Clinical trials: Hepatic Malignancies
Cancer of the Bile Duct, Gallbladder Cancer
Study to Test the Benefit and Safety of GM-CT-01 in Combination With 5-FU to Treat Bile Duct and Gall Bladder Cancer
The purpose of this clinical trial is to determine whether the combination of the established chemotherapeutic agent 5-fluorouracil(5-FU) and the large carbohydrate molecule GM-CT-01 is beneficial in treating advanced gall…
- Trial name
- NCT00386516
- Testing
- GM-CT-01, 5-Fluorouracil
- Where
- 3 sites in United States
- Sponsor
- Galectin Therapeutics Inc.
Biliary Tract Cancer
Covered Versus Uncovered Biliary Stents for Biliary Malignancies
Patency duration of covered metal stents as compared with uncovered metal stents in the management of malignant strictures of the extra-hepatic biliary tree.
- Trial name
- NCT02102984
- Testing
- covered biliary stents, uncovered biliary stents
- Where
- Italy
- Volunteers
- 140 people
- Sponsor
- Nuovo Ospedale Civile S.Agostino Estense
Hepatocellular Carcinoma
Efficacy of Radiation Therapy and Transarterial Chemoembolization (TACE) to Treat Hepatocellular Carcinoma (HCC)
In this study, the investigators are to prospectively evaluate patient's survival, tumor response, and safety of RT followed by TACE in Child A patients with unilobar portal vein invasion.
- Trial name
- RTANDTACE (NCT01432314)
- Testing
- Radiation therapy, Transarterial chemoembolization
- Sponsor
- Asan Medical Center
Non Small Cell Lung Cancer
Multiple-portal VATS Versus Uniportal VATS Lobectomy for Non-small Cell Lung Cancer
This study evaluate multiple-portal VATS and uniportal VATS lobectomy for NSCLC, half of participants will receive multiple VATS, while the other half will receive uniportal VATS lobectomy.
- Trial name
- MVUVLC (NCT02462356)
- Testing
- Uniportal VATS, Conventional VATS
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Polycystic Ovary Syndrome (PCOS), Metabolic Dysfunction-Associated Steatotic Liver Disease
Biomarker Panel for PCOS-Associated Liver Steatosis in Adolescent Girls (COMPASS-pedPCOS)
This single-center, prospective, observational, cross-sectional mechanistic pilot study will evaluate whether polycystic ovary syndrome (PCOS) contributes to hepatic steatosis in adolescent girls independently of adiposity.
- Conditions
- Polycystic Ovary Syndrome (PCOS), Metabolic Dysfunction-Associated Steatotic Liver Disease, Pediatric Obesity, Hyperandrogenism
- Trial name
- COMPASSpedPCOS (NCT07731373)
- Testing
- Extended Serum Biomarker and Hormonal Panel, Liver Elastography with Controlled Attenuation Parameter, Targeted Genotyping of PNPLA3 rs738409 and HSD17B13 rs72613567
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Kayseri City Hospital
Embolization, Vascular Tumor
Evaluation of a Simple-Prep Controlled Embolic
The objective of this study is to evaluate the safety and effectiveness of the GPX® Embolic Device when used as indicated for embolization requiring distal vessel penetration in 114 subjects in up to 25 investigational sites in…
- Conditions
- Embolization, Vascular Tumor, Renal Angiomyolipoma, Renal Cell Carcinoma
- Trial name
- GPX (NCT06453642)
- Testing
- GPX® Embolic Device
- Where
- 20 sites in United States, Canada and 1 more
- Volunteers
- 114 people
- Sponsor
- Fluidx Medical Technology, Inc.
Cancer Metastatic to the Liver, Hepatocellular Carcinoma
A Study to Assess PV-10 Chemoablation of Cancer of the Liver
This open-label study will evaluate the safety, tolerability, pharmacokinetics and effect on tumor growth following a single intralesional injection of PV-10 in subjects with either (a) hepatocellular carcinoma (HCC) that is not…
- Conditions
- Cancer Metastatic to the Liver, Hepatocellular Carcinoma, Metastatic Melanoma, Metastatic Ocular Melanoma
- Trial name
- NCT00986661
- Testing
- PV-10 (10% rose bengal disodium)
- Where
- 5 sites in United States
- Volunteers
- 78 people
- Sponsor
- Provectus Biopharmaceuticals, Inc.
Hepatocellular Carcinoma
Neoadjuvant Radiotherapy for HCC Involving Type I PVTT
The rate of patients with hepatocellular carcinoma (HCC) involving portal vein tumor thrombus (PVTT) is up to 50% in Guangxi province, China. Some of them will receive hepatic resection, especially those with type I or II PVTT.
- Trial name
- NCT04025437
- Testing
- Hepatectomy alone, Neoadjuvant radiotherapy
- Where
- China
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- Guangxi Medical University
Colorectal Liver Metastases, Colorectal Cancer
Utility of FDG-PET Scan on the Selection of Patients for Resection of Hepatic Colorectal Metastases
Objective(s) of the proposed study: The evaluation of the efficiency of 18F deoxyglucose-Positron Emission Tomography (FDG-PET) in staging patients eligible for hepatic resection of colorectal liver metastases in a randomized…
- Conditions
- Colorectal Liver Metastases, Colorectal Cancer, Neoplasm Metastasis
- Trial name
- NCT00119899
- Testing
- FDG-PET scan
- Where
- 4 sites in Netherlands
- Volunteers
- 150 people
- Sponsor
- Radboud University Medical Center
Colorectal Cancer, Metastatic Cancer
Portal Vein Embolization in Treating Patients With Liver Metastases From Primary Colorectal Cancer
RATIONALE: Embolization blocks blood flow to part of an organ and/or tumor. Blocking the portal vein on one side of the liver may cause the opposite side of the liver to increase in size and decrease the risk of liver failure…
- Trial name
- NCT00028626
- Testing
- embolization therapy
- Where
- United States
- Sponsor
- Memorial Sloan Kettering Cancer Center
Colorectal Cancer
Liver Infusions of Fluorouracil in Treating Patients With Dukes' A, Dukes' B, or Dukes' C Colon Cancer Undergoing Surgery
RATIONALE: Drugs used in chemotherapy, such as fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00427310
- Testing
- fluorouracil, Observation, sodium heparin
- Volunteers
- 1,158 people
- Sponsor
- NSABP Foundation Inc
Biliary Cancer
Covered Versus Uncovered SEMS for Palliation of Malignant Biliary Strictures.
The purpose of this study is to compare the duration of stent patency of a covered vs. an uncovered biliary self-expandable metal stents (SEMS) placed to relieve biliary obstruction in patients with inoperable extrahepatic…
- Trial name
- SEMS (NCT02930252)
- Testing
- Niti-S Biliary ComVi Stent, Niti-S stent (D type)
- Where
- Italy
- Volunteers
- 170 people
- Sponsor
- Azienda USL 1 Imperiese
Liver Neoplasms, Liver Cirrhosis
Infrahepatic Inferior Vena Cava Clamping Versus Selective Hepatic Vascular Exclusion Involving the Portal Triad Clamping
This clinical trial aims to compare infrahepatic inferior vena cava clamping (IIVCC) with selective hepatic vascular exclusion (SHVE) involving the portal triad clamping (PTC) in complex cirrhotic liver resection.
- Trial name
- NCT02405416
- Testing
- Infrahepatic inferior vena cava clamping, Selective hepatic vascular exclusion, Portal triad clamping
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Huazhong University of Science and Technology
Colorectal Liver Metastases
CyberKnife® for Hepatic Metastases From Colorectal Cancer
This prospective, multicenter study is intended to establish the efficacy and toxicity of treating unresectable colorectal liver metastases with accurately administered radiation using the CyberKnife stereotactic radiosurgery…
- Trial name
- NCT01318447
- Testing
- CyberKnife SBRT
- Where
- 6 sites in France, Germany and 1 more
- Volunteers
- 15 people
- Sponsor
- Accuray Incorporated
Sarcomatoid Carcinoma, Liver Cancer
Prognostic Impact of Adjuvant Therapy in Primary Hepatic Sarcomatoid Carcinoma
In recent years, researchers have conducted extensive studies on adjuvant therapy following surgical resection of liver cancer, exploring its potential benefits and seeking effective treatment strategies.
- Conditions
- Sarcomatoid Carcinoma, Liver Cancer, Adjuvant Therapy
- Trial name
- NCT06950814
- Testing
- postoperative adjuvant therapy
- Where
- China
- Volunteers
- 50 people
- Sponsor
- West China Hospital
Advanced Malignant Solid Neoplasm, Metastatic Malignant Neoplasm in the Liver
Trametinib in Treating Patients With Advanced Cancer With or Without Hepatic Dysfunction
This phase I trial studies the side effects and best dose of trametinib in treating patients with cancer that has spread to other places in the body and usually cannot be cured or controlled with treatment (advanced) with or…
- Conditions
- Advanced Malignant Solid Neoplasm, Metastatic Malignant Neoplasm in the Liver, Metastatic Malignant Solid Neoplasm, Unresectable Solid Neoplasm
- Trial name
- NCT02070549
- Testing
- Trametinib
- Where
- 11 sites in United States, Canada
- Volunteers
- 46 people
- Sponsor
- National Cancer Institute (NCI)
Advanced Cancer
Hepatic Impairment Study For Crizotinib In Advanced Cancer Patients
This study is designed to evaluate the potential effect of hepatic impairment on the pharmacokinetics and safety of crizotinib in advanced cancer patients.
- Trial name
- NCT01576406
- Testing
- crizotinib
- Where
- 20 sites in United States
- Volunteers
- 88 people
- Sponsor
- Pfizer
Hepatic Malignant Tumors, Pancreatic Cancer
Irreversible Electroporation for Inoperable Hepatic and Pancreatic Malignancy
The objectives of this study are to study the safety and effect of IRE as a treatment for inoperable hepatic and pancreatic malignancy.
- Trial name
- IRE (NCT02822716)
- Testing
- IRE treatment, Ultrasound
- Where
- Hong Kong
- Volunteers
- 11 people
- Sponsor
- Chinese University of Hong Kong
Liver Tumor
Laparoscopic Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy
The purpose of this research is evaluate the results with laparoscopic ALPPS procedure in a single center. The validity, feasibility and limitations were assessed objectively through our clinical prospective study.The…
- Trial name
- NCT02203409
- Testing
- Laparoscopic ALPPS
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shuguo Zheng, MD
Hepatic Cancer, Metastatic Cancer
Prevention and Treatment of Complications of Endovascular Methods in Patients With Malignant Liver Tumors
In the structure of malignant liver lesions, two main groups are distinguished - primary liver cancer and metastatic liver damage. The five-year survival rate of patients with malignant liver tumors does not exceed 6%.
- Conditions
- Hepatic Cancer, Metastatic Cancer, Chemotherapy Effect
- Trial name
- PATOC (NCT04764409)
- Testing
- Chemoembolization, Chemoinfusion
- Where
- Russia
- Volunteers
- 500 people
- Sponsor
- Central Clinical Hospital RZD-Medicine, Russian Federation