Clinical trials: Hepatic Cirrhosis
Hepatocellular Carcinoma
A Study Evaluating Atezolizumab, With or Without Bevacizumab, in Participants With Unresectable Hepatocellular Carcinoma and Child-pugh B7 and B8 Cirrhosis
The purpose of this study is to assess the safety of atezolizumab and bevacizumab, or atezolizumab alone, as first-line treatment in participants with unresectable, locally advanced or metastatic hepatocellular carcinoma (HCC)…
- Trial name
- Kirros (NCT06096779)
- Testing
- Atezolizumab, Bevacizumab
- Where
- 54 sites in United States, Puerto Rico
- Volunteers
- 30 people
- Sponsor
- Genentech, Inc.
Primary Biliary Cirrhosis
The Health Burden of Primary Biliary Cirrhosis (PBC) in Switzerland
PBC is a rare, autoimmune, cholestatic liver disease with genetic and environmental pathogenetic factors. Data about epidemiology of PBC in Switzerland are completely lacking.
- Trial name
- NCT02846896
- Where
- Switzerland
- Volunteers
- 501 people
- Sponsor
- Fondazione Epatocentro Ticino
Liver Steatosis, Fibrosis, Liver
Endoscopic Ultrasound Shear Wave for Liver Fibrosis in MASLD Patients: The RUMIPAMBA Trial
Currently, there is no description of the contribution of the endoscopic ultrasound (EUS)-guided shear wave elastography (SWE) when describing liver fibrosis in patients with screening criteria of metabolic dysfunction-associated…
- Trial name
- NCT06102980
- Testing
- Transparietal ultrasound (US)-based shear wave elastography (SWE) attenuation measurement, Transparietal ultrasound (US)-based shear wave elastography (SWE) stiffness measurement, Vibration-controlled transient elastography (VCTE) attenuation measurement
- Where
- Ecuador
- Volunteers
- 30 people
- Sponsor
- Instituto Ecuatoriano de Enfermedades Digestivas
Liver Cirrhosis, Hepatic Encephalopathy
Diagnosis of Covert/Minimal Hepatic Encephalopathy by Means of Continuous Reaction Time Measurement
The investigators wish to investigate how the Continuous Reaction Time (CRT) method can be used in the diagnosis and monitoring of covert hepatic encephalopathy (cHE)in patients with cirrhosis of the liver.
- Trial name
- NCT01773538
- Testing
- Lactulose and rifaximin, Branched Chain amino acids
- Where
- 2 sites in Denmark
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Mette Munk Lauridsen
Cirrhosis, Liver, Upper Gastrointestinal Bleeding
Terlipression Prevent Developing of Acute Kidney Injury During Upper-gastroentestinal Bleeding
The investigators studied the renal function index level in terlipressin treated cirrhotic patients with upper-gastrointestinal bleeding at different time point.
- Trial name
- NCT04358016
- Testing
- Terlipressin, Somatostatin
- Where
- China
- Volunteers
- 54 people
- Sponsor
- Changhai Hospital
Non Alcoholic Fatty Liver Disease
Non Invasive Assessment of Liver Fibrosis in Fatty Liver Disease
The purpose of this randomized clinical trial is to evaluate the utility of noninvasive markers for the detection of advanced fibrosis in patients newly diagnosed with Non-alcoholic Fatty Liver Disease (NAFLD) by ultrasound.
- Trial name
- NCT01874249
- Testing
- Electronic detailed information, NAFLD Score, Transient elastography
- Where
- Mexico
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Fundación Clínica Médica Sur
Liver Cirrhoses
Alterations in Intestinal Mucosal Barrier Visualized by Confocal Laser Endomicroscopy in Liver Cirrhosis: a Pilot Trial (AMBIC)
Clinical trial with medical devices. A diagnostic trial conducted to find a better (less invasive) procedure for predicting the onset of spontaneous bacterial peritonitis(SBP), which is a complication of liver cirrhosis with…
- Trial name
- AMBIC (NCT03878563)
- Testing
- Cellvisio 100 Series (fibered confocal microscopic system)
- Where
- 2 sites in Switzerland
- Volunteers
- 26 people
- Sponsor
- Dr.med. Monica Rusticeanu
Liver Cirrhosis, Esophageal and Gastric Varices
The Diagnostic Value of Subharmonic Imaging Technology Combined With Liver Stiffness and Platelet Count for High-risk Esophageal and Gastric Varices in Patients With Liver Cirrhosis
To evaluate the diagnostic value of the combined model of subharmonic-assisted pressure estimation (SHAPE), liver stiffness (LSM), and platelet count (PLT) for high-risk esophageal and gastric varices (HRV)
- Trial name
- NCT07151885
- Testing
- SHAPE
- Where
- China
- Volunteers
- 380 people
- Sponsor
- The First Hospital of Jilin University
Cirrhosis
The Use of Transient Elastography to Predict Clinical Decompensation in Patients With Early Cirrhosis
This is a prospective study designed to examine the role of transient elastography as a predictor of clinical decompensation in patients with early cirrhosis.
- Trial name
- NCT02258048
- Where
- United States
- Sponsor
- NYU Langone Health
HCC
Non Transplantable Recurrence After Percutaneous Thermal Ablation of HCC
Percutaneous thermal ablation (PTA), resection and liver transplantation (LT) are the standard curative options for hepatocellular carcinoma (HCC). LT yields the best long-term outcomes but is limited by graft shortage.
- Trial name
- NCT05202184
- Testing
- Percutaneous thermal ablation
- Where
- France
- Volunteers
- 213 people
- Sponsor
- University Hospital, Montpellier
Liver Fibroses
SWE Liver Stiffness as a Predictor of Progression of Chronic Liver Diseases
This study is a multicenter individual patient-based meta-analysis that will assess the performances of liver stiffness measurements performed with supersonic shear imaging shearwave elastography (SSI-SWE) in patients with liver…
- Trial name
- SWE Predict (NCT03389152)
- Testing
- Elastography
- Volunteers
- 2,148 people
- Sponsor
- SuperSonic Imagine
HIV
Switching From Protease Inhibitor/Ritonavir to Generic Single Tablet Regimen of Tenofovir Alafenamide/Emtricitibine/Dolutegravir
This is a phase III, multicenter, open-label, single-arm study of 190 virologically suppressed HIV-infected adults
- Trial name
- NCT03727152
- Testing
- generic single tablet TAF/FTC/DTG
- Where
- 2 sites in Thailand
- Volunteers
- 170 people
- Sponsor
- The HIV Netherlands Australia Thailand Research Collaboration
Liver Cirrhosis, Portal Hypertension
Impact of Fentanyl Analgesia on the Accuracy of HVPG Measurements in Patients With Portal Hypertension
Portal hypertension is a common complication of chronic liver disease and is associated with most clinical consequences of cirrhosis.
- Conditions
- Liver Cirrhosis, Portal Hypertension, Pain
- Trial name
- NCT04724148
- Testing
- Fentanyl
- Where
- China
- Volunteers
- 4 people
- Sponsor
- Hepatopancreatobiliary Surgery Institute of Gansu Province
Hepatic Insufficiency
Pharmacokinetics (PK) of Tipranavir/Ritonavir, Ribavirin, Pegylated Interferon (Peg INF) in Hepatitis C (HCV) Subjects With Mild Hepatic Impairment and in HCV, Hepatitis B (HBV), Hepatitis D Infected Subjects or Alcoholic Cirrhosis With Moderate Hepatic Impairment
The primary objectives were: To determine the effects of steady state TPV co-administered with low dose RTV on steady state PegIFN and RBV in HIV negative subjects with mild hepatic impairment (scheme A) To determine the effects…
- Trial name
- NCT02259855
- Testing
- Tipranavir, Ritonavir, Pegylated interferon
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Cirrhosis, Cirrhotic Cardiomyopathy
Metoprolol Succinate in Cardiac Remodeling Related to Cirrhosis
Cirrhotic cardiomyopathy is defined as a chronic cardiac dysfunction in patients with cirrhosis. It is suspected that this specific cardiac dysfunction contributes to the onset of complications in liver disease.
- Conditions
- Cirrhosis, Cirrhotic Cardiomyopathy, Cardiac Remodeling
- Trial name
- CARE Cirrhosis (NCT01676285)
- Testing
- Metoprolol succinate
- Where
- Brazil
- Volunteers
- 125 people
- Sponsor
- University of Sao Paulo
Alcoholic Cirrhosis
Clinical Trial to Evaluate the Efficacy and Safety of Cellgram-LC Administration in Patients With Alcoholic Cirrhosis
The goal of this clinical trial is to evaluate the efficacy and safety of Cellgram-LC in patients with alcoholic cirrhosis. The main questions it aims to answer are: Is Cellgram-LC superior to best supportive care (BSC) in…
- Trial name
- Cellgram-LC (NCT04689152)
- Testing
- Cellgram-LC, Best Supportive Care (BSC)
- Where
- 15 sites in South Korea
- Volunteers
- 200 people
- Sponsor
- Pharmicell Co., Ltd.
Liver Cirrhosis
Comparative Study of Novel Prognostic Scores in Patients With Liver Cirrhosis
1. To determine the prognostic performance of novel scores in predicting complications and in-hospital mortality in patients with liver cirrhosis. 2.
- Trial name
- NCT07238543
- Testing
- Usage of new scores
- Volunteers
- 100 people
- Sponsor
- Assiut University
Metabolic Dysfunction-associated Fatty Liver Cirrhosis
Fuzheng Huayu Tablets for Metabolic Dysfunction-Associated Fatty Liver Cirrhosis (Compensated): A Randomized, Double-Blind, Placebo-Controlled, Multicenter Clinical Study
This is a multicenter, randomized, double-blind, placebo-controlled clinical study to evaluate the efficacy and safety of Fuzheng Huayu Tablets in patients with metabolic dysfunction-associated fatty liver cirrhosis…
- Trial name
- NCT07663643
- Testing
- Fuzheng Huayu Tablets
- Volunteers
- 459 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Cirrhosis, Portal Vein Thrombosis
Safety of Anticoagulant Therapy After Endoscopic Treatment
The investigators aimed to verify the efficacy and safety of nadroparin calcium warfarin sequential (NWS) anticoagulation therapy after endoscopic therapy in PVT patients with cirrhosis and AVB.
- Conditions
- Cirrhosis, Portal Vein Thrombosis, Esophageal and Gastric Varices, Anticoagulant-induced Bleeding
- Trial name
- NCT04976543
- Testing
- nadroparin calcium-warfarin sequential anticoagulation
- Where
- China
- Volunteers
- 86 people
- Sponsor
- Qilu Hospital of Shandong University
Hepatocellular Carcinoma (HCC), Cirrhosis
mSEPT9 Biomarker for Predicting Hepatocellular Carcinoma Occurrence in Patients With Cirrhosis
This study aims to evaluate the role of the circulating epigenetic biomarker mSEPT9 in predicting the risk of hepatocellular carcinoma (HCC) in patients with cirrhosis.
- Conditions
- Hepatocellular Carcinoma (HCC), Cirrhosis, Risk Prediction for Liver Cancer, Epigenomics
- Trial name
- SEPT9_SuRV (NCT06778317)
- Testing
- Circulating mSEPT9 Biomarker Testing
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Central Hospital, Nancy, France
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.