Clinical trials: High Altitude, open to volunteers
Hypoxia, Mental Disorder
Going to Altitude With Anxious-depressive Symptoms
Introduction: Currently, there is a lack of international guidelines or clinical recommendations for individuals with mental illnesses (i.e., bipolar disorder, posttraumatic stress disorder) going on high altitude sojourns.
- Trial name
- Psychoxie (NCT05323864)
- Testing
- Hypoxia
- Where
- Austria
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Universitaet Innsbruck
Healthy, Healthy Adult
Sleep-Assessment in Patients Between High Altitude HA vs. Sea Level LA in Healthy Individuals H
To study the effect of relocation from high altitude (Quito Ecuador: 2850m) to sea level on sleeping parameters by polygraphy in healthy individuals, who live permanently >2600m.
- Conditions
- Healthy, Healthy Adult, High Altitude Effects, High Altitude
- Trial name
- NCT07801950
- Testing
- Descent from 2850m to sea level and re-ascent back to 2850m
- Where
- Switzerland
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Silvia Ulrich Somaini
High Altitude, Six-minute Walk Test
Assessment of Six-minute Walking Distance 6MWD Between High Altitude HA vs. Sea Level LA in Healthy Individuals H
To study the effect of descent from high altitude (Quito Ecuador: 2850m) to sea level on six-minute walking distance and scores in healthy individuals, who live permanently >2600m.
- Conditions
- High Altitude, Six-minute Walk Test, High Altitude Effects, Healthy
- Trial name
- NCT07801872
- Testing
- Descent from 2850m to sea level
- Where
- Switzerland
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Silvia Ulrich Somaini
Gastrointestinal Endoscopy
Etomidate Combined With Propofol Versus Propofol for Sedation in High-Altitude Patients During Gastroscopy: a Randomized Multicenter Clinical Trial
One of the most common adverse events during sedated gastrointestinal endoscopy is hypoxemia, which can lead to serious consequences.
- Trial name
- NCT07079176
- Testing
- etomidate combined with propofol, propofol
- Volunteers
- 732 people
- Sponsor
- RenJi Hospital
Respiratory Distress Syndrome, Pediatric, Altitude Hypoxia
Altitude and Outcomes in Pediatric ARDS: A Multicenter Study
This multicenter observational study will evaluate the association between geographic altitude, availability of critical care resources, and clinical outcomes in children with pediatric acute respiratory distress syndrome…
- Conditions
- Respiratory Distress Syndrome, Pediatric, Altitude Hypoxia, High Altitude Effects
- Trial name
- LARed-ALT (NCT07193771)
- Testing
- Geographic Altitude
- Where
- 20 sites in Bolivia, Chile and 3 more
- Volunteers
- 1,600 people
- Sponsor
- Latin American Pediatric Collaborative Network
Severe High Altitude Pulmonary Edema, Severe High Altitude Cerebral Edema
Key Diagnostic & Therapeutic Technologies for Severe Acute High Altitude Disease (SAHAD): Integration and Application
This study aims to establish a key technical system for the diagnosis and treatment of severe acute mountain sickness based on real-world clinical data in Xizang, develop standardized diagnosis and treatment protocols and an…
- Trial name
- SAHAD (NCT07639931)
- Testing
- Multicenter study of HAPE：CPAP or BiPAP Group, Multicenter study of HAPE group：NO Group, Protocol for Proteomics and Peptidomics Study of HAPE：Case Group
- Where
- China
- Volunteers
- 3,035 people, healthy volunteers welcome
- Sponsor
- Tibet Autonomous Region People's Hospital
Orthopedic Surgery, Postoperative Complications
Postoperative Complications of Orthopedic Surgery in Patients From High-altitude Regions
This study will focus on orthopedic surgery patients from high-altitude regions, utilizing smart wearables and monitoring tools to gather perioperative data, including heart rate, oxygen saturation, sleep quality, stress levels…
- Conditions
- Orthopedic Surgery, Postoperative Complications, High Altitude
- Trial name
- NCT06638658
- Volunteers
- 400 people
- Sponsor
- West China Hospital
Hematopoietic Stem Cell Transplantation (HSCT), Acute Myeloid Leukemia (AML)
High-Altitude Hematology Observation-Stem Cell Transplantation (HALO-SCT)
The High-Altitude Hematology Observation-Stem Cell Transplantation (HALO-SCT) study is the first prospective real-world cohort of hematologic diseases and transplantation in the Qinghai-Tibet Plateau.
- Conditions
- Hematopoietic Stem Cell Transplantation (HSCT), Acute Myeloid Leukemia (AML), Leukemias, Acute Myeloid, Myeloid Leukemias, Acute
- Trial name
- HALO-SCT (NCT07205523)
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Yigeng Cao,MD,PhD
High Altitude Hypoxia, Exercise
Ketone Monoester Supplements, High Altitude, and Brain Blood Flow During Exercise
The purpose of this trial is to investigate the effect of acute ketone monoester ingestion (0.6 g KME/kg body weight) on the occurrence of the ventilatory threshold and the subsequent response of blood velocity in cerebral…
- Trial name
- NCT07063732
- Testing
- Ketone Monoester (KME)
- Where
- 2 sites in United States, Canada
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- McMaster University
High Altitude Polycythemia
Remote Ischemic Conditioning for High Altitude Polycythemia in High-Altitude Immigrant Populations
This study is a multicenter, prospective, randomized, open-label, parallel-controlled clinical trial. The participants are adult patients with high-altitude polycythemia who have been long-term residents (for >6 months) in…
- Trial name
- NCT07562464
- Testing
- RIC
- Volunteers
- 222 people
- Sponsor
- Capital Medical University
Limb Dysfunction in Ischemic Stroke Patients at High-Altitude Regions
Clinical Efficacy of Electroacupuncture Therapy on Limb Dysfunction in Ischemic Stroke Patients at High-Altitude Regions: A Multi-center Randomized Double-blind Controlled Trial
The purpose of this clinical trial is to investigate the efficacy of electroacupuncture therapy for limb dysfunction in ischemic stroke patients residing at high-altitude regions.
- Trial name
- NCT07074600
- Testing
- Electroacupuncture Therapy
- Volunteers
- 60 people
- Sponsor
- Kaiyang Zheng
Pulmonary Arterial Hypertension (PAH), Pulmonary Vascular Disease
Assessment of Six-minute Walking Distance Between Sea Level LA vs. High Altitude HA After Re-ascent in Patients With Pulmonary Arterial Hypertension PAH
To study the effect of a re-ascent after a one-week stay at sea level (after prior descent from 2850m) to high altitude (Quito Ecuador: 2850m) on six-minute walking distance and other scores in patients with pulmonary arterial…
- Conditions
- Pulmonary Arterial Hypertension (PAH), Pulmonary Vascular Disease, Six-minute Walk Test, NYHA
- Trial name
- NCT07797166
- Testing
- Re-Ascent sea level to 2850m
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Silvia Ulrich Somaini
Pulmonary Arterial Hypertension (PAH), Pulmonary Vascular Disease
Assessment of Total Pulmonary Resistance sPAP/CO Between High Altitude HA vs. Sea Level LA in Patients With Pulmonary Arterial Hypertension PAH
To study the effect of relocation from high altitude (Quito Ecuador: 2850m) to sea level on pulmonary resistance (sPAP/CO) and other hemodynamic outcomes in patients with pulmonary arterial hypertension PAH, who live permanently…
- Conditions
- Pulmonary Arterial Hypertension (PAH), Pulmonary Vascular Disease, High Altitude, Echocardiography
- Trial name
- NCT07804524
- Testing
- Descent from 2850m to sea level
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Silvia Ulrich Somaini
High Altitude
The Study of Personalized Health Check-up Programs and Standards for High-altitude Migrant Populations
By using wearable devices to monitor and record the physiological data changes and health outcomes (incidence and severity of high-altitude illnesses) of high-altitude migrants at different stages (pre-entry, acute/chronic…
- Trial name
- NCT07018193
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Capital Medical University
Hypertensive Disorder of Pregnancy, Pulmonary Arterial Hypertension
A Prospective Longitudinal Observational Cohort Study of Pregnant Women Residing at High Altitude in Bolivia
In this study, the investigators will follow two small cohorts of pregnant women: a cohort of healthy women with uncomplicated pregnancies residing at high altitude, a control group of healthy women with uncomplicated pregnancies…
- Conditions
- Hypertensive Disorder of Pregnancy, Pulmonary Arterial Hypertension, Intrauterine Growth Restriction
- Trial name
- NCT07312227
- Where
- 2 sites in United States, Bolivia
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Reflux Esophagitis
A Prospective Cohort Study on Endoscopic Features of Upper Gastrointestinal Tract at High Altitude (Zaduo County)
To prospectively enroll participants undergoing gastroscopy at Zaduo County People's Hospital and perform paired analyses with matched cases from Jilin Province.
- Trial name
- NCT07755384
- Testing
- Sedated gastroscopy
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Jilin University
High Altitude Pulmonary Hypertension
Inhaled Nitric Oxide for High Amplitude Pulmonary Edema (HAPE)
High Altitude Pulmonary Edema (HAPE) is a critical, non-cardiogenic pulmonary edema that manifests in high-altitude conditions, marked by the rapid onset of symptoms such as dyspnea, cough, frothy sputum, and cyanosis.
- Trial name
- HAPE (NCT06852924)
- Testing
- Nitric Oxide Generation and Delivery System
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Novlead Inc.
Pulmonary Arterial Hypertension (PAH), Pulmonary Vascular Disease
Assessment of Lung Function (Lufu) at Sea Level LA vs. High Altitude HA in Patients With Pulmonary Arterial Hypertension PAH
To study the effect of a re-ascent to high altitude (Quito Ecuador: 2850m) after a one-week stay at sea level (after prior descent from 2850m) on lung function and pulmonary resistance/reactance in patients with pulmonary…
- Conditions
- Pulmonary Arterial Hypertension (PAH), Pulmonary Vascular Disease, High Altitude Effects, High Altitude
- Trial name
- NCT07804576
- Testing
- Re-ascent from sea level to 2850m
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Silvia Ulrich Somaini
Healthy, Healthy Adult
Assessment of Heart Rate Variability HRV During Descent DE From 2850m to Sea Level and During Re-ascent A From Sea Level to 2850m in Healthy Individuals H
To study the effect of relocation from high altitude (Quito Ecuador: 2850m) to sea level and re-ascent from sea level to 2850m on heart rate variability and other hemodynamic parameters in healthy individuals, who live…
- Conditions
- Healthy, Healthy Adult, High Altitude Effects, High Altitude
- Trial name
- NCT07801846
- Testing
- Descent and re-ascent (2850m, sea level)
- Where
- Switzerland
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Silvia Ulrich Somaini
Hypoxia
Intravenous Iron Effects on Performance at High Altitude
To compare the effects of IV iron versus placebo (saline) injection on arterial oxygen saturation, submaximal exercise responses, and 2-mile treadmill time-trial performance during acute exposure to hypobaric hypoxia (430 mmHg…
- Trial name
- NCT06686693
- Testing
- Injectafer
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine