Clinical trials: Hepatic Cirrhosis
Liver Cirrhosis
Human Umbilical Cord Mesenchymal Stem Cells Transplantation for Patients With Decompensated Liver Cirrhosis
Although liver transplantation provide a option to cure patients suffering with decompensated liver cirrhosis this condition, lack of donors, postoperative complications, especially rejection, and high cost limit its application.
- Trial name
- NCT01342250
- Testing
- conventional therapy plus low dose hUC-MSCs treatment, conventional therapy plus medium dose hUC-MSCs treatment, conventional therapy plus high dose hUC-MSCs treatment
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Shenzhen Beike Bio-Technology Co., Ltd.
Chronic Liver Disease
Prognosis Value of Non-invasive Methods for the Diagnosis of Chronic Liver Disease
The aim of this retrospective and prospective study is to evaluate the 20-year prognosis value of non-invasive methods for the diagnosis of chronic liver disease for predicting survival and complications of cirrhosis.
- Trial name
- PVNIM (NCT02060565)
- Where
- France
- Volunteers
- 10,000 people
- Sponsor
- Association HGE CHU Bordeaux Sud
Liver Failure, Critical Illness
Safety and Tolerance on Lipids of Parenteral and Enteral Nutrition in Critically Ill Patients With Liver Failure
The purpose of the study is to determine the tolerance on lipid metabolism and the safety of short-term parenteral nutrition as compared to enteral nutrition in critically ill patients with liver failure.
- Trial name
- SELLIFA (NCT00522730)
- Testing
- Parenteral nutrition, Enteral nutrition
- Where
- Belgium
- Volunteers
- 45 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Hepatitis C Virus (HCV)
A Study to Evaluate the Efficacy and Safety of Glecaprevir/Pibrentasvir in Adults With Chronic Hepatitis C Virus Genotype 1 - 6 Infection and Renal Impairment
This was a Phase 3b, open-label, non-randomized, multicenter study to evaluate the efficacy and safety of glecaprevir/pibrentasvir (GLE/PIB) in participants with chronic hepatitis C virus (HCV) genotype (GT) 1 - 6 infection…
- Trial name
- EXPEDITION-5 (NCT03069365)
- Testing
- Glecaprevir/pibrentasvir
- Where
- 38 sites in United States, Canada and 8 more
- Volunteers
- 101 people
- Sponsor
- AbbVie
Cirrhosis, Hepatic Encephalopathy
HEAL STUDY (Hepatic Encephalopathy and Albumin Study)
Patients with continued cognitive impairment after episodes of HE have few options beyond lactulose and rifaximin in the US. Therefore using IV albumin in a randomized, double-blind, placebo-controlled trial, which could…
- Conditions
- Cirrhosis, Hepatic Encephalopathy, Minimal Hepatic Encephalopathy, Covert Hepatic Encephalopathy
- Trial name
- HEAL (NCT03585257)
- Testing
- 25% IV albumin
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Hunter Holmes Mcguire Veteran Affairs Medical Center
Cirrhotic Patients With Ascites
Evaluation of Copeptin in Patients With Cirrhosis and Ascites
Copeptin is a glycopeptide released by the post-pituitary gland. In case of decrease in blood volume or blood pressure, it is secreted in the serum in an equimolar quantity to arginine vasopressin (AVP) .
- Trial name
- CIRCOPEP (NCT03318601)
- Testing
- Blood taking
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Cirrhosis, Liver, Liver Diseases
Give a MANNA a Fish, Teach a MANNA to Fish
This study is a randomized pilot seeking to address low patient adherence to a low sodium diet as a strategy to improve outcomes of patients with cirrhosis of the liver.
- Conditions
- Cirrhosis, Liver, Liver Diseases, Malnutrition
- Trial name
- NCT03969199
- Testing
- Intervention
- Sponsor
- University of Pennsylvania
Small Intestinal Bacterial Overgrowth, Liver Cirrhosis
Effycacy of Rifaximin on Reverse Minimal Hepatic Encephalopathy and Elimation Small Intestinal Bacterial
A total of 46 patients diagnosed with liver cirrhosis will be recruited. All patients will be evaluated with five psychometric tests and critical flicker frequency to diagnosis minimal hepatic encephalopathy (MHE).
- Trial name
- NCT02439307
- Testing
- Rifaximin
- Where
- Mexico
- Volunteers
- 11 people
- Sponsor
- Coordinación de Investigación en Salud, Mexico
Nonalcoholic Fatty Liver, Nonalcoholic Steatohepatitis
Comparative and Additive Diagnostic Performance of Magnetic Resonance Elastography (MRE) and Corrected-T1 (cT1) for Fibrosis and Inflammation in Nonalcoholic Steatohepatitis (NASH) Using Histology As Reference
This pilot study will evaluate conventional and investigational MR imaging and spectroscopic sequences and collect data to help plan more definitive future studies.
- Conditions
- Nonalcoholic Fatty Liver, Nonalcoholic Steatohepatitis, Liver Fibroses, Liver Inflammation
- Trial name
- NCT04389593
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, San Diego
Cirrhoses, Liver, Splenectomy; Status
Laparoscopic Partial Splenectomy for Hypersplenism in Liver Cirrhosis Patients
In this study,the researchers compared the changes in immune function-related indicators in patients with liver cirrhosis following laparoscopic partial splenectomy,to determine whether this surgical intervention can enhance…
- Conditions
- Cirrhoses, Liver, Splenectomy; Status, Partial
- Trial name
- LPSH (NCT07205471)
- Testing
- Laparoscopic Partial Splenectomy
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Northern Jiangsu People's Hospital
PBC, Primary Biliary Cholangitis (PBC)
Epidemiology of PrImary Biliary Cholangitis in Spain
Primary biliary cholangitis (PBC) is a rare, long-term liver disease that can slowly damage the bile ducts, eventually leading to cirrhosis and, in some cases, the need for a liver transplant.
- Trial name
- EPIC-PBC (NCT07821463)
- Where
- Spain
- Volunteers
- 3,000 people
- Sponsor
- Fundacio Privada Mon Clinic Barcelona
Cirrhosis
Sensitivity of Alternative NRL972 Detection Methods in Healthy Subjects
The disposition of NRL972 after a 15-second intravenous injection of 2 mg NRL972 is distinctly slower in patients with hepatic cirrhosis and acute hepatitis than in healthy control subjects.
- Trial name
- NCT01164332
- Testing
- NRL972
- Where
- Hungary
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Norgine
NAFLD, Liver Fibrosis
Different Doses of ZED1227 vs. Placebo in NAFLD
This is a double-blind, randomized, multicenter, placebo-controlled, comparative, exploratory phase II dose-finding trial. The trial will be conducted with four treatment groups in the form of a parallel group comparison and will…
- Trial name
- NormaliZED (NCT05305599)
- Testing
- ZED1227
- Where
- Germany
- Volunteers
- 186 people
- Sponsor
- Dr. Falk Pharma GmbH
Hepatic Encephalopathy
Microbiota, Sarcopenia, and Hepatic Encephalopathy Change in Cirrhotic Patients Before and After Rehabilitation
Through this plan, it will provide many benefits to patients with liver cirrhosis complicated with sarcopenia and/or hepatic encephalopathy, their family members, and the government in Taiwan: 1.
- Trial name
- NCT06040814
- Testing
- Rehabilitation Training
- Where
- Taiwan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Liver Cirrhosis, Liver
SALT for Patients With Hepatic Cirrhosis
Hepatitis B virus (HBV) infection is a very difficult public health problem in the world. Patients often experience the trilogy of "hepatitis-cirrhosis-liver cancer".
- Trial name
- NCT06153914
- Testing
- Sequential Adult Left Lateral Liver Transplantation
- Volunteers
- 47 people
- Sponsor
- RenJi Hospital
Hepatitis C, Chronic
Telaprevir Open-Label Study in Co-Infected Patients
The purpose of this study is to collect safety and tolerability data on telaprevir treatment in combination with Peg-IFN-alfa and RBV in patients with HIV/genotype 1 chronic HCV coinfection with severe fibrosis or compensated…
- Trial name
- NCT01500616
- Testing
- Telaprevir
- Where
- 29 sites in Belgium, Germany and 6 more
- Volunteers
- 122 people
- Sponsor
- Janssen-Cilag International NV
AKI in Cirrhosis
SII in AKI With Cirrhosis
Acute Kidney Injury (AKI) is a common and serious complication in patients withAcute Kidney Injury (AKI) is a common and serious complication in patients with liver cirrhosis, affecting up to 20-50% of hospitalized cirrhotics and…
- Trial name
- NCT07452484
- Testing
- No intervention needed, SII, Serial systemic immune inflammation index
- Volunteers
- 100 people
- Sponsor
- Sohag University
Hepatocellular Carcinoma, Liver Cirrhosis
Abbreviated MRI for HCC Surveillance
This study aims to investigate the clinical feasibility of abbreviated liver MRI for HCC surveillance in a high-risk group.
- Conditions
- Hepatocellular Carcinoma, Liver Cirrhosis, Chronic Hepatitis
- Trial name
- NCT03731923
- Testing
- Biannual ultrasonography, Annual abbreviated liver MRI
- Where
- 2 sites in South Korea
- Volunteers
- 257 people
- Sponsor
- Seoul National University Hospital
Hepatitis, Autoimmune, Cholangitis
Remission Induction of Primary Biliary Cholangitis-autoimmune Hepatitis Overlap Syndrome
Biochemical response of primary biliary cholangitis-autoimmune hepatitis overlap syndrome induced by ursodeoxycholic acid only or combination therapy of immunosuppressive agents
- Conditions
- Hepatitis, Autoimmune, Cholangitis, Liver Cirrhosis, Biliary, Cholestasis
- Trial name
- NCT02936596
- Testing
- Ursodeoxycholic acid combination of immunosuppressive agents, Ursodeoxycholic Acid
- Where
- China
- Volunteers
- 53 people
- Sponsor
- Xiaoli Fan
Liver Cirrhosis
Coagulation in Cirrhosis
Out of fear of bleeding, liver cirrhosis patients are often treated prophylactically with blood and coagulation products before minor interventions.
- Trial name
- COUCH (NCT05667805)
- Testing
- Platelet Concentrate, Prothrombin Complex Concentrate, Restricitve Use
- Where
- Austria
- Volunteers
- 400 people
- Sponsor
- Medical University of Vienna
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