Clinical trials: Hepatic Cirrhosis
Tense Ascites, Liver Cirrhosis
Acute Hemodynamic Changes During Paracentesis
The aim of our study was to evaluate hemodynamic changes during routine paracentesis in tense ascites using non-invasive inert gas rebreathing.
- Trial name
- NCT02996188
- Testing
- routine therapeutic paracentesis
- Volunteers
- 36 people
- Sponsor
- Universitätsmedizin Mannheim
Liver Cirrhosis
Changes in Lab and Ultrasonography After Endoscopic Varisceal Treatment
laboratory and ultrasongraphicc changes after endoscopical varices treatment
- Trial name
- NCT03269786
- Testing
- Liver function tests (ALT,AST,ALBUMIN,BILIRUBIN,INR,PC,CBC), biannual ultrasonography
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Liver Transplant; Complications, Vasoplegia
Angiotensin II in Liver Transplantation
The purpose of this study is to determine the efficacy and safety of Angiotensin II as a second-line vasopressor (drug that raises the blood pressure) during liver transplantation.
- Trial name
- AngLT-1 (NCT04901169)
- Testing
- Angiotensin II, Saline
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of California, San Francisco
Cirrhosis, Neoplasms
Chemotherapy and Liver Cirrhosis in Frequently-associated Cancers
Cirrhosis and cancers of the upper digestive tract, colorectal and ENT share common risk factors. Liver cirrhosis can change the elimination of cancer drugs.
- Trial name
- CHIMIOSE (NCT04179773)
- Testing
- Current care study
- Where
- 2 sites in France
- Volunteers
- 7 people
- Sponsor
- University Hospital, Lille
Hepatic Encephalopathy
MNK-6105 for Patients With Cirrhosis and High Ammonia Levels Affecting Brain Function
This study is for patients with cirrhosis and hepatic encephalopathy who are in the hospital. This means they have a high ammonia level which is affecting their brain function.
- Trial name
- NCT04128462
- Testing
- MNK-6105, Standard of Care
- Sponsor
- Mallinckrodt
NAFLD, Diabetes
DIAbetes and NAFLD
Non-alcoholic hepatic steatosis (NAFLD) is characterised by the excessive accumulation of triglycerides in the liver and is often associated, in the absence of significant alcohol consumption, with insulin resistance and…
- Conditions
- NAFLD, Diabetes, NASH, Fibrosis, Liver
- Trial name
- DIANA (NCT06315361)
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Hepatitis C Virus Infection
Efficacy and Safety of Sofosbuvir/Velpatasvir ± Ribavirin for 12 Weeks in Adults With Chronic HCV Infection and Decompensated Cirrhosis
The primary objectives of this study are to evaluate the antiviral efficacy, safety, and tolerability of sofosbuvir/velpatasvir (SOF/VEL) fixed-dose combination (FDC) with or without ribavirin (RBV) for 12 weeks in adults with…
- Trial name
- NCT02996682
- Testing
- SOF/VEL, RBV
- Where
- 33 sites in Japan
- Volunteers
- 102 people
- Sponsor
- Gilead Sciences
Liver Cirrhosis
Natural Course and Prognosis of Hospitalized Patients With Cirrhosis
The aim of this prospective study is to evaluate the natural course and prognosis of hospitalized patients with liver cirrhosis.
- Trial name
- NCT05185154
- Where
- 4 sites in South Korea
- Volunteers
- 336 people
- Sponsor
- Kangbuk Samsung Hospital
Chronic Hepatic Pruritus, Cholestatic Liver Disease
Nemolizumab for the Treatment of Moderate to Severe Chronic Hepatic Pruritus
The purpose of this research is to investigate the efficacy of nemolizumab in the treatment of adults with moderate to severe chronic hepatic pruritus.
- Conditions
- Chronic Hepatic Pruritus, Cholestatic Liver Disease, Primary Biliary Cholangitis, Cholestasis
- Trial name
- NCT07843420
- Testing
- Nemolizumab-ilto
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Mayo Clinic
Liver Fibrosis, Cirrhosis, Liver
Prolonged Release Pirfenidone Versus Placebo in Compensated Cirrhosis.
This will be a multicenter, double-blind clinical trial to evaluate the safety and efficacy of two doses of prolonged release pirfenidone, compared against placebo plus conventional therapy in patients with compensated liver…
- Conditions
- Liver Fibrosis, Cirrhosis, Liver, Chronic Liver Disease
- Trial name
- ODISEA (NCT06267794)
- Testing
- Pirfenidone 1200 mg, Pirfenidone 1800 mg
- Volunteers
- 180 people
- Sponsor
- Jorge L Poo
Cirrhosis, Liver, Vaccination Failure
Evaluation of Intradermal Hepatitis B Vaccine After IMIQUIMOD's Application, in Cirrhotics Who Did Not Respond to the Usual Vaccine Regimen
In a population of cirrhotics patients who did not responde to an anti-HBV vaccination according to the recommended vaccination, the goal is to : Describe the proportion of patients with HBs antibody levels greater than 10mUI/mL…
- Conditions
- Cirrhosis, Liver, Vaccination Failure, HBV, Vaccine Reaction
- Trial name
- IDMODVHB (NCT05028322)
- Testing
- IMIQUIMOD cream, HEPATITIS B SURFACE ANTIGEN
- Volunteers
- 60 people
- Sponsor
- Central Hospital, Nancy, France
Cirrhosis
To Compare Efficacy and Safety of Lactulose Versus Polyethylene Glycol for Treatment of Overt Hepatic Encephalopathy in Cirrhotics.
All patients presenting to the emergency department of Institute of Liver and Biliary Sciences with known cirrhosis and hepatic encephalopathy with grade II will be included in the study.
- Trial name
- NCT03448770
- Testing
- PEG- 17 gm sachet, Lactulose : 20-30gm
- Where
- India
- Volunteers
- 110 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Portal Hypertension, Cirrhosis
Esophageal Capsule Endoscopy in Children
The portal hypertension (PHT) is the main complication in patients presenting with cirrhosis. It can be the direct cause of bleeding by rupture of the esophageal or gastric varices and can also contribute to the development of…
- Trial name
- PREVOCAP (NCT01551966)
- Testing
- Wireless esophageal capsule endoscopy ( PillCam Eso2)
- Where
- 7 sites in France
- Volunteers
- 100 people
- Sponsor
- Hospices Civils de Lyon
HCV Related Cirrhosis
To Evaluate the Safety and Efficacy of Sofosbuvir and Ribavirin in Patients With HCV (Genotype 3) Related Decompensated Cirrhosis
In this prospective randomized trial, A Minimum of 300 consecutive patients of decompensated HCV (Hepatitis C Virus) related cirrhosis, presenting to the Institute of Liver and Biliary Sciences hospital will be included and those…
- Trial name
- NCT02464631
- Testing
- Sofosbuvir + Ribavirin 1, Sofosbuvir + Ribavirin 2, Sofosbuvir + Ribavirin 3
- Where
- India
- Volunteers
- 62 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Liver Cirrhosis, Transjugular Intrahepatic Portosystemic Shunt (TIPS)
Incidence and Predictors of Post-TIPS Heart Failure in Patients With Cirrhosis
The purpose of this study is to conduct a prospective trial to investigate the incidence of heart failure in cirrhosis patients undergoing transjugular intrahepatic portosystemic shunt ,and to analyze the the predictors and…
- Conditions
- Liver Cirrhosis, Transjugular Intrahepatic Portosystemic Shunt (TIPS), Heart Failure
- Trial name
- NCT05596253
- Testing
- TIPS
- Where
- China
- Volunteers
- 200 people
- Sponsor
- West China Hospital
Intrahepatic Cholangiocarcinoma (Icc)
Liquid Biopsy Using Exosomal miRNA Enables Risk Stratification of Potential Metastasis in Patients With Intrahepatic Cholangiocarcinoma.
Occult metastasis at the time of surgery is a major driver of poor outcomes in intrahepatic cholangiocarcinoma (ICC), yet reliable preoperative biomarkers to identify such patients are lacking.
- Trial name
- EXOMIC (NCT07224737)
- Testing
- EXOMIC small RNA sequencing, EXOMIC assay (qRT-PCR validation)
- Where
- United States
- Volunteers
- 230 people
- Sponsor
- City of Hope Medical Center
Cirrhosis, Liver
Molecular Mechanism of Exercise in Cirrhosis
This study aims to investigate the effects of 12 weeks of resistance or endurance exercise on patients with cirrhosis. Cirrhotic patients are prone to muscle loss (sarcopenia) and ammonia build up due to liver dysfunction.
- Trial name
- NCT05982769
- Testing
- Endurance Training 3 times per week, Resistance Exercise, Standard of Care
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- The Cleveland Clinic
Hepatitis B, Liver Fibrosis
Optimized Treatment of Peginterferon Alfa 2a/2b in Treatment Experienced Patients With HBV Related Liver Fibrosis
Compared to nucleoside/nucleotide analogues, peginterferon alfa 2a/2b may has more therapeutic efficacy in hepatitis B surface antigen or e antigen seroconversion and anti-tumor occurrence in chronic hepatitis b patients.
- Trial name
- HBV (NCT03920605)
- Testing
- Tenofovir Disoproxil Fumarate, Peginterferon Alfa-2a, Peginterferon Alfa-2b
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Cirrhosis, Liver
Cirrhotics Undergoing General Surgery
Surgery on cirrhotic patients represents a clinical challenge but intervening before these patients develop complications can prolong the likelihood of these patients making it to transplant for those transplant-eligible…
- Trial name
- NCT05202457
- Testing
- Elective surgery
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Danny Lascano
MASH - Metabolic Dysfunction-Associated Steatohepatitis
Study to Evaluate Resmetirom in Post-Liver Transplant Patients With MASH
A Phase 2 double-blind, randomized, placebo-controlled study to evaluate resmetirom in 2 cohorts of subjects with moderate to advanced fibrosis, consistent with stage F2 and F3 fibrosis, who have undergone liver transplant.
- Trial name
- NCT07335601
- Testing
- Resmetirom
- Where
- 17 sites in United States, Canada
- Volunteers
- 120 people
- Sponsor
- Madrigal Pharmaceuticals, Inc.
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