Clinical trials: Heroin Dependence
Heroin Addiction
Observational Study to Assess the Adequacy of Methadone Dosage, in Heroin Addicted Patients in a MMT.
The purpose of the study ( observational and prospective ) is to evaluate the efficacy and tolerability of the methadone maintenance treatment in patients addicted to heroin.
- Trial name
- METODO (NCT02062736)
- Where
- 5 sites in Italy
- Volunteers
- 500 people
- Sponsor
- L.Molteni & C. dei F.lli Alitti-Soc. di Esercizio S.p.A.
Opioid-Related Disorders, Heroin Dependence
Depot Naltrexone Mechanism of Action in Heroin Dependent Patients Using fMRI and SPECT
The aim of this project is to study brain functions of 20 heroin addicts (compared to brain functions of 20 healthy controls) just before and during a three month extended release naltrexone treatment using functional MRI and…
- Trial name
- XRNT (NCT01471145)
- Testing
- Naltrexone
- Where
- Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Opioid Use Disorder
Light Needle for Opioid Use Disorder
This randomized-controlled study investigates the effect of adjuvant light needle in the treatment of heroin addicts. One hundred heroin addicts older than 20 years old enrolled from the Addiction Treatment Center at Kaohsiung…
- Trial name
- OUD (NCT05341219)
- Testing
- Light needle therapy
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Chang Gung Memorial Hospital
Heroin Addiction
Efficacy Evaluation of Traditional Chinese Medicine JITAI Combined Comprehensive Model Among Heroin Addicts After Detoxification
The purpose of this research is to observe the efficacy of comprehensive treatment model to improve treatment compliance and relapse prevention.
- Trial name
- NCT01580163
- Testing
- JITAI Combined with psychological intervention, Methadone, Traditional Chinese Medicine JITAI
- Where
- 2 sites in China
- Volunteers
- 554 people
- Sponsor
- Shanghai Mental Health Center
Cocaine-Related Disorders, Heroin Dependence
Treatment Efficacy for Drug Abuse and AIDS Prevention - 1
The purpose of this study is to assess the safety and effectiveness of buprenorphine for treatment of concurrent intravenous heroin and cocaine dependence.
- Trial name
- NCT00000210
- Testing
- Buprenorphine
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Behavior, Addictive, Cocaine Abuse
Employment-based Reinforcement to Motivate Drug Abstinence in the Treatment of Drug Addiction. - 2
The purpose of this study is to determine whether long-term exposure to the Therapeutic Workplace intervention could sustain drug abstinence over an extended period of time in heroin- and cocaine-dependent, unemployed…
- Conditions
- Behavior, Addictive, Cocaine Abuse, Cocaine Dependence, Heroin Dependence
- Trial name
- NCT00249457
- Testing
- Contingency management
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Johns Hopkins University
Opioid-Dependence Among Adolescents
Science-Based Treatment for Opioid-Dependent Adolescents
The purpose of this study is to evaluate ways to optimize outcomes from combined behavioral-pharmacological treatment for opioid-dependent youth.
- Trial name
- NCT00182572
- Testing
- buprenorphine, naltrexone, behavior therapy
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- National Development and Research Institutes, Inc.
Heroin Addiction, Substance Use Disorders
Malmö Treatment Referral and Intervention Study
This study aims to study and implement active referral of heroin users from a syringe exchange programme to evidence-based treatment for heroin addiction.
- Trial name
- MATRIS (NCT01457872)
- Testing
- Strength-based case management, Control condition - referral only
- Where
- Sweden
- Volunteers
- 79 people
- Sponsor
- Region Skane
Opioid Dependence
Acute Effects of Cortisol on Heroin Craving in Opioid Dependence (Ghost-Basel)
To investigate the effects of cortisol on heroin craving and stress reaction in heroin addicted subjects Randomized, double-blind, placebo-controlled, cross-over, single administration of study medication Study…
- Trial name
- Ghost-Basel (NCT01718964)
- Testing
- Cortisol 20 mg, Mannitol
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- Prof. Dominique de Quervain, MD
Heroin Dependence, Opiate Dependence
Community Reinforcement and Family Training for Drug Abuse Treatment Retention/HIV Risk Reduction
The planned research will adapt an intervention of known efficacy to target a new outcome of significant importance to public health.
- Conditions
- Heroin Dependence, Opiate Dependence, Substance Dependence
- Trial name
- NCT00609089
- Testing
- CRAFT-T, Treatment as usual
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- University of Cincinnati
Opioid Dependence
The Separate and Combined Effects of Vivitrol and Opiate Abstinence Reinforcement in the Treatment of Opioid Dependence
In this 5-year study, the investigators propose to evaluate the separate and combined effects of the FDA-approved formulation of extended release naltrexone (Vivitrol®) and employment-based reinforcement of opiate abstinence in…
- Trial name
- NCT01556425
- Testing
- Vivitrol, Employment-based opiate abstinence reinforcement, Usual Care Control
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Johns Hopkins University
Heroin Dependence, Amphetamine Dependence
An Open-label Study of Oral Paliparidone for the Treatment of Patients With Co-occurring Opioid and ATS Dependence
The proposed study will evaluate the tolerability, acceptability and potential efficacy of paliparidone for the treatment of co-occurring opioid and amphetamine-type stimulant (ATS) dependence.
- Trial name
- NCT02541513
- Testing
- paliparidone
- Where
- Malaysia
- Volunteers
- 40 people
- Sponsor
- Universiti Sains Malaysia
Heroin Dependence
Study Comparing Liquid and Tablet Buprenorphine Formulations - 5
The purpose of this study is to compare liquid and tablet buprenorphine formulations.
- Trial name
- NCT00000302
- Testing
- Buprenorphine
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Opiate Dependence, HIV Infections
Integrating Buprenorphine Into HIV Treatment
We hypothesize that integrating drug treatment into HIV treatment will improve HIV outcomes as well as drug treatment outcomes in heroin users. This study will test this hypothesis by randomizing patients to two groups.
- Trial name
- NCT00241930
- Testing
- Integrating drug treatment into HIV services
- Where
- 3 sites in United States
- Volunteers
- 60 people
- Sponsor
- Organization to Achieve Solutions in Substance Abuse (OASIS)
Opioid Dependence, Heroin Dependence
Memantine as a Supplement to Naltrexone in Treating Heroin Dependence
Prospective participants will undergo a screening process at the clinic to determine eligibility. After screening, eligible patients will complete an 8-day inpatient detoxification, followed by a 12-week outpatient phase.
- Trial name
- NAMHS (NCT00476242)
- Testing
- Vivitrol, memantine
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- New York State Psychiatric Institute
Heroin Dependence, Opioid-Related Disorders
Addition of Naltrexone to Methadone Taper
There is a continuing search for more effective opiate detoxification treatments. This study's purpose is to investigate the effects of adding very low doses of naltrexone to a methadone tapering treatment in opioid dependent…
- Conditions
- Heroin Dependence, Opioid-Related Disorders, Substance-Related Disorders
- Trial name
- NCT00135759
- Testing
- Naltrexone
- Where
- United States
- Volunteers
- 174 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine-Related Disorders, HIV
Diversion to Treatment for Injection Drug Users Arrested for Possession of Heroin
More Americans are arrested for drug offenses than for any other crime. In 2009, over 294,000 arrests were made for possession of cocaine or heroin.
- Conditions
- Cocaine-Related Disorders, HIV, Heroin Dependence
- Trial name
- NCT01723527
- Testing
- Methadone, Buprenorphine, Employment-based drug abstinence reinforcement
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Johns Hopkins University
Heroin Dependence, Opioid-Related Disorders
Effects of Post-Session Supplemental Hydromorphone on Drug Seeking Behavior in Opioid Dependent Individuals
The purpose of this study is to determine whether knowledge of post-session hydromorphone (HYD) availability reduces drug seeking behavior in heroin dependent individuals.
- Trial name
- NCT00218361
- Testing
- Hydromorphone
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Wayne State University
Heroin Dependence
Reinforcing Effects of Intranasal (IN) Buprenorphine Versus Buprenorphine/Naloxone
The study is designed to compare the abuse liabilities of intranasal buprenorphine and buprenorphine/naloxone in individuals who are physically dependent on sublingual buprenorphine.
- Trial name
- NCT01760473
- Testing
- Intranasal challenge drug
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute