Clinical trials: High-altitude Pulmonary Edema
Mountain Sickness
Three New Ideas to Protect Special Forces From the Stress of High Altitude
Acute Mountain Sickness (AMS) is a well-documented syndrome that affects 42% of non-acclimatized individuals traveling to altitudes above 10,000 feet.
- Trial name
- NCT02463357
- Testing
- Quercetin, Nifedipine extended release, Methazolamide
- Where
- United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Acute Mountain Sickness
Altitude Sickness Prevention and Efficacy of Comparative Treatments
This study is designed to be the first to examine the novel drug budesonide for prevention of acute mountain sickness in comparison to acetazolamide and in the context of rapid ascent to high altitude.
- Trial name
- ASPECT (NCT02604173)
- Testing
- Budesonide, Acetazolamide
- Where
- United States
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Stanford University
Acute Mountain Sickness
Study Looking at End Expiratory Pressure for Altitude Illness Decrease (SLEEP-AID)
The study is examining if an over-the-counter device (Theravent) worn while sleeping can reduce acute mountain sickness upon awakening in a high altitude trekking population.
- Trial name
- SLEEP-AID (NCT01842906)
- Testing
- Theravent, Control
- Where
- Nepal
- Volunteers
- 219 people, healthy volunteers welcome
- Sponsor
- Stanford University
Glucose Metabolism, High Altitude
High Altitude and Exogenous Carbohydrate Oxidation
Recent studies have reported that oxidation of exogenous carbohydrate is reduced under acute hypobaric hypoxic (high altitude; HA) conditions compared to normoxia (sea level; SL) in native lowlanders.
- Trial name
- NCT03851744
- Testing
- Sea Level, High Altitude
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
High Altitude Pulmonary Edema
Effect of Acetazolamide on Subclinical High-Altitude Pulmonary Edema Detected by Lung Ultrasonography
The overall goal of this study is to detect preclinical signs of HAPE by lung ultrasonography and evaluate the effectiveness of acetazolamide at decreasing pulmonary edema by using ultrasound.
- Trial name
- NCT03490916
- Testing
- Acetazolamide
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Vincent Kan
Acute Mountain Sickness
Drug Combination on Exercise Performance at High Altitude
This study is being conducted to determine the effectiveness of using two FDA approved medications in concert to reduce the likelihood of sickness due to low oxygen levels and to reduce the decrement in physical performance at…
- Trial name
- NCT01902758
- Testing
- ambrisentan and theophylline
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Montana
Hypoxia, Altitude Hypoxia
The Psychophysiological Effect of Simulated and Terrestrial Altitude
The aim of this study is to compare the psychophysiological effects of terrestrial altitude with a normobaric, hypoxic situation.
- Conditions
- Hypoxia, Altitude Hypoxia, Altitude Sickness, Altitude
- Trial name
- Hypoxia (NCT04075565)
- Testing
- Terrestrial altitude, Cloud 9
- Where
- 3 sites in Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Applied Sciences and Arts of Southern Switzerland
Altitude Sickness
Prevention of Altitude Illness With Non-steroidal Anti-inflammatory Study (PAINS)
This is a research study on Altitude Illness. From the information collected and studied in this project we hope to learn more about Altitude Illness, including factors that may affect and prevent the development and progression…
- Trial name
- NCT01171794
- Testing
- Ibuprofen
- Where
- United States
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Stanford University
Hypoxia
The Effect of Chronic Nitrate Supplementation on Acute Mountain Sickness and Exercise Performance in Hypoxia
The study will aim to describe and evaluate the effect of chronic beetroot juice supplementation on acute mountain sickness symptoms and exercise in a hypoxic environment.
- Trial name
- NCT03101904
- Testing
- Beetroot Juice
- Where
- United Kingdom
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Bangor University
Hypoxia, Altitude
Effect of an H1 Receptor Antagonist on Exercise Performance in Hypoxia
This study seeks to determine whether a simple, single intervention of Cetirizine / Zyrtec® use can improve exercise performance of active individuals when acutely exposed to altitude.
- Trial name
- NCT03192488
- Testing
- Cetirizine, Hypoxia
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Indiana University
Effects of High Altitude, Hypoxia
Induced Changes in Ventilatory Responsiveness and Altitude Exposure
The main purpose of this study is to determine if a drug (acetyl-cysteine or ACCY) can increase the amount of oxygen in your body at a high altitude of 11,500 feet.
- Conditions
- Effects of High Altitude, Hypoxia, Inadequate or Impaired Breathing Pattern or Ventilation, Abnormal Blood Oxygen Pressure
- Trial name
- NCT01241513
- Testing
- NAC
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
High Altitude Pulmonary Hypertension
The Safety Evaluation of Aminophylline and Ambrisentan When Administered Orally Alone and in Combination to Healthy Volunteers
This is a Phase I, three period, two sequence, open-label, randomized, crossover study, with the primary objective of testing the safety and tolerability of combined oral doses of aminophylline and ambrisentan in healthy human…
- Trial name
- GQ01 (NCT01530464)
- Testing
- Aminophylline, Ambrisentan, Aminophylline plus ambrisentan
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Thies Schroeder
Mountain Sickness
Safety Evaluation of Aminophylline and Methazolamide
This safety study is the first in a series of studies testing the application of the combination of aminophylline and methazolamide.
- Trial name
- NCT01587027
- Testing
- Aminophylline, Methazolamide, Aminophylline and Methazolamide
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Poudre Valley Health System
Prophylaxis of Acute Mountain Sickness
Acetazolamide for the Prevention of High Altitude Illness: a Comparison of Dosing
This is a phase 4, randomized, double-blinded interventional trial comparing alternative doses of Acetazolamide for the prevention of High Altitude Illness.
- Trial name
- NCT01993667
- Testing
- Low Dose Acetazolamide, Normal Dose Acetazolamide
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University of Utah
High Altitude
Effects of Pioglitazone on Exogenous Carbohydrate Oxidation During Steady-State Exercise at High Altitude
Apparent hypoxia-induced insulin insensitivity along with alterations in glucose kinetics suggests reduction in glucose uptake by the peripheral tissue is a primary factor contributing to reductions in exogenous glucose oxidation…
- Trial name
- NCT06164665
- Testing
- Pioglitazone 15mg
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Hypertension, Pulmonary, Altitude Sickness
Efficacy Study of Riociguat and Its Effects on Exercise Performance and Pulmonary Artery Pressure at High Altitude
During ascent to high altitude there is a physiologic response to hypoxia that results in an elevated pulmonary arterial pressure associated with decreased exercise performance, altitude-induced pulmonary hypertension, and high…
- Trial name
- NCT02024386
- Testing
- Riociguat
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Richard Moon