Clinical trials: Hepatic Cirrhosis
Cirrhosis, Periodontitis
Oral Gut Liver Axis in Cirrhosis
This will be a prospective study of cirrhotics and healthy controls comparing their oral microbiota, endotoxemia and systemic inflammation at baseline and at 30 days after clinically indicated systematic oral cleansing and…
- Conditions
- Cirrhosis, Periodontitis, Gingivitis
- Trial name
- NCT03030820
- Testing
- Dental Cleaning
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Hepatitis C, Chronic
A Study to Evaluate the Safety and Effect of Co-administration of ABT-450 With Ritonavir (ABT-450/r) and ABT-267 in Adults With Chronic Hepatitis C Virus Infection
The purpose of this study is to evaluate the safety and efficacy of co-administration of ABT-450 (also known as paritaprevir) with ritonavir (ABT-450/r) and ABT-267 (also known as ombitasvir) in adults with chronic hepatitis C…
- Trial name
- PEARL-I (NCT01685203)
- Testing
- ABT-450/r, ABT-267, Ribavirin (RBV)
- Volunteers
- 316 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Cirrhosis, Liver, Immune Suppression
S100A8/A9 and Innate Immunity in Liver Disease
This observational study evaluates the concentration of immune protein S100A8/A9 in different liver failure syndromes, its interaction with the immune system and validity as an immunotherapeutic target to improve survival in…
- Conditions
- Cirrhosis, Liver, Immune Suppression, Liver Failure, Acute on Chronic, Ascites Hepatic
- Trial name
- NCT05793983
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- St George's, University of London
Non-Alcoholic Fatty Liver Disease, Steatohepatitis, Nonalcoholic
Accuracy of Imaging Techniques in Diagnosing Steatohepatitis and Fibrosis in NAFLD Patients
Non-alcoholic fatty liver disease (NAFLD) is a highly prevalent condition, and when fatty liver is associated with inflammation and hepatocellular injury (steatohepatitis), it can lead to fibrosis, cirrhosis, liver failure and…
- Conditions
- Non-Alcoholic Fatty Liver Disease, Steatohepatitis, Nonalcoholic, Liver Fibroses
- Trial name
- ImagingNAFLD (NCT04785937)
- Testing
- Ultrasound and Magnetic Resonance
- Where
- Italy
- Volunteers
- 28 people
- Sponsor
- Azienda USL Reggio Emilia - IRCCS
Cirrhosis
Comparison of Standard Dose Versus Once a Day Intravenous Albumin in Spontaneous Bacterial Peritonitis
The standard recommended management of spontaneous bacterial peritonitis (SBP) includes a third-generation cephalosporin (cefotaxime or ceftriaxone) and high dose albumin (1.5g/kg on day 1 and 1g/kg on day 3).
- Trial name
- NCT02756741
- Testing
- ALBUMIN
- Volunteers
- 40 people
- Sponsor
- All India Institute of Medical Sciences
Cirrhosis With Esophageal Varices
To Compare the Efficacy and Safety of Carvedilol With or Without Simvastatin in Patients With Portal Hypertension and Esophageal Varices.
After successful screening of patients based on inclusion criteria, we will measure the baseline Hepatic Venous Pressure Gradient.
- Trial name
- NCT02465645
- Testing
- Carvedilol, Carvedilol + Simvastatin
- Where
- India
- Volunteers
- 220 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Cirrhotic Ascites
Phase II/III of Recombinant Human Serum Albumin
This is a randomized, double-blind, position-controlled, parallel group phase II/III clinical study of recombinant human serum albumin (rHSA) in cirrhotic ascites patients.
- Trial name
- NCT05858853
- Testing
- Recombinant Human Serum Albumin, Human serum albumin
- Where
- 25 sites in China
- Volunteers
- 92 people
- Sponsor
- Beijing Protgen Biotechnology Development Co., Ltd.
Liver Cirrhosis
Umbilical Cord Mesenchymal Stem Cells for Patients With Liver Cirrhosis
Liver cirrhosis (LC) represents a late stage of progressive hepatic fibrosis characterized by distortion of the hepatic architecture and formation of regenerative nodules.
- Trial name
- NCT01220492
- Testing
- conventional plus MSC treatment
- Where
- China
- Volunteers
- 266 people
- Sponsor
- Beijing 302 Hospital
Cirrhosis
EDUCATE-C: Education on Cirrhosis -- Assessing Text vs Video
A randomized controlled trial of written text vs video education to patients with cirrhosis.
- Trial name
- EDUCATE-C (NCT07216807)
- Testing
- Video Education, Text education
- Where
- United States
- Volunteers
- 218 people
- Sponsor
- University of Michigan
Hepatocellular Carcinoma, Liver Cancer
Comparison of Criteria for Liver Transplantation in Hepatocellular Carcinoma
Hepatocellular cancer is the 6th most common seen disease in the world and the 3rd in cancer-related deaths. Liver transplantation is the primary curative treatment of HCC, as it eliminates liver cancer and underlying cirrhosis.
- Conditions
- Hepatocellular Carcinoma, Liver Cancer, Advanced Adult Hepatocellular Carcinoma, Cirrhosis, Liver
- Trial name
- NCT04576572
- Where
- Turkey (Türkiye)
- Volunteers
- 424 people
- Sponsor
- Inonu University
Hepatocellular Carcinoma
A Dose Escalation Trial of Radiation Therapy (RT) for Hepatocellular Carcinoma (HCC)
Hepatocellular carcinoma (HCC) is one of the leading malignancies in Taiwan. Surgery and local ablative therapy remain the treatment of choice for curative purpose.
- Trial name
- NCT00960167
- Testing
- 3DCRT or IMRT
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- National Taiwan University Hospital
Primary Biliary Cholangitis
Open-Label Extension Study of Saroglitazar Magnesium in Participants With Primary Biliary Cholangitis
Open-Label Extension Study of Saroglitazar Magnesium in Participants With Primary Biliary Cholangitis
- Trial name
- NCT06427395
- Testing
- Saroglitazar Magnesium 1 mg
- Where
- 28 sites in United States, Argentina and 1 more
- Volunteers
- 102 people
- Sponsor
- Zydus Therapeutics Inc.
Hepatic Cirrhosis, Liver Fibrosis
A Study of Experimental Medication BMS-986036 in Adults With Nonalcoholic Steatohepatitis (NASH) and Liver Cirrhosis
This is a study of experimental medication BMS-986036 given to adults with Nonalcoholic Steatohepatitis (NASH; the buildup of fat and inflammation in the liver that is not caused by alcohol) and liver cirrhosis (liver damage…
- Conditions
- Hepatic Cirrhosis, Liver Fibrosis, Nonalcoholic Fatty Liver Disease (NAFLD), Nonalcoholic Steatohepatitis
- Trial name
- FALCON 2 (NCT03486912)
- Testing
- BMS-986036
- Where
- 91 sites in United States, Japan
- Volunteers
- 155 people
- Sponsor
- Bristol-Myers Squibb
Liver Cirrhosis, Coagulopathy
Management of Coagulopathy in Cirrhotic Patients Undergoing Invasive Procedures
Recently it has been acknowledged that cirrhotic patients present with "rebalanced hemostasis" that results from decreased levels of both pro-coagulant and anti-coagulant factors, that is not well reflected by conventional…
- Trial name
- NCT02987712
- Testing
- Thromboelastography based protocol
- Volunteers
- 120 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Portal Vein, Cavernous Transformation of, Portal Vein Thrombosis
TIPS for Variceal Rebleeding in Cirrhotic Patients With Occlusive Portal Vein Thrombosis and CTPV
To date, there is no treatment strategies for these patients according to American Association of the Study of Liver Disease (AASLD) practice guidelines and Baveno V consensus.
- Conditions
- Portal Vein, Cavernous Transformation of, Portal Vein Thrombosis, Liver Cirrhosis, Bleeding Esophageal Varices
- Trial name
- NCT02853526
- Testing
- TIPS, Propranolol, Endoscopic therapy
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Zaibo Jiang
Liver Cirrhoses
Efficacy and Safety of Early TIPS (Transjugular Intrahepatic Portosystemic Shunts) in the Management of Cirrhosis With Recurrent Ascites.
All consecutive patients with cirrhosis of liver who satisfy the criteria will be included and will be evaluated clinically along with all routine investigations and standard medical therapy will be continued among these…
- Trial name
- NCT04013074
- Testing
- Transjugular Intrahepatic Portosystemic Shunt, Standard Medical Treatment
- Where
- India
- Volunteers
- 80 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Cirrhosis, Bowel Preparation
Evaluation of a Modified Bowel Preparation Regimen in Cirrhotic Patients Undergoing Colonoscopy
Inadequate bowel preparation compromises colonoscopy quality and diagnostic accuracy, and cirrhosis is a recognized independent predictor of poor bowel cleansing.
- Trial name
- CIRRHOPREP (NCT07668778)
- Testing
- 2-L PEG plus bisacodyl plus 3-day low fibre diet, 2-L PEG plus 1-day low fibre diet
- Where
- 4 sites in Portugal
- Volunteers
- 252 people
- Sponsor
- Hospital do Divino Espírito Santo de Ponta Delgada
Cirrhosis, Liver
Acute-On-Chronic Liver Failure In Cirrhotic Patients
Cirrhosis is a condition characterized by diffuse fibrosis, severe disruption of the intrahepatic arterial and venous flow, portal hypertension and, ultimately, liver cell failure.
- Trial name
- NCT04790435
- Where
- Egypt
- Volunteers
- 109 people
- Sponsor
- Sohag University
Non-alcoholic Fatty Liver Disease
Efficacy and Safety of Oltipraz in the Patients With Non-alcoholic Fatty Liver Disease
Dithiolethiones, a novel class of adenosine monophosphate-activated protein kinase (AMPK) activators, prevent insulin resistance through AMPK-dependent p70 ribosomal S6 kinase-1 (S6K1) inhibition.
- Trial name
- PMK-N01GI1 (NCT01373554)
- Testing
- Oltipraz
- Where
- 5 sites in South Korea
- Volunteers
- 60 people
- Sponsor
- PharmaKing
Ascites
High Dose Albumin in Refractory Ascites
Advanced cirrhosis with complications is a serious problem imposing a heavy financial burden on health care system. Moreover, ascites is associated with increase in mortality rates among cirrhotic patients.
- Trial name
- NCT05867602
- Testing
- Albumin
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Baylor College of Medicine
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