Clinical trials: Hepatobiliary Disorders
Fatty Liver, Diabetes Mellitus, Type 2
Effects of Ginger on Nonalcoholic Fatty Liver Disease in T2DM
The investigators want to evaluate the effects and safety of ginger in treatment of nonalcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes mellitus (T2DM).
- Trial name
- GinLivDM (NCT02289235)
- Testing
- Ginger
- Where
- Iran
- Volunteers
- 76 people
- Sponsor
- Shiraz University of Medical Sciences
Non-Alcoholic Fatty Liver Disease
Multi-Parametric MRI Assessment of the Liver in the Dallas-FortWorth Metroplex Population
To build a Registry of volunteers by inviting them to get a LiverMultiScan(LMS)and collecting their contact information to seek interest in participating in future studies.
- Trial name
- DFWRegistry (NCT04336618)
- Testing
- Liver MultiScan
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Perspectum
Non-Alcoholic Fatty Liver Disease, Non-alcoholic Steatohepatitis
Endoscopic Ultrasound Shear Wave Elastography in Patients With Non-alcoholic Fatty Liver Disease
The goal of this observation study is to assess whether endoscopic ultrasound shear wave elastography (EUS-SWE) may be a useful tool for liver fibrosis screening in patients with elevated body mass index and non alcoholic fatty…
- Conditions
- Non-Alcoholic Fatty Liver Disease, Non-alcoholic Steatohepatitis, Obesity
- Trial name
- NCT05728697
- Testing
- Endoscopic ultrasound shear wave elastography
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- Brigham and Women's Hospital
Alcoholic Liver Disease
Role of CCL2 in Alcoholic Liver Diseases
Immune dysregulations, including cytokines and chemokines secretions occurs in alcoholic liver disease. Serum levels and liver expression of CCL2 are increased in patients with alcoholic hepatitis but the role of this chemokine…
- Trial name
- NCT01128010
- Volunteers
- healthy volunteers welcome
- Sponsor
- Erasme University Hospital
Exocrine Pancreatic Insufficiency, Fatty Liver, Nonalcoholic
Fatty Liver and Pancreatic Steatosis
The goal of this observational study is to determine the prevalence of pancreatic steatosis in patients with fatty liver and determine the prevalence of exocrine pancreatic insufficiency (EPI) in these patients.
- Conditions
- Exocrine Pancreatic Insufficiency, Fatty Liver, Nonalcoholic, Pancreatic Steatosis
- Trial name
- NCT06757348
- Testing
- Fecal elastase, Ecoendoscopy, Fibroscan
- Where
- Argentina
- Volunteers
- 61 people
- Sponsor
- Maria Marta Piskorz
Acute Kidney Injury, Arterial Hypertension
Study Evaluating Novel Biomarkers of AKI (Acute Kidney Injury) in Post-operative Patients
To validate the use of [TIMP-2]●[IGFBP-7] to predict AKI in patients undergoing major intra abdominal surgery.
- Conditions
- Acute Kidney Injury, Arterial Hypertension, Obesity, Cardio Vascular Disease
- Trial name
- NCT02499185
- Testing
- Nephro Check Test, serum creatinine measurement
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Universitair Ziekenhuis Brussel
NAFLD, Obesity
Intermittent Fasting, Mediterranean Diet and NAFLD
This study aims to evaluate the effects of Intermittent Fasting (IF) 14/10 compared with the Low Glycemic Index Mediterranean Diet on NAFLD.
- Conditions
- NAFLD, Obesity, Intermittent Fasting, Mediterranean Diet
- Trial name
- RC2024-21 (NCT06615817)
- Testing
- Intermittent Fasting
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis
Fatty Liver, Fatty Liver, Alcoholic
Fatty Liver Disease Collaborative Research in China
A multi-center, prospective cohort study on the natural history of fatty liver disease in China
- Conditions
- Fatty Liver, Fatty Liver, Alcoholic, Non-alcoholic Fatty Liver Disease
- Trial name
- FLDCR (NCT02391168)
- Where
- 6 sites in China
- Volunteers
- 3,000 people
- Sponsor
- Fatty Liver and Alcoholic Liver Disease Study Group, China
Non-alcoholic Fatty Liver Disease
Different Doses of BI 1467335 Compared to Placebo in Patients With Clinical Evidence of NASH
The primary objective of this study is the proof of mechanism and support of dose finding, together with the safety evaluation in patients with clinical evidence of NASH.
- Trial name
- NCT03166735
- Testing
- BI 1467335
- Where
- 44 sites in United States, Belgium and 7 more
- Volunteers
- 114 people
- Sponsor
- Boehringer Ingelheim
Non-alcoholic Fatty Liver Disease, Childhood Obesity
A Carbohydrate-restricted Diet to Reverse Fatty Liver in Adolescents With Obesity
The purpose of this study is to determine the effects of a low carbohydrate diet vs a low fat diet on improvement in aminotransferases, hepatic fat infiltration, markers of inflammation, insulin resistance, and body composition…
- Conditions
- Non-alcoholic Fatty Liver Disease, Childhood Obesity, Insulin Resistance
- Trial name
- NCT02787668
- Testing
- Carbohydrate-restricted diet, Control, low-fat diet
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of Alabama at Birmingham
NASH - Nonalcoholic Steatohepatitis
Novel MRE Technique to Assess a Risk Factor for Liver Cancer
The aim of this proposal is to investigate a novel imaging method to identify patients with non-alcoholic steatohepatitis (NASH) who are at risk for hepatocellular carcinoma (HCC).
- Trial name
- NCT05165446
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Natalie Torok
Non-Alcoholic Fatty Liver Disease
Lifestyle Guidance Methods in NAFLD
To determine the efficiency of lifestyle modification (due to a dietitian or digital application) compared to standard of care.
- Trial name
- INDIANA (NCT05792488)
- Testing
- Coach, App, Standard of care
- Where
- Belgium
- Volunteers
- 300 people
- Sponsor
- Ziekenhuis Oost-Limburg
Hepatic Impairment, Healthy Volunteers
Effect Of Hepatic Impairment on the Pharmacokinetics, Safety and Tolerability of PF-06865571 In Subjects With Hepatic Impairment and in Healthy Subjects
The current study is proposed to evaluate whether there is any clinically meaningful effect of hepatic impairment on the plasma PK of PF-06865571.
- Trial name
- NCT04091061
- Testing
- PF-06865571 100 mg
- Where
- 2 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Pfizer
Non-alcoholic Fatty Liver Disease, Sleep Apnea, Obstructive
Obstructive Sleep Apnea and Non-alcoholic Fatty Liver Disease
Obstructive sleep apnea (OSA) and nonalcoholic fatty liver disease (NAFLD) are frequently encountered in patients with metabolic syndrome (MS). Several data suggest that OSA per se could be a risk factor of liver injury.
- Trial name
- NASHSAS (NCT03373643)
- Testing
- OSA screening
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Angers
Liver Diseases
Energy Therapy and Meditation Based Practice for Sleep Difficulties
Sleep difficulties have been identified as one of the most distressing symptoms for adolescents with Chronic Liver Disease (CLD), Autoimmune Liver Disease (AILD) and Liver Transplantation (LT), sleep difficulties have a direct…
- Trial name
- ET&MforSD (NCT05003050)
- Testing
- Meditation, Pranic Healing
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- King's College Hospital NHS Trust
Chronic Hepatitis C Virus Infection
Safety, Tolerability and Efficacy of XTL 2125 in HCV-Infected Patients Who Are Interferon-Alpha Non-Responders or Relapsers
The study will be a randomized, double blind, placebo controlled, dose rising study in Interferon alpha (IFN-alpha) non-responder HCV infected patients or HCV patients who have relapsed following IFN-alpha therapy.
- Trial name
- NCT00255359
- Testing
- XTL-2125
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Hadassah Medical Organization
Cirrhosis, Liver, End Stage Liver DIsease
Testing LiverWatch, a Home-Based Remote-Monitoring Intervention for Advanced Liver Disease
Remote healthcare monitoring for cirrhosis has shown promise in overcoming barriers to accessing specialty care, improving healthcare quality, and reducing mortality.
- Conditions
- Cirrhosis, Liver, End Stage Liver DIsease, Symptoms and Signs, Physical Inactivity
- Trial name
- NCT06136221
- Testing
- LiverWatch Intervention
- Where
- 2 sites in United States
- Volunteers
- 110 people
- Sponsor
- University of Pennsylvania
Liver Cirrhosis, Non-Alcoholic Fatty Liver Disease
Ultrasound Assessment of Sarcopenia in Patients With Chronic Liver Disease: the SARCOLIVER Study
Sarcopenia is a complex multifactorial syndrome which could be present in older age (primary sarcopenia) or earlier in chronic disease (secondary sarcopenia).
- Conditions
- Liver Cirrhosis, Non-Alcoholic Fatty Liver Disease, Hepatocellular Carcinoma
- Trial name
- SARCOLIVER (NCT06101758)
- Testing
- Handgrip strength test, total body Dual Energy X-Ray Absorptiometry (DXA), Muscle ultrasound
- Where
- Italy
- Volunteers
- 125 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Obesity, Diabetes Mellitus, Type 2
Bariatric Surgery-Induced Shift in Gut Microbiome and NAFLD
This study is designed as a prospective pilot study for longitudinal assessment of fecal microbiome related to medical and surgical weight loss.
- Conditions
- Obesity, Diabetes Mellitus, Type 2, NAFLD
- Trial name
- NCT04263376
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- The Cleveland Clinic
Alcohol-related Liver Disease
Alcohol Biomarkers in Post-Liver Transplant Patients
The aim of this study is to compare the predictive validity and reliability of PEth testing at detecting alcohol use in post liver transplant patients. A prospective cohort study will be used to test the primary hypothesis.
- Trial name
- NCT01812226
- Where
- 2 sites in United States
- Volunteers
- 214 people
- Sponsor
- Northwestern University
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