Clinical trials: Hernias, Diaphragmatic, Congenital
Persistent Fetal Circulation Syndrome, Diaphragmatic Hernia
Antibody Secreting Cell and Cyotokine Profiles in Neonates on ECMO
Infants are placed on ECMO for correction of reversible respiratory failure. Often, because a few of the reasons for respiratory failure show us similar things in the baby, it is difficult to determine exactly which is causing…
- Conditions
- Persistent Fetal Circulation Syndrome, Diaphragmatic Hernia, Meconium Aspiration, Sepsis
- Trial name
- NCT00371241
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- The University of Texas Health Science Center, Houston
Congenital Diaphragmatic Hernia
Machine and Deep Learning for Congenital Diaphragmatic Hernia (CLANNISH)
Congenital Diaphragmatic Hernia (CDH) is characterized by an incomplete diaphragm formation, resulting in poor lung development (pulmonary hypoplasia), associated with altered vascularization of the lung (pulmonary hypertension)…
- Trial name
- CLANNISH (NCT04609163)
- Testing
- data collection
- Volunteers
- 50 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Severe Congenital Diaphragmatic Hernia
FETO With Long Tail Balloon for a Treatment of Severe CDH
Congenital diaphragmatic hernia (CDH) has an incidence of 1:2200 to 1:4000 newborns. The survival rate depends on the extent of the lung hypoplasia and pulmonary hypertension.
- Trial name
- LongTailFETO (NCT03431792)
- Testing
- Long Tail Balloon
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Martin-Luther-Universität Halle-Wittenberg
Congenital Diaphragmatic Hernia
Children With Congenital Diaphragmatic Hernia and the Quality of Their Daily Lives
Background: Congenital diaphragmatic hernia is a rare disease, resulting from a developmental malformation of the diaphragm. Over the last years, management of the affected children has improved significantly.
- Trial name
- NCT07432672
- Where
- Austria
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Congenital Diaphragmatic Hernia
Fetoscopic Endoluminal Tracheal Occlusion
The purpose of this research study is to see if the FETO surgery and FETO release (surgery to remove the device) works and is safe for babies with severe right or left Congenital Diaphragmatic Hernia (CDH).
- Trial name
- FETO (NCT03674372)
- Testing
- Fetoscopic Endoluminal Tracheal Occlusion (FETO)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Colorado, Denver
Diaphragmatic Hernia
Fetoscopic Tracheal Balloon Occlusion in Left Diaphragmatic Hernia
Left diaphragmatic hernia detected during fetal life carries a high risk for postnatal lung failure due to lung underdevelopment and pulmonary hypertension.
- Trial name
- NCT00373438
- Testing
- Fetoscopic tracheal balloon occlusion
- Where
- Germany
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bonn
Congenital Diaphragmatic Hernia, Pulmonary Hypoplasia
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia (FETO)
The purpose of this research is to gather information on the safety and effectiveness of a new procedure called Fetoscopic Endoluminal Tracheal Occlusion (FETO).
- Conditions
- Congenital Diaphragmatic Hernia, Pulmonary Hypoplasia, Pulmonary Artery Hypertension
- Trial name
- FETO (NCT03138863)
- Testing
- BALT GoldbBAL2 Detachable Balloon, Catheter System
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Rodrigo Ruano
Gastroschisis, Congenital Diaphragmatic Hernia
An Exploratory Physiological Study of Post-operative Recovery in Surgical Neonates and Dimethylarginine:Arginine Levels
The SuNDiAL study will measure levels of two naturally occurring amino acids: Arginine and Asymmetric Dimethylarginine (ADMA) in neonates undergoing abdominal surgery in the first 5 days of life due to congenital abdominal…
- Conditions
- Gastroschisis, Congenital Diaphragmatic Hernia, Duodenal Atresia, Oesophageal Atresia With Tracheo-Oesophageal Fistula
- Trial name
- SuNDiAL (NCT06731855)
- Testing
- Abdominal Surgery for congenital gut malformation in the first 5 days of life.
- Where
- 2 sites in United Kingdom
- Volunteers
- 30 people
- Sponsor
- Liverpool Women's NHS Foundation Trust
Congenital Diaphragmatic Hernias
Contribution of PRF in CDH in Children With Prothetic Patch Closure
Improved management of giant congenital diaphragmatic hernias (CDH) in neonates : decreased risk of morbidity and mortality due to prosthesis release.
- Trial name
- HECODIAP (NCT03861182)
- Testing
- Biological functionalization of the prosthetic materials by PRF
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Congenital Diaphragmatic Hernia, Pulmonary Hypoplasia
Safety and Efficacy of FETO in CDH Phase III
Tracheal occlusion IDE approved by FDA for congenital diaphragmatic hernia fetuses and standard of care control group
- Conditions
- Congenital Diaphragmatic Hernia, Pulmonary Hypoplasia, Pulmonary Hypertension
- Trial name
- CDH FETO (NCT07187206)
- Testing
- FETO, Fetal Endoluminal Tracheal Occlusion
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Congenital Diaphragmatic Hernia, Congenital Abnormalities
Prospective Registry for Long-term Outcomes Following FETO in Severe Left and Right CDH
This registry study aims to confirm that FETO increases neonatal survival to discharge and reduces long-term morbidity in fetuses with isolated left CDH and o/e LHR < 30%, or isolated right CDH and o/e LHR ≤ 45%, compared to…
- Conditions
- Congenital Diaphragmatic Hernia, Congenital Abnormalities, Neonatal Diseases and Abnormalities, Hernia, DIaphragmatic, Congenital
- Trial name
- NCT07166172
- Testing
- Fetal Treatment Arm (FETO Group)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Johns Hopkins University
Congenital Diaphragmatic Hernia
Airway Inflammation in Congenital Diaphragmatic Hernia Patients
We propose to examine Congenital Diaphragmatic Hernia (CDH) patients for evidence of airway inflammation as a first step to characterize the reported bronchodilator responsiveness.
- Trial name
- NCT02453750
- Testing
- Hypersaline, Bronchodilator Response
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- The Hospital for Sick Children
Congenital Diaphragmatic Hernia
Trial of FETO for Severe Congenital Diaphragmatic Hernia
This is a single site pilot trial to study the feasibility of Fetoscopic Endoluminal Tracheal Occlusion (FETO) therapy in the most severe group of fetuses with congenital diaphragmatic hernia (CDH) at Ann \& Robert H.
- Trial name
- FETO (NCT05450653)
- Testing
- FETO with Goldballoon Detachable Balloon (GOLDBAL2) along with the delivery Microcatheter (BALTACCI-BDPE100)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Aimen F. Shaaban, MD
Congenital Diaphragmatic Hernia, Omphalocele
Functional Evaluation of the Fetal Lung by Functional Magnetic Resonance Imaging - Blood Oxygenation Level Dependent (MRI-BOLD), in Congenital Diaphragmatic and Parietal Malformations
The objective is to evaluate the quality of the response to the Blood Oxygen Level Dependent effect in fetuses with diaphragmatic hernias and abdominal wall malformations and to correlate with postnatal respiratory outcome.
- Conditions
- Congenital Diaphragmatic Hernia, Omphalocele, Gastroschisis
- Trial name
- BOLD FETUS (NCT04186039)
- Testing
- Functional magnetic resonance imaging - Blood Oxygenation Level Dependent
- Where
- France
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Congenital Diaphragmatic Hernia
Retrospective Comparative Study on Imaging Between the Bochdalek Hernia and Congenital Diaphragmatic Eventration
The imaging manifestations of diaphragmatic hernia and diaphragmatic distension were retrospectively analyzed and summarized, combined with the surgical findings, to summarize the differences in indirect signs of diaphragmatic…
- Trial name
- NCT05985564
- Testing
- imaging diagnosis
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Children's Hospital of Chongqing Medical University
Congenital Diaphragmatic Hernia
Pilot Trial of Fetoscopic Endoluminal Tracheal Occlusion (FETO) in Severe Left Congenital Diaphragmatic Hernia (CDH)
Despite advances in prenatal diagnosis and postnatal therapies, including ECMO (Extracorporeal Membrane Oxygenation), inhaled nitric oxide therapy, and ventilator strategies that minimize ventilator-induced lung injury, morbidity…
- Trial name
- NCT04583644
- Testing
- Fetoscopic Endoluminal Tracheal Occlusion Surgery
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Hanmin Lee
Congenital Diaphragmatic Hernia
Fetal Endotracheal Occlusion (FETO) in Fetuses With Severe Congenital Diaphragmatic Hernia
The goal of this pilot trial is to learn more about the role of Fetal Endotracheal Occlusion (FETO) as an intervention in fetuses with severe congenital diaphragmatic hernia (CDH).
- Trial name
- NCT06281717
- Testing
- Fetal Endotracheal Occlusion (FETO)
- Where
- United States
- Sponsor
- Eyal Krispin
Premature Baby, Pulmonary Hypertension of Newborn
Measuring Heart Health in Both Term, Preterm and Unwell Newborn Babies With an Advanced Ultrasound Method: Speckle Tracking Echocardiography
This study aims to improve how neonatologists check the heart function of newborn babies, especially those who are sick. While standard heart ultrasound scans are useful, a more advanced and sensitive technique called 2D speckle…
- Conditions
- Premature Baby, Pulmonary Hypertension of Newborn, Hypoxic Ischaemic Encephalopathy (HIE), Congenital Diaphragmatic Hernia
- Trial name
- NCT07364682
- Where
- United Kingdom
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Birmingham Women's NHS Foundation Trust
Congenital Diaphragmatic Hernia
Fetal Endotracheal Occlusion (FETO) in Severe and Extremely Severe Congenital Diaphragmatic Hernia
Congenital diaphragmatic hernia (CDH) occurs when the diaphragm fails to fully fuse and leaves a portal through which abdominal structures can migrate into the thorax.
- Trial name
- FETO (NCT00881660)
- Testing
- Goldballoon Detachable Balloon and delivery microcatheter
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Michael A Belfort
Hernias, Diaphragmatic, Congenital, Hernia; Diaphragm Defect, Congenital
Physiological-based Cord Clamping in Congenital Diaphragmatic Hernia
Pulmonary hypertension is a major determinant of postnatal survival in infants with a congenital diaphragmatic hernia (CDH). The current care during the perinatal stabilisation period in infants born with this rare birth defect…
- Conditions
- Hernias, Diaphragmatic, Congenital, Hernia; Diaphragm Defect, Congenital, Pulmonary Hypertension
- Trial name
- PinC (NCT04373902)
- Testing
- Physiological-based cord clamping
- Where
- 9 sites in Australia, Austria and 5 more
- Volunteers
- 144 people
- Sponsor
- Erasmus Medical Center