Clinical trials: Hepatic Cirrhosis
Ascites, Paracentesis
Medical-economic Evaluation of the Care of Refractory Ascites by Implantation of Alfapump® Device in Cirrhotic Patients
The hypothesis is that the Alfapump® strategy would be more effective in terms of QALYs generated , and that the cost of Alfapump® device and its implantation will be totally or partially offset by the reduction in the number of…
- Conditions
- Ascites, Paracentesis, Cirrhosis
- Trial name
- ARIAPUMP (NCT03506893)
- Testing
- Alphapump, Ascites puncture
- Where
- 10 sites in France
- Volunteers
- 90 people
- Sponsor
- University Hospital, Grenoble
Liver Cirrhosis, Decompensated Cirrhosis of Liver
A Novel COMBinATorial Therapy With Albumin and Enoxaparin in Patients With Decompensated Cirrhosis at High-risk of Poor Outcome (COMBAT Trial).
The goal of this clinical trial is to determine primarily whether a combinatorial therapy based on the administration of human albumin and enoxaparin is safe and effective in patients with decompensated cirrhosis discharged from…
- Conditions
- Liver Cirrhosis, Decompensated Cirrhosis of Liver, Acute on Chronic Liver Failure (ACLF)
- Trial name
- COMBAT (NCT05895136)
- Testing
- Human albumin, Enoxaparin, Standard medical treatment
- Where
- 9 sites in France, Germany and 3 more
- Volunteers
- 90 people
- Sponsor
- European Foundation for Study of Chronic Liver Failure
Hepatorenal Syndrome, Renal Failure
Role Of Angiogenic Factors In The Development Of Hepatorenal Syndrome
This Study will look at the effect of substances called "angiogenic factors"(development of new blood vessels) have on the development of severe liver disease.
- Conditions
- Hepatorenal Syndrome, Renal Failure, Liver Diseases
- Trial name
- NCT00734136
- Testing
- Blood Draws and a hepatectomy specimen, Blood draw - pre operative standard of care
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Lahey Clinic
Liver Cirrhoses
Risk Factors of Liver Fibrosis Among First Degree Relatives of Patients With NASH Related Cirrhosis (NRC)
The study aim to identify the risk factors of liver fibrosis among first degree relatives. This study consists of 2 parts (Cross Sectional and Case Control Study).
- Trial name
- NCT04057287
- Testing
- No intervention
- Where
- India
- Volunteers
- 670 people, healthy volunteers welcome
- Sponsor
- Institute of Liver and Biliary Sciences, India
Liver Cirrhosis, Liver Disease
Ischemic Preconditioning of Liver in Cadaver Donors
The long-term goals of this proposal are to develop clinical protocols of donor preconditioning to improve liver graft function and ameliorate complications of poor graft function after liver transplantation.
- Trial name
- NCT00245830
- Testing
- Ischemic Preconditioning
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Medicine and Dentistry of New Jersey
Cirrhosis
Carvedilol + VSL#3 Versus Endoscopic Variceal Ligation for Primary Prophylaxis of Esophageal Variceal Bleeding in Cirrhotic Patients Non Responder to Carvedilol.
Patients of cirrhosis will be enrolled who have large esophageal varices, which have never bled. After successful screening baseline hepatic venous pressure gradient (HVPG) will be measured.
- Trial name
- NCT01196481
- Testing
- Carvedilol+VSL#3, Endoscopic variceal ligation
- Where
- India
- Volunteers
- 40 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Upper Gastrointestinal Bleeding (UGIB), Variceal Bleeding
Tranxemic Acid and Vitamin K Injection to Control Upper Gastrointestinal Bleeding in Cirrhotic Patients
The goal of this randomized controlled clinical trial is to evaluate the efficacy of Tranexamic acid and vitamin K injection versus placebo in control of upper gastrointestinal bleeding (UGIB) in Egyptian cirrhotic patients.
- Conditions
- Upper Gastrointestinal Bleeding (UGIB), Variceal Bleeding, Cirrhosis
- Trial name
- NCT06881628
- Testing
- Tranexamic Acid and vitamin K
- Where
- Egypt
- Volunteers
- 194 people
- Sponsor
- Tanta University
Liver Fibrosis, Positron Emission Tomography
68Ga-FAPI PET/CT in Liver Fibrosis Patients
To evaluate the potential value of 68Ga-FAPI-04 positron emission tomography/computed tomography (PET/CT) for the diagnosis and prognosis in liver fibrosis disease.
- Trial name
- GFAPILF (NCT04533828)
- Testing
- 68Ga-FAPI-04
- Where
- China
- Volunteers
- 50 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Hepatitis C Virus Infection
Efficacy and Safety of Sofosbuvir+Ribavirin in Genotype 2 HCV-infected U.S. Veterans With Cirrhosis
This study will examine the safety, tolerability, and antiviral efficacy of sofosbuvir (SOF)+ribavirin (RBV) in treatment-naive and treatment-experienced United States Veterans with compensated cirrhosis and genotype 2 HCV…
- Trial name
- VALOR-HCV (NCT02128542)
- Testing
- Sofosbuvir, RBV
- Where
- 17 sites in United States
- Volunteers
- 66 people
- Sponsor
- Gilead Sciences
Chronic Hepatitis C, Hepatitis C Virus
A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Co-administration of ABT-493 and ABT-530 With and Without Ribavirin in Subjects With HCV Genotype 1, 4, 5, and 6 Infection
The purpose of this Phase 2, open-label, 2-part, multicenter study was to evaluate the efficacy, safety, and pharmacokinetics of co-administration of ABT-493 and ABT-530 with and without ribavirin (RBV) at different doses in…
- Conditions
- Chronic Hepatitis C, Hepatitis C Virus, HCV
- Trial name
- NCT02243280
- Testing
- ABT-493, ABT-530
- Volunteers
- 174 people
- Sponsor
- AbbVie
Liver Cirrhosis
Care Algorithm and Clinic Decision System on Hepatic Rehabilitation in Patients With Liver Cirrhosis
Liver cirrhosis is an important public health problem that causes morbidity and mortality. In order to provide hepatic rehabilitation of patients with liver cirrhosis, interventions that provide active care practices by patients…
- Trial name
- ReLiver-NApp (NCT06995196)
- Testing
- ReLiver-N App
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Cirrhosis, Liver
Microbiome Translocation in Different Circulatory Compartments in Decompensated Cirrhosis
Acquired dysfunctional immunity in cirrhosis predisposes patients to frequent bacterial infections contributing to disease progression and may lead to the development of acute-on-chronic liver failure (ACLF).
- Trial name
- NCT04195724
- Testing
- mNGS for pathogen detection
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Nanfang Hospital, Southern Medical University
NAFLD, NASH With Fibrosis
Dasatinib and Quercetin to Treat Fibrotic Non-alcoholic Fatty Liver Disease
To examine the effect of dasatinib plus quercetin on liver fibrosis in individuals with biopsy proven NAFLD with fibrosis by performing a double-blind randomized controlled proof-of-principle study
- Conditions
- NAFLD, NASH With Fibrosis, Liver Fibrosis
- Trial name
- NCT05506488
- Testing
- Dasatinib 100 MG + Quercetin (1000 MG)
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Liver Cirrhosis, Portal Hypertension
Endoscopic Ruler for the Assessment of Variceal Bleeding Risks (CHESS2005)
The presence of varices is a serious complication of portal hypertension in liver disease. To prevent variceal haemorrhage, screening and surveillance aims to detect high-risk varices related to varices size and determine the…
- Conditions
- Liver Cirrhosis, Portal Hypertension, Gastroesophageal Varices
- Trial name
- NCT04639323
- Testing
- Endoscopic ruler
- Where
- 7 sites in China
- Volunteers
- 266 people
- Sponsor
- Hepatopancreatobiliary Surgery Institute of Gansu Province
Hepatitis C, Chronic, Cirrhosis
Comparative Effectiveness and Tolerability of Boceprevir vs Telaprevir
1. The primary objective is to study the comparative effectiveness and tolerability of boceprevir vs. telaprevir in HCV treatment, within the VA population. 2.
- Trial name
- NCT02113631
- Testing
- Telaprevir, Boceprevir, Peg-IFN
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Louis Stokes VA Medical Center
Schistosomiasis, Liver Fibrosis
Antioxidant Supplements in the Reversal of Schistosomal Peri-portal Fibrosis
Liver fibrosis is the most serious complication of schistosomiasis mansoni. However only limited proportion of subjects with infection develop this pathology and there is limited knowledge on risk factors for the differential…
- Conditions
- Schistosomiasis, Liver Fibrosis, Periportal Fibrosis, Oxidative Stress
- Trial name
- NCT01260012
- Testing
- Praziquantel+antioxidant suppl, Praziquantel+antioxidant
- Where
- Ethiopia
- Volunteers
- 414 people
- Sponsor
- Addis Ababa University
Primary Biliary Cholangitis, Liver Fibrosis
Patients With Primary Biliary Cholangitis(PBC)
Primary Biliary Cholangitis (PBC) is a chronic autoimmune cholestatic liver disease characterized by the progressive destruction of small intrahepatic bile ducts, leading to chronic cholestasis, hepatic fibrosis, and, in advanced…
- Conditions
- Primary Biliary Cholangitis, Liver Fibrosis, Cirrhosis, Liver, Blood Sugar; High
- Trial name
- GLYPP (NCT07629128)
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Hepatitis B, Liver Fibrosis
Optimized Treatment of Peginterferon Alfa 2a/2b in Treatment Experienced Patients With HBV Related Liver Fibrosis
Compared to nucleoside/nucleotide analogues, peginterferon alfa 2a/2b may has more therapeutic efficacy in hepatitis B surface antigen or e antigen seroconversion and anti-tumor occurrence in chronic hepatitis b patients.
- Trial name
- HBV (NCT03920605)
- Testing
- Tenofovir Disoproxil Fumarate, Peginterferon Alfa-2a, Peginterferon Alfa-2b
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Age-Related Macular Degeneration, Allergies
Tissue Repository Providing Annotated Biospecimens for Approved Investigator-directed Biomedical Research Initiatives
To collect, preserve, and/or distribute annotated biospecimens and associated medical data to institutionally approved, investigator-directed biomedical research to discover and develop new treatments, diagnostics, and…
- Conditions
- Age-Related Macular Degeneration, Allergies, Alpha-Gal Syndrome, Alzheimer Disease
- Trial name
- NCT05635266
- Testing
- Specimen sample
- Where
- United States
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Sanguine Biosciences
Primary Biliary Cholangitis
Phase I/II Trial of Human Umbilical Cord Mesenchymal Stromal Cells for UDCA-Refractory Primary Biliary Cholangitis
This phase I/II clinical trial evaluates human umbilical cord-derived mesenchymal stromal cell (hUC-MSC) injection in patients with primary biliary cholangitis (PBC).
- Trial name
- MSC-PBC-I/II (NCT07795151)
- Testing
- Standard background therapy, hUC-MSC Dose Level 1, hUC-MSC Dose Level 2
- Where
- China
- Volunteers
- 68 people
- Sponsor
- Beijing 302 Hospital
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