Clinical trials: Hepatobiliary Disorders
Alpha 1-Antitrypsin Deficiency
4-PBA: Will it Increase the Level of Alpha 1-Antitrypsin(AAT) in Persons With AAT Deficiency?
The purpose of this study is to find out whether 4-PBA will increase the level of AAT in persons with AAT deficiency whether or not they have liver disease.
- Trial name
- NCT00067756
- Testing
- 4-PBA
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Florida
Nonalcoholic Fatty Liver, Nonalcoholic Steatohepatitis
Non-invasive Evaluation of Liver Fibrosis, Steatosis, and NASH in NAFLD
1. To evaluate hepatic fibrosis and steatosis using MR imaging, transient elastography (TE), and serum biomarker 2. To develop non-invasive diagnosis marker for NASH and advanced fibrosis
- Trial name
- NCT03725631
- Testing
- Imaging and serologic evaluation of fibrosis and steatosis
- Where
- South Korea
- Volunteers
- 150 people
- Sponsor
- Korea University Guro Hospital
NAFLD, Accupuncture
Treatment of Non Alcoholic Fatty Liver Disease With Lifestyle Modification and Acupuncture
Nonalcoholic fatty liver disease (NAFLD) is the most common cause of liver dysfunction worldwide. NAFLD may progress to nonalcoholic steatohepatitis (NASH) and in turn to cirrhosis.
- Trial name
- NCT02006329
- Testing
- acupuncture
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Ziv Hospital
Fatty Liver, Nonalcoholic, Weight Loss
Feasibility of Immersive Virtual Reality Dietician Program in Metabolic-dysfunction Associated Steatotic Liver Disease
Metabolic-dysfunction associated steatotic liver disease, often referred to as "fatty liver disease", is a leading cause of liver failure.
- Conditions
- Fatty Liver, Nonalcoholic, Weight Loss, Virtual Reality, Implementation Science
- Trial name
- NCT06215131
- Testing
- In-person dietary weight loss counseling, Virtual reality dietary weight loss counseling
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Milton S. Hershey Medical Center
Viral Hepatitis, Liver Fibrosis
Non-invasive Biomarkers of Fibrosis in Pediatric Liver Diseases
This study is being conducted to develop new techniques for early diagnosis of liver disease. These techniques are: Shearwave Elastography (SWE) ultrasound and blood biomarkers.
- Conditions
- Viral Hepatitis, Liver Fibrosis, Liver Disease, Hepatitis B
- Trial name
- NCT01988753
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Baylor College of Medicine
Metabolic Dysfunction Associated Steatotic Liver Disease, Non-Alcoholic Fatty Liver Disease (NAFLD)
Non-Invasive Diagnostic Tests for MASLD in Pediatric Population
This study aims to test the utility of Velacur ultrasound as a non-invasive, rapid, point of care diagnostic tool for detecting the presence and amount of hepatic steatosis in children and adolescents aged 2 - 20 years.
- Trial name
- NCT06218589
- Testing
- Velacur, MRI, Blood sample collection for biomarkers
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- Emory University
Anemia, Liver Disease
Phase 2 Study of PEG-Intron in Hereditary Hemorrhagic Telangiectasia
The purpose of the study is to evaluate the safety and tolerability of pegylated interferon alpha-2b (PEG-Intron) in patients with severe complications related to Hereditary hemorrhagic telangiectasia (HHT).
- Conditions
- Anemia, Liver Disease, Hypoxemia
- Trial name
- NCT00588146
- Testing
- Pegylated Interferon Alpha2b, Standard care
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Mayo Clinic
NAFLD
French Cohort for the Study of Non-invasive Tests of Liver Lesions in NAFLD/NASH (FreSH Cohort)
Currently, the management of non-alcoholic fatty liver disease (NAFLD) patients has two main limitations. First, there is no approved treatment in NAFLD.
- Trial name
- FreSH (NCT03695796)
- Testing
- biopsy-proven NAFLD patients with non-invasive tests of liver fibrosis (blood tests, elastography devices) and biobank
- Where
- 16 sites in France, Guadeloupe
- Volunteers
- 1,005 people
- Sponsor
- University Hospital, Angers
Nonalcoholic Steatohepatitis (NASH)
A Sub Study of the Study Evaluating the Safety, Efficacy, and Pharmacokinetics of Miricorilant in Patients With Presumed Nonalcoholic Steatohepatitis (NASH)
This optional sub study is a part of the phase 1b, Open-Label Study is to assess the safety, efficacy of miricorilant in patients with presumed Nonalcoholic Steatohepatitis (NASH)
- Trial name
- NCT05320146
- Testing
- MRI-PDFF
- Where
- 9 sites in United States
- Volunteers
- 22 people
- Sponsor
- Corcept Therapeutics
Chronic Liver Disease, Steatohepatitis
Non-Invasive Evaluation of Fibrosis and Steatosis in Chronic Hepatopathy
The purpose of this study is to evaluate non-invasive parameters for staging and grading of chronic hepatopathy in comparison to liver biopsy.
- Conditions
- Chronic Liver Disease, Steatohepatitis, Fibrosis
- Trial name
- NCT01246388
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Tischendorf, Jens, M.D.
Colorectal Adenocarcinoma Metastatic in the Liver, Liver Ablation
International Study on Treatment of Patients With Metastatic Colorectal Liver Lesions Patients With IRE
Procedural data will be recorded from patients with liver metastases from colorectal cancer who have received at least one course of systemic chemotherapy and who have been assessed by an appropriately constituted MDT (or…
- Conditions
- Colorectal Adenocarcinoma Metastatic in the Liver, Liver Ablation, Liver Cancer, Adult
- Trial name
- LIVERMET-IRE (NCT07191548)
- Testing
- Irreversible Electroporation
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Angiodynamics, Inc.
Liver Cirrhosis
SASL Swiss Cirrhosis Cohort
This is a national prospective long-term multicentre observational cohort study following patients with cirrhosis in order to systematically and longitudinally record epidemiological, clinical, histological, psychosocial and…
- Trial name
- SSCiCoS (NCT06092385)
- Testing
- Data collection
- Where
- 10 sites in Switzerland
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Alcoholic Hepatitis, Alcohol-related Liver Disease
Investigating HepQuant DuO Test as a Biomarker in Alcohol-related Liver Disease
This is a study to measure liver recovery in patients with recent alcohol-associated liver injury by assessing liver function and physiology using HepQuant DuO.
- Trial name
- NCT07060547
- Testing
- HepQuant DuO Test
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- HepQuant, LLC
Liver Diseases
Egyptian Liver Library: Rebuilding the Pyramid of Liver Disease Evidence in Egypt
A lot of publications about liver disease are available worldwide. Egypt is one of the countries having a large number of publications in hepatology. There are defects in reviewing this evidence and making use of it.
- Trial name
- ELL (NCT04465747)
- Testing
- Publications
- Where
- Egypt
- Volunteers
- 5,068 people
- Sponsor
- Al-Azhar University
Hepatic Insufficiency
Hepato Biliary Scintigraphy to Assess the Risk of Postoperative Liver Failure Hepatectomies
Extended hepatectomies of 4 or more segments are complicated by high rates of morbidity and mortality, mainly related to hepatic liver failure.
- Trial name
- SCINTIVOL (NCT02753517)
- Testing
- Hepatobiliary scintigraphy
- Where
- 12 sites in France
- Volunteers
- 326 people
- Sponsor
- University Hospital, Lille
Fatigue
Anti-fatigue Effect of Korean Red Ginseng in Patients With Non-alcoholic Hepatitis
Background: Korea red ginseng (KRG) has anti-carcinogenic activity, anti-oxidant activity, and cancer related anti-fatigue. Methods: Seventy five patients with non-alcoholic hepatitis were prospectively randomized to receive 3…
- Trial name
- NCT02331589
- Testing
- KRG (Korea Red ginseng)
- Volunteers
- 75 people
- Sponsor
- Chuncheon Sacred Heart Hospital
Non-alcoholic Fatty Liver Disease
Dietary Allowance of Methyl Donor Nutrients to Minimize Risks of Non-alcoholic Fatty Liver Progression
Investigate the methyl donors requirement of NAFLD patients to correct the malnutrition, lipid-toxicity, microbiota dysfunction, and metabolomics biomarkers.
- Trial name
- NCT05291104
- Testing
- Folic acid, choline chloride
- Where
- Taiwan
- Volunteers
- 51 people
- Sponsor
- Fu Jen Catholic University Hospital
Non-alcoholic Fatty Liver Disease (NAFLD), Non-alcoholic Steatohepatitis (NASH)
Simultaneous Quantification of Liver Fat Content, Fatty Acid Composition, and Fibrosis Using Spin-lock MRI for Steatohepatitis Assessment
Non-alcoholic fatty liver disease is a major health problem worldwide. It includes simple steatosis and NASH which has inflammation in the liver, with or without fibrosis.
- Trial name
- NCT05384652
- Where
- Hong Kong
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Non-Alcoholic Fatty Liver Disease, Time Restricted Feeding
Effects of Time-restricted Eating Supported by Mobile Technology in Patients With Non-alcoholic Fatty Liver Disease: Randomized Controlled Trial
In non-alcoholic fatty liver disease (NAFLD), it is established that calorie restriction is the most essential dietary modification.
- Conditions
- Non-Alcoholic Fatty Liver Disease, Time Restricted Feeding, Mobile Technology
- Trial name
- NCT05579158
- Testing
- Mobile application and wearable device, Time-restricted eating
- Where
- South Korea
- Volunteers
- 337 people, healthy volunteers welcome
- Sponsor
- Hanyang University
NAFLD, Alcoholic Hepatitis
EUS Guided Liver Biopsy - Will it Give Better Yield, More Tissue With Less Complication?
Liver biopsy would be done by Endoscopic Ultrasound using Acquire needle.
- Trial name
- NCT04235855
- Testing
- Endoscopic USG guided Liver biopsy, Percutaneous Liver Biopsy
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Asian Institute of Gastroenterology, India
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.