Clinical trials: High Cardiovascular Risk Patients
Kidney Failure, Chronic
Lung Water by Ultrasound Guided Treatment in Hemodialysis Patients (The Lust Study).
Volume overload is a leading risk factor for death and cardiovascular events in end stage renal disease patients maintained on chronic dialysis, particularly in those with myocardial ischemia and heart failure which represent a…
- Trial name
- LUST (NCT02310061)
- Testing
- Extra-vascular lung water measurements by ultrasound (LW-US), Standard protocol of fluid management in hemodialysis
- Where
- 19 sites in France, Germany and 7 more
- Volunteers
- 383 people
- Sponsor
- Fondazione C.N.R./Regione Toscana "G. Monasterio", Pisa, Italy
Venous Thromboembolism (VTE), Exercise Therapy
Early Exercise-Based Rehabilitation in Patients Hospitalized for Acute Pulmonary Embolism
Up to half of patients with pulmonary embolism (PE) suffer from impaired quality of life, reduced physical capacity, and symptoms like shortness of breath even three months after diagnosis, despite standard treatment with…
- Conditions
- Venous Thromboembolism (VTE), Exercise Therapy, Quality of Life (QOL), Anxiety Depression
- Trial name
- RehabPE (NCT07143539)
- Testing
- Exercise-based rehabilitation program
- Where
- 6 sites in Switzerland
- Volunteers
- 160 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Renovascular Hypertension, Renovascular Hypertension With Renal Failure
Effects of Percutaneous Transluminal Renal Angioplasty of Atherosclerotic Renal Artery Stenosis in High-Risk Patients.
The goal of this clinical trial is to document a beneficial effect of percutaneous transluminal renal angioplasty (PTRA) of atherosclerotic renal artery stenosis in high-risk patients selected according to the criteria used in…
- Conditions
- Renovascular Hypertension, Renovascular Hypertension With Renal Failure, Heart Failure, Renal Artery Stenosis Atherosclerotic
- Trial name
- DAN-PTRAII (NCT05834803)
- Testing
- Optimal medical therapy (OMT), Catheter-based angiography, Measurement of translesional pressure gradients
- Where
- 3 sites in Denmark
- Volunteers
- 80 people
- Sponsor
- University of Aarhus
Deep Vein Thrombosis
Single Comprehensive Ultrasound to Rule Out DVT in High-risk Patients
To determine the rate of thromboembolic complications (including death attributed to thromboembolic disease) in patients with a score rated as "DVT likely" on a formalized scoring system, when anticoagulation therapy is withheld…
- Trial name
- NCT00333697
- Testing
- Comprehensive Duplex Ultrasound (diagnostic study)
- Where
- 2 sites in United States
- Volunteers
- 199 people
- Sponsor
- Intermountain Health Care, Inc.
Perioperative Myocardial Infarction, Perioperative Myocardial Injury
Monitoring of Vital Signs for Phenotyping of Perioperative Myocardial Infarction/Injury After Noncardiac Surgery
The goal of this observational prospective cohort study is to learn about the pathophysiology of perioperative myocardial infarction/injury in high-risk patients undergoing major non-cardiac surgery.
- Trial name
- PMI-VITAL (NCT05866874)
- Where
- Switzerland
- Volunteers
- 875 people
- Sponsor
- University Hospital, Basel, Switzerland
Leukemia, Lymphoma
Combination Chemotherapy With or Without Idarubicin and Peripheral Stem Cell Transplantation in Treating Patients With Leukemia or Myelodysplastic Syndrome
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining chemotherapy with peripheral stem cell transplantation may allow the doctor to give higher doses…
- Conditions
- Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm, Myelodysplastic Syndromes
- Trial name
- NCT00002989
- Testing
- busulfan, cyclophosphamide, idarubicin
- Where
- 9 sites in Belgium, France and 3 more
- Volunteers
- 207 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Carotid Artery Disease
CHOICE: Carotid Stenting For High Surgical-Risk Patients
The purposes of this study is to 1) Provide additional information that the commercially available Abbott Vascular Carotid Stent Systems and Embolic Protection Systems can be used successfully by a wide range of physicians under…
- Trial name
- NCT00406055
- Testing
- RX ACCULINK , RX ACCUNET , XACT , EMBOSHIELD and EMBOSHIELD Nav6
- Where
- United States
- Volunteers
- 18,855 people
- Sponsor
- Abbott Medical Devices
22q11 Deletion Syndrome
Indicated Prevention With Long-chain Polyunsaturated Omega-3 Fatty Acids in Patients With 22q11 Microdeletion Syndrome.
The purpose of the present trial is to investigate the effects of omega-3 PUFAs in individuals aged 12-26 years with 22q11DS at ultra-high risk for developing a first episode of psychosis.
- Trial name
- NCT02070211
- Testing
- omega-3 PUFAs, Standard care
- Where
- Holy See
- Volunteers
- 80 people
- Sponsor
- Bambino Gesù Hospital and Research Institute
Cardiovascular Risk Factors
Clinical Intervention Study in the Primary Care Setting of Patients With High Plasma Fibrinogen (EFAP)
Objectives: To study the possible effects of an intensive lifestyle change program on, the plasma fibrinogen levels in patients with no cardiovascular disease, with a high fibrinogen and normal cholesterol levels, and moderate…
- Trial name
- EFAP (NCT01089530)
- Testing
- Lifestyle intensive group
- Where
- Spain
- Volunteers
- 436 people
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Coronary Stenoses
TAILored Versus COnventional AntithRombotic StratEgy IntenDed for Complex HIgh-Risk PCI
This study evaluates the efficacy and safety of tailored antithrombotic therapy with early (<6-month post-PCI) intensified (low-dose ticagrelor [120 mg loading, then 60 mg bid maintenance] and aspirin) and late (>6-month…
- Trial name
- TAILORED-CHIP (NCT03465644)
- Testing
- Tailored antithrombotic strategy, Conventional antithrombotic strategy
- Where
- 22 sites in South Korea
- Volunteers
- 2,018 people
- Sponsor
- Duk-Woo Park, MD
Tumor, Stroke
Different Intraoperative Blood Pressure Management on Postoperative Cognitive Function in Tumor Patients（PRECISION）
This is a randomized controlled study to explore whether perioperative blood pressure management with different strategies can reduce the incidence of delirium and postoperative cognitive impairment and serious perfusion related…
- Trial name
- PRECISION (NCT06711432)
- Testing
- Norepinephrine or phenylephrine
- Where
- China
- Volunteers
- 214 people
- Sponsor
- Zhejiang Cancer Hospital
Congestive Heart Failure, Heart Failure
Heart Failure Event Advance Detection Trial
Patients who are admitted with acutely decompensated heart failure and are receiving intravenous diuretics will be recruited to undergo testing using the Indicor Device.
- Conditions
- Congestive Heart Failure, Heart Failure, Decompensated Heart Failure
- Trial name
- HEADstart (NCT04223271)
- Testing
- Indicor
- Where
- United States
- Volunteers
- 165 people
- Sponsor
- Vixiar Medical, Inc.
Arrhythmogenic Cardiomyopathy (AC, ARVD/C)
Cardiac Rehabilitation in Patients With High-Genetic-Risk Arrhythmogenic Cardiomyopathy: The HGEN-CARE-AC Trial
The goal of this clinical trial is to evaluate a structured and personalized cardiac rehabilitation program for patients diagnosed with arrhythmogenic cardiomyopathy (ACM) who carry high-risk genetic mutations.
- Trial name
- HGEN-CARE-AC (NCT07708311)
- Testing
- Cardiac Rehabilitation Programme
- Volunteers
- 70 people
- Sponsor
- Juan Jiménez Jáimez
Heart Attack, Enlarged Heart
Sodium Glucose Co-Transporter 2 (SGLT2) and STEMI
The purpose of the research is to determine whether a class of medication called SGLT2 inhibitor will improve the heart's function and reduce its enlargement after a heart attack.
- Trial name
- NCT05305911
- Testing
- SGLT-2 inhibitors
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- Minneapolis Heart Institute Foundation
Cardiovascular Diseases
A Study of AMR101 to Evaluate Its Ability to Reduce Cardiovascular Events in High-Risk Patients With Hypertriglyceridemia and on Statin
AMR101 (icosapent ethyl [ethyl-EPA]) is a highly purified ethyl ester of eicosapentaenoic acid (EPA) developed by Amarin Pharma Inc.
- Trial name
- REDUCE-IT (NCT01492361)
- Testing
- AMR101, Statin therapy
- Where
- 410 sites in United States, Australia and 9 more
- Volunteers
- 8,179 people
- Sponsor
- Amarin Pharma Inc.
High Risk PCI, Coronary Arterial Disease (CAD)
Prospective Evaluation for Receiving SynFlow 3.0 Interventional Circulatory Support in High-risk PCI: A Randomized Controlled Trial
This study is conducted to compare the effectiveness of a new percutaneous mechanical circulatory support device called SynFlow 3.0 with VA-ECMO in high-risk percutaneous coronary intervetnion(PCI) patients.
- Trial name
- PERSIST Ⅲ (NCT06853470)
- Testing
- VA-ECMO circulatory support, SynFlow 3.0 circulatory support, percutaneous coronary intervention
- Where
- China
- Volunteers
- 222 people
- Sponsor
- ForQaly Medical (Shanghai) Co., Ltd
Plasma Cell Myeloma
Carfilzomib, Pomalidomide, and Dexamethasone in Treating Patients With High-Risk Multiple Myeloma
This phase II trial studies how well carfilzomib, pomalidomide, and dexamethasone work in treating patients with high-risk multiple myeloma.
- Trial name
- NCT03756896
- Testing
- Carfilzomib, Dexamethasone, Pomalidomide
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Emory University
Reducing the Elevated Blood Pressure for Diabetic Hypertensive Patients
Metformin Versus Vildagliptin for Diabetic Hypertensive Patients
This is a controlled study to measure the efficacy of using metformin or vildagliptin for type 2 diabetic patients who suffers from hypertension to reduce cardiovascular risk resulting from both diabetes and hypertension using…
- Trial name
- NCT03253562
- Testing
- Metformin Pill, Vildagliptin 50 mg
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- MTI University
Multiple Myeloma
Evaluation iNduction, Consolidation and Maintenance Treatment With Isatuximab , Carfilzomib, LEnalidomide and Dexamethasone
A Clinical Phase II, multicenter, Open-label study evaluating iNduction, consolidation and maintenance treatment with Isatuximab (SAR650984), Carfilzomib, LEnalidomide and Dexamethasone (I-KRd) in Primary diagnosed high-risk…
- Trial name
- NCT03104842
- Testing
- Isatuximab, Carfilzomib, Lenalidomide
- Where
- 17 sites in Germany
- Volunteers
- 246 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Pulmonary Hypertension
Iloprost in High Risk Cardiac Surgical Patients
In this study effects of the intra operative, prophylactic inhalation of Iloprost (Ventavis) before and during extracorporal circulation on perioperative morbidity and outcome in high risk cardiac surgical patients is…
- Trial name
- Ilocard (NCT00927654)
- Testing
- Iloprost (Ventavis)
- Where
- 6 sites in Germany
- Volunteers
- 253 people
- Sponsor
- Ludwig-Maximilians - University of Munich