Clinical trials: High-Flow Nasal Oxygen Therapy
Respiratory Failure
Noninvasive Technique and High Flow Nasal Oxygen in Respiratory Failure
After obtaining Institutional Ethical Committee approval of Faculty of Medicine, Minia University and written informed consent from patients or first- degree relatives, this prospective randomized non-blind comparative study will…
- Trial name
- NCT07521254
- Testing
- HFNC, NIV
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Minia University
Dyspnea
High-flow Nasal Oxygen in Palliative Care: Pilot Study
In palliative care, the relief of the dyspnea is necessary. Medications for the reduction of dyspnea have side effects. High-flow nasal cannula oxygen therapy (HFNC) is a new way to deliver oxygen.
- Trial name
- OXYPALL (NCT03423888)
- Testing
- high-flow nasal cannula oxygen therapy (HNFC)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Toulouse
COPD
Closed Loop Oxygen Control in Chronic Obstructive Pulmonary Disease (COPD) Patients Treated With Nasal High Flow in the Hospital
The trial aims to evaluate whether the Airvo 3 device in OptiO2 mode can maintain patients' SpO2 levels within the target range better than manual oxygen titration in hospitalized COPD patients with hypoxemia/respiratory distress.
- Trial name
- NCT07222410
- Testing
- Closed loop oxygen control, Manual titration
- Where
- 4 sites in United States
- Volunteers
- 70 people
- Sponsor
- Fisher and Paykel Healthcare
Hypoxia, Obesity
Nasopharyngeal Airway Combined With Nasal High-flow Oxygen Therapy During Painless Gastroscopy in Obesity Patients
Gastroscopy is a commonly used, direct, and reliable method for screening and diagnosing digestive tract diseases. However, as an invasive examination, it can cause adverse reactions such as pain, nausea, vomiting, and choking…
- Conditions
- Hypoxia, Obesity, Gastrostomy
- Trial name
- NCT06966934
- Testing
- NPA
- Where
- China
- Volunteers
- 364 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Oxygen, pH
Comparison of the Effects of High-flow Nasal Cannula Oxygen and Jet Ventilation Techniques
Endoscopic microsurgical procedures of the larynx (direct examination-bx, microlaryngeal resection) require the anesthesiologist and surgeon to work in the same area throughout the procedure, and while ventilation is provided…
- Conditions
- Oxygen, pH, End-tidal Carbon Dioxide
- Trial name
- NCT05746949
- Testing
- oxygenization techniques
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Pneumonia, Hypoxaemia
Use of Bubble Continuous Positive Airway Pressure Compared to Nasal Prong Oxygen or Humidified High Flow in Children Under Five With Severe Pneumonia and Hypoxaemia
Continuous Positive Airway Pressure (CPAP) is a common form of support for patients admitted to Intensive Care Units (ICUs) of industrialized countries with respiratory distress (1).
- Trial name
- NCT01396759
- Testing
- Bubble continuous positive airway pressure, Humidified high flow air / O2 mix at 2 l/kg/min, Standard O2 supplementation by nasal cannula at 0.5 - 2 l/min
- Where
- Bangladesh
- Volunteers
- 975 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Chronic Obstructive Pulmonary Disease
High Flow Nasal Oxygen Versus Usual Care in COPD Pulmonary Rehabiliation
To compare the effects of high flow nasal oxygen with usual care during an outpatient 6-week pulmonary rehabilitation program after hospitalization for COPD exacerbation.
- Trial name
- NCT03940040
- Testing
- Usual care, High flow nasal oxygen
- Where
- Singapore
- Volunteers
- 22 people
- Sponsor
- Changi General Hospital
Pregnancy Related, Anesthesia
Pre-oxygenation With High-flow Nasal Cannula in Caesarian Section Under General Anesthesia
The investigators and other groups have demonstrated that high-flow nasal oxygen used during preoxygenation for emergency surgery is at least equally effective as preoxygenation compared to standard tight fitting mask.
- Conditions
- Pregnancy Related, Anesthesia, Oxygen Deficiency, Cesarean Section Complications
- Trial name
- PRIOROB (NCT04711317)
- Testing
- Nasal high flow oxygen
- Where
- 4 sites in Sweden
- Volunteers
- 34 people
- Sponsor
- Karolinska University Hospital
Respiratory Failure
Flow veRsus OxygeNaTion In acutE ReSpiratory Failure
High flow nasal oxygen therapy has been widely used but guidelines as to the optimal starting flow rate and oxygen percentage are not available.
- Trial name
- Frontiers (NCT03223948)
- Testing
- 'Optiflow'
- Where
- United Kingdom
- Volunteers
- 180 people
- Sponsor
- NHS Greater Glasgow and Clyde
Exacerbation Copd, Acute Respiratory Distress
High Flow Nasal Cannula Versus Non-Invasive Ventilation in Exacerbations of Chronic Obstructive Pulmonary Disease
Chronic obstructive lung disease is a disabling disease that affects people usually after several years of smoke tobacco exposure and affects millions of patients worldwide.
- Conditions
- Exacerbation Copd, Acute Respiratory Distress, Acute Hypercapnic Respiratory Failure
- Trial name
- HiFOLD (NCT03033251)
- Testing
- Non Invasive Ventilation, High Flow Oxygen Cannula 50, High Flow Oxygen Cannula 30
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Unity Health Toronto
Diaphragm Ultrasonography, Lung Ultrasound
The Role of Lung and Diaphragm Ultrasonography in Predicting Clinical Progression in Hypoxemic Respiratory Failure
The goal of this observational study is to evaluate whether the risk of intubation in patients with hypoxemic respiratory failure who were monitored in the intensive care unit and received non-invasive mechanical ventilation and…
- Conditions
- Diaphragm Ultrasonography, Lung Ultrasound, Hypoxemic Respiratory Failure
- Trial name
- NCT06706830
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 91 people
- Sponsor
- Simge Evren
Heart Failure, Noninvasive Ventilation
High Flow Nasal Oxygen and Acute Left Heart Failure
Acute left heart failure (ALHF) is a sudden attack or deterioration of abnormal left heart function, which may impair myocardial contractility and increase cardiac loading, further result in decreased cardiac output, abrupt…
- Conditions
- Heart Failure, Noninvasive Ventilation, Oxygen Therapy
- Trial name
- HFNO (NCT03607357)
- Testing
- High Flow Nasal Oxygen, Non-invasive Ventilation
- Where
- China
- Volunteers
- 123 people
- Sponsor
- Nanjing Jiangbei People's Hospital
Bronchiolitis
Study of High-flow Oxygen Therapy Against Standard Therapy in Bronchiolitis
Bronchiolitis is a common illness of the respiratory tract caused by infection of the tiny airways within the lungs called bronchioles.
- Trial name
- Hi-Flo (NCT01498094)
- Testing
- High Flow Nasal Cannula Oxygen Therapy, Standard low flow oxygen
- Where
- Canada
- Volunteers
- 79 people
- Sponsor
- University of British Columbia
Gastric Distention
High-Flow Heated and Humidified Oxygen Therapy and Gastric Distension
High Flow Heated and Humidified Nasal Oxygen therapy (HFHHNO) has been increasingly used in emergency medicine to assist patients with short term respiratory failure and to provide adequate oxygen to the body prior to intubation.
- Trial name
- HFHHNOGastric (NCT03134937)
- Testing
- High-Flow Heated and Humidified Oxygen Therapy (HFHHNO)
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Lung Disease, Acute Respiratory Distress Syndrome
Palliative Use of High-flow Oxygen Nasal Cannula in End-of-life Lung Disease Patients
The prevalence of severe dyspnoea among terminally ill patients has been reported as 70% and 90% for lung cancer and chronic obstructive pulmonary disease (COPD) patients, respectively.
- Trial name
- NCT02253667
- Testing
- HFONC, Conventional oxygen therapy
- Where
- Portugal
- Sponsor
- Hospital Sao Joao
Hypoxia
Oxygen Supplementation During Bronchoscopy: High Flow Versus Low Flow Oxygen
In general bronchoscopy is a safe procedure with low rate of complications. Indeed, contraindications to flexible bronchoscopy are mostly relative rather than absolute.
- Trial name
- NCT02253706
- Testing
- High flow nasal oxygen supplementation, low flow nasal oxygen supplementation
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Shaare Zedek Medical Center
Cystic Fibrosis
HFNT During Exercise in CF
Cystic fibrosis (CF) is a genetic condition characterised by recurrent lung infections, inflammation and progressive lung damage.
- Trial name
- NCT03965832
- Testing
- HFNT during exercise, Standard oxygen therapy/RA
- Where
- United Kingdom
- Volunteers
- 23 people
- Sponsor
- The Leeds Teaching Hospitals NHS Trust
Hypoxemic Respiratory Failure
A Pilot Study Comparing Oxygen Delivery Via Helmet Interface Versus High Flow Nasal Cannula
Our main objective is to collect feasibility data on helmet NIPPV and other clinical elements in to eventually prepare for a full scale randomized trial based on findings of this pilot study.
- Trial name
- NOVA-pilot (NCT04035460)
- Testing
- Helmet, High Flow Nasal Oxygen
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Baystate Medical Center
Intubation, Cardiovascular Surgical Procedure
Reducing Reintubation Risk in High-Risk Cardiac Surgery Patients With High-Flow Nasal Cannula
The iCAN trial is a pragmatic randomized controlled trial that aims to test the hypothesis that HFNC versus usual care oxygenation strategies applied immediately after initial extubation after cardiac surgery decreases the…
- Trial name
- NCT04782817
- Testing
- Recommendation for high flow nasal cannula oxygen therapy order set, Provider choice standard care order set
- Where
- United States
- Volunteers
- 3,568 people
- Sponsor
- Vanderbilt University Medical Center