Clinical trials: Hepatobiliary Disorders
Liver; Disease, Inflammatory
Effect of Sugarcane Juice on Liver Patients
This study aims to investigate the potential benefits of sugarcane juice on liver health in patients who are suffering from liver-related conditions.
- Trial name
- NCT06558669
- Testing
- Fresh Sugarcane juice
- Where
- Pakistan
- Volunteers
- 400 people
- Sponsor
- Pir Mehr Ali Shah Arid Agriculture University
Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)
Study on Risk Factors and Prognosis of MASLD
This longitudinal cohort study will enroll individuals with MASLD (and/or those at risk) and follow them over time to identify clinical and metabolic risk factors for disease progression and to evaluate predictors of long-term…
- Trial name
- NCT07433205
- Where
- China
- Volunteers
- 922 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
NAFLD, Hiv
Lifestyle Modification Programme for HIV-infected Individuals With Fatty Liver
Non-alcoholic fatty liver disease (NAFLD) is rising in prevalence, and will likely become the predominant cause of chronic liver disease in HIV-infected individuals.
- Trial name
- NCT03913351
- Testing
- Lifestyle modification
- Where
- Hong Kong
- Volunteers
- 96 people
- Sponsor
- Chinese University of Hong Kong
Liver Fibrosis, Cirrhosis, Liver
Prolonged Release Pirfenidone Versus Placebo in Compensated Cirrhosis.
This will be a multicenter, double-blind clinical trial to evaluate the safety and efficacy of two doses of prolonged release pirfenidone, compared against placebo plus conventional therapy in patients with compensated liver…
- Conditions
- Liver Fibrosis, Cirrhosis, Liver, Chronic Liver Disease
- Trial name
- ODISEA (NCT06267794)
- Testing
- Pirfenidone 1200 mg, Pirfenidone 1800 mg
- Volunteers
- 180 people
- Sponsor
- Jorge L Poo
End Stage Liver Disease, Hepatitis C
Study of Liver Transplant For End-Stage Liver Disease Caused By Chronic Hepatitis C Infection
The purpose of this study is to compare three treatment regimens in patients who have received a liver transplant for end-stage liver disease caused by Chronic Hepatitis C infection.
- Trial name
- NCT00163657
- Testing
- Daclizumub, Tacrolimus, Cyclosporine
- Where
- United States
- Volunteers
- 312 people
- Sponsor
- Baylor Research Institute
Non-alcoholic Steatohepatitis
A Research Study Looking at How the Medicine NNC0194-0499 Behaves in Japanese and Non-Asian Men
This study looks at how a new medicine called NNC0194-0499 works in the body of Japanese men and non-Asian men. Japanese participants will either get NNC0194-0499 or placebo - which treatment participants get is decided by…
- Trial name
- NCT04722653
- Testing
- NNC0194-0499
- Where
- Japan
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Fatty Liver, NAFLD
Effect of CoQ10 on the Outcome of MAFLD Patients
So far there has been no universal treatment for MAFLD since it has a complex etiology that involves ethnic, genetic, metabolic and environmental factors.
- Trial name
- NCT05984745
- Testing
- Coenzyme Q10 Forte® capsules
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Obesity and Type 2 Diabetes, NAFLD - Non-Alcoholic Fatty Liver Disease
OneSTOP (One-Stop Telehealth Obesity Program) for Multidisciplinary Weight Management and Related Comorbidities
The goal of this clinical trial is to learn if the use of a care model including teleconsults and the EMPOWER app can induce clinically significant weight loss and metabolic improvements in obese adults with diabetes and…
- Conditions
- Obesity and Type 2 Diabetes, NAFLD - Non-Alcoholic Fatty Liver Disease, Hypertension, Dyslipidaemia
- Trial name
- OneSTOP (NCT06890169)
- Testing
- OneSTOP program, Standard of care weight management program
- Where
- Singapore
- Volunteers
- 120 people
- Sponsor
- Changi General Hospital
Pruritus With Chronic Liver Disease
Phase II Study of TRK-820 Soft Capsules - Intractable Pruritus in Patients With Chronic Liver Disease -
The efficacy and safety of TRK-820 are to be evaluated in the treatment of intractable pruritus in patients with Chronic Liver Disease by administering 2.5, 5 and 10 microg of this drug or placebo for 28 days in four groups with…
- Trial name
- NCT00638495
- Testing
- Nalfurafine Hydrochloride (TRK-820)
- Where
- Japan
- Volunteers
- 120 people
- Sponsor
- Toray Industries, Inc
HIV Infections, Liver Diseases
A Study of Zidovudine in HIV-Infected Patients With Liver Disease
To examine the pharmacokinetics (blood levels) and bioavailability of zidovudine (AZT) given to patients with HIV infection and chronic liver disease.
- Trial name
- NCT00001001
- Testing
- Zidovudine
- Where
- 5 sites in United States
- Volunteers
- 39 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Nonalcoholic Steatohepatitis, Type 2 Diabetes Mellitus
A Study in Adult Patients With Nonalcoholic Steatohepatitis Who Also Have Type 2 Diabetes
The purpose of this study is to assess the effect of TEV-45478, as compared with placebo, on liver health and liver fat content in patients with T2DM who also have Nonalcoholic Steatohepatitis (NASH).
- Trial name
- NASH (NCT02769091)
- Testing
- TEV-45478
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Obesity, NAFLD
Vigorous- Versus Moderate-intensity Exercise to Reduce Liver Fat in Adults With Obesity and NAFLD
Non-alcoholic fatty liver disease (NAFLD) arising from obesity has become a global health concern. Although exercise is a cornerstone approach for managing NAFLD, detailed exercise prescription guidelines are unavailable.
- Trial name
- NCT06124456
- Testing
- Usual Care Control Group, Moderate-intensity Exercise Intervention, Vigorous-intensity Exercise Intervention
- Where
- Hong Kong
- Volunteers
- 330 people
- Sponsor
- The University of Hong Kong
MASLD
Dietary Strategies for MASLD (Metabolic Dysfunction-Associated Steatotic Liver Disease)
This is a non-blinded, three-arm, parallel, 6-month randomized, longitudinal, and controlled intervention trial. designed to compare the effects of three dietary regimes (Mediterranean diet, low-carbohydrate diet and standard…
- Trial name
- NCT07304336
- Testing
- Low-Carb diet, Mediterranean diet, Standard Lifestyle Recommendations
- Where
- Italy
- Volunteers
- 173 people
- Sponsor
- University of Turin, Italy
Non Alcoholic Steatohepatitis
Vitamin E Versus Vitamin E Plus Pentoxiphyllin in Patients With Nonalcoholic Steatohepatitis: A Prospective Randomized Clinical Trial
Nonalcoholic fatty liver disease (NAFLD) is a spectrum of hepatic pathology, ranging from simple steatosis, steatohepatitis, to cirrhosis.
- Trial name
- NCT01279434
- Testing
- Vitamin E plus Pentoxiphyllin, Vitamin E
- Where
- India
- Sponsor
- Institute of Liver and Biliary Sciences, India
Non-Alcoholic Fatty Liver Disease, Renal Transplant Complication Pre-Existing Disease
Transient Elastograghy to Detect Non Alcoholic Fatty Liver Disease in Renal Transplantation Recipients.
a. Primary (main): The presence of non alcoholic fatty liver disease in post renal transplantation recipients by non invasive methods as transient elastograghy b-Secondary (subsidiary): to evaluate if transient elastograghy could…
- Trial name
- NCT05894993
- Testing
- transient elastograghy
- Volunteers
- 50 people
- Sponsor
- Amany Khaled Ali Ahmed
Diabetes, Nonalcoholic Fatty Liver Disease
Effects of Exercise on Patients With Nonalcoholic Fatty Liver Disease- A Comparative Randomized Controlled Trial
background: Obesity, diabetes mellitus type II and fatty liver disease combining with low levels of physical activity are prominent health risks for mortality and morbidity.
- Conditions
- Diabetes, Nonalcoholic Fatty Liver Disease, Obesity, Exercise
- Trial name
- [PTREC] (NCT03774511)
- Testing
- High-Intensity Interval Exercise & Moderate Intensity Interval Exercise
- Where
- Egypt
- Volunteers
- 48 people
- Sponsor
- Ahlia University
Non-alcoholic Fatty Liver Disease
Effects of Aerobic Exercise on Lean Non-alcoholic Fatty Liver Disease (NAFLD)
NAFLD is increasingly being identified in lean individuals, especially in Chinese population. Among the NAFLD patients, the lean NAFLD accounts for 15.9%-23.0%.
- Trial name
- NCT04882644
- Testing
- Aerobic Exercise
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Liver Cancer (Primary and Metastatic)
A Cohort Study (Risk Prediction of HCC in Patients With Chronic Liver Disease)
Evaluating the effectiveness of standardized HCC risk stratification management in improving early diagnosis rates in patients with chronic liver disease
- Trial name
- NCT07820644
- Where
- China
- Volunteers
- 15,000 people
- Sponsor
- Cai Qingxian
Acute and Chronic Hepatic Failure With Developing Coma
Evaluation of Mechanisms Responsible for Coma in Patients Affected by Fulminant, Acute and Chronic Hepatic Failure
The purpose of this study is to understand mechanisms associated with the development of coma during hepatic failure. As of today, those mechanisms are not understood and it is difficult to intervene and prevent coma development…
- Trial name
- NCT01582087
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- The University of Texas Medical Branch, Galveston
NAFLD, Nutrient; Excess
Effects of Dietary Nutrients on Liver and Adipose Tissue Metabolism
In health,adipose tissue stores fat from the diet. If the fat tissue stops storing dietary fat then this increases the chance of it being stored in the liver, which is related to increased risk of heart disease and type 2…
- Trial name
- NCT03090347
- Testing
- Overconsumption of specific dietary nutrient
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Oxford