Clinical trials: High Risk Medications
Adolescent Dysmenorrhea
Adolescent Dysmenorrhea : Prevalence, Severity, Experience and Management in the Use of Medication in High School Girls in Ille-et-Vilaine
Dysmenorrhea or painful menstruation is a common symptom of menses. Dysmenorrhea is defined as a painful, cramping sensation in the lower abdomen or back associated with menstrual periods and is classified into primary and…
- Trial name
- DAPsvs (NCT04007471)
- Testing
- Anonymous survey
- Where
- France
- Volunteers
- 979 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Drug-induced Crystalline Nephropathy, Drug-induced Crystalluria
Drug-induced Crystalluria in Sulfamethoxazole, High Dose Ciprofloxacin and High Dose Amoxicillin
This study examines in hospitalized patients, treated with sulfamethoxazole, high dose ciprofloxacin or high dose iv amoxicillin, the incidence of drug-induced urinary crystal formation and its association with acute kidney…
- Conditions
- Drug-induced Crystalline Nephropathy, Drug-induced Crystalluria, Infections Treated With Sulfamethoxazole, High Dose Ciprofloxacin or High Dose iv Amoxicillin
- Trial name
- CRYSTALLINE (NCT07772752)
- Testing
- Crystalluria examination
- Where
- Belgium
- Volunteers
- 290 people
- Sponsor
- Universitair Ziekenhuis Brussel
Substance Abuse, Offenders
Effects of Manualized Treatment in a Seamless System
The specific aims of this project are: 1. To conduct a randomized block experiment to test the effectiveness of different models of the seamless supervision/treatment system and traditional criminal justice supervision on…
- Conditions
- Substance Abuse, Offenders, Criminal Thinking, HIV Risk Behaviors
- Trial name
- Man Tx (NCT01372033)
- Testing
- Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 251 people
- Sponsor
- George Mason University
Acute Lymphoblastic Leukemia (ALL)
Glucarpidase Effect on Severe Delayed HDM-clearance in Children Treated With High-dose Mtx in ALL
Early intervention in children and adolescents who experience delayed MTX-clearance and renal dysfunction in ALL treatments with the enzyme Glucarpidase which rapidly hydrolyses MTX to non-toxic metabolites to avoid life…
- Trial name
- NOPHOCPG2 (NCT01305655)
- Testing
- Glucarpidase
- Where
- 5 sites in Denmark, Finland and 3 more
- Volunteers
- 47 people
- Sponsor
- Nordic Society for Pediatric Hematology and Oncology
Delirium
PROfylactic Haloperidol in Patients Defined as High Risk for DElirium With Delirium Risk mOdel
The hospital pharmacy at the Zuyderland Medical Centre developed the DElirium MOdel (DEMO) to predict which patients are at risk of developing a delirium in patients aged 60 or older.
- Trial name
- PRODEO (NCT03199950)
- Testing
- Haloperidol
- Where
- Netherlands
- Volunteers
- 1,366 people, healthy volunteers welcome
- Sponsor
- Zuyderland Medisch Centrum
Liver Transplantation
Pilot Study of Immunosuppression Drug Weaning in Liver Recipients Exhibiting Biomarkers of High Likelihood of Tolerance
Immunosuppressive drugs can be successfully withdrawn in a fraction of liver transplant patients. Specific peripheral blood gene expression markers can be employed to select patients with a high likelihood of being tolerant.
- Trial name
- NCT01445236
- Testing
- Immunosuppresion withdrawal
- Where
- Spain
- Volunteers
- 25 people
- Sponsor
- Hospital Clinic of Barcelona
Established Atherosclerotic Cardiovascular Disease (ASCVD) or ASCVD Risk, Elevated Cholesterol
A Research Study Looking at the Effect of Food Intake on How the Medicine NN0385-0434 Behaves in the Body of Healthy Participants
In this study participants will receive NNC0385-0434. NNC0385-0434 is being developed for the treatment of hypercholesterolemia, a fat metabolism disorder characterized by high levels of cholesterol in the blood.
- Conditions
- Established Atherosclerotic Cardiovascular Disease (ASCVD) or ASCVD Risk, Elevated Cholesterol, Healthy Volunteers
- Trial name
- NCT05091073
- Testing
- NNC0385-0434
- Where
- Germany
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Acute Mountain Sickness
A Trial of Acetazolamide Versus Placebo in Preventing Mountain Sickness During Rapid Ascent
Acute mountain sickness is a common ailment in people venturing over 2500 m altitude. Pilgrims to high altitudes are at an added risk since they are unaware and they gain height faster than the recommendations.
- Trial name
- NCT01418157
- Testing
- Acetazolamide
- Where
- Nepal
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- Oxford University Clinical Research Unit, Vietnam
Aspiration
Study on General Population of the Effect on Airway Protection of Drugs Used During Induction of General Anesthesia
Upper esophageal sphincter is a high pressure zone of the pharynx and protects airway from aspiration of esophageal or gastric contents.
- Trial name
- NCT04413422
- Testing
- type of hypnotic used for induction of general anesthesia
- Volunteers
- 20 people
- Sponsor
- Hospital San Carlos, Madrid
Acute Myeloid Leukaemia, High Risk Myelodysplastic Syndrome
A Trial to Establish the Feasibility of Combining Either the Tyrosine Kinase Inhibitor AC220,CXCR4 Inhibitor Plerixafor or HSP90 Inhibitor Ganetespib With Chemotherapy in Older Patients With Acute Myeloid Leukaemia and High Risk Myelodysplastic Syndrome.
The AML18 Pilot Trial will evaluate the feasibility of three interventions that are planned to be included in the forthcoming NCRI AML18 Trial.
- Trial name
- AML18 Pilot (NCT01236144)
- Testing
- Plerixafor, AC220, Ganetespib
- Where
- 13 sites in United Kingdom
- Volunteers
- 113 people
- Sponsor
- Cardiff University
Hypertension
Efficacy and Safety of Azilsartan Medoxomil in Participants With Essential Hypertension
The purpose of this study is to determine the safety and efficacy of azilsartan medoxomil, once daily (QD), compared to placebo and olmesartan in participants with essential hypertension.
- Trial name
- NCT00696241
- Testing
- Azilsartan medoxomil and olmesartan, Olmesartan
- Where
- 85 sites in United States, Argentina and 1 more
- Volunteers
- 1,275 people
- Sponsor
- Takeda
Cardiomyopathy Due to Drug, Breast Cancer
2D Speckle-tracking Echocardiography in Chemotherapy-induced Cardiomyopathy With Cardiovascular Risk Factors
The aims of this study is to evaluate the role of 2D speckle-tracking echocardiography in diagnosis chemotherapy related left ventricular dysfunction in breast cancer patients with cardiovascular risks
- Conditions
- Cardiomyopathy Due to Drug, Breast Cancer, Cardiovascular Risk Factor
- Trial name
- NCT04547465
- Testing
- Echocardiography
- Where
- Vietnam
- Volunteers
- 300 people
- Sponsor
- Gia Dinh People Hospital
Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia
The Patient Cohort of the National Center for Precision Medicine in Leukemia
If for years the treatment strategy of leukemia and related disorders (LRDs, including acute leukemias and predisposition syndromes) has been based solely on whether the patient could receive or not intensive chemotherapy and…
- Conditions
- Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, High-risk Myelodysplastic Syndrome, Secondary Myelofibrosis in Myeloproliferative Disease
- Trial name
- eTHEMA (NCT05326919)
- Testing
- Biobanking
- Where
- 3 sites in France
- Volunteers
- 3,000 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Health Behavior, Motor Activity
Healthy Habits Program for High Cardiovascular Risk Patients: Randomized Controlled Clinical Trial
The purpose of this study is to determine the effectiveness of a program to improve habits in a population with cardiovascular disease, comparing two different educational techniques (cognitive behavioral therapy group vs.
- Conditions
- Health Behavior, Motor Activity, Food Habits
- Trial name
- NCT01861977
- Testing
- Cognitive Behavioral Therapy, Informational Workshop
- Where
- Argentina
- Volunteers
- 101 people
- Sponsor
- Hospital Italiano de Buenos Aires
Adolescent Health, Adolescent Problem Behavior
The Seattle Social Development Project: An Implementation of the Raising Healthy Children Intervention
The Seattle Social Development Project (SSDP) included a three-part intervention for teachers, parents, and students in grades 1 to 6.
- Trial name
- SSDP (NCT04075019)
- Testing
- The Raising Healthy Children intervention, including teacher training, child skill development, and parent training
- Volunteers
- 808 people, healthy volunteers welcome
- Sponsor
- University of Washington
Ann Arbor Stage III Diffuse Large B-Cell Lymphoma, Ann Arbor Stage IIX (Bulky) Diffuse Large B-Cell Lymphoma
Testing CC-486 (Oral Azacitidine) Plus the Standard Drug Therapy in Patients 75 Years or Older With Newly Diagnosed Diffuse Large B Cell Lymphoma
This phase II/III trial compares the side effects and activity of oral azacitidine in combination with the standard drug therapy (reduced dose rituximab-cyclophosphamide, doxorubicin, vincristine, and prednisone [R-miniCHOP])…
- Conditions
- Ann Arbor Stage III Diffuse Large B-Cell Lymphoma, Ann Arbor Stage IIX (Bulky) Diffuse Large B-Cell Lymphoma, Ann Arbor Stage IV Diffuse Large B-Cell Lymphoma, Diffuse Large B-Cell Lymphoma Activated B-Cell Type
- Trial name
- NCT04799275
- Testing
- Biospecimen Collection, Computed Tomography, Cyclophosphamide
- Where
- 176 sites in United States
- Volunteers
- 422 people
- Sponsor
- National Cancer Institute (NCI)
Coronary Artery Disease
Comparison of Scoring Balloon and Conventional Balloon Predilation Before Drug Coated Balloon for de Novo Lesion in Patients With High Bleeding Risk
This study is designed to investigate whether scoring balloon (non-slip element, NSE) predilation compared to non-compliant (NC) balloon predilation for de novo lesion in patients with high bleeding risk and planning to receive…
- Trial name
- PREPARE-NSE (NCT03817801)
- Testing
- NSE balloon, NC balloon
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Peripheral Arterial Disease
Cost-utility Analysis, Cost-effectiveness Analysis, Budget Impact Analysis
Cardiovascular pathologies (CV), the second leading cause of death just behind tumors, are particularly frequent in France and strongly mobilize the resources of the healthcare system (ambulatory and health facility).
- Trial name
- DAMAGE (NCT04283565)
- Testing
- Systematic screening of AOMI by BPI measurement., Management of CVRF by a motivationnal interviewing.
- Where
- France
- Volunteers
- 614 people
- Sponsor
- University Hospital, Tours
Hypercholesterolemia
Effect of Combination Therapy With Two Drugs (Colesevelam and Ezetimibe) in Patients With High Cholesterol
Assess the efficacy of WelChol® plus Zetia® in treating patients with high cholesterol
- Trial name
- NCT00185107
- Testing
- Colesevelam Hydrochloride, Ezetimibe, Simvastatin
- Where
- 7 sites in United States
- Volunteers
- 45 people
- Sponsor
- Daiichi Sankyo
Overweight, Obesity
Meta-analysis of Fructose-Containing Sugar Sweetened Beverages (SSBs) and Weight Change
Since uncontrolled observational studies first linked fructose to the epidemic of obesity almost a decade ago, it has become a focus of intense concern regarding its role in the obesity epidemic.
- Conditions
- Overweight, Obesity, Diabetes, Prediabetes
- Trial name
- NCT01608607
- Testing
- Fructose-containing sugar sweetened beverages
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- John Sievenpiper