Clinical trials: Heroin
Drug Overdose
Bioavailability of Nasal Naloxone and Injected Naloxone Compared
Opioid overdoses have in the last decade counted for about 230 untimely deaths annually in Norway. The government is currently implementing a strategy for combating this epidemic.
- Trial name
- OPI-15-002 (NCT02598856)
- Testing
- Intranasal (IN) naloxone 1x, Intranasal (IN) naloxone 2, Intravenous (IV) naloxone
- Where
- Norway
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Heroin Addiction, Substance Use Disorders
Malmö Treatment Referral and Intervention Study
This study aims to study and implement active referral of heroin users from a syringe exchange programme to evidence-based treatment for heroin addiction.
- Trial name
- MATRIS (NCT01457872)
- Testing
- Strength-based case management, Control condition - referral only
- Where
- Sweden
- Volunteers
- 79 people
- Sponsor
- Region Skane
Behavior Therapy, Cocaine
The Efficacy of Methadyl Acetate (LAAM) and Contingency Management Procedures for Treating Dual Opioid and Cocaine Abuse - 1
Although LAAM, a derivative of methadone, has been successfully used as an alternative to methadone maintenance in opioid addicts, its effect on concurrent opioid and cocaine abuse has not been ascertained.
- Conditions
- Behavior Therapy, Cocaine, Contingency Management, Heroin Dependence
- Trial name
- NCT00158288
- Testing
- LAAM
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Opioid Dependence
Safety and Efficacy of Probuphine in the Treatment of Opioid Dependence
Buprenorphine (BPN) is an approved treatment for opioid dependence, however, in taking oral tablets, patients experience withdrawal and cravings when the variable BPN levels in the blood are low.
- Trial name
- NCT00447564
- Testing
- Probuphine
- Where
- 18 sites in United States
- Volunteers
- 163 people
- Sponsor
- Titan Pharmaceuticals
Drug Overdose, Opioid-Related Disorders
Buccal Versus Injectable Naloxone: a Phase I Healthy Volunteer Study
Naloxone is the standard treatment in response to cases of suspected opiate overdose. Buccal formulation of naloxone is a novel alternative to the licensed naloxone injection which, by removing the risk of accidental…
- Trial name
- NCT02733822
- Testing
- Naloxone
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- King's College London
Heroin Dependence, Opioid-Related Disorders
Buprenorphine/Naloxone Treatment for Opioid Dependence-Experiment II-2 - 5
The purpose of this study is to assess the abuse liability and reinforcing effects of intravenous buprenorphine and buprenorphine/naloxone combinations in heroin-dependent volunteers
- Trial name
- NCT00000330
- Testing
- Opioid-Related Disorders
- Where
- United States
- Sponsor
- University of Colorado, Denver
Opiate Dependence, Heroin Dependence
Behavioral Naltrexone Therapy for Promoting Adherence to Oral Naltrexone vs Extended Release Injectable Depot Naltrexone
In pilot study now proposed, we plan to randomly assign 60 opioid dependent patients to the new model, Depot-BNT, or to BNT plus oral naltrexone for a 6-month trial.
- Trial name
- Depot-BNT (NCT00577408)
- Testing
- depot naltrexone, Oral Naltrexone
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- New York State Psychiatric Institute
Adherence, Depression
Skills Based Counseling for Adherence and Depression in HIV+ Methadone Patients - 1
Patients with HIV, depression, and opioid-dependence are at high risk for poor health outcomes. This is a two-arm randomized controlled trial of cognitive-behavioral therapy for depression and HIV medication adherence in patients…
- Conditions
- Adherence, Depression, Heroin Dependence, Methadone
- Trial name
- NCT00218634
- Testing
- CBT-AD, ETAU
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- Massachusetts General Hospital
Heroin Dependence
Pharmacogenomics Study of Sleep Disturbance and Neurocognitive Impairments in the Opioid Addicts
Opioid abuse is a complex problem, which not only impacts on addicts' physical and psychological health individually, but also threats the society.
- Trial name
- NCT01668706
- Where
- 5 sites in Taiwan
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- National Health Research Institutes, Taiwan
Opioid Dependence, Substance-Related Disorders
Buprenorphine/Naloxone in the Treatment of Heroin Dependence - 14
The purpose of this study is the safety and efficacy of Buprenorphine/Naloxone in the treatment of opioid dependence. A compassionate use study.
- Trial name
- NCT00015340
- Testing
- Buprenorphine/naloxone
- Where
- 5 sites in United States
- Volunteers
- 582 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine-Related Disorders, Heroin Dependence
Treatment Efficacy for Drug Abuse and AIDS Prevention - 1
The purpose of this study is to assess the safety and effectiveness of buprenorphine for treatment of concurrent intravenous heroin and cocaine dependence.
- Trial name
- NCT00000210
- Testing
- Buprenorphine
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
IV Drug Usage, HIV Infections
Tele-Harm Reduction
The purpose of this study is to test 2 different methods for offering medications that treat HIV, cure Hepatitis C Virus (HCV) (if applicable) and treat substance use disorder (if desired) to people who inject drugs.
- Conditions
- IV Drug Usage, HIV Infections, Hepatitis C
- Trial name
- T-SHARP (NCT05208697)
- Testing
- Tele-Harm Reduction, off-site linkage
- Where
- 3 sites in United States
- Volunteers
- 100 people
- Sponsor
- University of Miami
Substance Use Disorders, Opiate Dependence
The Effect of Self-Forgiveness on Self-Stigma in Addiction.
This study has an experimental design and will examine the difference in pre-test and post-test data on the Self-Forgiveness Dual Process Scale (SFDPS) (Griffin, Worthington, Davis, Hook, \& Maguen, 2018) and the Substance Abuse…
- Conditions
- Substance Use Disorders, Opiate Dependence, Opiate Withdrawal Syndrome, Opioid-use Disorder
- Trial name
- NCT03971097
- Testing
- Six Step Model of Self-Forgiveness, Treatment as Usual (TAU)
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- University of Pittsburgh
HIV, Substance Abuse
Adherence to HIV Therapy in Heroin Addicts: Oral vs XR-NTX
Substance use, particularly the compulsive behaviors associated with addiction, lead to unhealthy behaviors including non-adherence to antiretroviral therapy (ART) and treatment failure.
- Conditions
- HIV, Substance Abuse, HIV Infections
- Trial name
- NCT01101815
- Testing
- Oral Naltrexone, Naltrexone Implant, Group Drug Counseling Manual Driven
- Where
- 2 sites in Russia
- Volunteers
- 200 people
- Sponsor
- University of Pennsylvania
Hepatitis C, Chronic, Substance Abuse Treatment Centers
Hepatitis C Among Opioid Addicts in Opioid Maintenance Treatment in Zurich, Switzerland
Hepatitis C viral infection is common among opioid addicts in Zurich, Switzerland. The majority undergoes a maintenance treatment with methadone, heroin or buprenorphine.
- Conditions
- Hepatitis C, Chronic, Substance Abuse Treatment Centers, Opioid-Related Disorders
- Trial name
- HepCOP (NCT00473993)
- Sponsor
- Seidenberg, Arztpraxis A., M.D.
Heroin Dependence, Sleep Impairment
Methadone Maintenance Outcome Study in Taiwan: 5-year Follow-up
Methadone maintenance treatment (MMT) has been one of the most effective treatment choices for opioid addicts to reduce their heroin use, criminality and spread of HIV. In Taiwan, MMT has been introduced since 2006.
- Conditions
- Heroin Dependence, Sleep Impairment, Mortality, Quality of Life
- Trial name
- NCT02524912
- Volunteers
- 1,200 people
- Sponsor
- National Health Research Institutes, Taiwan
Heroin Dependence, Amphetamine Dependence
Mirtazapine as a Treatment for Co-Occurring Opioid and ATS Dependence in Malaysia
The purpose of this study is to evaluate tolerability, acceptability and potential efficacy of 4 months of maintenance treatment with Mirtazapine as compared to placebo for patients with co-occurring amphetamine-type stimulant…
- Trial name
- NCT02541526
- Testing
- Mirtazapine
- Where
- Malaysia
- Volunteers
- 80 people
- Sponsor
- Universiti Sains Malaysia
Opioid Dependency
A Six-Month Randomized Controlled Trial (RCT) of Probuphine Safety and Efficacy in Opioid Addiction
Probuphine (buprenorphine implant) is an implant placed just below the skin containing buprenorphine (BPN). BPN is an approved treatment for opioid dependence. This study will confirm the efficacy of Probuphine vs.
- Trial name
- NCT01114308
- Testing
- Probuphine (buprenorphine implant), Buprenorphine
- Where
- 20 sites in United States
- Volunteers
- 287 people
- Sponsor
- Titan Pharmaceuticals
Cocaine Abuse, Heroin Abuse
Effect of Clonidine on Responses to Imagery Scripts
Background: Research has shown that clonidine, a drug originally prescribed to treat high blood pressure and some symptoms of opioid withdrawal, can help block stress-induced relapse to heroin and cocaine seeking in rats.
- Trial name
- NCT00318760
- Testing
- Clonidine
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Drug Addiction
Survey of Buprenorphine Use Among "Out of Care" Population in France (P04933)(COMPLETED)
This study was a survey of drug users who obtain buprenorphine from the black market and have used buprenorphine during the last month.
- Trial name
- NCT00756353
- Volunteers
- 600 people
- Sponsor
- Indivior Inc.