Clinical trials: Hepatic Fibrosis
Hepatic Steatosis and Fibrosis in Rheumatoid Arthritis Patients
Hepatic Steatosis and Fibrosis in Rheumatoid Arthritis Patients
studying the prevalence of hepatic steatosis and fibrosis in a large scale of patients with RA and healthy controls
- Trial name
- NCT05679648
- Testing
- ultrasonography
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sohag University
HIV
Switching From Protease Inhibitor/Ritonavir to Generic Single Tablet Regimen of Tenofovir Alafenamide/Emtricitibine/Dolutegravir
This is a phase III, multicenter, open-label, single-arm study of 190 virologically suppressed HIV-infected adults
- Trial name
- NCT03727152
- Testing
- generic single tablet TAF/FTC/DTG
- Where
- 2 sites in Thailand
- Volunteers
- 170 people
- Sponsor
- The HIV Netherlands Australia Thailand Research Collaboration
Liver Fibrosis
Silybin - Vitamin E- Phospholipids Complex Reduces Liver Fibrosis in Patients With Chronic Hepatitis C Treated With Peg-IFN-a and RBV
Chronic hepatitis C is both a virologic and a fibrotic disease, with mortality resulting mainly from the complications of cirrhosis and HCC.
- Trial name
- NCT01935817
- Testing
- Silybin 94 mg + vitamin E 90 mg + phospholipids 194 mg complex
- Where
- Italy
- Volunteers
- 64 people
- Sponsor
- University of Catania
Fibrosis, Liver
Screening for Chronic Liver Diseases in General Population
Improving the care of patients with liver diseases in primary care and will allow patients with chronic liver disease to benefit from a course appropriate care.
- Trial name
- HEPGEN (NCT06366425)
- Testing
- Blood sample then fibroscan
- Where
- France
- Volunteers
- 260 people
- Sponsor
- University Hospital, Montpellier
Portal Vein Thrombosis, Cirrhosis, Liver
Preventing de Novo Portal Vein Thrombosis With Antithrombin-III in Patients With Cirrhosis
To prevent portal vein thrombosis (PVT) in patients with cirrhosis at risk for PVT by pharmacologic prophylaxis with intravenous antithrombin (AT-III).
- Trial name
- PiVoT (NCT04055389)
- Testing
- Antithrombin III
- Where
- United States
- Sponsor
- Jonathan Stine
HBV, Fibrosis, Liver
Chronic Hepatitis B Virus Infection in Zambia
Chronic hepatitis B virus infection is a common condition in Zambia. Among Zambian blood donors, up to 8% are chronically infected with HBV.
- Conditions
- HBV, Fibrosis, Liver, Cirrhosis, Liver, Alcoholic Hepatitis
- Trial name
- HUTCH (NCT03158818)
- Testing
- Standard of care
- Where
- Zambia
- Volunteers
- 326 people
- Sponsor
- University of Alabama at Birmingham
Liver Disease Chronic, Fibrosis, Liver
Effectiveness of Ultrasound in Liver Stiffness and Fat Quantification
Liver stiffness is a marker for scarring of the liver, which occurs after damage from various liver conditions. Scarring prevents normal liver function and can lead to liver failure.
- Conditions
- Liver Disease Chronic, Fibrosis, Liver, Liver Steatoses, Liver Fat
- Trial name
- NCT06111859
- Testing
- Ultrasound based Elastography and fat quantification
- Where
- United Kingdom
- Volunteers
- 180 people
- Sponsor
- King's College Hospital NHS Trust
Liver Fibrosis
Multiomics Study of Fibrosis Factors After Liver Transplantation and Exploration of Fibrosis Methylation Biomarkers
This is a retrospective observational study in liver transplantation recipients with or without allograft liver fibrosis. Based on the GM-seq and Tcr-Seq data, a novel diagnostic model including DNA-methylation and TCR-Seq…
- Trial name
- NCT05926778
- Testing
- Liver allograft fibrosis
- Where
- China
- Volunteers
- 60 people
- Sponsor
- RenJi Hospital
Cirrhosis, Liver Disease Chronic
Inferior Vena Cava Pressure as Alternative to Hepatic Venous Pressure for EUS-guided Portal Pressure Gradient Measurement
This study investigates a new, simplified approach to measuring blood pressure within the liver (portal hypertension) using Endoscopic Ultrasound-Guided Portal Pressure Gradient Measurement (EUS-PPG).
- Conditions
- Cirrhosis, Liver Disease Chronic, Portal Hypertension
- Trial name
- EUS-VEIN (NCT07703540)
- Testing
- HVP-PPG and IVCP-PPG
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- University Hospital Muenster
Alcoholic Liver Disease, Alcoholic Fibrosis of Liver
Early Detection of Alcoholic Liver Disease
This is an observational study to identify the prevalence of advanced liver fibrosis among patients with excessive alcohol intake using a non-invasive method (FibroScan®) and to characterize the main environmental, genetic and…
- Conditions
- Alcoholic Liver Disease, Alcoholic Fibrosis of Liver, Alcoholic Cirrhosis, Excessive Drinking
- Trial name
- NCT04070508
- Sponsor
- University of Pittsburgh
Cirrhosis
A Trial to Investigate the Efficacy of OPC-41061 Administered at a Dose of 7.5 mg in Patients With Hepatic Edema
OPC-41061 at 7.5 mg/day or placebo will be orally administered once daily for 7 days to cirrhosis patients with ascites despite having received treatment with conventional diuretics and the change in body weight from baseline at…
- Trial name
- NCT01050530
- Testing
- OPC-41061
- Where
- 8 sites in Japan
- Volunteers
- 162 people
- Sponsor
- Otsuka Pharmaceutical Co., Ltd.
Cirrhosis, Hepatic Encephalopathy
Eye Movement Testing for Diagnosing Encephalopathy in Patients With Liver Disease
This study involves utilizing a noninvasive computer application (Neurofit) that performs oculometric assessment of dynamic visual processing in patients with liver cirrhosis to see if the presence of advance liver disease…
- Trial name
- NCT04940416
- Testing
- Neurofit (oculometric testing)
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Stanford University
Cystic Fibrosis, Liver Fibrosis
Elastography of the Liver in Cystic Fibrosis Patients. Diagnostic and Prognostic Aspects
The aim of the study is to find CF patients at risk for cystic fibrosis related liver disease (CFLD). Comparison of ultrasound by two modalities and biochemical markers with histological evaluation of liver biopsy if present.
- Trial name
- NCT02603666
- Testing
- Fibroscan
- Volunteers
- 130 people
- Sponsor
- Karolinska University Hospital
Cirrhosis, Acute Liver Failure
Spectrum, Profile and Outcome of Infections in Patients With Cirrhosis and/ or Acute on Chronic Liver Failure
After successful screening diagnosis of cirrhosis and/or acute or chronic liver failure will be made. These patients will undergo detail clinical, biochemical and microbiological examination at baseline.
- Conditions
- Cirrhosis, Acute Liver Failure, Chronic Liver Failure
- Trial name
- NCT01872767
- Where
- India
- Volunteers
- 522 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Liver Fibrosis
Screening of Liver Fibrosis in Adults Without Known Liver Disease
SIRIUS is the "serious" response to the prevalence of liver cirrhosis in Slovakia. We plan to screen adult Slovaks without acute or life-threatening comorbidity and without known liver disease (except from non-alcoholic fatty…
- Trial name
- SIRIUS (NCT05486767)
- Testing
- Transient elastography
- Where
- 3 sites in Slovakia
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- F.D. Roosevelt Teaching Hospital with Policlinic Banska Bystrica
Non-Alcoholic Fatty Liver Disease (NAFLD), Non-Alcoholic Steatohepatitis (NASH)
The Sonic Incytes Liver Incytes System, Evaluation of Liver Fibrosis and Steatosis Versus MRE and MRI PDFF
The main purpose of this study is to compare the effectiveness of various non-invasive elastography techniques at determining liver stiffness measures in human subjects.
- Conditions
- Non-Alcoholic Fatty Liver Disease (NAFLD), Non-Alcoholic Steatohepatitis (NASH), Liver Fibroses, Liver Steatoses
- Trial name
- NCT04682600
- Testing
- Liver Incytes System
- Where
- United States
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Sonic Incytes
Liver Fibrosis
Prospective Evaluation of FibroScan in Patients Treated With Methotrexate
The aim of this study is to evaluate liver fibrosis using FibroScan and biochemical markers in patients treated with methotrexate.
- Trial name
- Methoscan (NCT00673101)
- Where
- France
- Volunteers
- 1,871 people
- Sponsor
- Association HGE CHU Bordeaux Sud
Cirrhosis, Varices, Esophageal
Probiotics for Portal Hypertension
Chronic peripheral and splanchnic vasodilatation are the hallmark hemodynamic abnormality in cirrhosis and contribute to the pathogenesis of portal hypertension.
- Trial name
- NCT01134692
- Testing
- Propranolol, Norfloxacin, VSL#3
- Where
- India
- Sponsor
- Govind Ballabh Pant Hospital
Cirrhosis
Ultrasonography SWE for Hepatic Fibrosis Evaluation
The purpose of this study is to measure diagnostic performance of ultrasound shear wave elastography to detect advanced hepatic fibrosis.
- Trial name
- NCT02673411
- Testing
- ultrasound shear wave elastography
- Where
- South Korea
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Chronic Liver Disease
Relative-dose-response Test (RDR) Adaptation for Chronic Liver Disease
The relative-dose-response test (RDR) is considered to be the most accurate method for evaluating vitamin A nutritional status (VANS) in patients suffering from liver disease, as it infers the reserves of the vitamin in the…
- Trial name
- NCT01634698
- Testing
- retinyl palmitate (UNICEF, Melbourne, Australia)
- Where
- Brazil
- Volunteers
- 178 people
- Sponsor
- Universidade Federal do Rio de Janeiro