Clinical trials: Hepatitis, Viral, Human
Hepatitis C, HIV
Eliminating Hepatitis C Virus
Initially, HCV Informatics (C-IT) will be used to filter the EMR data of the one million people who receive care at Mount Sinai and identify candidates for HCV testing (baby boomers, patients with HIV infection) and candidates…
- Conditions
- Hepatitis C, HIV, Type2 Diabetes
- Trial name
- NCT03401697
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Hepatitis C
Hepatitis C Prevalence in Men Who Have Sex With Men
This is an observational study aimed at determining the prevalence of hepatitis C in a specific population: men who have sex with men.
- Trial name
- NCT06606197
- Testing
- Having sex with other men
- Where
- Spain
- Volunteers
- 454 people
- Sponsor
- Consorci Sanitari de l'Alt Penedès i Garraf
Chronic Hepatitis B
Phase 2 Trial of Therapeutic Hepatitis B Vaccine (Mimogen-based) for Chronic Hepatitis B
The purpose is to evaluate efficacy and safety of therapeutic Hepatitis B Virus（HBV） vaccine (mimogen-based) treatment in chronic hepatitis B patients and to explore the most effective dosage and provide the rational for optimal…
- Trial name
- NCT00869778
- Testing
- εPA-44
- Where
- 15 sites in China
- Volunteers
- 360 people
- Sponsor
- Chongqing Jiachen Biotechnology Ltd.
Fibrosis, Liver
Diffusion-weighted Imaging Magnetic Resonance for Assessing Liver Fibrosis
Several noninvasive radiological techniques have been investigated for the diagnosis of liver fibrosis and cirrhosis among patients with chronic infection with hepatitis B virus or hepatitis C virus.
- Trial name
- NCT02682108
- Testing
- Diffusion-weighted magnetic resonance imaging (DW-MRI)
- Where
- Thailand
- Volunteers
- 121 people
- Sponsor
- Mahidol University
Chronic Hepatitis B
A Drug-drug Interaction (DDI) Study of Morphothiadine Mesilate/Ritonavir in Healthy Subjects
The purpose of this study is to evaluate the drug-drug-interaction (DDI), pharmacokinetics (PK) and tolerability of Morphothiadine Mesilate/Ritonavir combined with Entecavir or Tenofovir Disoproxil Fumarate in healthy subjects
- Trial name
- NCT03662568
- Testing
- GLS4, RTV, ETV
- Where
- China
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Sunshine Lake Pharma Co., Ltd.
Hepatitis B, Chronic
A Study Evaluating IL28B Polymorphism in Patients With HBeAg-Negative Chronic Hepatitis B Treated With Pegasys (Peginterferon Alfa-2a) in Study ML18253
This cross-sectional multicenter study will evaluate the IL28B polymorphism in patients with HBeAg-negative chronic hepatitis B treated with Pegasys (peginterferon alfa-2a) in the predecessor ML18253 study.
- Trial name
- NCT01697501
- Testing
- Interleukin 28B testing
- Where
- 12 sites in Italy
- Volunteers
- 88 people
- Sponsor
- Hoffmann-La Roche
Hepatitis C
A Study to Investigate the Potential Pharmacokinetic Interaction Between TMC435 and Methadone
The purpose of this study is to evaluate the effect of steady-state (constant concentration of medication in the blood) TMC435 (150 mg, once a day) on the steady state pharmacokinetics (what the body does to the medication) of R…
- Trial name
- NCT00915564
- Testing
- TMC435, Methadone
- Where
- Canada
- Volunteers
- 13 people
- Sponsor
- Tibotec Pharmaceuticals, Ireland
Hepatitis B
Study of Evaluating Safety and Immunogenicity of 10µg/0.5ml Hepatitis B Vaccine
The main objective of this study was to evaluate the safety and immunogenicity of 10µg/0.5ml and 5µg/0.5ml hepatitis B vaccine made by recombinant deoxyribonudeic acid techniques in saccharomyces cereviside yeast for infants and…
- Trial name
- NCT02152709
- Testing
- 3 dose of 10µg/0.5ml hepatitis B vaccine, 3 dose of 5µg/0.5ml hepatitis B vaccine
- Where
- China
- Volunteers
- 1,537 people, healthy volunteers welcome
- Sponsor
- Jiangsu Province Centers for Disease Control and Prevention
Chronic Hepatitis C
Study on Chronic Hepatitis C Treatment With Interferon Alpha, Ribavirin and Amantadine in Naive Patients
Adding Amantadine to standard anti-viral treatment can improve sustained response rates in patients with chronic hepatitis C
- Trial name
- NCT00146016
- Testing
- Amantadine
- Where
- Netherlands
- Volunteers
- 390 people
- Sponsor
- UMC Utrecht
Hepatitis B Infection, Pregnant Women
TAF in Early/Middle Pregnancy With CHB
The goal of this clinical trial is to study the efficacy and safety of Tenofovir alafenamide (TAF) vs Tenofovir disoproxil fumarate(TDF) in early and middle pregnancy with chronic hepatitis B.
- Conditions
- Hepatitis B Infection, Pregnant Women, Early Pregnancy
- Trial name
- TAF;CHB (NCT07668934)
- Testing
- TAF, TDF
- Where
- China
- Volunteers
- 816 people
- Sponsor
- The Third Affiliated Hospital of Guangzhou Medical University
Hepatitis B, Chronic
EYP001a Food Effect Study in Subjects With Chronic Hepatitis B Virus (HBV) Infection
The farnesoid X receptor (FXR) regulates hepatitis B virus replication through the bile acids pathway. EYP001a is a selective, synthetic FXR agonist under development for the treatment of hepatitis B.
- Trial name
- NCT03320616
- Testing
- EYP001a
- Where
- Netherlands
- Volunteers
- 11 people
- Sponsor
- Enyo Pharma
Depression
Genetic and Biochemical Markers of Interferon-Induced Depression.
The purpose of this study is to identify predictors and associated biochemical markers of interferon-induced depression. It is hypothesized that genetic variation in genes related to the serotonergic system may predict…
- Trial name
- NCT00252538
- Where
- 3 sites in United States
- Volunteers
- 133 people
- Sponsor
- US Department of Veterans Affairs
Hepatitis C
Racial Difference in HCV/Host Interactions
The purpose of this study is to evaluate a group of African Americans and Caucasians with hepatitis C virus (HCV), compare their response rates to combination treatment with pegylated interferon alfa-2b and ribavirin, and…
- Trial name
- NCT00071916
- Where
- 3 sites in United States
- Volunteers
- 260 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV-1-infection, Hepatitis B
B/F/TAF Switch Study for HIV-HBV Coinfection
The primary objective of this study is to evaluate the efficacy and safety of fixed dose combination (FDC) bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) in adults coinfected with both HIV-1 and hepatitis B.
- Trial name
- BEST-HBV (NCT03797014)
- Testing
- B/F/TAF
- Where
- 2 sites in United States
- Volunteers
- 28 people
- Sponsor
- University of Maryland, Baltimore
Cancer
S1204, Viral Screening in Newly Diagnosed Cancer Patients
The goal of this study is to estimate the prevalence of HIV, Hepatitis B and hepatitis C infection among newly diagnosed cancer patients presenting to community and academic oncology clinics.
- Trial name
- NCT01946516
- Where
- 58 sites in United States
- Volunteers
- 3,051 people
- Sponsor
- SWOG Cancer Research Network
Hepatitis B, Chronic
A Real-world Study: Analysis of the Efficacy of Antiviral Therapy in CHB Patients Over 30 Years Old, HBV DNA Positive and ALT Normal
This is a prospective observational study of CHB patients who have not received antiviral treatment but HBV DNA are positive.Investigators aim to explore the antiviral effect and influencing factors of patients over 30 years old…
- Conditions
- Hepatitis B, Chronic, Treatment
- Trial name
- NCT07637214
- Where
- China
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Tongji Hospital
Chronic Hepatitis C Infection
A Study to Evaluate Chronic Hepatitis C Infection in Adults With Genotype 1a Infection
The purpose of this study is to evaluate the safety and antiviral activity of ABT-450/ritonavir/ABT- 267 (ABT-450/r/ABT-267; ABT-450 also known as paritaprevir; ABT-267 also known as ombitasvir) and ABT-333 (also known as…
- Trial name
- PEARL-IV (NCT01833533)
- Testing
- ABT-450/r/ABT-267, ABT-333, Ribavirin
- Volunteers
- 305 people
- Sponsor
- AbbVie
HIV, Hepatitis C
Inter Cohorts and Clinical Centres Collaborations of Subjects Co-infected With HIV and HCV
The ANRS CO13 HEPAVIH cohort is a prospective and multicentric cohort created in 2005 with the originality to cover two therapeutic domains of key importance, AIDS and hepatitis C.
- Trial name
- CO13Hepavih (NCT03324633)
- Volunteers
- 1,850 people
- Sponsor
- ANRS, Emerging Infectious Diseases
Hepatitis C
Epidemiology of Chronic Hepatitis C and Disease Modelling
Hepatitis C (HCV) is a major health problem amongst people who inject drugs (PWID) and have limited contact with health care services. Halfway houses (HH) serve to reintegrate former drug users into society.
- Trial name
- EPIC (NCT03566563)
- Testing
- Screening
- Where
- Singapore
- Volunteers
- 520 people
- Sponsor
- Changi General Hospital
HIV Infections, Hepatitis B
A Comparison of Adefovir and Tenofovir for the Treatment of Lamivudine-Resistant Hepatitis B Virus in People With HIV
Control of hepatitis B virus (HBV) infection can be difficult in HIV infected people who have taken the antiviral lamivudine (3TC). These people may have HBV that has become resistant to 3TC.
- Trial name
- NCT00033163
- Testing
- Adefovir dipivoxil, Tenofovir disoproxil fumarate
- Where
- 15 sites in United States
- Volunteers
- 90 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
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