Ospedale Civile S.Agostino Estense
Chronic Pain
Evaluating a Virtual Stepped Care Portal in Youth Awaiting Tertiary Chronic Pain Care: An Implementation-Effectiveness Hybrid Type III Study
Pain is one of the most common symptoms of extreme stress in youth. Without treatment, short-term pain can last for months to years (called 'chronic pain'; CP), a problem already affecting 1 in 5 Canadian youth.
- Trial name
- NCT05894772
- Testing
- Power over Pain Portal
- Where
- 11 sites in Canada
- Volunteers
- 93 people
- Sponsor
- The Hospital for Sick Children
Cirrhosis, Liver, Sarcopenia
Body Composition Changes After TIPS and Associated Clinical Outcomes
The purpose of this study is to prospectively assess the impact of TIPS creation on muscle mass and physical function in patients with cirrhosis, and to determine whether these changes correlate with improved outcomes in patients…
- Trial name
- NCT05420753
- Testing
- Transjugular Intrahepatic Portosystemic Shunt (TIPS) creation
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Oregon Health and Science University
Hepatic Steatosis, Symptoms and Signs
A Clinical Trial of Chazhu Xiaozhi Decoction Against Non-alcoholic Fatty Liver Disease
The goal of this clinical trial is to learn if drug Chazhu Xiaozhi decoction works to treat non-alcoholic fatty liver disease in adults. It will also learn about the safety of drug Chazhu Xiaozhi decoction.
- Trial name
- NCT06442137
- Testing
- Chazhu Xiaozhi decoction
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Shanghai Municipal Hospital of Traditional Chinese Medicine
Hepatic Carcinoma
Huaier Granule for Prevention of Recurrence and Metastasis of Hepatocarcinoma After Radical Hepatectomy
To evaluate the efficacy and safety of Huaier Granule for prevention of recurrence and metastasis of hepatocarcinoma after radical hepatectomy.
- Trial name
- NCT01770431
- Testing
- Huaier Granule
- Where
- China
- Volunteers
- 1,044 people
- Sponsor
- Qidong Gaitianli Medicines Co., Ltd
Liver Cancer
HAIC Sequential TAE Combined With Lenvatinib and Tislelizumab in Unresectable HCC
Patients with unresectable hepatocellular carcinoma will receive hepatic arterial infusion chemotherapy (HAIC) sequential transarterial embolization combined with lenvatinib and tislelizumab.
- Trial name
- FRONT-1 (NCT05532319)
- Testing
- HAIC sequential TAE combined with lenvatinib and tislelizumab
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Guangxi Medical University
Bowel Obstruction Small
Diagnostic Performance of Arterial Time for CT Assessment of Parietal Enhancement Defect for the Diagnosis of Ischemia in Mechanical Small Bowel Occlusions: a Comparative Study With Portal Time
Intestinal obstruction is a frequent cause of emergency room visits and represents about 4-7% of the causes of acute abdominal pain syndrome and up to 30% in adults over 60 years old.
- Trial name
- PORTOGRELE (NCT04880421)
- Where
- France
- Volunteers
- 158 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Hepatic Impairment
A Study of LCZ696 in Subjects With Mild and Moderate Hepatic Impairment Compared With Normal Healthy Volunteers
This is a study to characterize the pharmacokinetics as well as safety and tolerability of a single oral dose of LCZ696 200 mg in subjects with mild and moderate hepatic impairment compared to matched healthy subjects
- Trial name
- NCT01621633
- Testing
- LCZ696
- Where
- Germany
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
Non Small Cell Lung Cancer
Multiple-portal VATS Versus Uniportal VATS Lobectomy for Non-small Cell Lung Cancer
This study evaluate multiple-portal VATS and uniportal VATS lobectomy for NSCLC, half of participants will receive multiple VATS, while the other half will receive uniportal VATS lobectomy.
- Trial name
- MVUVLC (NCT02462356)
- Testing
- Uniportal VATS, Conventional VATS
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Cirrhosis, Portal Hypertension
Body-weight Reduction Effect on Portal Hypertension in Compensated Cirrhosis
Obesity and metabolic abnormalities accelerate decompensation in compensated cirrhosis, driven by clinically significant portal hypertension (CSPH, HVPG≥10 mmHg).
- Conditions
- Cirrhosis, Portal Hypertension, Fatty Liver Disease, GLP-1
- Trial name
- B-REACH (NCT07797101)
- Testing
- Mazdutide injection
- Volunteers
- 50 people
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University
Hepatitis C, Liver Diseases
Electronic Record Assimilation and Subsequent Eradication of Hepatitis C
Given the disproportionately high risk of chronic hepatitis C virus (HCV) infection in the baby boomer cohort, population-based screening has been demonstrated cost effective.
- Trial name
- ERASE-C (NCT04873609)
- Testing
- Patient portal message
- Where
- United States
- Volunteers
- 1,600 people
- Sponsor
- Stanford University
Hepatic Impairment
Pharmacokinetics of Sotorasib in Healthy Participants and Participants With Moderate or Severe Hepatic Impairment
The main purpose of the study is to evaluate the pharmacokinetics (PK) of a single oral dose of sotorasib administered in participants with moderate or severe hepatic impairment compared to participants with normal hepatic…
- Trial name
- NCT04887064
- Testing
- Sotorasib
- Where
- 5 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Amgen
Lumbar Spinal Stenosis
Endoscopic Decompression Versus Microscopic Decompression in Lumbar Canal Stenosis
To compare between the clinical and surgical efficacies of bi-portal endoscopic and microscopic decompressive laminectomy in patients with degenerative lumbar spinal stenosis.
- Trial name
- NCT06381167
- Testing
- Endoscopic Decompressive Laminectomy
- Volunteers
- 52 people
- Sponsor
- Assiut University