Clinical trials: High Risk Cancer
Locally Advanced Clear Cell Renal Cell Carcinoma
Neoadjuvant Belzutifan Plus Pembrolizumab in High-Risk, Locally Advanced Clear Cell Renal Cell Carcinoma
The purpose of this study is to compare the safety and effectiveness of two new treatments: belzutifan alone or belzutifan in combination with pembrolizumab before kidney surgery and followed by a combination of belzutifan and…
- Trial name
- NEBULA (NCT07840001)
- Testing
- Belzutifan, Pembrolizumab
- Where
- Australia
- Volunteers
- 30 people
- Sponsor
- Peter MacCallum Cancer Centre, Australia
Endometrial Cancer, Sentinel Lymph Node
Accuracy of Sentinel Lymph Node Biopsy in Nodal Staging of High Risk Endometrial Cancer
The standard of care for women with high risk endometrial cancer is the removal of all visible lymph nodes in the pelvis and lower abdomen to identify if disease has spread to these areas.
- Conditions
- Endometrial Cancer, Sentinel Lymph Node, Indocyanine Green
- Trial name
- EndoSLN (NCT01886066)
- Testing
- Indocyanine Green (ICG)
- Where
- 2 sites in Canada
- Volunteers
- 156 people
- Sponsor
- University Health Network, Toronto
Breast Cancer
Intensified IAA With PBPC Support in Breast Tumors With Evidence of a HRD
This phase II/III trial will investigate the ability of chemotherapy with 'Intensified Aklylating Agents (IAA) to achieve a high pathological complete response (pCR) rate when employed in the preoperative chemotherapy of breast…
- Trial name
- NCT00448266
- Testing
- Intensified Cyclophophamide, Carboplatin and Thiotepa, dose dense adriamycine and cyclophosphamide
- Where
- Netherlands
- Volunteers
- 12 people
- Sponsor
- The Netherlands Cancer Institute
Lymphoma
Carmustine, Etoposide, Cyclophosphamide, and Stem Cell Transplant in Treating Patients With HIV-Associated Lymphoma
RATIONALE: Giving high-dose chemotherapy drugs, such as carmustine, etoposide, and cyclophosphamide, before a peripheral blood stem cell transplant stops the growth of cancer cells by stopping them from dividing or killing them.
- Trial name
- NCT00641381
- Testing
- carmustine, cyclophosphamide, etoposide
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- City of Hope Medical Center
Breast Cancer
Screening CEDM in Intermediate and High-Risk Patient Populations
This research study is being done to determine if Contrast Enhanced Digital Mammography (CEDM) can improve breast cancer detection and can be used as an additional screening method to the standard mammographic screening.
- Trial name
- NCT03859492
- Testing
- Contrast Enhanced Digital Mammography
- Where
- United States
- Volunteers
- 461 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Leukemia, Lymphoma
A Phase I Trial of Donor- Derived 19-28z CAR T Cells Following Allogeneic Transplant for the Treatment of CD19 Malignancies
The purposed of this study is to determine whether an infusion with specialized 'modified T cells' (or CD19 chimeric antigen T cells, also called CD19 CAR T cells) that target the B cell marker will reduce the risk of relapse…
- Conditions
- Leukemia, Lymphoma, Lymphoma, B-Cell
- Trial name
- NCT04556266
- Testing
- CAR T-Cell Infusion
- Where
- United States
- Sponsor
- Memorial Sloan Kettering Cancer Center
Leukemia
Combination Chemotherapy Followed By Filgrastim or Sargramostim in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia or Acute Lymphoblastic Leukemia
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Colony-stimulating factors such as filgrastim and sargramostim may increase the number of immune cells found…
- Trial name
- NCT00053131
- Testing
- filgrastim, sargramostim, cytarabine
- Where
- United States
- Sponsor
- Roswell Park Cancer Institute
Anaplastic Astrocytoma, Central Nervous System Neoplasm
Radiation Therapy, Temozolomide, and Lomustine in Treating Young Patients With Newly Diagnosed Gliomas
This phase II trial is studying how well giving radiation therapy together with temozolomide and lomustine works in treating young patients with newly diagnosed gliomas.
- Conditions
- Anaplastic Astrocytoma, Central Nervous System Neoplasm, Glioblastoma, Gliosarcoma
- Trial name
- NCT00100802
- Testing
- Laboratory Biomarker Analysis, Lomustine, Radiation Therapy
- Where
- United States
- Volunteers
- 118 people
- Sponsor
- Children's Oncology Group
Breast Neoplasm
Adjuvant Therapy for High-Risk Breast Cancer With Wkly Adriamycin & Oral Cytoxan With G-CSF for 12 Wks; Wkly Taxol x 12
The primary objectives of the study are to evaluate the feasibility and toxicity of treatment with 12 weeks of Adriamycin with daily oral Cytoxan with G-CSF support followed by 12 weeks of Taxol.
- Trial name
- NCT00194753
- Testing
- Paclitaxel, Doxorubicin, Cyclophosphamide
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Washington
Breast Cancer
Phase 2 Study of Lovastatin as Breast Cancer Chemoprevention
The study evaluates if a 6-month course of oral lovastatin at 80 mg/day would decrease abnormal breast duct cytology in women with a high inherited breast cancer risk.
- Trial name
- NCT00285857
- Testing
- Lovastatin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Stanford University
Liver Transplantation, Hepatocellular Carcinoma
Lenvatinib Therapy in HCC Patients After LDLT
New guidelines have been successfully established to distinguish the patients who were suitable for LT. This is important for long-term recurrence free and overall survival rate.
- Trial name
- NCT05572528
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Kaoshiung Chang Gung Memorial Hospital
Esophageal Cancer
High-dose Intensity Modulated Radiotherapy and Concurrent Chemotherapy in Esophageal Cancer
To assess the efficacy and feasibility of high-dose intensity-modulated radiotherapy with concurrent weekly paclitaxel and cisplatin for patients with locoregionally advanced esophageal cancer
- Trial name
- NCT03535207
- Testing
- high dose chemoradiotherapy
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
High Risk Melanoma
A Pilot Study of Ipilumimab and Radiation in Poor Prognosis Melanoma
This is a pilot study assessing the safety of the combination of ipilimumab administered concurrently with radiotherapy for patients with locally advanced or unresectable melanoma and patients at high risk for recurrence after…
- Trial name
- NCT01996202
- Testing
- Ipilumimab, Radiation
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Duke University
Gastric Cancer
Pilot Study for High Output Drainage Removal After Gastrectomy
*Objective: The study aims to evaluate whether there is a difference in intra-abdominal complication rates between patients discharged with or without a drainage tube following gastrectomy with high postoperative drainage…
- Trial name
- NCT06690112
- Testing
- Arm I (Drainage tube removal)
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Gangnam Severance Hospital
Sarcoma, Radiosurgery
Stereotaxic Body Irradiation of Oligometastase in Sarcoma (Stereosarc)
Up to 50% of soft tissue sarcoma (STS) patients will develop metastases in the course of their disease. Cytotoxic therapy is a standard treatment in this setting but yields average tumor response rates of 25% at first line and…
- Trial name
- Stereosarc (NCT03548428)
- Testing
- Atezolizumab, SBRT
- Where
- 17 sites in France
- Volunteers
- 103 people
- Sponsor
- Centre Antoine Lacassagne
Central Nervous System Tumors
OXC401-PO1s/WVU 1309 - A Pilot Study of Fosbretabulin With Bevacizumab in Recurrent High-Grade Gliomas
Pilot Trial of CA4P with Avastin in Recurrent Gliomas
- Trial name
- NCT01052363
- Testing
- Bevacizumab, CA4P
- Where
- United States
- Sponsor
- West Virginia University
Acute Myeloid Leukemia, High-risk Myelodysplastic Syndrome
ATRN-119 in Combination With Decitabine in Patients With TP53-Mutated AML or Higher-Risk MDS
This single-center, open-label, phase I study will evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary antileukemic activity of ATRN-119 (mosipasertib) alone and in combination with decitabine…
- Trial name
- NCT07617363
- Testing
- ATRN-119, Decitabine
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Washington University School of Medicine
Neoplasm Metastasis
Study to Evaluate a High Intensity Focused Ultrasound (HIFU) Procedure in Patient With Liver Metastases
The purpose of this study is to assess the feasibility, safety and efficacy of High Intensity Focused Ultrasound (HIFU) patients undergoing hepatectomy for colorectal liver metastases. This is a phase I/II study.
- Trial name
- HIFU (NCT01489787)
- Testing
- HIFU
- Where
- France
- Volunteers
- 38 people
- Sponsor
- Centre Leon Berard
Diffuse Glioma, Malignant Glioma
Intratumoral Extracellular Metabolic Impact of DFMO and AMXT 1501 in Patients With Diffuse or High Grade Glioma
This early phase I trial studies brain tumor (glioma) metabolism in response to eflornithine (DFMO) and polyamine transport inhibitor AMXT-1501 dicaprate (AMXT 1501) in patients with diffused or high grade glioma.
- Trial name
- NCT05717153
- Testing
- Biospecimen Collection, Computed Tomography, Eflornithine
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Mayo Clinic
Non-hodgkin Lymphoma, Relapsed Non-Hodgkin Lymphoma
CD79b-19 CAR T Cells in Non-Hodgkin Lymphoma
This research study involves the study of CD79b-19 CAR T cells for treating people with relapsed/refractory Non-Hodgkin Lymphoma and to understand the side effects when treated with CD79b-19 CAR T cells.
- Conditions
- Non-hodgkin Lymphoma, Relapsed Non-Hodgkin Lymphoma, Refractory Non-Hodgkin Lymphoma, Follicular Lymphoma
- Trial name
- NCT06026319
- Testing
- CD79b-19 CAR T cells, Cyclophosphamide, Fludarabine
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Marcela V. Maus, M.D.,Ph.D.
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