Clinical trials: Hepatocellular
Liver Tumor
Practical Application of Indocyanine Green Camera in Laparoscopic Liver Surgery
"Indocyanine Green (ICG) is a dye used as an indicator of hepatic function considering its capacity to be eliminated only by the bile. Thus, ICG tend to remain in liver tumors.
- Trial name
- CAMVIC (NCT03579199)
- Testing
- exploration of abdominal cavity and liver using a NIR/ICG camera
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hepatocellular Carcinoma, Cirrhosis
Estimation of Functional Liver Reserve Using Cholinesterases
Estimation of functional liver reserve in patients with hepatocellular carcinoma (HCC) in cirrhosis is of paramount importance to properly select candidates for surgical resection.
- Conditions
- Hepatocellular Carcinoma, Cirrhosis, Liver Neoplasm, Liver Disease
- Trial name
- NCT00883454
- Where
- Italy
- Volunteers
- 181 people
- Sponsor
- University of Milan
HCC - Hepatocellular Carcinoma, Chinese Herbal Medicine
Shuganhuazhuo Formula for Advanced Hepatocellular Carcinoma With Damp-Heat Syndrome
Primary liver cancer is a malignant tumor with a very poor prognosis. Hepatocellular carcinoma(HCC) accounts for approximately 80% of cases.
- Conditions
- HCC - Hepatocellular Carcinoma, Chinese Herbal Medicine, ICG (Indocyanine Green), Overall Survival (All-cause Mortality)
- Trial name
- DAWNbreak-120 (NCT07691645)
- Testing
- Shuganhuazhuo Formula, Targeted therapy, Immunotherapy
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Xiang-Qian
Liver Diseases
DILIN - Prospective Study
The purpose of this study is to identify individuals who have suffered a liver injury arising as an idiosyncratic reaction to a prescription drug or a complementary and alternative medicine.
- Trial name
- NCT00345930
- Where
- 6 sites in United States
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Duke University
Advanced Hepatocellular Carcinoma, Lung Cancer
Ablation of Pulmonary Oligometastasis Combined With System for Advanced Hepatocellular Carcinoma
Ablation has been an effective therapy in treating intrathoracic metastases. However, for hepatocellular carcinoma with pulmonary oligometastasis, ablation of metastases remains relatively unexplored and still needs clinical…
- Conditions
- Advanced Hepatocellular Carcinoma, Lung Cancer, Oligometastasis, Ablation
- Trial name
- NCT06644430
- Testing
- Ablation, system therapy
- Where
- China
- Volunteers
- 470 people
- Sponsor
- Sun Yat-sen University
Hepatocellular Carcinoma, Cannabis
A Pilot Study on the Effect of Cannabis Oil in Untreatable Liver Cancer Patients
to study the anti-tumor effect of cannabis oil (THC10% / CBD5%) in untreatable HCC patients based on mRECIST and RECIST criteria
- Trial name
- CanHep (NCT06518434)
- Testing
- Medical Cannabis
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- University Medical Center Groningen
Carcinoma, Hepatocellular
A Study Comparing Radiofrequency Ablation and Hepatic Resection for Hepatocellular Carcinoma
The purpose of this prospective randomized study is to compare the efficacy and safety of radiofrequency ablation and hepatic resection for small hepatocellular carcinomas with very homogeneous underlying conditions.
- Trial name
- NCT02482909
- Testing
- Hepatic resection, Radiofrequency ablation
- Volunteers
- 68 people
- Sponsor
- Seoul National University Hospital
Hepatocellular Carcinoma
An Investigational Immuno-therapy Study of Nivolumab Compared to Sorafenib as a First Treatment in Patients With Advanced Hepatocellular Carcinoma
The purpose of this study is to determine if nivolumab or sorafenib is more effective in the treatment of Advanced Hepatocellular Carcinoma.
- Trial name
- NCT02576509
- Testing
- Nivolumab, Sorafenib
- Where
- 138 sites in United States, Australia and 20 more
- Volunteers
- 743 people
- Sponsor
- Bristol-Myers Squibb
Primary Liver Cancer, Metastatic Liver Cancer
Multi-center Clinical Study on the Decision Tree of Precision Hepatectomy in China Precision Hepatectomy Decision Tree
Liver failure (PHLF) after hepatectomy is a relatively serious postoperative complication. Previous studies have shown that liver reserve function is related to PHLF.
- Conditions
- Primary Liver Cancer, Metastatic Liver Cancer, Benign Liver Neoplasms, Hepatic Echinococcosis
- Trial name
- NCT05986383
- Volunteers
- 820 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Hepatocellular Carcinoma
Nocardia Rubra Cell Wall Skeleton (N-CWS) Plus HAIC, Lenvatinib and Tislelizumab in Treating Patients With Advanced HCC
The purpose of this study is to evaluate the efficacy and safety of Nocardia rubra cell wall skeleton plus hepatic arterial infusion chemotherapy of oxaliplatin, 5-fluorouracil and leucovorin, lenvatinib and tislelizumab in…
- Trial name
- CCGLC-007 (NCT05533892)
- Testing
- Nocardia rubra cell wall skeleton, Hepatic arterial infusion chemotherapy, Lenvatinib
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Wan-Guang Zhang
Hepatocellular Carcinoma
Radiofrequency Ablation for Hepatocellular Carcinoma Using Octopus MP Electrodes
This study is to investigate the therapeutic effect and treatment results of radiofrequency ablation using the Octopus MP electrode capable of temperature monitoring and drug injection and a variable-length electrode for…
- Trial name
- NCT05666271
- Testing
- Radiofrequency ablation
- Where
- South Korea
- Volunteers
- 76 people
- Sponsor
- Seoul National University Hospital
Ventilation, Ablation Techniques
Use of Flow-Controlled Ventilation During CT-Guided Percutaneous Liver Tumor Ablation
Tumors in the liver can be treated using percutaneous ablation. At the Amsterdam UMC, this procedure is often performed under CT guidance by an interventional radiologist.
- Trial name
- EVOLVE (NCT07291271)
- Testing
- Flow controlled ventilation
- Where
- Netherlands
- Volunteers
- 41 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Hepatocellular Carcinoma, Esophageal Cancer
PLA for HCC and Esophageal ca Serum
The primary goal of this study is to quantify the biomarkers of pre-radiation therapy(RT), during-RT, and post-RT serum samples from hepatocellular carcinoma (HCC) and esophageal cancer patients undergoing definitive or…
- Trial name
- NCT01957241
- Where
- Taiwan
- Volunteers
- 164 people
- Sponsor
- National Taiwan University Hospital
Cirrhosis, Liver
EGCG for Hepatocellular Carcinoma Chemoprevention
This phase II trial tests epigallocatechin gallate (EGCG) for its efficacy and safety in preventing development of hepatocellular carcinoma (HCC) in patients with liver cirrhosis.
- Trial name
- CATCH-B (NCT06015022)
- Testing
- Epigallocatechin gallate (EGCG)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Texas Southwestern Medical Center
Cirrhosis, Liver, Hepatocellular Carcinoma
CT-guided Localization for Micro Hepatocellular Carcinoma Before Surgical Resection
In this project, the preoperative anatomical location of micro hepatocellular carcinoma under the guidance of CT can provide guidance for accurate surgical resection.
- Trial name
- CTMH (NCT05433467)
- Testing
- CT-guided localization for micro hepatocellular carcinoma before surgical resection
- Where
- China
- Volunteers
- 5 people
- Sponsor
- Northern Jiangsu People's Hospital
Hepatocellular Carcinoma
Transarterial Chemotherapy Compared With Oral Chemotherapy in the Treatment of Advanced Hepatocellular Carcinoma
In India, majority of our patients have advanced hepatocellular carcinoma (HCC) at presentation and hence are unsuitable for the available curative treatment options. In such patients the treatment options are mainly palliative.
- Trial name
- NCT02240771
- Testing
- Transarterial chemotherapy, Oral chemotherapy
- Where
- India
- Volunteers
- 124 people
- Sponsor
- All India Institute of Medical Sciences
Hepatocellular Carcinoma (HCC), IrAE
The Safety and Efficacy of Ondansetron in Reducing Immune Checkpoint Inhibitor-Related Toxicities
This study is a prospective, randomized, single-center randomized controlled clinical trial to investigate the safety and efficacy of ondansetron in reducing the toxicity associated with immune checkpoint inhibitor treatment.
- Trial name
- NCT07381634
- Testing
- ondansetron
- Where
- China
- Volunteers
- 134 people
- Sponsor
- First Affiliated Hospital of Wenzhou Medical University
Hepatocellular Carcinoma
Neoadjuvant and Adjuvant Lenvatinib in HCC Patients Treated by Percutaneous Ablative
Percutaneous ablation (PA) is the only non-surgical curative treatment of hepatocellular carcinoma (HCC). Due to its excellent tolerance, particularly in patients with portal hypertension or bearing comorbidities, it now…
- Trial name
- LENVABLA (NCT05113186)
- Testing
- Lenvatinib Pill
- Where
- France
- Volunteers
- 32 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hepatocellular Carcinoma, Liver Cancer
A Phase II Study to Evaluate the Effects of Sequential Therapy With the Anti c-MET/VEGFR Tyrosine Kinase Inhibitor (TKI), Cabozantinib, Followed by an Anti-PD-1 Antibody (Nivolumab) in Patients With Advanced HCC Who Progressed on First-line Therapy
The purpose of this clinical research study is to learn about the safety and effectiveness of cabozantinib and nivolumab in people with hepatocellular carcinoma (HCC).
- Trial name
- NCT05039736
- Testing
- Cabozantinib, Nivolumab
- Sponsor
- M.D. Anderson Cancer Center
Hepatocellular Carcinoma (HCC)
TACE With Immune Agents for Angiogenesis in Hepatocellular Carcinoma
This study investigates the clinical efficacy and safety of transarterial chemoembolization (TACE) combined with the immune agent nivolumab compared to TACE alone for treating hepatocellular carcinoma (HCC).
- Trial name
- NCT07053202
- Testing
- Nivolumab, Transarterial Chemoembolization (TACE)
- Where
- China
- Volunteers
- 140 people
- Sponsor
- The First Hospital of Hebei Medical University