Clinical trials: Hernia, Diaphragmatic
Cholecystitis, Perforated Duodenal Ulcer
Incentive Spirometry and Upper Abdominal Laparoscopic Surgery
To compare the effects of volume-oriented versus flow-oriented incentive spirometry on pulmonary function tests and functional capacity in patients of upper abdominal laparoscopic surgery.
- Conditions
- Cholecystitis, Perforated Duodenal Ulcer, Diaphragmatic Hernia, Benign Pancreas Tumor
- Trial name
- NCT04716166
- Testing
- Volume-oriented incentive spirometry, Flow-oriented incentive spirometry
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Riphah International University
Paraesophageal Hernia
Gastropexy as a Treatment Option for Paraesophageal Hernia
The present proposal aims to asses which is the optimal treatment strategy in a clinical study in patients with paraoesophageal hernia (PEH), a condition often found in elderly, fragile patients The investigator want to study the…
- Trial name
- NCT06096402
- Testing
- no intervention, but surgical practice as usual is continued. Its a pragmatic study
- Where
- 3 sites in Denmark, Norway
- Volunteers
- 220 people
- Sponsor
- University Hospital of North Norway
Paraesophageal Hernia
Short Esophagus in Type II-IV Hiatus Hernia
Background: The existence, diagnosis and treatment of short esophagus is one of the controversies of the past which has recently re-emerged.
- Trial name
- SEHH (NCT01587859)
- Testing
- laparoscopic surgery
- Where
- 2 sites in Italy
- Volunteers
- 34 people
- Sponsor
- University of Bologna
Shoulder Pain, Hiatal Hernia
Pain Relief After Hiatal Hernia Repair Surgery
Referred shoulder pain (pain felt when the problem is actually in a different location) is very common after laparoscopic (small, narrow cut) hernia surgery.
- Trial name
- NCT04936711
- Testing
- Resteck Shiatsu Neck and Back Massager, Marcaine
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Norton Thoracic Institute
Pulmonary Hypertension of Newborn, Diaphragm Defect
Effect of a Parenteral Emulsion With Omega3 on Neonates With PPHN and CDH
The purpose of this study is to evaluate the effect of a parenteral emulsion containing n-3 long-chain polyunsaturated fatty acids (LC-PUFA) in fish oil on clinical outcomes, markers of inflammation and oxidative stress, and pain…
- Trial name
- CDH-PPHN-N3 (NCT04031508)
- Testing
- lipid injectable emulsion with Fish oil
- Where
- Mexico
- Volunteers
- 40 people
- Sponsor
- Coordinación de Investigación en Salud, Mexico
Congenital Diaphragmatic Hernia
Preliminary Study of Pediatric Diaphragmatic Elastography
This diaphragmatic elastography study is a preliminary pilot study to have first values of diaphragmatic stiffness in patients with a history of diaphragmatic hernia and to estimate the difference in stiffness compared to a group…
- Trial name
- ECHODIA (NCT06666140)
- Testing
- Ultrasonic elastography
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Strasbourg, France
Hiatal Hernia, Sleeve Gastrectomy
Laparoscopic Hiatal Hernia Repair With Mesh Cruroplasty
The study you're referring to explores a surgical strategy for patients undergoing Laparoscopic Sleeve Gastrectomy (LSG) who also have a Hiatal Hernia (HH).
- Trial name
- NCT07491003
- Testing
- Hiatal Hernia (HH) repair using mesh cruroplasty during a Laparoscopic Sleeve Gastrectomy (LSG)
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Zagazig University
Hernia, Paraesophageal Hernia
Randomized, Prospective Controlled Trial of Paraesophageal Hernia Repair With Small Intestinal Submucosa (SIS)
The purpose of this randomized study is to determine whether a type of mesh derived from a layer of pig small intestine (SIS) is of benefit in treating paraesophageal hernias versus standard surgical suture repair.
- Trial name
- NCT00272922
- Testing
- hernia repair
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Cook Group Incorporated
Trisomy 13 Syndrome, Arthrogryposis Congenita Multiplex With Intestinal Atresia
Palliative Care Needs of Children With Rare Diseases and Their Families
The palliative care needs of family caregivers of children with rare diseases and their children are largely unmet, including the need for support to prepare for future medical decision making.
- Conditions
- Trisomy 13 Syndrome, Arthrogryposis Congenita Multiplex With Intestinal Atresia, Asparagine Synthetase Deficiency, CHARGE Syndrome
- Trial name
- FACE-Rare (NCT06938542)
- Testing
- Family Centered pediatric palliative care for family caregivers of children with rare diseases.
- Where
- United States
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Children's National Research Institute
Congenital Diaphragmatic Hernia, Pulmonary Hypertension
Efficacy of Inhaled Nitric Oxide in Congenital Diaphragmatic Hernia
This multicenter, prospective, single-arm study aims to evaluate the efficacy of inhaled nitric oxide (iNO) in neonates with congenital diaphragmatic hernia (CDH) and early pulmonary hypertension.
- Trial name
- INOCDH (NCT07247240)
- Testing
- Inhaled Nitric Oxide
- Where
- 4 sites in South Korea
- Volunteers
- 40 people
- Sponsor
- Asan Medical Center
Tracheo Esophageal Fistula, Congenital Diaphragmatic Hernia
Cerebral Blood Flow in Neonates During Thoracoscopic Surgeries
the aim of this study is to compare the effect of different modes of mechanical ventilation by using volume-controlled ventilation and pressure-controlled ventilation on cerebral blood flow monitored by cerebral oximetry during…
- Trial name
- NCT04507295
- Testing
- cerebral oximetry ( INVOS 5100 )
- Volunteers
- 30 people
- Sponsor
- Cairo University
Paraesophageal Hernia
Gastropexy in the Repair of Patients With Paraesophageal Hernias
Patients scheduled for surgery for primary paraesophageal herniation are randomized to either conventional surgical hernia repair or with the addition of gastropexy.
- Trial name
- PEH3 (NCT06107634)
- Testing
- Gastropexy, Paraesophageal hernia repair
- Where
- 6 sites in Sweden
- Volunteers
- 150 people
- Sponsor
- Ersta Diakoni
Hernia, DIaphragmatic, Congenital
Work of Breathing Description in Neonates With Congenital Diaphragmatic Hernia in NAVA and in Conventional Ventilation.
Congenital diaphragmatic hernia (CDH) is a congenital malformation associated with significant mortality and respiratory morbidity, particularly related to prolonged mechanical ventilation.
- Trial name
- NAVA-DIAPH (NCT03250793)
- Testing
- Physiologic study measuring work of breathing which can be estimated by the esophageal and trans-diaphragmatic pressure-time product obtained by an esophageal transducer
- Where
- France
- Volunteers
- 8 people
- Sponsor
- Hospices Civils de Lyon
Fetal Surgery, Myelomeningocele
Fetal Surgery Interview Study: Parental Perceptions of Fetal Surgery
Open maternal-fetal surgery is currently used on fetuses with myelomeningocele (MMC). Fetoscopic or minimal access fetal surgery is also being used to treat fetuses with congenital diaphragmatic hernia (CDH).
- Conditions
- Fetal Surgery, Myelomeningocele, Congenital Diaphragmatic Hernia
- Trial name
- NCT03788122
- Testing
- In-depth interview
- Where
- 2 sites in Belgium, United Kingdom
- Volunteers
- 40 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Congenital Diaphragmatic Hernia
Fetoscopic Endoluminal Tracheal Occlusion
The purpose of this research study is to see if the FETO surgery and FETO release (surgery to remove the device) works and is safe for babies with severe right or left Congenital Diaphragmatic Hernia (CDH).
- Trial name
- FETO (NCT03674372)
- Testing
- Fetoscopic Endoluminal Tracheal Occlusion (FETO)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Colorado, Denver
Congenital Diaphragmatic Hernia
Fetal Endotracheal Occlusion (FETO) in the Resolution of Pulmonary Hypertension in Fetuses With Severe CDH
Congenital diaphragmatic hernia (CDH) occurs when the diaphragm fails to fully fuse and leaves a portal through which abdominal structures can migrate into the thorax.
- Trial name
- NCT03980717
- Testing
- Goldbal Detachable Balloon and delivery microcatheter
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Michael A Belfort
Congenital Diaphragmatic Hernia
Microbiome and Volatile Organic Compounds in Patients With CDH
Despite improved prenatal diagnostics and therapeutic possibilities, congenital diaphragmatic hernia (CDH) represents a cross-disciplinary challenge.
- Trial name
- CDHVOCS (NCT03787160)
- Testing
- initial VOC, initial fecal microbiome, initial pulmonary microbiome
- Where
- Austria
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Hernia, Diaphragmatic
Early Childhood Follow-up of Congenital Diaphragmatic Hernia Survivors
The primary objective of this study is to determine the medical and neurodevelopmental outcomes of congenital diaphragmatic hernia (CDH) survivors at school-age (4-6 years) follow-up.
- Trial name
- CDH (NCT01029665)
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Duke University
Hiatal Hernia
Miromatrix Biological Mesh for Hiatal Hernia Repair
Miromatrix Medical has developed MIROMESH® - a new, noncrosslinked, acellular mesh derived from the highly vascularized porcine liver.
- Trial name
- NCT02436681
- Testing
- MIROMESH
- Where
- 6 sites in United States
- Volunteers
- 50 people
- Sponsor
- Miromatrix Medical Inc.
Hernia, Hiatal, Pneumoperitoneum
Low Pressure Pneumoperitoneum Using AirSeal® for Reduction in Postoperative Shoulder Pain Following Robot Assisted Hiatal Hernia Repair
The goal of this clinical trial is to evaluate the incidence and severity of post-operative shoulder pain following elective robot-assisted hiatal hernia repair in hopes of reducing pain and associated costs as well as clinic and…
- Conditions
- Hernia, Hiatal, Pneumoperitoneum, Postoperative Pain, Shoulder Pain
- Trial name
- NCT06737068
- Testing
- Low pressure pneumoperitoneum (8-10mmHg) with AirSeal device, Standard pressure pneumoperitoneum (13- 15 mmHg) with AirSeal device
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Riverside University Health System Medical Center