Clinical trials: Hereditary Motor and Sensory Neuropathy
Charcot-Marie-Tooth Disease With Sorbitol Dehydrogenase Deficiency (CMT-SORD)
Confirmatory Study of Govorestat in CMT-SORD
This study is designed to assess the long-term efficacy and clinical benefit of AT-007 in patients with CMT-SORD. This randomized, double-blind study will assess the effect of govorestat compared to placebo in patients with…
- Trial name
- NCT07191912
- Testing
- Govorestat
- Where
- 13 sites in United States, Australia and 5 more
- Sponsor
- Applied Therapeutics, Inc.
Hereditary Spastic Paraplegia
Robot-assisted Walking Treatment in Hereditary Spastic Paraplegia (HSP)
Patients will undergo a combined rehabilitation treatment consisting of 15 sessions on Lokomat and 15 sessions of physical therapy over three weeks for a total of 30 sessions. Two sessions/day for 5 days a week.
- Trial name
- NCT06728787
- Testing
- Robot-Assisted Gait Training
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- IRCCS Eugenio Medea
Palmaris Longus Muscle, Absence of, Carpal Tunnel Syndrome
Electrophysiological Changes Based on the Palmaris Longus
One of the most important causes of carpal tunnel syndrome is increased pressure in the canal. With the loading of the palmaris longus at 20 degrees of wrist extension, the pressure within the canal increases more than the load…
- Conditions
- Palmaris Longus Muscle, Absence of, Carpal Tunnel Syndrome, EMG Syndrome
- Trial name
- NCT04619849
- Testing
- EMG, Palmaris Longus Test
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Istanbul Medipol University Hospital
Persistent Post-concussive Syndrome, Concussion Post Syndrome
Hyperbaric Oxygen Effects on Persistent Post-concussive Symptoms
Persistent post-concussive symptoms (PPCS) are a source of significant burden among a subset of patients with concussion with prevalence rates previously reported between 11 - 82% based on timing of assessment, diagnostic…
- Trial name
- HOINPCS (NCT05173818)
- Testing
- Hyperbaric oxygen at 1.5 ATA
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Essentia Health
Hereditary Spastic Paraplegia
Flexibility, Resistance, Aerobic, Movement Execution Training in Adults With Hereditary Spastic Paraplegia
Hereditary Spastic Paraplegia (HSP) is a group of inherited neurological disorders that cause progressive weakness and stiffness (spasticity) in the legs, reducing balance and walking ability.
- Trial name
- FRAME (NCT06742697)
- Testing
- Flexibility, Resistance, Aerobic, Movement Execution training
- Where
- 2 sites in Italy
- Volunteers
- 20 people
- Sponsor
- IRCCS Eugenio Medea
Lumbar Spinal Stenosis, Carpal Tunnel Syndrome (CTS)
124I-Evuzamitide PET/CT Imaging In Patients With Lumbar Spinal Stenosis and Carpal Tunnel Syndrome
This clinical trial will use the amyloid-binding radiotracer, 124I-evuzamitide, to potentially detect amyloid, in the heart and elsewhere, in patients who have a history of lumbar spinal stenosis and/or carpal tunnel syndrome.
- Conditions
- Lumbar Spinal Stenosis, Carpal Tunnel Syndrome (CTS), Cardiac Amyloidosis
- Trial name
- NCT06907849
- Testing
- 124I-evuzamitide
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Tennessee Graduate School of Medicine
Carpal Tunnel Syndrome (CTS)
Compare the Effect of Radiofrequency (TECAR) and Ultrasound on Sensation, Hand Dexterity, and Quality of Life in Patients With Carpal Tunnel Syndrome.
The purpose of the current study is to: Compare the effect of radiofrequency (TECAR) therapy and ultrasound on sensation, manual dexterity, and quality of life in individuals diagnosed with carpal tunnel syndrome (CTS).
- Trial name
- TECAR (NCT07700316)
- Testing
- Radiofrequency, Therapeutic Ultrasound
- Where
- Egypt
- Volunteers
- 42 people
- Sponsor
- Delta University for Science and Technology
Manual Therapy, Extracoropral Shock Wave Therapy
Effectiveness of Manual Therapy and Extracoropral Shock Wave Therapy in Patients With Carpal Tunnel Syndrome
This study aimed to compare the effectiveness of manual therapy and extracorporeal shock wave therapy in patients with mild to moderate carpal tunnel syndrome.
- Conditions
- Manual Therapy, Extracoropral Shock Wave Therapy, Carpal Tunnel Syndrome
- Trial name
- NCT07074509
- Testing
- Manual therapy, Extracorporeal shock wave therapy
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Tanta University
Charcot Marie Tooth Disease (CMT)
CMT Gait, Mobility, Balance - AOFAS Grant
The overall objective of the proposed research is to begin to better understand the potential benefits and limitations of ankle -foot orthosis (AFO) use in the context of mobility and balance during gait for individuals with…
- Trial name
- NCT07188415
- Testing
- Ankle-foot Orthoses
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Bopha Chrea
Spastic Paraplegia, Hereditary
Therapeutic Metabolic Intervention in Patients With Spastic Paraplegia SPG5
The purpose of this project is to study the efficacy of three candidate molecules (Xenbilox, Tahor and Resveratrol) in order to decrease the production of oxysterols by reducing the synthesis of cholesterol and/or regulate the…
- Trial name
- SPA-M (NCT02314208)
- Testing
- Xenbilox, Resveratrol, Tahor
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Carpal Tunnel Syndrome
Continuous And Pulsed Ultrasound Treatments On Carpal Tunnel Syndrome
The aim of this placebo-controlled study was to evaluate the effects of pulsed and continuous ultrasound treatments combined with splint therapy on patients with mild and moderate idiopathic carpal tunnel syndrome
- Trial name
- NCT02054247
- Testing
- ultrasound, pulsed ultrasound
- Volunteers
- 46 people
- Sponsor
- Eskisehir Osmangazi University
Musculoskeletal Diseases, Median Nerve Disease
Comparison of Ultrasound-Guided Injection With Median Nerve Decompression Surgery in Carpal Tunnel Syndrome
The aim of this study is to compare ultrasound-guided perineural injection of the median nerve with classic minimal incision surgical technique for median nerve decompression in patients diagnosed with mild, moderate, and severe…
- Conditions
- Musculoskeletal Diseases, Median Nerve Disease, Carpal Tunnel Syndrome, Ultrasound-Guided Injection
- Trial name
- NCT06243848
- Testing
- Minimal Incision Surgery for median nerve decompression, Ultrasound-guided perineural injection with 5 cc 5% Dextrose
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Afyonkarahisar Health Sciences University
Carpal Tunnel Syndrome
Role of Ultrasonography in the Diagnosis of Carpal Tunnel Syndrome
This prospective study aims to evaluate the median nerve in Carpal Tunnel Syndrome by high-frequency ultrasound and color Doppler in comparison with clinical and Nerve conduction studies.
- Trial name
- NCT04976998
- Testing
- imaging
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sohag University
Piriformis Syndrome
The Effects of Ultrasound Guided Ozone and Lidocaine Injections in Piriformis Syndrome
Piriformis Syndrome (PS) is defined as a trap neuropathy that involves compression of the sciatic nerve by the piriformis muscle, leading to a number of symptoms along with sciatic pain, initially in the hip muscles.
- Trial name
- NCT06130618
- Testing
- Ozone, Lidocain
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people
- Sponsor
- Ankara City Hospital Bilkent