Clinical trials: Hepatic Neoplasm
Hepatocellular Carcinoma Non-resectable
DEB-TACE+RALOX-HAIC vs DEB-TACE for Large HCC
This study is conducted to evaluate the efficacy and safety of transarterial chemoembolization with drug-eluting beads (DEB-TACE) combined with hepatic artery infusion chemotherapy (HAIC) with oxaliplatin and raltitrexed…
- Trial name
- NCT06397235
- Testing
- DEB-TACE+HAIC, DEB-TACE
- Where
- China
- Volunteers
- 130 people
- Sponsor
- Second Affiliated Hospital of Guangzhou Medical University
Cholangiocarcinoma, Cholangiocarcinoma Non-resectable
Expanded Access for the Treatment of Advanced Cholangiocarcinoma With ABC294640 (Yeliva ®)
This is an expanded access program (EAP) for eligible participants who do not qualify for participation in, or who are otherwise unable to access, the ongoing clinical trial ABC-108.
- Conditions
- Cholangiocarcinoma, Cholangiocarcinoma Non-resectable, Cholangiocarcinoma, Perihilar, Cholangiocarcinoma, Extrahepatic
- Trial name
- NCT03414489
- Testing
- ABC294640
- Sponsor
- RedHill Biopharma Limited
Hepatocellular Carcinoma
Sirolimus-Based Immunosuppression Therapy in OLT for Patients With HCC Exceeding Milan Criteria
The purpose of this study is to evaluate the influence of sirolimus on outcome after OLT for HCC exceeding Milan criteria.
- Trial name
- NCT00554125
- Testing
- sirolimus
- Where
- China
- Volunteers
- 220 people
- Sponsor
- Fudan University
Hepatocellular Carcinoma, Liver Neoplasms
A Phase II Single-Arm Clinical Study to Evaluate the Efficacy and Safety of Carbon Ion Radiotherapy With Atezolizumab and Bevacizumab Combination Therapy in Patients With Advanced Hepatocellular Carcinoma
This single-center, prospective phase II clinical trial evaluates the safety and therapeutic efficacy of combining carbon ion radiotherapy with the standard first-line regimen of atezolizumab and bevacizumab in patients with…
- Conditions
- Hepatocellular Carcinoma, Liver Neoplasms, Carcinoma, Hepatocellular
- Trial name
- NCT07246668
- Testing
- Carbon Ion Radiotherapy Atezolizumab Bevacizumab
- Where
- South Korea
- Volunteers
- 52 people
- Sponsor
- Yonsei University
Hepatocellular Carcinoma
Efficacy of Sirolimus In Liver Transplantation for Hepatocellular Carcinoma (HCC)
The purpose of this study is to evaluate the anti-tumor effect of sirolimus-based immunosuppressive regimen in patients following living donor liver transplantation for hepatocellular carcinoma exceeding Milan criteria with…
- Trial name
- Sirolimus (NCT01374750)
- Testing
- Sirolimus, m-TOR inhibitor free
- Where
- South Korea
- Volunteers
- 45 people
- Sponsor
- Seoul National University Hospital
Hepatocellular Carcinoma
Safety and Efficacy of Lenvatinib and Anti-PD1 Antibody Combined With Radiotherapy Neoadjuvant Treatment for Resectable Hepatocellular Carcinoma With PVTT
Patients with hepatocellular carcinoma with PVTT can benefit from surgical resection and radiotherapy. As the rapid development of systematic treatment in hepatocellular carcinoma, ICIs neoadjuvant therapy is being actively…
- Trial name
- NCT05225116
- Testing
- Sintilimab, Lenvatinib, radiotherapy
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Hepatocellular Carcinoma, Lung Metastasis
The Efficacy of 5-fluorouracil/Mitomycin for the Patients With Pulmonary Metastasis of Hepatocellular Carcinoma
The aim of this study is to evaluate the efficacy of 5-fluorouracil + Mitomycin for the patients with pulmonary metastasis of hepatocellular carcinoma who had progressive disease with sorafenib.
- Trial name
- NCT01953406
- Testing
- 5-fluorouracil, Mitomycin
- Where
- South Korea
- Sponsor
- Seoul National University Hospital
Hepatocellular Carcinoma
PD-1 Antibody and Lenvatinib Plus TACE-HAIC for Potential Resectable HCC: a Single-arm, Phase 2 Clinical Trial
Hepatocellular carcinoma (HCC) is one of the most commonly malignant tumors around the world. Hepatic resection or liver transplantation is the radical method to cure the disease.
- Trial name
- PLATIC (NCT04814043)
- Testing
- PD-1 inhibitor
- Where
- China
- Volunteers
- 57 people
- Sponsor
- Sun Yat-sen University
Cholangiocarcinoma
The Expression of CD24 "do-not-eat-me" Signal in Cholangiocarcinoma
The investigators found an inverse relationship between CD24 and MiR-122 levels. Then the investigators found that CD24 that goes up with MiR-122 down makes macrophages unable to engulf the tumor cells. All this in mice.
- Trial name
- CD24CCA (NCT06707025)
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Hadassah Medical Organization
Cancer of Pancreas
Echo-endoscopy Biopsy Impact on the Circulating Tumor Cell Level
The aim of this work is to evaluate the impact of endoscopic procedures on the circulating tumoral cells level in order to evaluate the potential effects of an endoscopic procedure in the management of pancreatic tumors.
- Trial name
- EUS-CTC (NCT04677244)
- Testing
- Blood sample in portal vein
- Where
- France
- Volunteers
- 42 people
- Sponsor
- Institut Paoli-Calmettes
Hepatocellular Carcinoma (HCC)
Hepatocellular Carcinoma 3 Gene Methylation Combination Detection Kit (PCR Fluorescent Probe Method) Multicenter Clinical Trial
This clinical trial aims to systematically evaluate the clinical performance and accuracy of the HepaAiQ test kit, a multi-gene methylation assay based on PCR with fluorescent probe detection.
- Trial name
- NCT06842563
- Where
- China
- Volunteers
- 900 people
- Sponsor
- Singlera Genomics Inc.
Esophageal Cancer, Gastric Cancer
Vorinostat, Irinotecan, Fluorouracil, and Leucovorin in Treating Patients With Advanced Upper Gastrointestinal Cancer
RATIONALE: Vorinostat may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as irinotecan, fluorouracil, and leucovorin, work in different ways to stop the…
- Conditions
- Esophageal Cancer, Gastric Cancer, Liver Cancer
- Trial name
- NCT00537121
- Testing
- fluorouracil, irinotecan hydrochloride, leucovorin calcium
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Roswell Park Cancer Institute
Hepatocellular Carcinoma
To Evaluate the Safety and Efficacy of Microwave Ablation Therapy in Patients With Primary Liver Cancer
Through the implementation of prospective, multi-center, single-group target value research to verify the safety and effectiveness of the microwave ablation treatment system for the ablation treatment of primary liver cancer.
- Trial name
- NCT04520906
- Testing
- microwave ablation
- Where
- 13 sites in China
- Volunteers
- 61 people
- Sponsor
- Suzhou Hengruihongyuan Medical Technology Co. LTD
Neuroendocrine Tumor, Liver Metastases
Intra-arterial Hepatic (IAH) Infusion of Radiolabelled Somatostatin Analogs in GEP-NET Patients With Dominant Liver Metastases
The management of liver metastases in neuroendocrine neoplasms is challenging. Peptide receptor radionuclide therapy with radiolabeled somatostatin analogs (SSA) is one of the most promising therapeutic options.
- Conditions
- Neuroendocrine Tumor, Liver Metastases, Neuroendocrine Gastroenteropancreatic Tumour
- Trial name
- LUTARTERIAL (NCT04837885)
- Testing
- Positron emission tomography computed tomography (PET/CT) with Intra-hepatic (IAH) injection, Positron emission tomography computed tomography (PET/CT) with Intravenous (IV) injection, LUTATHERA® by intra-arterial hepatic (IAH) injection
- Where
- 4 sites in France
- Volunteers
- 23 people
- Sponsor
- University Hospital, Bordeaux
Aneurysm, Arteriovenous Malformations
Patient Skin Dose in Interventional Radiology
Studies on radiation induced patients' skin lesions in interventional radiology highlighted the need for optimized and personalized patient dosimetry and adapted patient follow-up.
- Conditions
- Aneurysm, Arteriovenous Malformations, Coronary Occlusion, Lung Neoplasms
- Trial name
- DPPRI (NCT04246125)
- Testing
- Interventional radiology : skin dose measurements
- Where
- 5 sites in France
- Volunteers
- 87 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hepatocellular Carcinoma
Magnetic Resonance With Gadoxetic Acid for the Diagnosis of Hepatocellular Carcinoma in Patients With Liver Cirrhosis. Evaluation of Its Impact for the Non-invasive Diagnosis
This is a study to evaluate the primovist as a new contrast agent useful to diagnostic of hepatocellular carcinoma
- Trial name
- PRIGA (NCT01575574)
- Testing
- GADOXETIC ACID
- Where
- Spain
- Volunteers
- 74 people
- Sponsor
- Sara Varea
Liver Cancer, Advanced Solid Tumors
Hepatic Arterial Infusion of Oxaliplatin, Fluorouracil, Leucovorin, and Avastin
PRIMARY: To determine the toxicity and tolerability of intra-arterial hepatic oxaliplatin every three weeks administered in combination with systemic intravenous Fluorouracil, Leucovorin and bevacizumab to patients with advanced…
- Trial name
- NCT00507585
- Testing
- Fluorouracil, Avastin, Leucovorin
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- M.D. Anderson Cancer Center
Hepatocellular Cancer, Microwave Ablation
Study of Microwave Spherical Ablation and Traditional Microwave Ablation in Single Hepatocellular Carcinoma ≤5cm
Comparison of the progression-free survival, overall survival, local progression rates, complete ablation rates and the complications rate of MSA and traditional MWA in the treatment of single hepatocellular carcinoma with a…
- Conditions
- Hepatocellular Cancer, Microwave Ablation, Microwave Spherical Ablation, Prognosis
- Trial name
- NCT05361538
- Testing
- True circular microwave needle
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Tianjin Third Central Hospital
HCC - Hepatocellular Carcinoma
A Study of IMM2510 + IMM27M Combination Therapy in Patients With Advanced Hepatocellular Carcinoma
This is a Phase 2, open-label, multicenter,study designed to evaluate the safety, tolerability, pharmacokinetics, and preliminary antitumor activity of IMM2510(Anti-PD-L1 and VEGF trap recombinant - Page 1 of 5 - protein) combine…
- Trial name
- NCT07687914
- Testing
- IMM2510, IMM27M
- Volunteers
- 50 people
- Sponsor
- ImmuneOnco Biopharmaceuticals (Shanghai) Inc.
Hepatocellular Carcinoma
Trial of Transcatheter Arterial Chemoembolization (TACE) With Sorafenib for Locally Advanced Hepatocellular Carcinoma (HCC)
To evaluate the time to progression of the combination therapy of Transcatheter Arterial Chemoembolization (TACE) and sorafenib in patients with previously untreated advanced or metastatic hepatocellular carcinoma.
- Trial name
- NCT01170104
- Testing
- Sorafenib, TACE (Transcatheter arterial chemoembolization)
- Where
- South Korea
- Volunteers
- 63 people
- Sponsor
- Chung-Ang University
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