Clinical trials: Hepatobiliary Surgery
Hepatocellular Carcinomas, Cholecystectomy, Laparoscopic
A Multicenter Prospective Observational Study of Computer-aided Risk Perception and Prognosis Prediction in the Whole Process of Laparoscopic Hepatobiliary and Pancreatic Surgery
Artificial intelligence technology is used to realize high-quality 3D scene reconstruction, whole process segmentation, scene activity understanding for common surgery guidance in hepatobiliary surgery, as well as intelligent…
- Conditions
- Hepatocellular Carcinomas, Cholecystectomy, Laparoscopic, Hepatectomy, Pancreatoduodenectomy
- Trial name
- NCT06647264
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Hepatobiliary Neoplasm
Immersive Virtual Reality Environment for Complex Cognitive Skills Curricular Training in Liver Surgery
Investigators hypothesize that a virtual reality (VR) environment enhances general surgery residents' performance compared to Desktop Interface (DI)-based visualization of 3D models in decision making for patients with liver…
- Trial name
- LiVeRTrainer (NCT04959630)
- Testing
- Clinical decision making based on visualizing liver 3D models in Virtual Reality (VR) environment or via a Desktop Interface (DI)
- Where
- 2 sites in Belgium, Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Colorectal Cancer, Hepatobiliary Cancer
Exercise Preconditioning with Cancer Surgeries
Studies have shown that people who are more physically fit prior to surgery do better after surgery. For this reason, it may be helpful for people who are going to have abdominal surgery for cancer to exercise before surgery to…
- Conditions
- Colorectal Cancer, Hepatobiliary Cancer, Gynecologic Cancer
- Trial name
- ExPre 01 (NCT04923672)
- Testing
- Moderate continuous exercise, High intensity interval exercise
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Virginia
Liver Diseases, Pancreas Disease
Effect of Goal-directed Fluid Therapy on Postoperative Complications
It has been known that the recent application of a goal-directed fluid therapy (GDFT) to the intraoperative fluid infusion in patients contributes to decreasing the prevalence of postoperative complications and shortening the…
- Trial name
- NCT03169998
- Testing
- EV1000 platform
- Where
- South Korea
- Volunteers
- 375 people
- Sponsor
- Seoul National University Bundang Hospital
Liver Neoplasms, Liver/Hepatobiliary Cancer
CE-IOUS Impact on Surgical Strategy of Liver Tumours and Liver Metastases
Contrast-enhanced intraoperative ultrasound (CE-IOUS) plays an increasingly important role in the surgical therapy planning of primary liver lesions as well as liver metastases.
- Conditions
- Liver Neoplasms, Liver/Hepatobiliary Cancer, Colorectal Cancer Metastatic, Metastases
- Trial name
- NCT05261113
- Testing
- CE-IOUS
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- University of Regensburg
Cholestatic Pruritus
The Effect of Intraoperative Infusion of Esketamine on Cholestatic Pruritus in Patients Undergoing Hepatobiliary Surgery
To explore the effect of esketamine on cholestatic pruritus in patients undergoing hepatobiliary surgery
- Trial name
- NCT07760740
- Testing
- Esketamine, normal Saline
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Tianjin Medical University General Hospital
Hepatobiliary Disease, Hepatobiliary Disorders
A Randomized Controlled Trial Evaluating the Role of Negative Pressure Wound Therapy (NPWT) for Incisional Surgical Site Infections in Patients Undergoing Hepatopancreatobiliary Surgery
To compare the rates of incisional surgical site infections (iSSIs) within 7 days of hepatopancreatobiliary (HPB) surgery using negative pressure wound therapy (NWPT) versus using standard sterile gauze dressing.
- Conditions
- Hepatobiliary Disease, Hepatobiliary Disorders, Surgical Site Infection
- Trial name
- NPWT (NCT05481398)
- Testing
- Negative Pressure Wound Therapy
- Where
- Pakistan
- Volunteers
- 46 people
- Sponsor
- Murk Niaz
Postoperative Complications, Pulmonary Complication
Low-Dose Norepinephrine With Conservative Fluid Therapy in Hepatobiliary Surgery
This prospective randomized controlled study aims to compare the effect of low-dose norepinephrine combined with conservative goal-directed fluid therapy versus conventional fluid therapy on postoperative pulmonary complications…
- Trial name
- NCT07892586
- Testing
- Conventional Fluid Therapy, Low-Dose Norepinephrine, Conservative Goal-Directed Fluid Therapy
- Volunteers
- 100 people
- Sponsor
- Assiut University
Advanced Cholangiocarcinoma (Part 1)
A Real-World Study of Precision Treatment for Advanced Cholangiocarcinoma Based on Molecular Subtyping
This is a multi-center, real-world study aiming to evaluate the efficacy and safety of precision treatment for advanced cholangiocarcinoma (CCA) with different molecular subtypes.
- Trial name
- NCT07164703
- Testing
- Targeted drugs or immunotherapies for cholangiocarcinoma based on targetable gene mutations.
- Where
- China
- Volunteers
- 55 people
- Sponsor
- Mao-Lin Yan
Liver Neoplasms, Hepatobiliary Diseases
Outcomes After Liver and Biliary Resection at a High-Volume Center
The goal of this observational study is to evaluate clinical and oncologic outcomes in adult patients undergoing liver and/or biliary resection for benign and malignant diseases.
- Conditions
- Liver Neoplasms, Hepatobiliary Diseases, Cholangiocarcinoma, Hepatocellular Carcinoma
- Trial name
- BILIVER (NCT07556835)
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- Azienda USL Toscana Centro
Hepatic Complication
Implication of Fluid Strategies Upon Hepatic Outcome in Hepatobiliary Surgery
compare the effect of two different protocol of fluid therapy in patients undergoing elective hepatobiliary surgery under general anesthesia regarding hemodynamics and SGPT change pre- and postoperative.
- Trial name
- NCT03923816
- Testing
- Conservative fluid strategy: 12 mL/kg/h of Lactated Ringer (LR).&Restrictive fluid strategy:6 mL/kg/h of Lactated Ringer (LR).
- Volunteers
- 100 people
- Sponsor
- Assiut University
Liver Diseases, Pancreas Disease
Enhanced Recovery After Surgery for Hepatobiliary-Pancreatic Surgery
ERAS protocols have been utilized extensively in abdominal and non abdominal surgery over the past 20 years. These protocols incorporate evidence based, multi-disciplinary peri-operative care components.
- Trial name
- NCT03772392
- Testing
- HPB resection
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- University of Edinburgh
Hepatobiliary Neoplasm
Holographic Augmented Reality Versus Screen Visualisation of 3D Rendering Models for the Pre-operative Evaluation and Planning of Liver Resections
The goal of this trial is to compare the evaluation of 3D liver models visualised as holograms with HoloLens 2 and on digital PDF files in HPB surgical trainees.
- Trial name
- NCT06049836
- Testing
- Holograms, PDF
- Where
- Italy
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Federico II University
Gallstones
Contrastive Study for Minimally Invasive Cholecystolithotomy With Gallbladder Reservation and Laparoscopic Cholecystectomy
To explore the therapeutic effects for treatment of cholecystolithiasis by minimally invasive cholecystolithotomy with gallbladder reservation and laparoscopic cholecystectomy.
- Trial name
- NCT01822262
- Testing
- minimally invasive cholecystolithotomy with gallbladder reservation, laparoscopic cholecystectomy
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Chengyi Sun
Post Operative Pain, Analgesia
Ultrasound Guided Erector Spinae Plane Block Versus Retrolaminar Plane Block
Retrolaminar block (RLB) and erector spinae plane block (ESPB) are alternative approaches to paravertebral block (PVB) and are advantageous in that they are easier and safer techniques compared with the traditional PVB.
- Trial name
- NCT05705739
- Testing
- retrolaminar block, ESPB
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Minia University
Postoperative Nausea and Vomiting, Hepatobiliary Surgery
External Validation of the Apfel Risk Score and Koivuranta Score to Predict Postoperative Nausea and Vomiting in Patients With Liver Cancer
Postoperative nausea and vomiting (PONV) is a common complication among surgical patients. The incidence ranging from 20% to 50% depends on different population studied.
- Conditions
- Postoperative Nausea and Vomiting, Hepatobiliary Surgery, Prediction Model
- Trial name
- NCT05014737
- Testing
- no intervention
- Where
- China
- Volunteers
- 214 people
- Sponsor
- Shanghai Zhongshan Hospital
Pancreatic Cancer, Esophageal Cancer
Perioperative Geriatrics Intervention for Older Cancer Patients Undergoing Surgical Resection
The purpose of this research study is to addresses the challenge of managing the unique perioperative needs of older cancer patients undergoing surgical resection.
- Conditions
- Pancreatic Cancer, Esophageal Cancer, Gastric Cancer, Rectal Cancer
- Trial name
- NCT02810652
- Testing
- Usual Care, Perioperative Geriatrics Intervention
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Massachusetts General Hospital
Hepatobiliary Surgery, Liver Diseases
Feasibility Analysis of LCD-SLA 3D Printing Technology for Overall Surgical Planning of Liver Malignant Tumors
This study aims to evaluate the effectiveness of 3D-printed liver models in hepatobiliary surgery planning compared to traditional digital simulations. It is conducted in three phases: 1.
- Trial name
- NCT06526754
- Testing
- 3D-Printed Liver Model, Digital Simulation-Based Surgical Planning
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Yang Jihong
Hepatic Neoplasms, Biliary Tract Neoplasms
Clinical Outcomes of Preoperative and Postoperative Rehabilitation in the Patients With HBP Malignancy
Clinical Outcomes of Preoperative and Postoperative Rehabilitation in the Patients With HBP Malignancy.
- Conditions
- Hepatic Neoplasms, Biliary Tract Neoplasms, Pancreatic Neoplasms
- Trial name
- PReHeBP (NCT02784353)
- Testing
- Perioperative rehabilitation program, Conventional
- Where
- South Korea
- Volunteers
- 158 people
- Sponsor
- Asan Medical Center
Hepatobiliary Surgery, Prophylactic Antibiotics
Prophylactic Antibiotics in Preventing Surgical Site Infection After Hepatobiliary Surgery in High-Resistant Settings
To analyse the efficacy of different preoperative prophylactic antimicrobial regimens for perioperative infection prevention in patients undergoing hepatobiliary surgery in a high antimicrobial resistance setting.
- Trial name
- PASH (NCT07620223)
- Testing
- Piperacillin-tazobactam
- Where
- China
- Volunteers
- 378 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School