Clinical trials: Hepatic Malignancies
Hepatectomy, Cancer, Metastatic
Efficacy and Tolerability of Hemopatch After Hepatic Resection
Previous in vitro and in vivo studies detected the Hemopatch Sealing Hemostat® to be a new versatile, self-adhering hemostatic sealing pad consisting of a polyethylene glycol-coated collagen.
- Conditions
- Hepatectomy, Cancer, Metastatic, Hemostasis
- Trial name
- NCT03323359
- Testing
- Hemopatch, Common Surgical Techniques
- Where
- Italy
- Volunteers
- 98 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Hepatocellular Carcinoma (HCC)
Sequential T and I With H101 Via HAI for BCLC C Stage HCC: A Prospective Single-Center Single-Arm Pilot Study
Indication: Hepatocellular carcinoma (HCC) patients at Barcelona Clinic Liver Cancer (BCLC) stage C. Study Objectives: This study aims to use a prospective single-center single-arm pilot approach to preliminarily obtain data on…
- Trial name
- NCT06685354
- Testing
- hepatic arterial infusion of recombinant human type 5 adenovirus
- Where
- China
- Volunteers
- 11 people
- Sponsor
- Henan Cancer Hospital
Gastroesophageal Varices, JAK2 Mutation
Anticoagulation in Gastroesophageal Varices and JAK2 Mutation
Myeloproliferative neoplasms (MPNs), including polycythemia vera, essential thrombocythemia, and primary myelofibrosis, may lead to gastroesophageal varices.
- Conditions
- Gastroesophageal Varices, JAK2 Mutation, Myeloproliferative Neoplasm
- Trial name
- NCT04527666
- Testing
- Anticoagulation Agents
- Volunteers
- 40 people
- Sponsor
- Shanghai Zhongshan Hospital
Pancreatic Neoplasm Malignant Head Primary
A New Anatomical Classification of Portal Vein Location of Pancreas Tumors
In this retrospective study, we recorded the location of pancreatic tumors and relation/proximity to the portal vein. The surgical difficulty and requirement of additional interventions were also evaluated.
- Trial name
- NCT04416685
- Testing
- primary repair, segmental resection, graft reconstruction
- Volunteers
- 43 people
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Neuromuscular Blockade, Intraoperative Bleeding
Bleeding in Laparoscopic Liver Surgery
Blood loss during liver resection surgery affects patients morbidity, short and long-term mortality. Among non-surgical interventions to minimize intraoperative blood loss and perioperative blood products transfusion, maintaining…
- Conditions
- Neuromuscular Blockade, Intraoperative Bleeding, Hepatic Cancer
- Trial name
- MODELS (NCT04609410)
- Testing
- Neuromuscular blockade
- Where
- Italy
- Volunteers
- 48 people
- Sponsor
- Università Vita-Salute San Raffaele
Colorectal Cancer With Hepatic Metastases
A Study of AK112 in Combination With VG2025 in Colorectal Cancer With Liver Metastases
An open-label, multicenter, phase Ib/II study of AK112 in combination with VG2025 for advanced colorectal cancer with liver metastases.
- Trial name
- NCT07357220
- Testing
- VG2025, AK112
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Akeso
Liver Metastases, Recurrent Colon Cancer
Hepatic Arterial Infusion of Floxuridine, Gemcitabine Hydrochloride, and Radiolabeled Monoclonal Antibody Therapy in Treating Liver Metastases in Patients With Metastatic Colorectal Cancer Previously Treated With Surgery
RATIONALE: Drugs used in chemotherapy, such as floxuridine and gemcitabine hydrochloride, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Conditions
- Liver Metastases, Recurrent Colon Cancer, Recurrent Rectal Cancer, Stage IV Colon Cancer
- Trial name
- NCT00645710
- Testing
- gemcitabine hydrochloride, floxuridine, proteomic profiling
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- City of Hope Medical Center
Hepatocellular Carcinoma, Hepatic Chemotherapy
HAIC Compared With TACE in Huge Hepatocellular Carcinoma
This study intends to compare the efficacy of transcatheter arterial chemical embolization (TACE) with hepatic arterial infusion chemotherapy (HAIC) for patients with intermediate-advanced huge hepatocellular carcinoma.
- Conditions
- Hepatocellular Carcinoma, Hepatic Chemotherapy, Liver Cancer
- Trial name
- NCT06641713
- Testing
- TACE, HAIC
- Where
- China
- Volunteers
- 664 people
- Sponsor
- Sun Yat-sen University
Pain Control, Liver Cancer
Hepatic Hilar Nerve Block Versus Sham in Pain Control During Liver Ablation and TACE Procedures
This study is aimed at assessing the effectiveness of a novel liver specific nerve block in improving pain control during painful liver interventional radiology procedures including liver tumoral ablation and trans arterial…
- Trial name
- NCT04769713
- Testing
- Hepatic Hilar Nerve Block Needle placement, Injection of Ropivacaine in the hepatic hilum for the hepatic hilar nerve block
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Liver Fibroses, HepatoCellular Carcinoma
Long-term Outcomes of Chronic Hepatitis C Patients Post Sofosbuvir-based Treatment
Primary Objective: To evaluate the long-term outcomes including liver related morbidity, mortality and hepatocellular carcinoma (HCC) development as compared to those of historical control with interferon(IFN)-based treatment.
- Conditions
- Liver Fibroses, HepatoCellular Carcinoma, Cryoglobulinemia, Metabolic Disease
- Trial name
- LONGHEAD (NCT03042520)
- Testing
- Observation only
- Where
- 26 sites in South Korea, Taiwan
- Volunteers
- 200 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
CTCs, Pancreatic Cancer
EUS-guided CTCs + Multi-omics: Predicting Pancreatic Cancer Recurrence and Metastases
The investigators conduct a single-center, prospective, observational study to explore the value of EUS-guided portal vein circulating tumor cells (PV-CTCs) and their subtypes combined with multi-omics tests in the early warning…
- Conditions
- CTCs, Pancreatic Cancer, Liver Metastases, Relapse
- Trial name
- NCT07448376
- Testing
- CTC
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Huazhong University of Science and Technology
Gastroesophageal Varices Hemorrhage, Gastrointestinal Cancer
Management of Oxaliplatin-related Gastroesophageal Variceal Bleeding
In this randomized controlled study, we aim to compare the efficacy and safety of these two interventions in patients with oxaliplatin-induced gastroesophageal variceal bleeding.
- Conditions
- Gastroesophageal Varices Hemorrhage, Gastrointestinal Cancer, Received Oxaliplatin-based Chemotherapy
- Trial name
- NCT05141617
- Testing
- Endoscopic treatment, TIPS
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shanghai Zhongshan Hospital
Hepatic Cancer, Liver Neoplasms
LC Bead LUMI Radio-Opaque Embolic Beads to Detect and Characterize the Vascularity of Hepatic Tumors
Background: Liver cancer begins in the cells of the liver. It can be treated with chemotherapy, radiation, or even a liver transplant. A less invasive treatment may be able to help some people with liver cancer.
- Conditions
- Hepatic Cancer, Liver Neoplasms, Hepatocellular Cancer, Liver Cancer
- Trial name
- NCT02649868
- Testing
- Transarterial embolization (TAE), LC Bead LUMI
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Hepatocellular Carcinoma, Liver Cancer
ET1402L1-ARTEMIS™2 T Cells in Alpha Fetoprotein (AFP) Expressing Hepatocellular Carcinoma
Clinical study to evaluate safety (primary objectives) and efficacy (secondary objective) of ET1402L1-ARTEMIS™2 T cells in patients with alpha fetoprotein positive (AFP+ ) hepatocellular carcinoma (HCC).
- Conditions
- Hepatocellular Carcinoma, Liver Cancer, Liver Neoplasms, Metastatic Liver Cancer
- Trial name
- NCT03888859
- Testing
- ET1402L1-ARTEMIS™ T cells -IV, ET1402L1-ARTEMIS™ T cells -intra-hepatic artery, ET1402L1-ARTEMIS™ T cells -Intratumoral Injections
- Where
- China
- Volunteers
- 12 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Estrogen Receptor Negative, Head and Neck Squamous Cell Carcinoma
Talazoparib in Treating Patients With Advanced or Metastatic Solid Tumors That Cannot Be Removed by Surgery and Liver or Kidney Dysfunction
This phase I trial studies the side effects and best dose of talazoparib in treating patients with solid tumors that have spread to other places in the body and usually cannot be cured or controlled with treatment (advanced) or…
- Conditions
- Estrogen Receptor Negative, Head and Neck Squamous Cell Carcinoma, HER2/Neu Negative, Hormone-Resistant Prostate Cancer
- Trial name
- NCT02567396
- Testing
- Laboratory Biomarker Analysis, Pharmacological Study, Talazoparib
- Sponsor
- National Cancer Institute (NCI)
Liver Cancer
Effect of Smoked Plum and Chewing Gum on Postoperative Bowel Function Following Hepatic Resection
Every patient undergoing surgery in the abdomen, such as hepatic resection, will experience temporary paralysis of bowel function.
- Trial name
- SP/GC-HCC (NCT02649153)
- Testing
- smoked plum, gum chewing
- Where
- China
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Guangxi Medical University
Neoplasms
Rucaparib Hepatic Impairment Study in Patients With a Solid Tumor
Phase 1, open-label, parallel group, PK, safety and tolerability study in patients with an advanced solid tumor and either normal hepatic function (Group 1, n = 8) or moderate hepatic impairment (Group 2, n = 8) according to the…
- Trial name
- NCT03521037
- Testing
- Rucaparib camsylate
- Where
- 6 sites in Poland, Slovakia and 1 more
- Volunteers
- 16 people
- Sponsor
- pharmaand GmbH
Colorectal Neoplasms, Floxuridine
Induction Treatment for Initially Unresectable Colorectal Liver Metastases: Combined Hepatic Arterial Infusion Pump Therapy With Systemic Therapy
The goal of this randomized clinical trial is to investigate induction treatment with Hepatic Arterial Infusion Pump therapy combined with systemic therapy (HAIP-SYST) in chemotherapy-naive patients with unresectable colorectal…
- Conditions
- Colorectal Neoplasms, Floxuridine, Liver Metastases, Vascular Access Device
- Trial name
- PUMP-IT RCT (NCT06857773)
- Testing
- Intra arterial infusion Floxuridine (FUDR) combined with systemic therapy, Hepatic arterial infusion pump (HAIP), Systemic therapy (standard of care)
- Where
- Netherlands
- Volunteers
- 306 people
- Sponsor
- The Netherlands Cancer Institute
Liver Neoplasms, Hepatic Cancer
Fusion Guided Thermal Ablation Combined With External Beam Radiation for Hepatic Neoplasms
Background: Pilot study to assess feasibility for combining treatment modalities that should be synergistic (radiation and thermal ablation).
- Conditions
- Liver Neoplasms, Hepatic Cancer, Liver Cancer
- Trial name
- NCT01862718
- Testing
- Thermal Ablation, Standard External Beam Radiation Therapy
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Biliary Tract Cancer
Study of Hepatic Arterial Infusion to Treat Biliary Tract Carcinomas
This Phase II clinical trial is to study the effectiveness and safety of continuous hepatic arterial infusion (HAI) of Oxaliplatin and Fluorouracil in Patients with Unresectable Biliary tract carcinomas, and to explore a better…
- Trial name
- NCT01572324
- Testing
- Oxaliplatin, Fluorouracil, Leucovorin, Capecitabine
- Where
- China
- Volunteers
- 37 people
- Sponsor
- Peking University