Clinical trials: Hepatic Chemotherapy
Cholangiocarcinoma
Efficacy Study of Intra-hepatic Administration of Therasphere® in Association With Intravenous Chemotherapy to Treat Cholangiocarcinoma
The purpose of this study is to assess efficacy and tolerance of intra-hepatic administration of Yttrium 90-labelled microsphere (Theraspheres®, Nordion) in association with intravenous chemotherapy with Gemcitabin and Cisplatin…
- Trial name
- MispheC (NCT01912053)
- Testing
- Therasphere® in association with Gemcitabine and Cisplatin
- Where
- 7 sites in France
- Volunteers
- 41 people
- Sponsor
- Center Eugene Marquis
Hepatocellular Carcinoma With PVTT
HAIC Combine Tislelizumab and Lenvatinib in the Treatment of HCC With Type IV (Vp4) Portal Vein Tumor Thrombus (HAI-TL)
To estimate the safety and efficacy of hepatic artery infusion chemotherapy (HAIC) combine Tislelizumab and Lenvatinib (HAI-TIS-LEN) in the Treatment of hepatocellular carcinoma (HCC) with type IV(Vp4) portal vein tumor thrombus…
- Trial name
- HAI-TL (NCT06210334)
- Testing
- Tislelizumab, Lenvatinib
- Where
- China
- Volunteers
- 54 people
- Sponsor
- Li Xiao Wei
Metastatic Colorectal Cancer
A Trial of Perioperative CV301 Vaccination in Combination With Nivolumab and Systemic Chemotherapy for Metastatic CRC
This is a multi-center Phase II randomized study. We plan to enroll 78 patients with biopsy-proven hepatic-limited metastatic colorectal cancer deemed resectable after multi-disciplinary discussion.
- Trial name
- NCT03547999
- Testing
- mFOLFOX6, MVA-BN-CV301, FPV-CV301
- Where
- 7 sites in United States
- Volunteers
- 17 people
- Sponsor
- Patrick Boland
Hepatocellular Carcinoma, Hepatic Chemotherapy
TACE Combined Surgery for the Resectable Huge HCC
Huge hepatocellular carcinoma (HCC) is defined as a tumor with a maximum diameter greater than 10 cm. With advancements in surgical techniques, hepatectomy can be performed safely in some patients with huge HCC without vascular…
- Conditions
- Hepatocellular Carcinoma, Hepatic Chemotherapy, Liver Cancer, Surgery
- Trial name
- NCT06898398
- Testing
- TACE, Surgery
- Where
- China
- Volunteers
- 326 people
- Sponsor
- Sun Yat-sen University
Intrahepatic Cholangiocarcinoma
HAIC Plus Targeted Therapy and/or PD-1 Inhibitors for Unresectable Intrahepatic Cholangiocarcinoma
Intrahepatic cholangiocarcinoma (ICC) is associated with poor prognosis. This study aims to explore the efficacy and safety FOLFOX-HAIC in combination with targeted therapy and/or PD-1 inhibitors for patients with initially…
- Trial name
- NCT05489692
- Testing
- hepatic arterial infusion chemotherapy (HAIC) of oxaliplatin, fluorouracil, and leucovorin (FOLFOX)
- Where
- China
- Volunteers
- 43 people
- Sponsor
- Sun Yat-sen University
Colorectal Cancer
Fruquintinib With or Without HAI-FOLFOX for Refractory Colorectal Cancer
The objective of this clinical trial is to evaluate the efficacy and safety of combining fruquintinib with hepatic artery infusion (HAI)-FOLFOX in the treatment of refractory colorectal cancer with liver metastasis.
- Trial name
- NCT06441565
- Testing
- Fruquintinib, Fluorouracil, Oxaliplatin
- Where
- China
- Volunteers
- 84 people
- Sponsor
- Sun Yat-sen University
Intrahepatic Cholangiocarcinoma, Chemotherapy Effect
HAI-Floxuridine, or SIRT, Combined With Gemox For Patients With Intra-Hepatic Cholangiocarcinoma Not Amenable to Resection (TOMCAT)
Patients with intrahepatic cholangiocarcinoma (IHC) have relatively aggressive tumors, and the prognosis for most of these patients is dismal.
- Trial name
- TOMCAT (NCT06313203)
- Testing
- Floxuridine, Selective Internal Radiation Therapy (SIRT)
- Where
- Norway
- Volunteers
- 39 people
- Sponsor
- Oslo University Hospital
Cancer
Chemotherapy Toxicity Reduction Via Urea Cycle Support
Patients undergoing bone marrow transplantation (BMT) and peripheral blood stem cell transplants (PBSCT) frequently develop organ dysfunctions, much of which may be initiated by damage to the liver and to cells lining blood…
- Trial name
- NCT00223730
- Testing
- Citrulline
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Vanderbilt University
Secondary Malignant Neoplasm of Liver
Computertomography-guided Wire Marking of the Liver
The aim of the study is to evaluate if it is possible to mark with a wire colorectal hepatic metastases after complete response to a neoadjuvant chemotherapy.Primary the investigators want to investigate if the wire marking is a…
- Trial name
- NCT01457599
- Testing
- Computertomography-guided marking of colorectal liver metastases
- Where
- Austria
- Volunteers
- 20 people
- Sponsor
- Medical University of Graz
Hepatocellular Carcinoma
Adjuvant Hepatic Arterial Infusional Chemotherapy After Curative Resection of Hepatocellular Carcinoma
Several adjuvant therapies have been attempted to reduce uni-centric, and intra- or extrahepatic recurrence after curative surgical resection for hepatocellular carcinoma (HCC).
- Trial name
- NCT01088581
- Testing
- Adjuvant group
- Where
- South Korea
- Volunteers
- 101 people
- Sponsor
- Yonsei University
Childhood Hepatocellular Carcinoma, Childhood Malignant Liver Neoplasm
Cisplatin and Combination Chemotherapy in Treating Children and Young Adults With Hepatoblastoma or Liver Cancer After Surgery
This partially randomized phase II/III trial studies how well, in combination with surgery, cisplatin and combination chemotherapy works in treating children and young adults with hepatoblastoma or hepatocellular carcinoma.
- Conditions
- Childhood Hepatocellular Carcinoma, Childhood Malignant Liver Neoplasm, Fibrolamellar Carcinoma, Hepatoblastoma
- Trial name
- NCT03533582
- Testing
- Biospecimen Collection, Carboplatin, Cisplatin
- Where
- 205 sites in United States, Australia and 4 more
- Volunteers
- 537 people
- Sponsor
- Children's Oncology Group
Colo-rectal Cancer, Liver Metastases
A Study of Systemic Chemotherapy With CPT-11 Plus HAI (FUDR+L-OHP) in Patients With Initially Unresectable CRCLM
The aim of the trial is to optimize response rates and rates of secondary resections of metastases in patients with initially non-resectable metastatic colorectal cancer Liver Metastasis.
- Trial name
- NCT03493061
- Testing
- Irinotecan, Oxaliplatin, Floxuridine
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Sun Yat-sen University
Solid Tumors
Tabectedin to Treat Children and Adolescents With Cancer
Background: Trabectedin is an experimental drug that kills some cancer cells in the laboratory and in mice by interfering with genetic material (DNA) in cancer cells.
- Trial name
- NCT01453283
- Testing
- Trabectedin (ecteinascidin-743, ET-743, YONDELIS [R])
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- National Cancer Institute (NCI)
Hepatocellular Carcinoma
Hepatic Artery Infusion Chemotherapy (HAIC) Plus Durvalumab for Advanced Hepatocellular Carcinoma
Hepatic artery infusion chemotherapy (HAIC) and anti-programmed cell death protein-1ligand (PD-L1) immunotherapy have shown promising outcomes in patients with advanced hepatocellular carcinoma (HCC), respectively.
- Trial name
- NCT04945720
- Testing
- Hepatic artery infusion chemotherapy（HAIC）, Durvalumab
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Sun Yat-sen University
Intrahepatic Cholangiocarcinoma
HAIC With FOLFOX Versus Systemic Chemotherapy With GP for Unresectable ICC
The purpose of this study is to evaluate the efficacy and safety of hepatic arterial infusion chemotherapy (HAIC) of oxaliplatin, 5-fluorouracil and leucovorin compared systemic chemotherapy of gemcitabine and cisplatin in…
- Trial name
- NCT04961970
- Testing
- oxaliplatin , fluorouracil, and leucovorin, gemcitabine and cisplatin
- Where
- China
- Volunteers
- 188 people
- Sponsor
- Shi Ming
Pancreatic Cancer, Metastasis
Chemotherapy and Surgical Resection in Patients With Hepatic Oligometastatic Adenocarcinoma of the Pancreas
This is an interventional, open-label, non-randomised, multicentre, single-arm phase II clinical trial. Eligible patients with hepatic oligometastatic adenocarcinoma of the pancreas will receive neoadjuvant combination…
- Conditions
- Pancreatic Cancer, Metastasis, Surgery, Oligometastatic Disease
- Trial name
- HOLIPANC (NCT04617457)
- Testing
- nal-irinotecan (nal-iri) (Onyvide), oxaliplatin (ox), 5-fluouracil (5-FU), folinic acid (FA)
- Where
- 11 sites in Germany
- Volunteers
- 150 people
- Sponsor
- University of Cologne
Hepatocellular Carcinoma (HCC)
A Two-Arm, Multicenter, Non-Randomized Controlled Study on the Efficacy of Yttrium-90 (Selective Internal Radiation Therapy) Therapy and Hepatic Arterial Infusion Chemotherapy (Hepatic Artery Infusion Chemotherapy) for Potentially Resectable Intermediate and Advanced Hepatocellular Carcinoma
The objective of this clinical trial is to compare the effects of yttrium-90 (SIRT) treatment and hepatic arterial perfusion chemotherapy (HAIC) on progression-free survival (PFS) in patients with potentially resectable HCC in…
- Trial name
- NCT07070076
- Testing
- Yttrium-90, HAIC
- Where
- China
- Volunteers
- 286 people
- Sponsor
- Li Qiang
Unresectable Intrahepatic Cholangiocarcinoma
A Trial of Systemic Chemotherapy in Combination With Conventional Transarterial Chemoembolization in Patients With Advanced Intra-Hepatic Cholangiocarcinoma
The study will be a single-center, single-arm, Phase II study of gemcitabine and cisplatin in combination with conventional trans-arterial chemoembolization therapy in adult patients with advanced ICC.
- Trial name
- NCT02994251
- Testing
- gemcitabine, Cisplatin, Conventional TACE (transarterial chemoembolization) with Doxorubicin/Mitomycin-C
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Yale University
Malignant Biliary Tract Tumors
A Prospective, Open-Label, Randomized Controlled Clinical Study Comparing Hepatic Arterial Infusion Chemotherapy (HAIC) With Capecitabine as Adjuvant Therapy After Radical Surgery for Malignant Biliary Tract Tumors
3. Study Design 3.1.1 Study Site and Overall Population Overview This study is a prospective, open-label, randomized controlled clinical trial designed to observe and evaluate the efficacy and safety of hepatic arterial infusion…
- Trial name
- NCT07790445
- Testing
- Oxaliplatin + 5-Fluorouracil/Leucovorin, Capecitabine
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Zhai Wenlong
Hepatocarcinoma
HAIC Combined With Anlotinib and TQB2450 as Adjuvant Therapy in HCC Patients With High Risk of Recurrence After Resection
This is a single center, non-randomized, open, multi-cohort clinical, exploratory Phase II study, to evaluate the efficacy and safety of HAIC combined with TQB2450 and anlotinib as adjuvant therapy in hepatocellular carcinoma…
- Trial name
- NCT05311319
- Testing
- HAIC+TQB2450+Anlotinib
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Fudan University