Clinical trials: Hepatic Cirrhosis
Hepatic Encephalopathy, Cirrhosis, Liver
Investigational Microbiota Restoration Therapeutic for Hepatic Encephalopathy
Individuals with cirrhosis are likely to develop overt hepatic encephalopathy for which diagnostic modalities and treatment options are limited.
- Trial name
- NCT04155099
- Testing
- RBX7455
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Ochsner Health System
Liver Fibrosis, Liver Cirrhosis
Efficacy and Safety of Oltipraz in the Patients With Liver Fibrosis and Cirrhosis
This study investigated the effectiveness and safety of oltipraz therapy in treating patients with cirrhosis induced by chronic hepatitis type B or C.
- Trial name
- NCT00956098
- Testing
- oltipraz
- Where
- 2 sites in South Korea
- Volunteers
- 81 people
- Sponsor
- HK inno.N Corporation
Cirrhosis, Acute Decompensation
Study of microRNAs in a Decompensated Cirrhosis
Cirrhotic patients are at higher risk of sepsis due to impaired innate and adaptive immune responses. Septic complications represent a major issue in the management of cirrhotic patients, with a 1-month mortality rate of 23%…
- Trial name
- EmiC (NCT03905746)
- Testing
- blood sample at Day 0, blood sample at Day 2 and Day 7, stool sample at Day 0
- Where
- France
- Volunteers
- 444 people
- Sponsor
- Hospices Civils de Lyon
HBV, Alcoholic Hepatitis
Chronic Hepatitis B Virus Clinical Epidemiology in a Representative Sample of Zambian Adults
The purpose of this study is to recruit a random and representative sample of individuals within several Zambian communities for markers of Hepatitis B Virus (HBV) and to characterize chronic HBV infection and indications for…
- Conditions
- HBV, Alcoholic Hepatitis, Liver Fibroses
- Trial name
- HEP-ZED (NCT03149627)
- Testing
- Estimates - prevalence of lifetime/chronic HBV infection
- Where
- Zambia
- Volunteers
- 5,003 people
- Sponsor
- University of Alabama at Birmingham
Cirrhosis, Ascites
A (M)Ulti-center, Prospective, (O)Pen Label, Uncontrolled Feasibility (S)Tudy to Assess the Safety and Effectiveness of an Automatic Low Flow (A)Scites (Alfa) Pump (I)n Patients With (C)Irrhosis and Refractory or Recurrent Ascites
The study is a multi-center, prospective, open label, uncontrolled feasibility study enrolling 30 patients with refractory or recurrent ascites and cirrhosis at up to 6 sites.
- Trial name
- MOSAIC (NCT02400164)
- Testing
- alfapump system
- Where
- 6 sites in United States, Canada
- Volunteers
- 30 people
- Sponsor
- Sequana Medical N.V.
Cirrhosis Alcoholic, Fatigue Symptom
Inflammatory and Neuroimmune Guided Investigation of Underlying Fatigue in Patients With Cirrhosis
Fatigue is a common and debilitating symptom of cirrhosis, the advanced stage of chronic liver disease. Around two-thirds of people with cirrhosis experience fatigue, which can affect their ability to carry out everyday…
- Trial name
- IGNITE (NCT07899736)
- Volunteers
- 50 people
- Sponsor
- King's College London
Liver Cirrhosis
Anticoagulation for Advanced Cirrhotic Patients After TIPS
Recent studies demonstrated that liver cirrhosis was associated with a hypercoagulability state. Besides, bacterial translocation plays an important role in the pathogenesis and complications in patients with decompensated…
- Trial name
- NCT03005444
- Testing
- Rivaroxaban
- Where
- 11 sites in China
- Volunteers
- 254 people
- Sponsor
- Air Force Military Medical University, China
Patients Without a Medical History of Thrombosis or Hemorrhage, Hemophilic Patient
Evaluation of the Inter-center Variability of the Measurement of Thrombin Generation by the ST Genesia System
The thrombin generation test is a global test for the study of coagulation that allows the fine study of the balance between procoagulant and anticoagulant factors.
- Conditions
- Patients Without a Medical History of Thrombosis or Hemorrhage, Hemophilic Patient, Patient With FV Leiden Mutation, Patient With Cirrhosis
- Trial name
- EVIGE (NCT05422157)
- Where
- France
- Volunteers
- 71 people
- Sponsor
- University Hospital, Clermont-Ferrand
Cholestatic Pruritus
Study to Evaluate the Safety and Efficacy of Oral CR845 (Difelikefalin) in Patients With Primary Biliary Cholangitis (PBC) and Moderate-to-Severe Pruritus
This is a multicenter, randomized, double-blind, placebo-controlled study to evaluate the safety and efficacy of twice-daily (BID) oral CR845 1.0 mg in patients with PBC with moderate-to-severe pruritus.
- Trial name
- NCT03995212
- Testing
- CR845 1.0 mg
- Where
- 14 sites in United States
- Volunteers
- 14 people
- Sponsor
- Cara Therapeutics, Inc.
Decompensated Cirrhosis
A Clinical Trial Evaluating the Safety, Tolerability, and Preliminary Efficacy of HCL001 Cell Injection (Homologous Allogeneic Hepatocytes) in Patients With Decompensated Cirrhosis
This study protocol is designed to evaluate the clinical efficacy, safety, and tolerability of HCL001 cell injection in the treatment of decompensated cirrhosis.
- Trial name
- NCT06306781
- Testing
- HCL001 cell (homologous allogeneic hepatocytes) injection
- Volunteers
- 18 people
- Sponsor
- RenJi Hospital
Portal Hypertension, Liver Cirrhosis
Laparoscopic Versus Open Devascularization for Portal Hypertension, a Randomized Controlled Trial
Many patients with portal hypertension require surgical treatment each year,and Hassab's operation, or esophagogastric devascularization and splenectomy, is an elective procedure.
- Trial name
- NCT02178319
- Testing
- open surgical procedure, laparoscopic surgical procedure
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Xi'an Jiaotong University
Eating Disorders, Eating Disorder Binge
Study of Prevalence of Eating Disorder in Liver Transplant Patients
The main goal of this observational study is to measure the prevalence of binge eating disorder in liver transplant patients by evaluating the responses to the Bulimia Test.
- Conditions
- Eating Disorders, Eating Disorder Binge, Liver Transplant; Complications, Alcohol Use Disorder
- Trial name
- Pré-THETA (NCT06093919)
- Where
- 2 sites in France
- Volunteers
- 118 people
- Sponsor
- Centre Hospitalier Henri Laborit
Cirrhosis, Portal Hypertension
A Study Evaluating the Utility of Ambrisentan in Lowering Portal Pressure in Patients With Liver Cirrhosis
Endothelin is a human hormone which has been associated with increased portal pressure in patients with liver cirrhosis (also called portal hypertension). Ambrisentan blocks the effects of endothelin.
- Conditions
- Cirrhosis, Portal Hypertension, Ascites
- Trial name
- NCT03827200
- Testing
- Ambrisentan
- Where
- 6 sites in Spain
- Volunteers
- 19 people
- Sponsor
- Noorik Biopharmaceuticals AG
Muscle Cramp, Cirrhosis
Effect of Branched-chain Amino Acids (BCAA) to Muscle Cramps in Patients With Cirrhosis
The goal of this randomized controlled trial is to compare the efficacy and safety of branched-chain amino acids (BCAA) versus placebo for treating muscle cramps in cirrhotic patients.
- Conditions
- Muscle Cramp, Cirrhosis, Quality of Life
- Trial name
- NCT05724485
- Testing
- Branched-chain Amino Acid
- Where
- Thailand
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Hepatitis B, Chronic, Fibrosis
Emtricitabine Plus Adefovir Dipivoxil for Naive Chinese HBV Related Cirrhosis Patients
This study evaluates generic emtricitabine(FTC) plus adefovir dipivoxil in Chinese naive HBV related cirrhosis patients. Patients were divided into 2 groups: compensated HBV related cirrhosis patients and decompensated HBV…
- Trial name
- NCT02327689
- Testing
- Emtricitabine plus adefovir dipivoxil
- Volunteers
- 400 people
- Sponsor
- Asian-Pacific Alliance of Liver Disease, Beijing
Cirrhosis
Use of the French Healthcare Insurance Database
Hepatocellular carcinoma (HCC) has become the second most common cause of cancer death in the world, estimated responsible for nearly 745,000 deaths in 2012 (9.1% of all cancer deaths).
- Trial name
- SAMHEPAT (NCT02983968)
- Testing
- Description of the cirrhosis management
- Where
- France
- Volunteers
- 75,868 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Fatigue, Primary Biliary Cirrhosis
B-Cell Depleting Therapy (Rituximab) as a Treatment for Fatigue in Primary Biliary Cirrhosis
Primary Biliary Cirrhosis (PBC) is a liver disease that predominantly affects females, can present for the first time at any age and which develops over many years.
- Trial name
- RITPBC (NCT02376335)
- Testing
- Rituximab
- Where
- United Kingdom
- Volunteers
- 71 people
- Sponsor
- Newcastle-upon-Tyne Hospitals NHS Trust
Non-Alcoholic Fatty Liver Disease, Non-Alcoholic Steatohepatitis
CHronic Hepatopathies Associated With ALcohol Consumption aNd metAbolic Syndrome
The aim is to determine the metabolic factors, host immune factors, and medical imaging data associated with the development of HepatoCellular Carcinoma (HCC) in patients with alcohol-related liver disease or dysmetabolic…
- Conditions
- Non-Alcoholic Fatty Liver Disease, Non-Alcoholic Steatohepatitis, Alcohol-related Liver Disease, Cirrhosis, Liver
- Trial name
- CHALNA2 (NCT05623150)
- Testing
- Liver biopsy
- Where
- France
- Volunteers
- 710 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Hepatitis C
Biomarkers of Liver Fibrosis
Chronic liver injury leads to the accumulation of proteins in the liver that form dense scars. Liver scar formation is typically a slow process that leads to major organ damage and loss of function over the course of many years.
- Trial name
- NCT02438917
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Cirrhosis, Liver, Portal Hypertension
LiveSMART Trial to Prevent Falls in Patients With Cirrhosis
This multicenter trial is being conducted to determine if sequential lactulose and Tele (virtual) Tai-Chi reduces the rate of injurious fall, non-injurious falls, incident overt Hepatic Encephalopathy (HE), and death or liver…
- Trial name
- NCT05794555
- Testing
- Enhanced Usual Care, Lactulose, Investigator recommended exercise
- Where
- 3 sites in United States
- Volunteers
- 233 people
- Sponsor
- University of Michigan
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