Clinical trials: Hepatitis C Virus (HCV)
HIV Infections, HCV Infection
APPROACH 2.0: HIV, HCV and Syphilis Testing Through Pharmacies
Human Immunodeficiency Virus (HIV), hepatitis C (HCV), and syphilis are sexually transmitted and blood borne infections (STBBI) that affect millions of people worldwide and rates are rising in Canada.
- Conditions
- HIV Infections, HCV Infection, Syphilis Infection
- Trial name
- NCT05534633
- Testing
- Choice of STBBI test(s)
- Where
- Canada
- Volunteers
- 407 people, healthy volunteers welcome
- Sponsor
- Memorial University of Newfoundland
Chronic Hepatitis C
Acoustic Radiation Force Impulse-Imaging in Comparison to Transient Elastography for Liver Fibrosis Staging in HCV
This study will evaluate the effectiveness of Acoustic Radiation Force Impulse (ARFI)- Imaging compared to Transient Elastography (FibroScan) in differentiating liver fibrosis in patients with chronic hepatitis C.
- Trial name
- NCT01113814
- Testing
- FibroScan, Acoustic Radiation Force Impulse (ARFI)- Imaging
- Where
- 9 sites in France, Germany and 1 more
- Sponsor
- Johann Wolfgang Goethe University Hospital
Liver Function
The Effect of Chinese Herbal Formula (KSY) on HCV Carrier With Abnormal Liver Function
The aim of the study is to examine whether the Chinese herbal formula (KSY) is effective on HCV Carrier With Abnormal Liver Function.
- Trial name
- NCT01708733
- Testing
- KSY
- Where
- Taiwan
- Volunteers
- 57 people
- Sponsor
- Taipei City Hospital
Hepatitis C Infection, HIV Infection
Glecaprevir/Pibrentasvir Fixed-dose Combination Treatment for Acute Hepatitis C Virus Infection
The purpose of this study was to assess the efficacy of a fixed dose combination (FDC) of glecaprevir/pibrentasvir (G/P) given for 4 weeks for treatment of acute hepatitis C (HCV), with or without HIV-1 coinfection.
- Trial name
- PURGE-C (NCT04042740)
- Testing
- Glecaprevir/Pibrentasvir (G/P)
- Where
- 12 sites in United States, Brazil
- Volunteers
- 45 people
- Sponsor
- Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
Liver Failure
Hepatitis C Virus (HCV) Positive Liver Grafts in HCV Negative Recipients
To provide proof-of-concept data on the efficacy/safety of transplanting HCV positive donor grafts in HCV sero-negative liver recipients who are currently listed.
- Trial name
- NCT03650920
- Testing
- Liver Transplantation
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- Loma Linda University
Hepatitis C, Chronic
A Study of Ritonavir-Boosted Danoprevir in Combination With Pegasys (Peginterferon Alfa-2a) and Copegus (Ribavirin) in Patients of Asian Origin With Chronic Hepatitis C Genotype 1 With or Without Cirrhosis
This Phase II, open-label, parallel-arm study will evaluate the safety, tolerability, pharmacokinetics and antiviral activity of ritonavir-boosted danoprevir in combination with Pegasys (peginterferon alfa-2a) and Copegus…
- Trial name
- NCT01749150
- Testing
- danoprevir + ritonavir, peginterferon alfa-2a [Pegasys], ribavirin [Copegus]
- Where
- 13 sites in South Korea, Taiwan and 1 more
- Volunteers
- 61 people
- Sponsor
- Hoffmann-La Roche
Chronic Hepatitis C
Clinical Trial to Assess Safety and Efficacy of Combination Therapy: Hydroxychloroquine, Pegylated Interferon Alpha-2a and Ribavirin in Chronic Hepatitis C Subjects Non-responders to the Standard of Care Therapy.
The study is aimed to investigate the safety, tolerability and efficacy of a fixed dose combination therapy of: Hydroxychloroquine (HCQ), Pegylated Interferon Alpha-2a (PEG-IFN alpha-2a) and Ribavirin (RBV) in Chronic Hepatitis C…
- Trial name
- NCT01272310
- Testing
- Hydroxychloroquine (HCQ), Pegylated Interferon Alpha-2a (Peg-IFN alpha-2a) and Ribavirin
- Volunteers
- 36 people
- Sponsor
- Sheba Medical Center
Hepatitis C
Implementation and Evaluation of Care Coordination in Linkage to Care for Hepatitis C Following Release From New York City Jails
This study assesses the impact of a hepatitis C care coordination program on rates of linkage to hepatitis C care following release from New York City jails.
- Trial name
- NCT04036760
- Testing
- Research transitional care coordination
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- NYU Langone Health
Chronic Hepatitis C
Efficacy of Long-term Ribavirin in Non-responders With Chronic Hepatitis C and Advanced Fibrosis
The rate of sustained virological response to a course of standard antiviral therapy (peg-interferon plus ribavirin) of patients with chronic hepatitis C infected by genotype 1 with advanced fibrosis (>F2) is rather low.
- Trial name
- RIBACIR (NCT00840489)
- Testing
- Ribavirin, Colchicine
- Where
- 3 sites in Spain
- Volunteers
- 50 people
- Sponsor
- Hospital Universitario Ramon y Cajal
Hepatitis C, Renal Insufficiency, Chronic
HCV Treatment Immune Response With Grazoprevir/Elbasvir Before or After Renal Transplant
The purpose of this study is to determine whether patients treated for chronic hepatitis C (HCV) with zepatier (grazoprevir/elbasvir) prior to kidney transplant will have a stronger immune response compared to patients treated…
- Conditions
- Hepatitis C, Renal Insufficiency, Chronic, Disorder of Transplanted Kidney
- Trial name
- NCT02902120
- Testing
- Post-transplant Grazoprevir and Elbasvir
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Maryland, Baltimore
Hepatitis C Virus Infection
Efficacy and Safety of Glecaprevir (ABT-493)/Pibrentasvir (ABT 530) (GLE/PIB) in Combination With Sofosbuvir and Ribavirin in Participants With Hepatitis C Virus Who Did Not Respond to Treatment in a Previous AbbVie Clinical Study
The purpose of this study was to evaluate the efficacy and safety of co-administration of glecaprevir (ABT-493)/pibrentasvir (ABT 530) plus sofosbuvir (SOF) plus ribavirin (RBV) in hepatitis C virus (HCV) genotype (GT) 1 …
- Trial name
- MAGELLAN-3 (NCT02939989)
- Testing
- Sofosbuvir, Glecaprevir/Pibrentasvir, Ribavirin
- Where
- 26 sites in United States, Australia and 10 more
- Volunteers
- 33 people
- Sponsor
- AbbVie
IV Drug Usage, HIV Infections
Tele-Harm Reduction
The purpose of this study is to test 2 different methods for offering medications that treat HIV, cure Hepatitis C Virus (HCV) (if applicable) and treat substance use disorder (if desired) to people who inject drugs.
- Conditions
- IV Drug Usage, HIV Infections, Hepatitis C
- Trial name
- T-SHARP (NCT05208697)
- Testing
- Tele-Harm Reduction, off-site linkage
- Where
- 3 sites in United States
- Volunteers
- 100 people
- Sponsor
- University of Miami
PT-NANBH
Safety, Tolerability, and Efficacy of 24 Weeks Simeprevir+Sofosbuvir for Chronic Hepatitis C Genotype 1
The goal of this pilot study is to examine both efficacy and tolerability in patients with HCV genotype 1 and mild decompensation with Child-Pugh-Turcott score of 6 or lower.
- Trial name
- NCT02485080
- Testing
- Simeprevir, Sofosbuvir
- Where
- 2 sites in United States
- Sponsor
- Stanford University
HCV
Safety of Sofosbuvir ,Daclatasvir in HCV Patients and RAVS in Resistent and Relapsed Cases
To identify side effects of Sofosbuvir/ Daclatasvir treatment regimen of chronic HCV GT-4 infection. To assess the occurrence and the prevalence of RAVs in patients with treatment failure and relapse after sofosbuvir and…
- Trial name
- RAVs (NCT03572140)
- Testing
- RAVS In relapsed and resistent cases
- Volunteers
- 297 people
- Sponsor
- Assiut University
Hepatitis C Virus (HCV)
A Study of Viekira/Exviera for Korean Hepatitis C Patients According to the Standard for Re-examination of New Drugs
Post-marketing surveillance study to evaluate the real world safety and effectiveness of Viekira/ Exviera (paritaprevir/ritonavir/ombitasvir and dasabuvir) administered under a normal, routine treatment practice by Korean…
- Trial name
- HCV PMS (NCT03201718)
- Where
- 59 sites in South Korea
- Volunteers
- 505 people
- Sponsor
- AbbVie
Chronic Hepatitis C, Renal Transplant
Peginterferon Alfa-2a Plus Ribavirin Combination Treatment in Chronic Hepatitis C Post-Renal Transplant Patients
There is a distinct lack of published literature on the effect of combination treatment of PEG-interferon and ribavirin on post-renal transplantation hepatitis C virus (HCV) patients.
- Trial name
- NCT00881582
- Testing
- Pegylated interferon alfa-2a plus ribavarin
- Where
- 2 sites in Saudi Arabia
- Volunteers
- 32 people
- Sponsor
- King Abdulaziz Medical City
Hepatitis C
Telaprevir in Genotype 3 HCV
Patients with genotype 3 hepatitis C who have advanced liver disease (cirrhosis) have a very high chance of developing fatal complications of their disease unless they receive effective treatment.
- Trial name
- TIG3 (NCT02087111)
- Testing
- Telaprevir, 40 Kd Pegylated interferon alfa 2a, Ribavirin
- Where
- 4 sites in United Kingdom
- Volunteers
- 14 people
- Sponsor
- Queen Mary University of London
Hepatitis C Virus (HCV)
Efficacy Study Of Oral Glecaprevir/Pibrentasvir Tablet In Pediatric (12 Years and Older) And Adult Treatment-Naive Participants With Chronic Hepatitis C Genotypes 1 To 6 And Liver Cirrhosis
Hepatitis C Virus (HCV) infection is among the most common of all chronic liver diseases. HCV predominantly affects liver cells and causes the liver to become inflamed and damaged.
- Trial name
- EASY (NCT04352309)
- Where
- 6 sites in Russia
- Volunteers
- 99 people
- Sponsor
- AbbVie
HCV Negative Status, HCV Risk Behavior
A Trial to Reduce Hepatitis C Among Injection Drug Users - 1
The purpose of this study is to examine the efficacy of a brief motivational intervention on the cumulative incidence of Hepatitis C.
- Trial name
- NCT00218192
- Testing
- Behavior Therapy
- Where
- United States
- Volunteers
- 277 people
- Sponsor
- Butler Hospital
Hepatitis C Virus (HCV)
A Study of Glecaprevir (GLE)/Pibrentasvir (PIB) in Treatment-Naive Adults With Chronic Hepatitis C Virus (HCV) Genotype 1-6 Infection and Compensated Cirrhosis
A Phase 3b, single arm, open-label, multicenter study in treatment naïve adults with chronic HCV infection and compensated cirrhosis to assess the safety of 8 weeks of treatment with glecaprevir/pibrentasvir and to demonstrate…
- Trial name
- EXPEDITION-8 (NCT03089944)
- Testing
- Glecaprevir/Pibrentasvir
- Where
- 113 sites in United States, Bulgaria and 17 more
- Volunteers
- 343 people
- Sponsor
- AbbVie
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