Clinical trials: Hepatitis b Virus
Chronic Hepatitis B
Stopping TDF Treatment After Long Term Virologic Suppression in HBeAg-negative CHB
The primary objective of this study is to evaluate hepatitis B surface antigen (HBsAg) loss and seroconversion in participants who stop tenofovir disoproxil fumarate (TDF) (Stop TDF arm) compared to participants who continue TDF…
- Trial name
- FINITE CHB (NCT01320943)
- Testing
- TDF, Stop TDF
- Where
- 13 sites in Germany
- Volunteers
- 43 people
- Sponsor
- Gilead Sciences
Hepatitis C, Hepatitis B
Insulin Resistance Associated With Chronic Hepatitis C (CHC) and the Effect of Antiviral Therapy
The literature suggests that there may be an association between hepatitis C and type 2 diabetes mellitus independent of the presence of cirrhosis, the likely mechanism for which is insulin resistance.
- Trial name
- NCT00188240
- Testing
- Pegasys; Copegus.
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- University Health Network, Toronto
Vertical Disease Transmission, HBV
Hepatitis B Virus Vertical Transmission From HIV-HBV Co-infected Women
Vertical HIV transmission has been dramatically reduced by the use of combined antiretroviral therapy in HIV-infected pregnant women.
- Trial name
- NCT02044068
- Where
- France
- Volunteers
- 35 people
- Sponsor
- Hopital Lariboisière
Chronic Hepatitis B
Metformin as Add-on to the Standard Therapy in Patients With Chronic Hepatitis B
This is a randomized, double-blind, placebo-controlled trial to assess the efficacy and safety of metformin as add-on to entecavir therapy in patients with chronic hepatitis B.
- Trial name
- NCT04182321
- Testing
- Metformin & Entecavir
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Fu-Sheng Wang
Hepatitis B, Chronic Hepatitis B
TLR-9 Adjuvanted Vaccination for Chronic Hepatitis B
The goal of this clinical trial is to learn if HEPLISAV-B, a vaccine that is approved to prevent hepatitis B infection in people that are not already infected, is safe in people already chronically infected with hepatitis B.
- Trial name
- BOOST-9 (NCT04843852)
- Testing
- Hepatitis B Vaccine Recombinant, Adjuvanted Intramuscular Solution [HEPLISAV-B]
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Maryland, Baltimore
Chronic Hepatitis B Virus Infection
Investigate the Efficacy and Safety of BRII-835 (VIR-2218) and PEG-IFNα Combination Therapy in Chronic HBV Patients
This study will evaluate the efficacy and safety of PEG-IFNα alone or in combination with different dose levels of BRII-835 (VIR-2218) in participants with chronic hepatitis B virus (HBV) infection.
- Trial name
- NCT05970289
- Testing
- PEG-IFNα, BRII-835
- Where
- 28 sites in Australia, China and 3 more
- Volunteers
- 86 people
- Sponsor
- Brii Biosciences Limited
HBV
Access HBV Assays - European Union (EU) Clinical Trial Protocol -
The objective of this protocol is the collection and testing of clinical samples to determine the clinical performance of the Access HBV serological marker assays on the DxI 9000 Access Immunoassay Analyzer.
- Trial name
- NCT04904835
- Testing
- Access HBV serological marker assays on the DxI 9000 Access Immunoassay Analyzer and CE-marked predicate assays
- Where
- 5 sites in France
- Volunteers
- 21,210 people
- Sponsor
- Beckman Coulter, Inc.
Hepatitis B
Safety and Antiviral Activity of Clevudine in Patients Who Have Completed the L-FMAU-301 or L-FMAU-302 Trials
The purpose of this study is to determine safety and efficacy of clevudine 10 mg qd for 24 weeks after completion of 24-week treatment with clevudine 30 mg qd with 12 weeks follow-up period
- Trial name
- NCT00362505
- Testing
- Clevudine
- Where
- 32 sites in South Korea
- Sponsor
- Bukwang Pharmaceutical
Chronic Hepatitis B
Long Term Follow-up of Pegylated-Interferon Alpha-2b
The aim of this study was to investigate the long term outcome of Peginterferon alpha-2b with or without the addition of lamivudine in patients with chronic hepatitis B
- Trial name
- NCT00146705
- Testing
- blood samples are taken once
- Where
- Netherlands
- Volunteers
- 266 people
- Sponsor
- Foundation for Liver Research
Hepatitis B, Chronic
Patients With Chronic Hepatitis B and Low Viremia Not Receiving Antiviral Therapy
This observational long-term follow-up study will evaluate demographic, clinical, histological, biochemical, and virological parameters of patients with chronic hepatitis B and low viremia who do not require antiviral therapy…
- Trial name
- NCT01090531
- Where
- 6 sites in Germany
- Volunteers
- 1,000 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Chronic Hepatitis B
A Study of ALG-020572 Drug to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics After Single Doses in Healthy Volunteers and Multiple Doses in CHB Subjects
A Randomized Study of ALG-020572 Drug to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics After Single and Multiple Doses in Healthy Volunteers and CHB Subjects
- Trial name
- NCT05001022
- Testing
- ALG-020572
- Where
- 3 sites in New Zealand, United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Aligos Therapeutics
Chronic Hepatitis B
A Study of Switch From Nucleotide to Peginterferon Alfa-2a in CHB Patients Achieving HBeAg Loss and HBV DNA <200IU/ml
A Randomized, open-label, multicenter study. The patients after 1-3 years NAs treatment and having achieved HBeAg loss and HBV DNA <200IU/ml will be switched to Pegasys for 48 or 96 weeks (with a 12 weeks period of overlap with…
- Trial name
- New Switch (NCT01464281)
- Testing
- Peginterferon alfa 2a
- Where
- China
- Volunteers
- 300 people
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University
Acute-On-Chronic Liver Failure, Hepatitis B
Efficacy of Addition of Fecal Microbiota Transplant (FMT) and Plasma Exchange to Tenofovir in Comparison to Monotherapy With Tenofovir in ACLF-HBV
A randomized controlled trial to study the efficacy of addition of FMT \& plasma exchange to tenofovir compared to monotherapy with tenofovir in patients with HBV reactivation who develops Acute on chronic liver failure.
- Trial name
- NCT04431375
- Testing
- Plasma Exchange, Tenofovir, Fecal Mircobiota Transplantation
- Where
- India
- Volunteers
- 70 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Hepatitis B
Effectiveness of the Hepatitis B Vaccine Post-Hematopoietic Stem Cell Transplant
Background: Stem cell transplants (SCTs) are important in treating many diseases. There are two main types of transplants. Autologous stem cells come from the person getting the cells.
- Trial name
- NCT03511794
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Hepatitis B
HBRN: Immune Regulation and Costimulation in Natural History and Therapeutic Outcome of Chronic Hepatitis B
This is an ancillary to the NIDDK-sponsored treatment trials titled: Combination Therapy of Pegylated Interferon Alfa-2a and Tenofovir Versus Tenofovir Monotherapy in Chronic Hepatitis B (NCT01369212) and Combination Entecavir…
- Trial name
- NCT01796457
- Where
- 8 sites in United States, Canada
- Volunteers
- 40 people
- Sponsor
- University of Pennsylvania
Cirrhosis, End Stage Liver Disease
Mild Hypothermia and Acute Kidney Injury in Liver Transplantation
Acute kidney injury (AKI), or worsening kidney function, is a common complication after liver transplantation (20-90% in published studies).
- Conditions
- Cirrhosis, End Stage Liver Disease, Acute Kidney Injury, Liver Transplant; Complications
- Trial name
- MHALT (NCT03534141)
- Testing
- Esophageal cooling/warming device, Mild hypothermia, Normothermia
- Where
- 3 sites in United States
- Volunteers
- 175 people
- Sponsor
- University of California, San Francisco
Chronic Hepatitis B (HBeAg-negative)
HBsAg Loss Adding Pegylated Interferon in HBeAg-negative Patients
Chronic hepatitis B (CHB) affects more than 350 million people worldwide. The most common form in Europe is CHB HBeAg-negative. Antiviral treatment of CHB HBeAg-negative patients includes chronic administration of nucleos(t)ide…
- Trial name
- NCT02743182
- Testing
- Pegylated interferon alfa-2a
- Volunteers
- 119 people
- Sponsor
- José Antonio Carrion
Cancer, Hepatitis B
Widespread vs. Selective Screening for Hepatitis B Infection Prior to Chemotherapy
This trial studies hepatitis B screening strategies of new cancer patients scheduled to undergo chemotherapy. Patients with cancer and hepatitis B virus infection are at risk of reactivation of infection after chemotherapy.
- Conditions
- Cancer, Hepatitis B, HBV, Hepatitis B Infection
- Trial name
- NCT01970254
- Testing
- Hepatitis B Screening, Survey Administration
- Where
- United States
- Volunteers
- 2,206 people
- Sponsor
- M.D. Anderson Cancer Center
Chronic Hepatitis B Infection
A Phase I Clinical Study of AHB - 171 in Healthy Participants(HP) and Chronic Hepatitis B (CHB) Participants
The goal of this clinical trial is to evaluate the safety, tolerability, immunogenicity and Pharmacokinetics (PK) characteristics of AHB-171 Injection in healthy participants (Part A) and participants with chronic hepatitis B…
- Trial name
- NCT07511218
- Testing
- AHB-171 Injection, Nucleos(t)ide Analogue (NA)
- Where
- 2 sites in China
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Ausper Biopharma Co., Ltd.
Hepatitis B, Chronic
A Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single and Multiple Doses of RO7049389 in Healthy Volunteers and Chronic Hepatitis B Virus (HBV) Infected Participants
This study is a multicenter, three-part study. Parts 1 and 2 are randomized, investigator- and participant-blinded, placebo-control, single-ascending dose (SAD) and multiple-ascending dose (MAD) study to evaluate the safety…
- Trial name
- NCT02952924
- Testing
- Midazolam, RO7049389
- Where
- 21 sites in Australia, Bulgaria and 6 more
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- Hoffmann-La Roche