Clinical trials: High-Altitude Illness
High Altitude
Protocol for Evaluating Physiological and Psychological Adaptation Mechanisms in Tibetan Plateau Environments
This study is a single-center prospective observational study. It plans to use a series of physiological and medical instruments and international common physiological and psychological questionnaires.
- Trial name
- NCT06557928
- Testing
- measurement
- Where
- China
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
ARDS
Diagnostic Criteria of ARDS at High Altitudes in Western China
The severity of ARDS in high altitude areas was classified according to the Berlin standard high altitude area Oxygenation.
- Trial name
- NCT04215666
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Affiliated Hospital of Qinghai University
Acute Mountain Sickness
Change in Peripheral Oxygen Saturation by Using Different Breathing Procedures in High Altitude
In this investigation the researchers explore whether different types of breathing procedures can improve the peripheral oxygen saturation to reduce the risk of becoming a acute mountain sickness or a high altitude pulmonary…
- Trial name
- NCT01468194
- Testing
- Breathing procedure 1, Breathing procedure 2
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Giessen
Aortic Stenosis, Altitude
Short-term Exposure to High Altitude in Patients With Asymptomatic Aortic Stenosis
Aortic stenosis is a common disease with increasing prevalence due to an aging population. Aortic valve replacement is indicated for symptomatic severe aortic stenosis.
- Trial name
- ASALT (NCT06894550)
- Testing
- Participants will be escorted to high altitude and undergo a series of test
- Where
- Switzerland
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
High Altitude
Effects of Pioglitazone on Exogenous Carbohydrate Oxidation During Steady-State Exercise at High Altitude
Apparent hypoxia-induced insulin insensitivity along with alterations in glucose kinetics suggests reduction in glucose uptake by the peripheral tissue is a primary factor contributing to reductions in exogenous glucose oxidation…
- Trial name
- NCT06164665
- Testing
- Pioglitazone 15mg
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
High Altitude Pulmonary Hypertension
Highlanders With High Altitude Pulmonary Hypertension (HAPH), 6 Minute Walk Distance (6MWD) Assessed at 3200m With and Without Supplemental Oxygen Therapy (SOT)
The investigators aim to study the effect of SOT in highlanders with high altitude pulmonary hypertension (HAPH) who permanently live >2500m on 6-minute walk distance (6MWD) assessed at 3200m.
- Trial name
- NCT06489743
- Testing
- 6-minute walk test (6MWT)
- Where
- Kyrgyzstan
- Volunteers
- 24 people
- Sponsor
- University of Zurich
Erythrocytosis, Mountain Sickness
Study of Cobalt's Role in Excessive Erythrocytosis Among High Altitude Dwellers in Cerro de Pasco, Peru
Chronic mountain sickness is characterized by excessive red blood cell production which causes sludging of the vascular system. This high viscosity blood causes heart failure, cognitive dysfunction, and strokes.
- Trial name
- CoCMS (NCT01187108)
- Testing
- N-acetylcysteine, Acetazolamide
- Where
- Peru
- Volunteers
- 85 people
- Sponsor
- University of Colorado, Denver
Pulmonary Arterial Hypertension (PAH), Pulmonary Vascular Disease
Assessment of Total Pulmonary Resistance sPAP/CO Between Sea Level LA vs. High Altitude HA After Re-ascent in Patients With Pulmonary Arterial Hypertension PAH
To study the effect of a re-ascent after a one-week stay at sea level (after prior descent from 2850m) to high altitude (Quito Ecuador: 2850m) on pulmonary resistance (sPAP/CO) and other hemodynamic outcomes in patients with…
- Conditions
- Pulmonary Arterial Hypertension (PAH), Pulmonary Vascular Disease, High Altitude, Echocardiography
- Trial name
- NCT07804693
- Testing
- Re-Ascent from sea level to 2850m
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Silvia Ulrich Somaini
High Altitude
Establishing the Reference Interval for Pulse Oxygen Saturation in Neonates at High Altitude
The now widely used reference interval for pulse oxygen saturation of the neonate after 24 hours of birth has been developed relying on data from low altitude.It is not suitable for neonates at high altitude.
- Trial name
- NCT05115721
- Testing
- no intervention
- Where
- China
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Nanjing Medical University
Right Heart Function, Chronic Obstructive Pulmonary Disease
Effect of Acetazolamide on Right Heart Function at Rest in Lowlanders With COPD Traveling to High Altitude
The purpose of this randomized, placebo-controlled double-blind trial is to evaluate the effect of acetazolamide on right heart function at rest in lowlanders with chronic obstructive pulmonary disease (COPD) traveling to high…
- Conditions
- Right Heart Function, Chronic Obstructive Pulmonary Disease, Altitude Sickness
- Trial name
- NCT04915365
- Testing
- Acetazolamide
- Where
- Kyrgyzstan
- Volunteers
- 100 people
- Sponsor
- University of Zurich
ARDS, High Altitude
Definition of ARDS in Qinghai Province: Verification of Berlin Definition Plateau Criteria
The severity stratification criteria for acute respiratory distress syndrome (ARDS) in Xi'ning Qinghai province (mean altitude: 2200m) were clarified according to the oxygenation index (PaO2/FiO2).
- Trial name
- NCT04199650
- Where
- China
- Volunteers
- 253 people
- Sponsor
- Southeast University, China
High Altitude Pulmonary Hypertension
High Altitude (HA) Residents With High Altitude Pulmonary Hypertension (HAPH), Pulmonary Artery Pressure (PAP) Assessed at HA (3200 m) vs LA (760 m)
To study the effect of relocation from 3200 m (Aksay) to 760 m (Bishkek) in patients with high altitude pulmonary hypertension (HAPH) who permanently live >2500 m on pulmonary artery pressure (PAP)
- Trial name
- NCT06489704
- Testing
- Echocardiography
- Where
- Kyrgyzstan
- Volunteers
- 24 people
- Sponsor
- University of Zurich
Covid19, SARS-CoV2 Infection
Coronaltitude - Multicentric Evaluation of the Impact on Hypoxia Sensitivity of Patients With COVID-19
In this study, the investigators will examine the extent to which having suffered coronavirus disease 2019 (COVID19) impacts one's sensibility to hypoxia by means of the 'Richalet test'.
- Conditions
- Covid19, SARS-CoV2 Infection, Hypoxia, Altitude
- Trial name
- NCT05167357
- Testing
- COVID19
- Where
- France
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Institut de Formation et de Recherche en Médecine de Montagne
Resting Metabolic Rate, Appetite
Effects of Overnight Low Oxygen Exposure on Energy Balance
This research study will evaluate changes in resting metabolic rate, appetite, and heart rate variability following overnight exposure (8 h/night) to normobaric hypoxia (NH) or normobaric normoxic (NN).
- Conditions
- Resting Metabolic Rate, Appetite, Heart Rate Variability
- Trial name
- NCT04151927
- Testing
- Normobaric Hypoxia, Normobaric Normoxia
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Florida State University
High Altitude Pulmonary Hypertension, Sleep Apnea
Sleep Related Breathing Disturbances and High Altitude Pulmonary Hypertension in Kyrgyz Highlanders
High altitude pulmonary hypertension, a form of altitude illness that occurs in long-term residents at altitudes >2500 m, is characterized by dyspnea, hypoxemia, impaired exercise performance and hypertension in the pulmonary…
- Trial name
- NCT01621061
- Where
- Kyrgyzstan
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- University of Zurich
High Altitude, Hypobaric Hypoxia
The Effect of Acute High Altitude Exposure on Rescuer Performance and Patient Care
Rescue services in mountainous regions are frequently called to missions at altitudes >3000 m. Under the difficult conditions of acute exposure to altitude, the crews then have to undertake demanding medical and rescue measures.
- Conditions
- High Altitude, Hypobaric Hypoxia, Risk Reduction
- Trial name
- NCT06446427
- Testing
- Acute high altitude exposure, Acute high altitude exposure, with supplementary oxygen, Subacute high altitude exposure, after having spent a night at high altitude
- Where
- 2 sites in Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Pulmonary Disease, Cardiovascular Disease
Cardio-Respiratory Health and Indoor Pollution
The aim of this study is to assess in the sample of population resident in the KHUMBU valley (NEPAL): 1. the respiratory function decline by means of spirometry and the respiratory health by means of questionnaire and six-minute…
- Trial name
- NCT01329159
- Where
- Italy
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Università degli Studi di Ferrara
High Altitude Pulmonary Edema, Non-Invasive Positive Pressure Ventilation
Non-Invasive Positive Pressure Ventilation Management of High Altitude Pulmonary Edema
Trial of Non-Invasive Positive Pressure Ventilation Management of High Altitude Pulmonary Edema
- Conditions
- High Altitude Pulmonary Edema, Non-Invasive Positive Pressure Ventilation, Hypoxia
- Trial name
- NCT04288219
- Testing
- Non-Invasive Positive Pressure Ventilation, Nifedipine, supplemental oxygen
- Where
- Nepal
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Pregnancy, IUGR
Effects of High Altitude on AMPK Activation
Pregnancy elicits adaptive changes in uteroplacental blood flow, which are altered at high altitude and may contribute to the observed 3-fold increase in intrauterine growth restriction (IUGR) and preeclampsia (PreE).
- Conditions
- Pregnancy, IUGR, Preeclampsia
- Trial name
- NCT02391519
- Testing
- Collection of myometrial, cord blood, and placental tissue samples
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Pulmonary Arterial Hypertension (PAH), Pulmonary Vascular Disease
Assessment of Six-minute Walking Distance Between Sea Level LA vs. High Altitude HA After Re-ascent in Patients With Pulmonary Arterial Hypertension PAH
To study the effect of a re-ascent after a one-week stay at sea level (after prior descent from 2850m) to high altitude (Quito Ecuador: 2850m) on six-minute walking distance and other scores in patients with pulmonary arterial…
- Conditions
- Pulmonary Arterial Hypertension (PAH), Pulmonary Vascular Disease, Six-minute Walk Test, NYHA
- Trial name
- NCT07797166
- Testing
- Re-Ascent sea level to 2850m
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Silvia Ulrich Somaini