Clinical trials: Hepatic Malignancies
Hepatic Neoplasm, Hepatic Cancer
Effective Dose and Safety of Esketamine During Ultrasound-guided Hepatic Tumor Thermal Ablation
Effective pain management during percutaneous thermal ablation of liver tumors outside the operating room remains a significant challenge.
- Trial name
- NCT07034950
- Testing
- Intravenous esketamine using Dixon's up-and-down sequential method, Intravenous the dose of esketamine ED95, Intravenous fentanyl 1 μg∙kg-1
- Where
- China
- Volunteers
- 79 people
- Sponsor
- The First Affiliated Hospital of Xiamen University
Hepatocellular Carcinoma
Hepatic Resection Versus TACE+RFA for BCLC Stage B Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is the sixth most common cancer in the world. For patients with intermediate HCC (BCLC stage B), transarterial chemoembolization (TACE) has been recommended as the standard therapy in many clinical…
- Trial name
- NCT02616926
- Testing
- Hepatic resection, TACE, RFA
- Where
- 3 sites in China
- Volunteers
- 538 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Liver Neoplasms, Hepatic Resection
Erector Spinae Plane Block Versus Thoracic Epidural Analgesia for Open Liver Resection
Background: Open liver resection is associated with severe postoperative pain. While thoracic epidural analgesia (TEA) is considered the gold standard for pain control, its clinical application is often limited by postoperative…
- Conditions
- Liver Neoplasms, Hepatic Resection, Liver Cancer
- Trial name
- NCT07642336
- Testing
- Continuous Erector Spinae Plane block, Thoracic Epidural Analgesia (TEA)
- Where
- Vietnam
- Volunteers
- 60 people
- Sponsor
- Nguyen Toan Thang
Anatomic Stage 0 Breast Cancer AJCC v8, Anatomic Stage I Breast Cancer AJCC v8
Web-Based Symptom Monitoring and Self-Management Portal (YES) for Adolescent and Young Adult Breast Cancer Survivors
This clinical trial compares a web-based patient-reported symptom monitoring and self management portal, the Young, Empowered \& Strong (YES), to standard therapy in managing symptoms in adolescent and young adult breast cancer…
- Conditions
- Anatomic Stage 0 Breast Cancer AJCC v8, Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8, Anatomic Stage IB Breast Cancer AJCC v8
- Trial name
- YES (NCT04906200)
- Testing
- Best Practice, Internet-Based Intervention, Survey Administration
- Where
- 3 sites in United States
- Volunteers
- 400 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Colorectal Cancer Liver Metastases
DRAGON 1- Training, Accreditation, Implementation and Safety Evaluation of Combined PVE/HVE
Brief Summary: Some colorectal liver metastases can only be resected after inducing liver regeneration by portal vein embolization (PVE) to increase size function of the future liver remnant (FLR).
- Trial name
- DRAGON (NCT04272931)
- Testing
- Portal and Hepatic Vein Embolization
- Where
- 42 sites in United States, Australia and 11 more
- Volunteers
- 111 people
- Sponsor
- Maastricht University
Colorectal Cancer, Hepatic Metastases
Targeted Delivery of Chemotherapy With Ultrasound and Microbublles
The oscillations of ultrasound (US) contrast agent microbubbles under their activation by US waves engender a modulation of the permeability of biological barriers amplifying hence the extravasation of drugs and/or fluorescent…
- Trial name
- SONCHIMIO (NCT03458975)
- Testing
- MRI, Perfusion CT scan, Contrast enhanced ultrasound
- Where
- France
- Volunteers
- 7 people
- Sponsor
- University Hospital, Tours
Malignant Hepatobiliary Neoplasm
Endoscopic Ultrasonography Guided Biliary Drainage
Endoscopic ultrasonography is a widely accepted modality for the diagnosis of gastrointestinal and pancreatic-biliary diseases. Endoscopic ultrasonography-guided biliary drainage has attracted attention as an alternative…
- Trial name
- NCT03195075
- Testing
- Endoscopic ultrasonography guided biliary drainage, Percutaneous trans-hepatic biliary drainage
- Volunteers
- 40 people
- Sponsor
- Assiut University
Locally Advanced Cancer, Metastatic Cancer
Identification of In-hospital Patients in Need of Palliative Care Using a New Simplified Screening Tool
Every day many patients affected by chronic life-limiting illnesses are admitted into Internal Medicine wards, coming from the Emergency Department.
- Conditions
- Locally Advanced Cancer, Metastatic Cancer, Chronic Respiratory Failure, Chronic Heart Failure
- Trial name
- SST2017 (NCT04143230)
- Testing
- Screening for PC by means of two different screening tools
- Where
- Italy
- Volunteers
- 660 people
- Sponsor
- A.O.U. Città della Salute e della Scienza
Hepatocellular Carcinoma Non-resectable
PD-1 Monoclonal Antibody, Lenvatinib and TACE in the Treatment of HCC
The vast majority of primary liver cancer (90%) is hepatocellular carcinoma (HCC), and the majority of HCC patients have been locally advanced or metastatic disease when they are diagnosed in clinics.
- Trial name
- PLTHCC (NCT04273100)
- Testing
- PD-1 mAb combined with TACE and lenvatinib
- Where
- China
- Volunteers
- 56 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Liver Tumors Not Resectable in One Surgical Procedure
ALLPS VERSUS PVO Randomized Controlled Trial
This randomized phase II trial compares how well associating liver partition with portal vein ligation for staged hepatectomy (ALPPS) or portal vein occlusion (PVO) works in treating patients with liver cancer.
- Trial name
- ALPPS (NCT01775267)
- Testing
- Associating liver partition and portal vein ligation for staged hepatectomy, Portal vein embolization or ligation
- Where
- 3 sites in United States, Argentina and 1 more
- Volunteers
- 7 people
- Sponsor
- University of Zurich
Prostatic Neoplasms
Prostate Localization During Radiotherapy Using a Ni-Ti Stent and Electronic Portal Imaging - Protocol II
A new method for localization of the prostate during external beam radiotherapy. The method is based on insertion of a new thermo-expandable Ni-Ti stent.
- Trial name
- NCT00250224
- Testing
- Radiotherapy stent
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Aalborg University Hospital
Liver Tumours
Feasibility of Electromagnetic Acoustic Imaging of Liver Tumours
A single-centre, industry sponsored, proof-of-concept pilot study to assess the feasibility of Electromagnetic Acoustic Imaging (EMA) as an imaging platform in the visualization of hepatic tumours.
- Trial name
- NCT02827786
- Testing
- Electromagnetic Acoustic Imaging
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Enhanced Medical
Advanced Malignancies and Hepatic Impairment
Pharmacokinetics and Safety Study of Pelabresib in Patients With Advanced Malignancies and Hepatic Impairment
The primary purpose of this study is to evaluate the impact of hepatic function on the pharmacokinetic (PK) profile of pelabresib in participants with advanced malignancies who have either hepatic impairment (HI) or normal liver…
- Trial name
- NCT07422610
- Testing
- pelabresib
- Where
- 10 sites in France, Italy and 2 more
- Volunteers
- 24 people
- Sponsor
- Novartis Pharmaceuticals
Liver Cancer, Metastatic Cancer
Hepatic Arterial Infusion With Melphalan in Treating Patients With Unresectable Liver Cancer
RATIONALE: Heating melphalan to several degrees above body temperature and infusing it to the affected area directly around the tumor may kill more tumor cells.
- Trial name
- NCT00030082
- Testing
- isolated perfusion, melphalan
- Where
- United States
- Sponsor
- National Cancer Institute (NCI)
Transarterial Chemoembolization, Hepatocellular Carcinoma
TACE Plus HAIC With Oxaliplatin and Raltitrexed for BCLC Stage C HCC
Purpose：explore the effectiveness and safety of transarterial chemoembolization (TACE) plus Hepatic Arterial Infusion Chemotherapy (HAIC) with oxaliplatin and raltitrexed for Barcelona stage C hepatocellular carcinoma (HCC)
- Trial name
- OXRI (NCT04597970)
- Testing
- cTACE-HAIC
- Volunteers
- 66 people
- Sponsor
- Peking University Cancer Hospital & Institute
Advanced Biliary Tract Cancer
HAIC With Oxaliplatin, 5-FU and Bevacizumab Plus Intravenous Toripalimab for Advanced BTC
Hepatic arterial infusion chemotherapy (HAIC) deliver high concentration of chemotherapeutic agents directly to the liver tumor, was proved to be effective for intrahepatic and perihilar cholangiocarcinoma.
- Trial name
- NCT04217954
- Testing
- OXA, 5-FU and bevacizumab plus Toripalimab
- Where
- China
- Volunteers
- 32 people
- Sponsor
- Peking University
Hepatic Tumor, Renal Tumor
Evaluation of the Reproducibility of Ablation Volumes at One Month After Microwave Treatment Compared to the Manufacturer's Abacus: on the Kidney, Liver and Lung
Microwave thermal ablation (MO) is recognized as an alternative to surgery for the local-regional treatment of primary and secondary hepatic and renal tumors and for secondary pulmonary tumors in patients at anesthetic and/or…
- Trial name
- Ablation (NCT04072224)
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Colorectal Cancer
Role of MRI in the Evaluation of Hepatic Metastases of Colorectal Cancer
This study wants to evaluate the use of MRI in the managemente of mCRC with liver only metastases.
- Trial name
- RMN-CRC (NCT05950503)
- Testing
- Hepatic MRI
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Carcinoma, Hepatocellular, Liver Dysfunction
Evaluation of Remnant Liver Function Using Primovist-enhanced MRI Before Resection/Ablation of Hepatocellular Carcinoma
The purpose of this study is to determine whether the global and segmental hepatic uptake and excretion of Gd-EOB-DTPA on Gd-EOB-DTPA-enhanced liver MRI correlates with standard liver function test results in the patients with…
- Trial name
- LiFE (NCT01490203)
- Testing
- Gd-EOB-DTPA, MRI
- Where
- 4 sites in South Korea
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Hepatic Carcinoma, Chemoembolizaton
Transradial Versus Transfemoral Arterial Access in Liver Cancer Embolization: Randomized Trial to Assess Patient Outcomes and Satisfaction (BEST ACCESS Trial).
To evaluate the safety, advantages, and appropriateness of performing transarterial hepatic emobolization of liver cancer via arterial access from the radial artery versus conventional transfemoral arterial access.
- Conditions
- Hepatic Carcinoma, Chemoembolizaton, Transarterial Embolization
- Trial name
- ACCESS (NCT03163186)
- Testing
- Transarterial embolization
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Medical University of South Carolina
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