Clinical trials: High Grade Squamous Intraepithelial Lesions
Atypical Squamous Cells of Undetermined Significance, Cervical Cancer
SGN-00101 Vaccine in Treating Human Papillomavirus in Patients Who Have Abnormal Cervical Cells
This randomized phase II trial is studying how well SGN-00101 vaccine works compared to a placebo in treating human papillomavirus and preventing cervical cancer in patients with abnormal cervical cells.
- Conditions
- Atypical Squamous Cells of Undetermined Significance, Cervical Cancer, High-grade Squamous Intraepithelial Lesion, Low-grade Squamous Intraepithelial Lesion
- Trial name
- NCT00091130
- Testing
- HspE7, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 139 people
- Sponsor
- National Cancer Institute (NCI)
Cervical Intraepithelial Neoplasia Grade 2/3
Efficacy and Safety of Cevira® in Patients With Cervical Histologic High-grade Squamous Intraepithelial Lesions (HSIL)
A double blind, prospective, randomized, placebo controlled, multi-center phase 3 study to evaluate efficacy and safety of Cevira® in patients with cervical histologic high-grade squamous intraepithelial lesions (HSIL).
- Trial name
- APRICITY (NCT04484415)
- Testing
- Cevira®
- Where
- China
- Volunteers
- 402 people
- Sponsor
- Asieris MediTech (Hong Kong) Co., Ltd.
Uterine Cervical Cancer, High Grade Squamous Intraepithelial Lesions
A Multicenter Real-world Study of Screening of Cervical Cancer Based on Photoelectric Detection
The main purpose of this study is to explore the accuracy and clinical value of fluorescent photoelectric cervical lesion image detector as a screening and shunt tool for cervical lesions through a multi-center, large-sample…
- Conditions
- Uterine Cervical Cancer, High Grade Squamous Intraepithelial Lesions, Low Grade Squamous Intraepithelial Lesions
- Trial name
- NCT06481930
- Testing
- Detection of Cervical Lesions by Fluorescence Photoelectric Image
- Where
- China
- Volunteers
- 20,000 people
- Sponsor
- Lei Li
Anal Intraepithelial Neoplasia, Anal High-grade Squamous Intraepithelial Lesion
COrSIcA: Disease Measurement
Anal cancer can be prevented through detection and treatment of a recognised precancerous lesion, known as anal intra-epithelial neoplasia (AIN), specifically the anal high-grade squamous intra-epithelial lesion (aHSIL) subtype.
- Conditions
- Anal Intraepithelial Neoplasia, Anal High-grade Squamous Intraepithelial Lesion, Anal HSIL
- Trial name
- NCT05858021
- Testing
- Physical examination
- Volunteers
- 30 people
- Sponsor
- David Finch
HPV Infection, LSIL, Low-Grade Squamous Intraepithelial Lesions
Research About Impact of HPV Integration on the Prognosis of Women With Persistent HR-HPV Infection
Clinically, patients with persistent HR-HPV infection for more than 18 months or HR-HPV infection with CIN2 + need regular colposcopic biopsy to assess the outcome and progression of the disease.
- Conditions
- HPV Infection, LSIL, Low-Grade Squamous Intraepithelial Lesions, HSIL, High-Grade Squamous Intraepithelial Lesions, Virus Integration
- Trial name
- NCT05283239
- Testing
- Follow up
- Where
- 11 sites in China
- Volunteers
- 1,000 people
- Sponsor
- Fujian Maternity and Child Health Hospital
High-grade Cervical Intraepithelial Lesions
A Phase II Clinical Trial Evaluating the Efficacy and Safety of SYS6026 Injection in Participants With HPV16 or 18-related High-grade Cervical Squamous Intraepithelial Lesions
This trial is a multicenter, randomized, double-blind, placebo-controlled Phase II clinical study designed to evaluate the efficacy and safety of SYS6026 at different doses compared to placebo in treating patients with HPV16 or…
- Trial name
- NCT07702656
- Testing
- SYS6026
- Where
- China
- Volunteers
- 175 people
- Sponsor
- CSPC Megalith Biopharmaceutical Co.,Ltd.
HSIL, High Grade Squamous Intraepithelial Lesions, Recurrence
Intraoperative HPV Testing Evaluation
High-grade intraepithelial lesion/cervical intraepithelial neoplasia grade 2-3 is a premalignant cervical lesion caused by persistent high-risk human papillomavirus infection.
- Trial name
- NCT04190472
- Testing
- IOP HPV test
- Volunteers
- 1,553 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Oxidative Stress, Low Grade Squamous Intraepithelial Lesion
Evaluation of Thioldisulfide Balance in Cervical Preinvasive Lesions
The purpose of this study is to investigate Thiol-disulfide balance in patients with cervical preinvasive lesions
- Conditions
- Oxidative Stress, Low Grade Squamous Intraepithelial Lesion, High-Grade Squamous Intraepithelial Lesions
- Trial name
- NCT04177641
- Testing
- Disulphide(μmol/L), Total Oxidant Capacity(μmolH2O2Equiv/L)
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Muğla Sıtkı Koçman University
High-grade Squamous Intraepithelial Lesions of the Cervix Associated With Human Papillomavirus (HPV) Type 16 and/or HPV Type 18 Infection
Evaluation of the Safety, Tolerability, Immunogenicity and Preliminary Efficacy of BBM-C101 Injection in Patients With Cervical High-Grade Squamous Intraepithelial Lesion(HSIL)
The goal of this study is to learn about the safety, tolerability, immunogenicity and preliminary efficacy of BBM-C101 injection in patients with High-Grade Squamous Intraepithelial Lesion of the cervix.
- Trial name
- NCT07668960
- Testing
- BBM-C101
- Where
- 4 sites in China
- Volunteers
- 60 people
- Sponsor
- Shanghai Mianyi Biopharmaceutical Co., Ltd.
High Grade Anal Canal Squamous Intraepithelial Neoplasia, HIV Infection
Health-Related Symptom Questionnaires in Measuring Quality of Life in HIV-Infected Participants Treated or Monitored for Anal Lesions
This research trial studies health-related symptom questionnaires in measuring quality of life in human immunodeficiency virus (HIV)-infected participants treated with or monitored for anal lesions.
- Trial name
- NCT02418494
- Testing
- Concept Elicitation, Comprehension Assessment
- Where
- 6 sites in United States
- Volunteers
- 85 people
- Sponsor
- AIDS Malignancy Consortium
Aids-related Malignancies, Lymphoma
Detecting Anal and Genital Human Papillomavirus Infection and Squamous Intraepithelial Lesions in HIV-Positive Patients Enrolled in AIDS Cancer Clinical Trials
RATIONALE: Diagnostic procedures, such as anal swab collection, digital rectal examination, and anal endoscopy and biopsy, may help find and diagnose anal and genital human papillomavirus infection and squamous intraepithelial…
- Conditions
- Aids-related Malignancies, Lymphoma, Precancerous Condition, Sarcoma
- Trial name
- NCT00695422
- Testing
- polymerase chain reaction, cytology specimen collection procedure, histological technique
- Where
- 10 sites in United States
- Volunteers
- 47 people
- Sponsor
- AIDS Malignancy Consortium