Clinical trials: Hepatitis, Viral, Human
Chronic Hepatitis B
Trial of Lamivudine Treatment in HBeAg Negative Chronic Hepatitis B Patients (in Asia)
The aim is to investigate whether Lamivudine 100mg daily is effective in the long term treatment of HBeAg negative chronic HBV infected patients with active liver disease in Asia
- Trial name
- NCT00338780
- Where
- China
- Sponsor
- Chinese University of Hong Kong
Chronic Hepatitis c
Frequency of Anxiety and Depression in Chronic Hepatitis C Patients Recieving Direct-Acting Antiviral Agents
The primary objective of this study is to prospectively analyse psychiatric outcomes, specifically depression and anxiety in patients with hepatitis C virus infection who are initiated on DAA therapy (sofosbuvir based regimen).
- Trial name
- NCT03894696
- Testing
- Direct Acting Antivirals
- Volunteers
- 200 people
- Sponsor
- Assiut University
Hepatitis C
Prisons Evaluation of a One-stop-shop InterVentiOn
A prospective historically controlled study to assess the effect of an intervention integrating point-of-care hepatitis C (HCV) RNA testing, non-invasive liver fibrosis assessment, fast-tracked direct-acting antiviral (DAA)…
- Trial name
- PIVOT (NCT04809246)
- Testing
- 'One-stop-shop' hepatitis clinic
- Where
- Australia
- Volunteers
- 541 people, healthy volunteers welcome
- Sponsor
- Kirby Institute
Hepatitis C Virus Infection
A Follow-up Study to Assess Resistance to ABT-072 in HCV-infected Subjects Administered ABT-072 in Prior ABT-072 Studies
This is a follow-up study with no treatment and only samples being collected.
- Trial name
- NCT00872196
- Testing
- ABT-072
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Hepatitis C Infection
36 vs 48 Wks Peg-Intron Plus Ribavirin for HCV Patients Without Rapid Virologic Response But Without HCV RNA at wk 8
Purpose: To compare the effectiveness of 36 weeks versus 48 weeks pegintron plus ribavirin treatment for hepatitis C virus(HCV) patients without rapid virologic response(RVR), but with undetectable HCV RNA at wk 8.
- Trial name
- NCT01683786
- Testing
- Pegintron + Riba
- Where
- 5 sites in Taiwan
- Volunteers
- 60 people
- Sponsor
- Chang Gung Memorial Hospital
Chronic Hepatitis b
Effects of Peginterferon Consolidation Therapy on Hepatic cccDNA Dynamics in CHB Patients Achieving Clinical Cure.
This is a single-center, prospective, exploratory clinical study. The study plans to enroll 30 chronic hepatitis B (CHB) patients which achieved HBsAg clearance based peginterferon α-2b treatment.
- Trial name
- NCT06920329
- Testing
- Peginterferon α-2b based injection
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Xiamen Hospital of Traditional Chinese Medicine
Hepatitis B
To Study the Efficacy of PEG-IFN Alpha in HBeAg Negative Chronic Hepatitis B Patients After Stopping Nucleotide Analogue Therapy.
Study population:Person with HBeAg negative CHB on TDF/ETV for more than 1 year Study design:Prospective,Interventional (single arm study) Sample size: All the patients fulfilling the inclusion criteria will be included in first…
- Trial name
- NCT03123653
- Testing
- Peg IFN 2b
- Where
- India
- Volunteers
- 118 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Hepatitis C
Grazoprevir/Elbasvir for Treatment of Hepatitis C Virus Genotype 4 Post Kidney Transplant
This is a prospective, interventional, case-control study at King Faisal Specialist Hospital \& Research Centre in post-renal transplant patients who are receiving Grazoprevir/Elbasvir combination.
- Trial name
- NCT03359746
- Testing
- Grazoprevir/Elbasvir
- Volunteers
- 40 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
Hepatitis C, Hepatitis C, Chronic
Effects of Health Literacy and HCV Knowledge on HCV Treatment Willingness in HIV-coinfected Patients
A clinical observational study for patients with HIV co-infected with hepatitis C that investigates the levels of their health literacy, hepatitis C and HIV knowledge.
- Conditions
- Hepatitis C, Hepatitis C, Chronic, HIV/AIDS
- Trial name
- NCT03413696
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of California, San Diego
Chronic Hepatitis C
A Study to Evaluate the Safety, Pharmacokinetics and Efficacy of the Combination of AL-335, Odalasvir, and Simeprevir
The purpose of this study is to evaluate the safety and tolerability of AL-335 in combination with odalasvir (ODV) with or without simeprevir (SMV) in participants with genotype (GT)1 or GT2 or GT3 chronic hepatitis C (CHC)…
- Trial name
- NCT02569710
- Testing
- AL-335, Odalasvir (ODV), Simeprevir (SMV)
- Where
- 11 sites in Mauritius, Moldova and 2 more
- Volunteers
- 161 people
- Sponsor
- Alios Biopharma Inc.
Hepatitis B, Chronic, Pregnancy
Emtricitabine for Naive Chinese Pregnant Chronic Hepatitis B Patients
This study evaluates generic emtricitabine(FTC) efficacy and safety in Chinese naive pregnant chronic hepatitis B patients. Single group patients were enrolled to receive emtricitabine till 48 weeks after delivery.
- Trial name
- NCT02327702
- Testing
- Emtricitabine
- Volunteers
- 200 people
- Sponsor
- Asian-Pacific Alliance of Liver Disease, Beijing
Hepatitis C Infection
Study of Hepatitis C Virus (HCV) Entry Inhibitor in Liver Transplant Recipients With HCV Infection
This study will test the safety and tolerability of HCV Entry Inhibitor ITX 5061 in Liver Transplant Recipients with Hepatitis C infection.
- Trial name
- NCT01560468
- Testing
- ITX 5061
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Schiano, Thomas D., MD
Chronic Hepatitis B
Targeting ANKRD11 Reverses HBV-Specific CD8+ T Cell Dysfunction and Tolerance
Achieving a functional cure for chronic hepatitis B (CHB) is largely hindered by the irreversible functional exhaustion and immune tolerance of hepatitis B virus (HBV)-specific CD8 positive T (CD8+ T) cells.
- Trial name
- NCT07777250
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Beijing Municipal Administration of Hospitals
Hepatitis B Virus Infection
The Role and Regulatory Mechanism of Germinal Center Immune Response in Hepatitis B Virus Infection
The purpose of this observational study is to investigate the structure and composition of germinal centers in individuals with chronic HBV infection.
- Trial name
- NCT07240350
- Testing
- Tissue resection
- Where
- China
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Nanfang Hospital, Southern Medical University
Hepatitis B and Hepatitis C (Disorder)
A Comprehensive HBsAg-positive Patients Centered Screening Strategy
HBV(hepatitis B virus) /HCV(hepatitis C virus) co-infection may accelerate liver disease progression and increase the risk of HCC(Hepatocellular Carcinoma)development.
- Trial name
- CHARSET (NCT03794791)
- Testing
- education, no education
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Hong Ren
Hepatitis C Virus
Study of Daclatasvir (BMS-790052) Add-on to Standard of Care in Treatment- naïve Patients
To establish that at least 1 dose of daclatasvir combined with standard of care (pegylated interferon and ribavirin) is safe and well tolerated and demonstrates extended rapid virologic response rates at least 35% greater than…
- Trial name
- HEPCAT (NCT01125189)
- Testing
- Daclatasvir, peg-interferon alfa-2a, ribavirin
- Where
- 64 sites in United States, Australia and 9 more
- Volunteers
- 558 people
- Sponsor
- Bristol-Myers Squibb
Hepatitis B
A Confirmatory Study of Hepabulin IV in HBsAg Positive Liver Transplantation Recipients
The purpose of this study is to Evaluate the efficacy and safety of Hepabulin IV (HBIG, a study drug) after liver transplantation.
- Trial name
- NCT01513850
- Testing
- Hepabulin IV
- Where
- South Korea
- Volunteers
- 87 people
- Sponsor
- SK Chemicals Co., Ltd.
Hepatitis B
This Study Aims to Determine the Incidence, of Hepatitis B Diagnosis Among Diabetes Mellitus Patients of 0-80 Years of Age
This study is being conducted to assess the risk of hepatitis B (HepB) diagnosis among diabetes mellitus (DM) and non-DM patients of 0-80 years of age with in a large population-based cohort in United Kingdom (UK) using data from…
- Trial name
- NCT02324218
- Testing
- Data collection
- Volunteers
- 161,429 people
- Sponsor
- GlaxoSmithKline
Chronic Hepatitis B Virus
Continue Entecavir Rollover From China
The purpose of the study is to determine if treatment with entecavir is safe and well tolerated in patients who completed dosing in a previous entecavir study in China, but are requiring further treatment of their chronic…
- Trial name
- NCT00975091
- Testing
- Entecavir
- Volunteers
- 600 people
- Sponsor
- Bristol-Myers Squibb
Hepatitis B, Hepatitis A
Long-Term Immune Persistence of GSK Biologicals' Combined Hepatitis A & B Vaccine Injected According to a 0,1,6 Month Schedule
The aim of this study is to evaluate the long-term persistence of hepatitis A and B antibodies at Years 11, 12, 13, 14 and 15 years after subjects received their first dose of a 3 dose vaccination schedule of combined hepatitis…
- Trial name
- NCT00289718
- Testing
- Twinrix™ adult
- Where
- Belgium
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
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