Clinical trials: High Blood Pressure in Pregnancy
Renovascular Hypertension, Renovascular Hypertension With Renal Failure
Effects of Percutaneous Transluminal Renal Angioplasty of Atherosclerotic Renal Artery Stenosis in High-Risk Patients.
The goal of this clinical trial is to investigate whether percutaneous transluminal renal angioplasty (PTRA) with stent placement of atherosclerotic renal artery stenosis is beneficial in high-risk patients selected according to…
- Conditions
- Renovascular Hypertension, Renovascular Hypertension With Renal Failure, Heart Failure, Renal Artery Stenosis Atherosclerotic
- Trial name
- DAN-PTRAII (NCT05834803)
- Testing
- Optimal medical therapy (OMT), Catheter-based angiography, Measurement of translesional pressure gradients
- Where
- 3 sites in Denmark
- Volunteers
- 80 people
- Sponsor
- University of Aarhus
Preeclampsia
Cardiovascular and Autonomic Reactivity in Women With a History of Pre-eclampsia
A history of preeclampsia is associated with a low plasma volume and higher sympathetic activity. Methyldopa will suppress sympathetic activity to normal values.
- Trial name
- NCT00117546
- Testing
- alpha methyldopa
- Where
- Netherlands
- Volunteers
- 35 people
- Sponsor
- Radboud University Medical Center
Hypertensive Disorder of Pregnancy, Pregnancy Complications
The Investigation of the Prediction Model and Prevention Strategy of Serious Pregnancy Complications in Hypertensive Disorders of Pregnancy Based on the Chinese Population
1. Evaluation of the efficacy of aspirin in preventing preeclampsia and its serious complications during pregnancy and postpartum. 2.
- Trial name
- HDP-RPP (NCT05089175)
- Testing
- Low-dose aspirin
- Where
- China
- Volunteers
- 4,500 people, healthy volunteers welcome
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Pre-eclampsia
Efficacy Of Supplemental L-Arginine in Preventing Preeclampsia in Pregnant Women
This study was designed to assess whether daily L-arginine supplementation could prevent preeclampsia in pregnant women at increased risk.
- Trial name
- NCT07912866
- Testing
- L-Arginine
- Where
- Pakistan
- Volunteers
- 108 people
- Sponsor
- Quaid-e-Azam Medical College
Kidney Failure, Chronic, Diabetic Nephropathies
Effects of Rituximab and Mycophenolate Mofetil (MMF) on Highly Sensitized Patients Awaiting Renal Transplant
This is a 12-month phase 2, prospective, open label study to evaluate the effect of rituximab with mycophenolate mofetil (MMF)on the PRA of 14 highly sensitized patients who just completed an 8 month trial of MMF treatment alone.
- Conditions
- Kidney Failure, Chronic, Diabetic Nephropathies, Glomerulonephritis, IGA, Hypertension, Renal
- Trial name
- NCT00446251
- Testing
- Rituximab, Mycophenolate mofetil (MMF)
- Volunteers
- 14 people
- Sponsor
- University of Washington
Hypertension, Chronic Kidney Disease
RAS Quantification in Patients With Aliskiren or Candesartan
Forced blockade of the renin-angiotensin-system (RAS) by using direct renin inhibition (DRI) has long been propagated to effectuate beneficial outcomes.
- Conditions
- Hypertension, Chronic Kidney Disease, Proteinuria
- Trial name
- RASQAL (NCT01827202)
- Testing
- RAS blockade discontinuation, Aliskiren, Candesartan
- Where
- Austria
- Volunteers
- 24 people
- Sponsor
- Medical University of Vienna
Renal Insufficiency, Chronic, Hypertension
Supporting Self-Management of Healthy Behaviors in Chronic Kidney Disease
The pilot cross-over study aims to examine the feasibility of a smartphone-based self-management supportive intervention, Supporting Self-Management of Healthy Behaviors (SMART-HABITS) in patients with chronic kidney disease…
- Trial name
- SMART-HABITS (NCT04858295)
- Testing
- Texting, mHealth app
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- University of Pennsylvania
Preeclampsia
Magnesium Sulfate in Obese Preeclamptics
The purpose of this study is to learn how medications participant will receive in the course of their delivery are metabolized (broken down by the body).
- Trial name
- NCT02835339
- Testing
- Magnesium sulfate 4g loading dose, 1g/hr infusion, Magnesium sulfate 6g loading dose, 2g/hr infusion
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Chronic Kidney Disease(CKD), Uncontrolled Hypertension
Intensification of Blood Pressure Lowering Therapeutics Based on Diuretics Versus Usual Management for Uncontrolled Hypertension IN Patients With Moderate to Severe Chronic Kidney Disease
Chronic kidney disease (CKD) is a major public health issue worldwide. Hypertension is the first risk factor in patients with CKD for mortality, cardiovascular disease and end-stage renal disease.
- Trial name
- THINK (NCT05732727)
- Testing
- Antihypertensive algorithm, Standard of care
- Where
- 40 sites in France
- Volunteers
- 720 people
- Sponsor
- University Hospital, Tours
Chronic Kidney Disease and Hypertension
A Phase III Study to Investigate the Efficacy and Safety of Baxdrostat in Combination With Dapagliflozin on CKD Progression in Participants With CKD and High Blood Pressure.
The purpose of this study is to measure the efficacy and safety of baxdrostat/dapagliflozin in participants ≥ 18 years of age with CKD and HTN.
- Trial name
- NCT06268873
- Testing
- Baxdrostat/dapagliflozin
- Where
- 565 sites in United States, Argentina and 36 more
- Volunteers
- 2,554 people
- Sponsor
- AstraZeneca
Preeclampsia
Analysis of the Levels of HLADR+ Extracellular Vesicles in Women With Preeclampsia as a Early Potential Biomarker
Analysis of the circulating levels of placenta-derived HLA-DR+ extracellular vesicles in the first, second and third trimester of pregnancy of women with high and low risk to develop preeclampsia.
- Trial name
- NCT06873737
- Testing
- Blood samples for inflammatory markers
- Where
- Italy
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Infant, Newborn, Respiratory Insufficiency
Inhaled PGE1 in Neonatal Hypoxemic Respiratory Failure
This pilot study was a randomized, placebo-controlled, clinical trial to test the safety of using the intravenous form of Prostaglandin E1 (PGE1) in an inhaled form for treatment of hypoxemic respiratory failure in term newborns.
- Conditions
- Infant, Newborn, Respiratory Insufficiency, Pulmonary Hypertension, Respiratory Distress Syndrome, Newborn
- Trial name
- IPGE1 (NCT00598429)
- Testing
- Inhaled Prostaglandin E1
- Where
- 11 sites in United States
- Sponsor
- NICHD Neonatal Research Network
Metabolic Syndrome, Diabetes
Cardiovascular-Kidney-Metabolic Syndrome in Shanghai Zicitizens
The main purpose of this study is to conduct follow-up assessments and update the cardiorenal outcomes among the STONE cohort that was established during 2016-2017.
- Conditions
- Metabolic Syndrome, Diabetes, Obesity and Overweight, Hypertension
- Trial name
- NCT07043166
- Where
- China
- Volunteers
- 4,094 people, healthy volunteers welcome
- Sponsor
- Shanghai Changzheng Hospital
High Risk Pregnant Women, Placental Insufficiency
Low Weight Heparin prOphylaxis for Placental-Mediated Complications of PrEgnancy
This is a Multicenter, randomized, open-label, parallel groups study to test the hypothesis that prophylactic low molecular weight heparin (LMWH) (enoxaparin) initiated before 14 weeks of gestation could improve maternal and…
- Conditions
- High Risk Pregnant Women, Placental Insufficiency, Preeclampsia
- Trial name
- HOPPE (NCT01388322)
- Testing
- Enoxaparin
- Where
- 4 sites in Spain
- Volunteers
- 361 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Hypertension in Pregnancy
Mindfulness & Mechanisms Study
Hypertensive disorders of pregnancy (HDP) are the most common medical condition affecting pregnancy and a leading cause of maternal morbidity and mortality in the Unites States.
- Trial name
- NCT04626245
- Testing
- Mindfulness training
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Lifespan
Cardiovascular Diseases, Heart Diseases
Oral Calcium in Pregnant Women With Hypertension
To determine of providing calcium supplementation to women with pre-existing hypertension reduces the level of blood pressure, requirement for antihypertensive drugs, and incidence of pre-eclampsia.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hypertension, Pre-Eclampsia
- Trial name
- NCT00000543
- Testing
- dietary supplements, calcium
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Head Trauma, Polytrauma
Comparative Study for the Validity of Various Severity Scoring System
Scoring systems for use in intensive care unit (ICU) patients have been introduced and developed over the last 30 years. They allow an assessment of the severity of disease and provide an estimate of in-hospital mortality
- Conditions
- Head Trauma, Polytrauma, Pre-Eclampsia, Sepsis
- Trial name
- NCT04683094
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Aswan University Hospital
Pre-Eclampsia
Diagnostic Value of MicroRNA 210 In Preeclampsia
Pre-eclampsia is a disorder of pregnancy characterized by hypertension (defined as systolic blood pressure 140mmHg or diastolic blood pressure ⩾90 mmHg) and proteinuria (300 mg or greater in a 24 h urine specimen and/or protein…
- Trial name
- NCT03193554
- Where
- 2 sites in Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assiut University
Pregnancy-Associated Hypertension, Gestational Hypertension
Community Health Worker Support to Lower Blood Pressure After a Pregnancy With High Blood Pressure
High blood pressure during or after pregnancy (such as preeclampsia, gestational hypertension, eclampsia, or Hemolysis, Elevated Liver enzymes, and Low Platelet (HELLP) syndrome) raises a mother's risk of heart disease later in…
- Conditions
- Pregnancy-Associated Hypertension, Gestational Hypertension, Preeclampsia, Eclampsia
- Trial name
- AW2H (NCT07778966)
- Testing
- Alabama Womb to Heart Solution (AW2H) Community Health Worker (CHW) Program, Usual postpartum care with self-measured blood pressure education and home blood pressure monitor
- Where
- United States
- Volunteers
- 174 people
- Sponsor
- University of Alabama at Birmingham
Hypertension, Pregnancy-Induced, HELLP Syndrome
PROTECT-Africa: Biomarker Validation for Preeclampsia Triage
Preeclampsia is a serious high blood pressure condition that can develop during pregnancy. It is one of the leading causes of death and illness for mothers and babies in Africa.
- Conditions
- Hypertension, Pregnancy-Induced, HELLP Syndrome, Eclampsia, Fetal Growth Retardation
- Trial name
- PROTECT-Africa (NCT07810439)
- Where
- Zimbabwe
- Volunteers
- 1,106 people
- Sponsor
- Africa Clinical Research Network (ACRN)
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