Clinical trials: Hepatic Failure
Hepatic Encephalopathy
Secondary Prophylaxis of Hepatic Encephalopathy in Cirrhotic Patients
The aim of this study is to compare the efficacy and safety of colistin versus lactulose for secondary prophylaxis of overt hepatic encephalopathy in patients with liver cirrhosis.
- Trial name
- NCT05279586
- Testing
- lactulose, colistin
- Volunteers
- 316 people
- Sponsor
- Madonna Magdy Fahmy
Cirrhoses, Liver, Hepatic Encephalopathy (HE)
Study on Proteomic and Microbiome Changes in Patients With Hepatic Encephalopathy (HE)
The objective of this observational study is to compare the differences in proteomics and gut microbiome between the liver cirrhosis group without hepatic encephalopathy and the hepatic encephalopathy group through proteomics and…
- Trial name
- NCT07150195
- Where
- China
- Volunteers
- 32 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Indocyanine Green, Postoperative Complications
One Way to Diagnose Hepatic Insufficiency the First Postoperative Day After Resection: Prospective Cohort Study
Introduction: Hepatic insufficiency is a complication that puts the life of the patient undergoing resective surgery at risk. Thus, the diagnosis should be made early.
- Conditions
- Indocyanine Green, Postoperative Complications, Acute Liver Failure
- Trial name
- IGHI (NCT04570800)
- Volunteers
- 44 people
- Sponsor
- Castilla-La Mancha Health Service
Hepatic Insufficiency, Liver Diseases
A Study Evaluating How Moderate Liver Impairment Affects the Absorption, Distribution, Metabolism, and Elimination of Sevabertinib After a Single Oral Dose
This is a research study to understand how liver impairment affects the way the body processes a new cancer medicine called sevabertinib (BAY 2927088).
- Conditions
- Hepatic Insufficiency, Liver Diseases, Pharmacokinetics, Drug Metabolism
- Trial name
- NCT07102095
- Testing
- Sevabertinib
- Where
- 2 sites in United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Bayer
Liver Cancer, Liver Failure
Quantitative MRI and Outcomes of Liver Resection
The present observational study aims to assess the benefit of this quantitative multiparametric magnetic resonance imaging (MRI) in clinical practice, to quantify future liver remnant performance, and to accurately predict the…
- Conditions
- Liver Cancer, Liver Failure, Bile Leak, Liver Metastases
- Trial name
- NCT06181318
- Testing
- Multiparametric MRI scan of the liver
- Volunteers
- 33 people
- Sponsor
- University Hospital Heidelberg
Hepatitis B, Acute-On-Chronic Liver Failure
Three Types of Nucleotide/Nucleoside Analogues Treatment in HBV Related ACLF
This study is to investigate the clinical efficacy of three types of nucleotide/nucleoside analogues in treatment of HBV-related acute-on-chronic liver failure.
- Trial name
- HBV (NCT03920618)
- Testing
- Entecavir, Tenofovir Disoproxil Fumarate, Tenofovir Alafenamide
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Liver Failure, Liver Transplant; Complications
Telemedicine Based Remote Home Monitoring After Liver Transplantation
A significant opportunity exists to involve patients and their caregivers in more effective perioperative care and transition to home for transplant patients.
- Trial name
- TelehealthOLT (NCT03878329)
- Testing
- remote home monitoring
- Volunteers
- 50 people
- Sponsor
- University of Cincinnati
Worsening Chronic Heart Failure, Diabetic Nephropathy
A Study to Learn How Finerenone (BAY94-8862) Moves Into, Through and Out of the Body, How it Affects the Body, and How Safe it is in Adult Participants With Different Degrees of Reduced Liver Function and in Healthy Participants With Similar Age, Weight and Gender Distribution
Researchers are looking for a better way to treat people who have worsening of chronic heart failure, a long-term condition where the heart does not pump blood as well as it should, as well as to treat patients who have diabetic…
- Trial name
- NCT04881994
- Testing
- Finerenone (BAY94-8862)
- Where
- Germany
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Bayer
Hepatic Encephalopathy
S. Endotoxin, Inflammatory Mediators and MRS Before and After Treatment in MHE
The purpose of this study is to examine S.endotoxins , inflammatory mediators and Magnetic Resonance Spectroscopy (MRS) before and after treatment in patients of cirrhosis and minimal hepatic encephalopathy.
- Trial name
- endtxninHE (NCT01446523)
- Testing
- Lactulose
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Govind Ballabh Pant Hospital
Liver Failure, End Stage Liver Disease
Dual Hypothermic Oxygenated Perfusion of DCD Liver Grafts in Preventing Biliary Complications After Transplantation
Rationale: Recent publications report good results of controlled donation after circulatory death (DCD) Maastricht category III liver transplantation when strict donor-recipient matching is applied and ischemia times are kept to…
- Conditions
- Liver Failure, End Stage Liver Disease, Biliary Tract Diseases
- Trial name
- DHOPE-DCD (NCT02584283)
- Testing
- Dual hypothermic oxygenated perfusion, Liver Assist®, Perfusion fluid
- Where
- 6 sites in Belgium, Netherlands and 1 more
- Volunteers
- 157 people
- Sponsor
- Robert J. Porte
Hepatic Steatosis, Pituitary Gland Failure
Hepatic Steatosis and Pituitary Gland Failure, Evaluation by Nuclear Magnetic Resonance (NMR) Imaging
The investigator put forward the hypothesis that liver fat mass in patients with pituitary gland failure is greater than that in a control population.
- Trial name
- SHAH (NCT02814240)
- Testing
- NMR, Blood samples, fibroscan
- Where
- France
- Volunteers
- 21 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Acute Liver Failure, Mitochondrial Diseases
Longitudinal Study of Mitochondrial Hepatopathies
The specific aims of this study are (1) to determine the clinical phenotypes and natural history of hepatic RC and FAO disorders, (2) to determine the correlation between genotype and phenotype, (3) to determine if circulating…
- Conditions
- Acute Liver Failure, Mitochondrial Diseases, End Stage Liver Disease, Respiratory Chain Deficiencies, Mitochondrial
- Trial name
- MITOHEP (NCT01148550)
- Where
- 16 sites in United States, Canada
- Volunteers
- 90 people
- Sponsor
- Arbor Research Collaborative for Health
Septic Shock and Acute Kidney Injury
Early Versus Late CRRT in ACLF Patients With Septic Shock and AKI
Consecutive patients with ACLF (Acute on Chronic Liver Failure) and septic shock with AKI (Acute Kidney Injury) who give written informed consent will be included in this prospective trial at ILBS.
- Trial name
- NCT03343340
- Testing
- Early CRRT, Late CRRT, Standard Medical Therapy
- Where
- India
- Volunteers
- 150 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Liver Decompensation, Hepatocellular Carcinoma
The Second Multicenter Hemophilia Cohort Study
The Second Multicenter Hemophilia Cohort Study (MHCS-II) will evaluate and prospectively follow approximately 4500 persons with hemophilia who were exposed to hepatitis C virus (HCV).
- Conditions
- Liver Decompensation, Hepatocellular Carcinoma, Non-Hodgkin Lymphoma
- Trial name
- NCT00341705
- Where
- 48 sites in United States, Brazil and 6 more
- Volunteers
- 2,565 people
- Sponsor
- National Cancer Institute (NCI)
Post-Hepatectomy Liver Failure, Liver Failure
CT Volumetry and Hepatic Vascular Deformation Mapping to Predict Post-Hepatectomy Liver Failure
Removing a large part of the liver (major hepatectomy) can cure primary and secondary liver cancers, but it carries the risk of post-hepatectomy liver failure (PHLF), a serious complication in which the liver left behind - the…
- Conditions
- Post-Hepatectomy Liver Failure, Liver Failure, Liver Neoplasms, Carcinoma, Hepatocellular
- Trial name
- BEYOND-SIZE (NCT07727759)
- Testing
- Preoperative CT volumetry with hepatic vascular deformation mapping (VDM)
- Where
- 3 sites in Egypt
- Volunteers
- 1,070 people
- Sponsor
- Minia University
Sepsis, ARDS
Microcirculation and Oxidative Stress in Critical Ill Patients in Surgical Intensive Care Unit
As medicine advances, many lives can be saved in the intensive care unit. However, when multiple organ failure occurs, the mortality rate of patients increases dramatically.
- Conditions
- Sepsis, ARDS, Liver Failure, Renal Failure
- Trial name
- NCT00808691
- Testing
- Critical care
- Where
- Taiwan
- Volunteers
- 124 people
- Sponsor
- National Taiwan University Hospital
Ventilation, ARDS
Respiratory Knowledge Portal Computer and Phone Application to Improve Quality of Mechanical Ventilation by Reducing the Number of Ventilator Associated Events, Injury Created by the Ventilator and Unsafe Setting of Alarms.
Ventilator associated events (VAE) is a quality metric defined by 48 hours of stability followed by 48 hours of escalation of ventilator settings within the ICU.
- Conditions
- Ventilation, ARDS, Respiratory Failure, Mechanical Ventilation
- Trial name
- NCT06737432
- Testing
- RKP Monitoring Software
- Where
- United States
- Volunteers
- 875 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Hepatic Insufficiency
Pharmacokinetics and Pharmacodynamics of BI 1356 in Subjects With Different Degrees of Liver Impairment as Compared to Healthy Subjects
To investigate the influence of mild, moderate, and severe liver impairment on the pharmacokinetics and pharmacodynamics of linagliptin in comparison with a control group with normal hepatic function after single or multiple oral…
- Trial name
- NCT02183376
- Testing
- BI 1356
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Hepatic Encephalopathy
Diet Management on Hepatic Encephalopathy of Patients With Variceal Bleeding After Intrahepatic Portosystemic Shunt Creation
Hepatic encephalopathy is a severe complication of transjugular intrahepatic portosystemic shunt (TIPS) treatment in patients with cirrhosis and variceal bleeding.
- Trial name
- DM-PTHE (NCT03372499)
- Testing
- diet management strategy for encephalopathy
- Where
- China
- Volunteers
- 86 people
- Sponsor
- Li Yang
Liver Failure, Renal Failure
Assessment of Renal Function in Cirrhotic Patients
The purpose of this study is to help determine whether cystatin C is a more sensitive laboratory measurement for renal function in cirrhotic patients.
- Trial name
- NCT01895114
- Where
- United States
- Volunteers
- 213 people
- Sponsor
- Baylor Research Institute