Clinical trials: Hepatic Hemodynamics
Portal Hypertension, Complications of Cirrhosis
Treatment for Prevention of Variceal Rebleeding Guided by the Hemodynamic Response
This is a prospective trial of random distribution, open, parallel group, in which patients with esophagic variceal bleeding will be randomized into two treatment groups, after controlling acute bleeding.
- Trial name
- NCT00563602
- Testing
- Hemodynamic guided therapy
- Where
- Spain
- Volunteers
- 140 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Portal Hypertension, Cirrhosis
MRI to Assess the Effect of Non-selective Beta-blocker in Patients With Cirrhosis
Background: Standardization and new therapeutic treatments of variceal bleeding has significantly reduced the mortality the last 25 years, but there is still a high 6-week mortality around 15-20% and 1-year mortality of about…
- Conditions
- Portal Hypertension, Cirrhosis, Esophageal Varices, Gastric Varices Bleeding
- Trial name
- NCT03438916
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Hvidovre University Hospital
Trauma (Including Fractures), Trauma Patients
Renal and Hepatic Abnormal Doppler Patterns in Trauma
The goal of this observational study is to learn about renal and hepatic blood flow abnormalities detected by bedside ultrasound in adult patients admitted to the intensive care unit (ICU) following major trauma.
- Conditions
- Trauma (Including Fractures), Trauma Patients, Kidney Disease, Hypovolemia
- Trial name
- RECREANT (NCT07492511)
- Testing
- Point of care ultrasound
- Where
- Italy
- Volunteers
- 350 people
- Sponsor
- Azienda Usl di Bologna
Refractory Ascites
Evaluation of Hemodynamic Parameters Following Transjugular Intrahepatic Portosystemic Shunt (TIPS)
During a TIPS procedure, a shunt or stent (mesh tube) is passed down the jugular vein (the vein above the collarbone in the neck) using fluoroscopy (real time x-rays) guidance.
- Trial name
- NCT04050683
- Testing
- Study - Transjugular Intrahepatic Portosystemic Shunt (TIPS), Control - Transjugular Intrahepatic Portosystemic Shunt (TIPS)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Medical College of Wisconsin
Alcoholic Cirrhosis
Hemodynamic Effects of Chronic Administration of Spironolactone and/or Propranolol in Alcoholic Cirrhotic Patients
The aim of this study was assesment of splanchnic and systemic hemodynamic effects of chronic administration (2 month) of spironolactone or propranolol, alone or in association in alcoholic cirrhotic patients.
- Trial name
- NCT00188045
- Testing
- Propranolol - Spironolactone
- Volunteers
- 54 people
- Sponsor
- University Hospital, Angers
Liver Transplantation (LT), End-stage Liver Disease (ESLD)
Restrictive Fluid Management In Liver Transplantation (REFIL)
The goal of the REFIL-2 study is to evaluate the effectiveness of a low splanchnic blood volume restrictive fluid management strategy (a strategy that involves limiting fluid administration and prioritizing the use of medications…
- Trial name
- REFIL-2 (NCT07695363)
- Testing
- Low splanchnic blood volume restrictive fluid management strategy, Phlebotomy, Optimized cardiac output liberal fluid management strategy
- Where
- 4 sites in Canada
- Volunteers
- 866 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Hepato-Renal Syndrome, Portal Hypertension
MRI to Assess the Effect of Terlipressin in Patients With Acute Hepatorenal Syndrome (HRS-AKI)
Heptorenal syndrome (HRS) is divided into two types. A non-acute kidney injury (NAKI-HRS), which is predominantly related to end-stage disease and a more acute kidney injury (HRS-AKI).
- Conditions
- Hepato-Renal Syndrome, Portal Hypertension, Acute Kidney Injury, Liver Diseases
- Trial name
- NCT03483272
- Where
- 2 sites in Denmark
- Volunteers
- 11 people
- Sponsor
- Hvidovre University Hospital
Cirrhosis, Portal Hypertension
Effects of a Novel Physical Exercise Program in Patients With Cirrhosis (the LFN-exercise Protocol)
This study evaluates the effects of a structured exercise (The LFN-exercise protocol) program plus diet, on cerebral hemodynamics (cerebral blood flow) and hepatic hemodynamics (portal pressure), as well as on nutritional status…
- Conditions
- Cirrhosis, Portal Hypertension, Exercise
- Trial name
- LFN-EP (NCT03932552)
- Testing
- Exercise, nutritional therapy
- Volunteers
- 28 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Cirrhosis, Ascites
Effect of Pioglitazone on Portal and Systemic Hemodynamics in Patients With Advanced Cirrhosis
The purpose of this study is to investigate the response to pioglitazone on the hepatic venous pressure gradient and peripheral vascular responsiveness to vasoconstrictors in patients with advanced (Child´s Grade B or C)…
- Conditions
- Cirrhosis, Ascites, Portal Hypertension
- Trial name
- NCT00570622
- Testing
- Pioglitazone
- Where
- Austria
- Volunteers
- 20 people
- Sponsor
- Medical University of Vienna
Portal Pressure Gradient (PPG) Measurement Guided by Endoscopic Ultrasound (EUS), Hepatic Cirrhosis
Evaluation of the Efficacy and Safety of Portal Pressure Gradient (PPG) Measurement Guided by Endoscopic Ultrasound (EUS) in the Therapeutic Algorithm of Patients with Liver Cirrhosis.
The development of Clinical significant PH (CSPH) is a major driver of complications. PPG is the strongest predictor of decompensation .
- Trial name
- GPP-USE (NCT06664307)
- Where
- Spain
- Volunteers
- 35 people
- Sponsor
- Hospital Universitario Virgen Macarena
Small-for-Size Syndrome
Octreotide vs. Splenic Artery Ligation for Portal Flow Modulation in Living Donor Liver Transplants (SCALOP Trial)
The goal of this clinical trial is to compare two treatments for regulating blood flow in small liver grafts during living donor liver transplantation (LDLT).
- Trial name
- SCALOP (NCT06974344)
- Testing
- Octreotide (drug), Splenic Artery Ligation (SAL)
- Where
- Saudi Arabia
- Volunteers
- 80 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
Small-For-Size Liver Syndrome, Ligation
Splenic Artery Ligation and Portocaval Shunt in Small-for-size Syndrome
Our study aimed at assessing the changes of portal vein pressure, portal vein flow and hepatic arterial flow (HAF) in liver remnants ≤ 30% of the standard liver volume by reducing portal vein overflow via ligation of the splenic…
- Conditions
- Small-For-Size Liver Syndrome, Ligation, Liver Regeneration, Splenic Artery
- Trial name
- splen ligation (NCT05459883)
- Testing
- splenic artery ligation
- Where
- Greece
- Volunteers
- 13 people
- Sponsor
- Aretaieion University Hospital
Cirrhosis, Portal Hypertension
4D-Flow MRI Assessment of Portal Hypertension and TIPS Outcomes in Cirrhosis
PORTAL-4D is a prospective, interventional, non-randomized, parallel-group diagnostic study conducted at Pitié-Salpêtrière Hospital (Paris, France).
- Trial name
- PORTAL-4D (NCT07554183)
- Testing
- 4D-Flow Liver and heart MRI with Gadolinium injection, Samples Without DNA
- Where
- 2 sites in France
- Volunteers
- 60 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Portal Hypertension
The Role of Somatostatin in the Hemodynamics of the Hepatic Circulation in Patients Undergoing Liver Resection
The purpose of the present clinical trial is to study the effect of somatostatin in the regulation of velocity and blood flow of the hepatic circulation in patients undergoing liver resection.
- Trial name
- NCT04010669
- Testing
- Somatostatin
- Volunteers
- 40 people
- Sponsor
- Laikο General Hospital, Athens
Healthy, Liver Disease
Magnetic Resonance Imaging of Blood Flow in the Liver and Abdomen
This study will use magnetic resonance imaging (MRI) to examine blood flow patterns in the arteries and veins of the liver and abdomen.
- Trial name
- NCT00001719
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
End Stage Liver Disease, Acute Kidney Injury
Effect of Preoperative Beta Blocker Use Postoperative Renal Function in the Patients Undergoing Liver Transplantation
This is prospective cohort study of patients classified by the premedication history of beta-blocker. The investigators aim to evaluate the hemodynamic effect of beta blocker through Swan-Ganz catheter monitoring and arterial…
- Trial name
- NCT03633812
- Testing
- Observational study, Beta blocker medication history
- Where
- 2 sites in South Korea
- Volunteers
- 477 people
- Sponsor
- Asan Medical Center
Cirrhosis, Erectile Dysfunction
Effect of Vardenafil on Erectile Dysfunction and Portal Hemodynamics in Patients With Liver Cirrhosis
The investigators want to analyze the effect of Vardenafil on Erectile Dysfunstion and portal hemodynamics in patients with liver cirrhosis.
- Trial name
- NCT02344823
- Testing
- Vardenafil, HVPG (Hepatic venous pressure measurement) baseline, HVPG (Hepatic venous pressure measurement) day 7
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Medical University of Vienna
Liver Cirrhosis, Portal Hypertension
Effect of Betablocker or Aldosterone Antagonist Therapy on Patients With Liver Cirrhosis
The study´s purpose is to investigate the effect of beta blockade or aldosterone antagonist therapy on oxygenation, peripheral and cardiac hemodynamics and humoral systems, in patients with liver cirrhosis.
- Trial name
- PEKASYS (NCT00332904)
- Testing
- propranolol, spironolactone
- Where
- Denmark
- Volunteers
- 22 people
- Sponsor
- Hvidovre University Hospital
Cirrhosis, Portal Hypertension
Efficacy and Safety of Simvastatin in the Treatment of Portal Hypertension
The purpose of this study is to evaluate the effects of continuous simvastatin administration on the hepatic venous pressure gradient (HVPG), as a surrogate marker of prognosis, and its safety in patients with cirrhosis and…
- Trial name
- NCT00594191
- Testing
- Simvastatin
- Where
- 3 sites in Spain
- Volunteers
- 59 people
- Sponsor
- Hospital Clinic of Barcelona
Liver Diseases, Liver Transplantation
Hepatic and Systemic Hemodynamic Modeling During Liver Surgery
" Despite the medical and surgical progress of the last two decades, the selection of candidates for liver surgery remains based on old principles and insufficiently sensitive to fine-tune the gesture to patient-specific…
- Trial name
- LSM (NCT05339984)
- Testing
- Partial hepatectomy (open approach), liver transplantation, Portal vein embolization
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris