Clinical trials: High Myopia, open to volunteers
Cataract
Comparing Monofocal IOLs in Highly Myopic Cataract Patients
Comparison of Postoperative Outcomes in Patients with High Myopia Undergoing Cataract Surgery Implanted with Extended Depth of Focus Intraocular Lens (ICB00) and Monofocal Intraocular Lens (ZCB00)
- Trial name
- NCT06905938
- Testing
- no intervention
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Wenzhou Medical University
Myopia, High Myopia
Efficacy and Safety of Spectacle Lenses With H.A.L.T. MAX Technology on High Myopia Control in Children and Adolescents
Children aged 7-14 years with high myopia were randomly assigned to a control group or an intervention group at a 1:1 ratio. The intervention group wore H.A.L.T.
- Trial name
- NCT07120737
- Testing
- H.A.L.T. MAX spectacles
- Where
- China
- Volunteers
- 224 people
- Sponsor
- Shanghai Eye Disease Prevention and Treatment Center
High Myopia
Risk of Posterior Staphyloma in Highly Myopic Europeans : From Epidemiology to Anatomy.
In this cross-sectionnal study the aim is to increase the understanding of posterior staphyloma through a unique European consortium.
- Trial name
- MYOFORTE (NCT06949579)
- Testing
- blood sampling for DNA
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Myopia, High Myopia
Clinical Results of Small Incision Lenticule Extraction (SMILE) for the Correction of High Myopia
Small Incision Lenticule Extraction (SMILE) was introduced in 2011 using the VISUMAX femtosecond laser (Carl Zeiss Meditec, Jena, Germany). It is designed for correction of myopia and myopic astigmatism.
- Trial name
- NCT04110067
- Testing
- Small Incision Lenticule Extraction (SMILE) with Visumax (Carl Zeiss Meditec, Jena)
- Where
- Germany
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Suphi Taneri
Diabetic Retinopathy (DR), Retinal Vein Occlusion (RVO)
High-throughput Large-model-based AI-assisted Diagnosis Using OCT
This observational study aims to establish key technologies for high-throughput, large-model-based AI-assisted diagnosis using optical coherence tomography (OCT) and OCT angiography (OCTA).
- Conditions
- Diabetic Retinopathy (DR), Retinal Vein Occlusion (RVO), Age-Related Macular Degeneration (AMD), Pathologic Myopia
- Trial name
- NCT07249307
- Testing
- No intervention
- Volunteers
- 2,000 people
- Sponsor
- Peking Union Medical College Hospital
Keratoconus, High Myopia
Anterior Segment and Corneal Parameters in Keratoconus and High Myopic Astigmatism Using Schiempflug Imaging
The purpose of this study was to compare Scheimpflug corneal tomography findings in keratoconus and high myopic astigmatic eyes, as well as to establish the parameters distinguishing keratoconus from high myopic astigmatism.
- Trial name
- NCT06739018
- Testing
- pentacam scheimpflug tomography
- Where
- 2 sites in Egypt
- Volunteers
- 66 people
- Sponsor
- Assiut University
High Myopia, Cataract
The Role of Capsular Tension Rings in Intraocular Lens Stability in High Myopia Cataract Patients: A Prospective Self-Controlled Study
Study Purpose: This prospective, self-controlled clinical study aims to evaluate the impact of capsular tension rings (CTR) on intraocular lens (IOL) stability in high myopia patients undergoing bilateral cataract surgery.
- Trial name
- NCT07052825
- Testing
- CTR implantation
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Jin Yang
Cataract, High Myopia
Artificial Intelligence for Highly Myopic Cataract
This study aims to establish a multi-center artificial intelligence model for the accurate calculation of intraocular lens and its clinical application in highly myopic cataract, so as to improve the accuracy of the prediction of…
- Conditions
- Cataract, High Myopia, Myopia, Automatic Judgement
- Trial name
- AI-HMC (NCT06616506)
- Testing
- newly-invented AI model
- Where
- China
- Volunteers
- 500,000 people
- Sponsor
- Shanghai High Myopia Study Group
Myopia, Refractive Ametropia
Comparison of Low- Versus High-Level Angle Kappa Compensation Strategies in SMILE Using the VisuMax 800: A Randomized Clinical Trial
The goal of this clinical trial is to compare two intraoperative kappa-angle compensation strategies during small incision lenticule extraction (SMILE) using the VisuMax 800 platform in patients with relatively large kappa-angle…
- Trial name
- NCT07512102
- Testing
- Apply high compensation to the Kappa angle., Apply low compensation to the Kappa angle.
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
High Myopia
SmoothCore Orthokeratology Plus M.O.V.E. Lenses vs. M.O.V.E. Lenses Alone for Myopia Control in Children With High Myopia
This clinical trial aims to determine whether a combination of overnight orthokeratology lenses and daytime myopia-control spectacles is more effective than myopia-control spectacles alone in slowing myopia progression and…
- Trial name
- NCT07854366
- Testing
- SmoothCore Technology Orthokeratology Combined with M.O.V.E. Lenses, M.O.V.E. Lenses Alone
- Volunteers
- 100 people
- Sponsor
- Beijing Tongren Hospital
Myopia, High-Grade, Myopia; Refractive Error
AOSLO-Based Precise Measurement of Retinal Hemodynamics: Development and Application Assessment
Changes in retinal hemodynamics play a key role in the development of various eye diseases. Currently, mainstream hemodynamic evaluation techniques have low resolution and poor measurement accuracy, limiting their widespread…
- Trial name
- NCT07051317
- Volunteers
- 120 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Myopia, Progressive, Choroid Disease
Choroidal Change on OCTA in Eyes With High Myopia
Myopia is a global healthy concern, especially the high myopia and pathological myopia among Asian populations. However, its mechanism still remains largely unclear.
- Trial name
- NCT04255524
- Testing
- Optic coherence tomography angiography (OCTA)
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
High Myopia
Wuhan High Myopia Study
The study aims to observe the long-term changes of ocular（especially fundus） structure and visual function in patients with high myopia, so as to provide evidence for the prevention, diagnosis and prognosis of high myopia.
- Trial name
- LOVE-WH (NCT06162234)
- Testing
- observational
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Renmin Hospital of Wuhan University
High Myopia
100 High Myopia Patient-reported Outcomes (PRO) and Performance Outcomes (PERFO)
Prospective, longitudinal, interventional, exploratory, non-randomized, single-center study including patients with pathological myopia .
- Trial name
- PPO100 (NCT07101146)
- Testing
- Quality of life questionnaire, Performance Outcomes (PerfO), Semi-structured interviews
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts
High Myopia, Cataract
Shanghai High Myopia Study
The purpose of this study is to evaluate the long-term visual outcome of the cataract surgery using a large-scale and comprehensive database of high myopic cataract and age-related cataract patients.
- Conditions
- High Myopia, Cataract, Visual Outcome, Genetic Anticipation
- Trial name
- NCT03062085
- Testing
- Cataract
- Where
- China
- Volunteers
- 60,000 people
- Sponsor
- Shanghai High Myopia Study Group
Myopia
Safety and Efficacy Study of A Viscoelastic-free Method for Implantable Collamer Lens (ICL) Implantation
This study evaluates the safety and efficacy of a viscoelastic-free method for Implantable Collamer Lens(ICL) implantation to treat high myopia.
- Trial name
- NCT03059043
- Testing
- viscoelastic-free implantation system, standard viscoelastic-assisted Implantation system
- Where
- 5 sites in China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Wenzhou Medical University
Myopia
A RCT of Spectacles With Aspherical Lenslets or 0.05% Atropine for Myopia Control
To date, randomized trials of low-concentration atropine eyedrops and specially designed spectacle lenses to slow the progression of myopia are limited in number and results are inconsistent in non-Asian children.
- Trial name
- NCT07095894
- Testing
- Atropine, Spectacles with HAL
- Where
- 18 sites in United States
- Volunteers
- 348 people
- Sponsor
- Jaeb Center for Health Research
Myopia
Evaluation of the Efficacy of Red Light in Adult Patients With High and Extreme Myopia
This study, led by Jie ying from the Ophthalmology Department of Beijing Tongren Hospital Affiliated to Capital Medical University, is a researcher-initiated clinical trial (IIT) designed to evaluate the therapeutic efficacy of…
- Trial name
- NCT07412678
- Testing
- Red light, Single vision spectacle lenses
- Where
- China
- Volunteers
- 128 people
- Sponsor
- Beijing Tongren Hospital
High Myopia
Comparison of Retinal Damage in ICL Implantation Using 3D Visualization System vs. Microscope
Implantable collamer lens (ICL) implantation is considered one of the most effective surgical treatments for high myopia. The procedure primarily involves adjusting the position of the ICL within the eye.
- Trial name
- NCT06966622
- Testing
- 3D visualization system with coaxial illumination, microscope with standard illumination
- Volunteers
- 40 people
- Sponsor
- Fuzhou Eye Hospital
Myopia
Control of Myopia in Young Children Using H.O.P.E. Lenses Combined With 0.02% Atropine Eye Drops
A multicenter, prospective, intervention study on the control of myopia in young children using high-order phase element array microstructure lenses (H.O.P.E.) in combination with low-concentration atropine eye drops (0.02%)
- Trial name
- NCT07846787
- Testing
- High-order Phase Element Array Microstructure Design Lens (H.O.P.E.), 0.02% Atropine Sulfate Eye Drops
- Where
- China
- Volunteers
- 264 people
- Sponsor
- Ruihua Wei