Clinical trials: Hepatic Neoplasm
Liver Cancer, Renal Cancer
A Randomized Controlled Trial of the Safety and Efficacy of Robotic Telesurgery Versus Laparoscopic Surgery
This is a randomized controlled trial that will be preceded by a safety trial focusing on the safety and efficacy of robotic telesurgery.
- Conditions
- Liver Cancer, Renal Cancer, Rectal Cancer
- Trial name
- NCT06369597
- Testing
- Robotic telesurgery, Laparoscopic surgery
- Where
- China
- Volunteers
- 177 people
- Sponsor
- Sun Yat-sen University
Colorectal Cancer, Hepatic Metastasis
Correlation Between RECIST, Morphologic Response by CT- Histopathologic Response in Hepatic Metastasis Secondary to Colorectal Cancer
The purpose of this study is to to evaluate the correlation of overall objective response according to RECIST v1.1. criteria evaluated by conventional imaging techniques, morphologic response by CT, and histopathologic response…
- Trial name
- AVAMET (NCT01493713)
- Testing
- Evaluate the correlation of overall different objective response.
- Where
- 21 sites in Spain
- Volunteers
- 83 people
- Sponsor
- Grupo Espanol Multidisciplinario del Cancer Digestivo
Cirrhosis, Hepatocellular Carcinoma
Simvastatin in Preventing Liver Cancer in Patients With Liver Cirrhosis
This phase II trial studies how well simvastatin works in preventing liver cancer in patients with liver cirrhosis. Simvastatin may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth.
- Trial name
- NCT02968810
- Testing
- Biospecimen Collection, Computed Tomography, Magnetic Resonance Imaging
- Where
- 5 sites in United States, Puerto Rico
- Volunteers
- 52 people
- Sponsor
- National Cancer Institute (NCI)
Liver Neoplasms, Liver/Hepatobiliary Cancer
CE-IOUS Impact on Surgical Strategy of Liver Tumours and Liver Metastases
Contrast-enhanced intraoperative ultrasound (CE-IOUS) plays an increasingly important role in the surgical therapy planning of primary liver lesions as well as liver metastases.
- Conditions
- Liver Neoplasms, Liver/Hepatobiliary Cancer, Colorectal Cancer Metastatic, Metastases
- Trial name
- NCT05261113
- Testing
- CE-IOUS
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- University of Regensburg
Hepatocellular Carcinoma
Durvalumab and Tremelimumab in Resectable HCC
Hepatocellular Carcinoma (HCC) is the third most common cause of death from cancer world wide and the incidence is rising globally. Despite surgical resection in appropriate patients, many patients recur.
- Trial name
- (NEOTOMA) (NCT05440864)
- Testing
- Tremelimumab
- Where
- 3 sites in Canada, Italy and 1 more
- Volunteers
- 28 people
- Sponsor
- University Health Network, Toronto
Liver Metastases From Colorectal Cancer (mCRC)
Radiomics of Colorectal Liver Metastases: Identification of New Prognostic Biomarkers.
Background: Liver metastases (CLM) affect about half of patients with colorectal cancer and dictate patients' prognosis. Prediction of prognosis is of paramount importance for patients allocation to the most adequate treatment…
- Trial name
- NCT06779734
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- Istituto Clinico Humanitas
Liver Cancer, Hepatocellular Carcinoma
Pressure-enabled Delivery in Radioembolization (TriNav Study)
The purpose of the study is to determine if the type of catheter used in the mapping procedure prior to radioembolization improves the delivery of radioactivity to tumor(s) in participants with liver cancer.
- Conditions
- Liver Cancer, Hepatocellular Carcinoma, Metastatic Colorectal Cancer
- Trial name
- PEDIR (NCT05128032)
- Testing
- Standard microcatheter, PEDD device
- Where
- 2 sites in United States
- Volunteers
- 29 people
- Sponsor
- Massachusetts General Hospital
Pancreatic Cancer, Thyroid Cancer
Integrated Cancer Repository for Cancer Research
The iCaRe2 is a multi-institutional resource created and maintained by the Fred \& Pamela Buffett Cancer Center to collect and manage standardized, multi-dimensional, longitudinal data and biospecimens on consented adult cancer…
- Conditions
- Pancreatic Cancer, Thyroid Cancer, Lung Cancer, Esophageal Cancer
- Trial name
- iCaRe2 (NCT02012699)
- Where
- 42 sites in United States
- Volunteers
- 999,999 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Solid Tumor
Study of EOC317 in Chinese Patients With Advanced Solid Tumors
This is an open-label, single-arm phase 1, dose escalation study of EOC317 in patients with advanced solid tumors.
- Trial name
- NCT03583125
- Testing
- EOC317
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Taizhou EOC Pharma Co., Ltd.
Colorectal Cancer With Liver Metastases
ElastoMRI Evaluation of Hepatic Metastases in Colorectal Cancer ( MetaIRM)
Currently, the tumor response of operated colorectal liver metastases is assessed by histology of the resection specimen.The histological data make it possible to define categories (responder, partial responder, non-responder).
- Trial name
- MetaIRM (NCT06552117)
- Testing
- an elastoMRI sequence
- Volunteers
- 50 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Carcinoma, Hepatocellular
CT Imaging for Guiding PA-TACE for HCC
Postoperative adjuvant transarterial chemoembolization (PA-TACE) may improve survival outcomes in a subset of patients with resected hepatocellular carcinoma (HCC), reliable biomarkers for the criterion for the selection of…
- Trial name
- NCT06156748
- Testing
- postoperative adjuvant transarterial chemoembolization
- Where
- China
- Volunteers
- 1,770 people
- Sponsor
- Zhujiang Hospital
Solid Tumor, Lung Cancer
Safety and Efficacy of CEA-Targeted CAR-T Therapy for Relapsed/Refractory CEA+ Cancer
This is a single arm study to evaluate the efficacy and safety of CEA-targeted CAR-T cells therapy for patients with relapsed/refractory CEA+ Cancer,and obtain the recommended dose and infusion plan.
- Conditions
- Solid Tumor, Lung Cancer, Colorectal Cancer, Liver Cancer
- Trial name
- NCT04348643
- Testing
- CEA CAR-T cells
- Where
- 2 sites in China
- Sponsor
- Chongqing Precision Biotech Co., Ltd
Hepatocellular Carcinoma
Transarterial Chemoembolization (TACE) Therapy of Hepatocellular Carcinoma (HCC) With Blocking Tumor Blood Temporarily and Enhancing Perfusion
According to radiology imaging, the patients of HCC are divided into two groups(hypovascular tumor group and moderately vascular tumor group).
- Trial name
- NCT00826384
- Testing
- balloon catheter
- Where
- China
- Volunteers
- 352 people
- Sponsor
- Eastern Hepatobiliary Surgery Hospital
Liver Tumor
TACE Combined With Lenvatinib and MWA in the Treatment of Locally Advanced Large Hepatocellular Carcinoma
To explore the objective effectiveness and safety of TACE combined with Lenvatinib in the treatment of advanced liver cancer. After successful down-stage, radical microwave ablation was further performed.
- Trial name
- NCT05555316
- Testing
- TACE combined with Lenvatinib
- Where
- China
- Volunteers
- 46 people
- Sponsor
- Sun Yat-sen University
Hepatocellular Carcinoma, Liver Cancer
Study of ET140202 T Cells in Adults With Advanced Hepatocellular Carcinoma
This is a open-label, dose escalation, multi-center, Phase I / Phase II study to assess the safety of an autologous T-cell product (ET140202) in adult subjects with advanced Alpha-fetoprotein (AFP) positive/Human Leukocyte…
- Conditions
- Hepatocellular Carcinoma, Liver Cancer, Liver Neoplasm, Metastatic Liver Cancer
- Trial name
- ET-109 (NCT03998033)
- Testing
- ET140202 autologous T cell product
- Where
- 3 sites in United States
- Volunteers
- 2 people
- Sponsor
- Eureka Therapeutics Inc.
Liver Neoplasms
Percutaneous Microwave Ablation Under Ultrasound Guidance for Liver Cancer: a Multicenter Analysis
Ultrasound-guided percutaneous MWA of liver cancer is a relatively new technique with favorable long-term outcomes.Butthe results are mainly from single center reports.A larger scale data need to be analyzed to evaluate the…
- Trial name
- NCT03045952
- Testing
- microwave ablation device
- Where
- China
- Volunteers
- 1,908 people
- Sponsor
- Chinese PLA General Hospital
Cancer-associated Thrombosis, Esophageal Cancer
A Randomized Phase II Open Label Study to Compare the Safety and Efficacy of Subcutaneous Dalteparin Versus Direct Oral Anticoagulants for Cancer-associated Venous Thromboembolism
This is an open label, multi-center, and randomized phase II trial designed to compare the safety and efficacy of direct oral anticoagulants and subcutaneous dalteparin in patients with acute venous thromboembolism and upper…
- Conditions
- Cancer-associated Thrombosis, Esophageal Cancer, Stomach Cancer, Hepatocellular Carcinoma
- Trial name
- PRIORITY (NCT03139487)
- Testing
- Rivaroxaban, Dalteparin, apixaban
- Where
- South Korea
- Volunteers
- 176 people
- Sponsor
- Asan Medical Center
Colorectal Cancer, Metastatic Cancer
Combination Chemotherapy in Treating Patients With Liver Metastases From Colorectal Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more cancer cells.
- Trial name
- NCT00002716
- Testing
- dexamethasone, floxuridine, fluorouracil
- Where
- 14 sites in United States, Australia and 2 more
- Volunteers
- 135 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Hepatocellular Carcinoma, Hepatectomy
Hepatectomy With or Without Transcatheter Arterial Chemoembolization for Stage IIIA Hepatocellular Carcinoma
The purpose of this study is to evaluate whether hepatectomy combining with adjuvant transcatheter arterial chemoembolization (TACE) for Stage IIIA hepatocellular carcinoma (HCC) resulting better long-term survival outcome when…
- Conditions
- Hepatocellular Carcinoma, Hepatectomy, Chemoembolization
- Trial name
- NCT00652587
- Testing
- hepatectomy and transcatheter arterial chemoembolization, hepatectomy
- Where
- China
- Volunteers
- 115 people
- Sponsor
- Sun Yat-sen University
Digestive Cancer, Metastatic Colorectal Cancer
TARGETed Therapy Drug MONITOring in DIGestive Oncology
Targeted therapy drug monitoring in digestive oncology: Dosage of plasma levels of various multikinase inhibitors (MKI) in patients treated for advanced digestive cancer (gastrointestinal stromal tumor (GIST), metastatic…
- Conditions
- Digestive Cancer, Metastatic Colorectal Cancer, Hepatocellular Carcinoma, GIST
- Trial name
- TARGETMONITO (NCT05443087)
- Testing
- Blood sampling to build population pharmacokinetics model
- Where
- 29 sites in France
- Volunteers
- 330 people
- Sponsor
- UNICANCER
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