Clinical trials: High-dose Chemotherapy
Lymphoma
Combination Chemotherapy and Peripheral Stem Cell Transplantation in Treating Older Patients With Refractory or Relapsed Intermediate-Grade Non-Hodgkin's Lymphoma
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Peripheral stem cell transplantation may allow doctors to give higher doses of chemotherapy drugs and kill…
- Trial name
- NCT00002982
- Testing
- filgrastim, carboplatin, carmustine
- Where
- United States
- Sponsor
- Memorial Sloan Kettering Cancer Center
Breast Cancer
Immunotherapy in Treating Patients With Metastatic Breast Cancer
RATIONALE: Immunotherapy using CEA-treated white blood cells may help a person's body build an immune response to and kill their tumor cells.
- Trial name
- NCT00003432
- Testing
- carcinoembryonic antigen RNA-pulsed DC cancer vaccine
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Duke University
Acute Myeloid Leukemia
Evaluation of "Dose-dense Therapy" by S-HAM in Comparison to Conventionally Timed Double Induction in Patients With Acute Myeloid Leukemia (AML)
Evaluation weather early chemotherapy attempts for remission induction can improve the results of patients with Acute Myeloid Leukemia (AML), as compared to the standard group.
- Trial name
- AMLCG 2008 (NCT01382147)
- Testing
- Ara-C, Mitoxantrone, Daunorubicin, Thioguanin
- Where
- 32 sites in Germany
- Volunteers
- 396 people
- Sponsor
- Prof. Dr. Wolfgang Hiddemann
Breast Cancer
Combination Chemotherapy Followed By Peripheral Stem Cell Transplantation in Treating Patients With Advanced Breast Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy with peripheral stem cell transplantation may allow the doctor to give higher doses of…
- Trial name
- NCT00004174
- Testing
- filgrastim, cyclophosphamide, paclitaxel
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Northwestern University
Lymphoma, Non-Hodgkin, Hodgkin Disease
Cytogenetic Analysis of Bone Marrow Specimen Prior to High Dose Chemotherapy and Autologous Stem Cell Transplantation in Patients With Non-Hodgkin's Lymphoma or Hodgkin's Disease
Cytogenetic Analysis of Bone Marrow Specimen Prior to High Dose Chemotherapy and Autologous Stem Cell Transplantation in Patients with Non-Hodgkin's Lymphoma or Hodgkin's Disease
- Trial name
- NCT00534820
- Testing
- Cytogenetic Analysis of Bone Marrow Specimen
- Where
- Saudi Arabia
- Volunteers
- 450 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
Multiple Myeloma
Clarithromycin in Multiple Myeloma Induction Therapy
This study evaluates the potential synergic anti-myeloma activity of clarithromycin when combined with VCD induction therapy in patients with newly diagnosed multiple myeloma.
- Trial name
- CLAIM (NCT02573935)
- Testing
- Clarithromycin, VCD induction therapy
- Where
- 7 sites in Denmark
- Volunteers
- 58 people
- Sponsor
- Henrik Gregersen
Multiple Myeloma
A Study of Bortezomib, Cyclophosphamide, and Dexamethasone in Patients With Untreated Multiple Myeloma and Planned for a High Dose Chemotherapy
The purpose of this study is to evaluate the safety and effectiveness of bortezomib in combination with a standard regimen of cyclophosphamide and dexamethasone.
- Trial name
- NCT00833560
- Testing
- Cyclophosphamide, Bortezomib, Dexamethasone
- Where
- 34 sites in Germany
- Volunteers
- 401 people
- Sponsor
- Janssen-Cilag G.m.b.H
Multiple Myeloma
Efficacy and Safety of Aprepitant in Subjects With Multiple Myeloma During and After High-dose Chemotherapy
1. Scientific background In patients with multiple myeloma high-dose chemotherapy followed by autologous stemcell transplantation is preferred to conventional therapy, since the superiority in respect to complete remission…
- Trial name
- EmNa (NCT00571168)
- Testing
- Emend
- Where
- Germany
- Volunteers
- 362 people
- Sponsor
- Heidelberg University
Leukemia
Allogeneic Hematopoietic Stem Cell Transplantation (AlloSCT) Initial Salvage Therapy for Induction Failure Acute Myeloid Leukemia (AML)
Objectives: Primary Objectives: 1. To determine the safety and feasibility of allogeneic hematopoietic stem cell transplantation (AHSCT) as initial salvage treatment for patients with primary induction failure (PIF) acute myeloid…
- Trial name
- NCT02441803
- Testing
- Busulfan, Fludarabine, Clofarabine
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- M.D. Anderson Cancer Center
Mucositis, Bone Marrow Transplantation
Prevention Chemotherapy Induced Mucositis by Zinc Sulfate
In this double blinded randomized study we evaluate effect of Zinc sulfate for prevention mucositis due to high dose chemotherapy in the patients undergoing bone marrow transplantation whose received Busulfan and/or…
- Trial name
- NCT01015183
- Testing
- Zinc Sulfate
- Where
- Iran
- Volunteers
- 60 people
- Sponsor
- Tehran University of Medical Sciences
Breast Cancer
Study of Nab-Paclitaxel in High Risk Early Breast Cancer
two-armed trial to compare E-nP-C against tailored dtEC-dtD in patients with high risk early breast cancer
- Trial name
- GAIN-2 (NCT01690702)
- Testing
- Epirubicin, nab-Paclitaxel, Cyclophosphamide
- Where
- Germany
- Volunteers
- 2,886 people
- Sponsor
- GBG Forschungs GmbH
Chemotherapy-induced Nausea and Vomiting
Low Dose Olanzapine to the Prophylaxis of Nausea and Vomiting Induced by Chemotherapy in Children and Adolescents
Chemotherapy-induced nausea and vomiting continues to be a significant problem in children and adolescents. Standard antiemetic therapy, including a 5-HT3 antagonist, aprepitant, and a corticosteroid, achieves complete control in…
- Trial name
- OZONE-V (NCT05346731)
- Testing
- Ondansetron, Dexamethasone, Aprepitant
- Where
- Russia
- Volunteers
- 210 people
- Sponsor
- Federal Research Institute of Pediatric Hematology, Oncology and Immunology
Nausea, Vomiting
A Multicenter, Randomized, Controlled Trial of SCH 619734 for the Treatment of Chemotherapy-Induced Nausea and Vomiting (Study P04351AM2)(COMPLETED)
This is a Phase 2, randomized, multicenter, parallel-group, double-blind, placebo-controlled study of various doses of SCH 619734 in subjects receiving cisplatin-based chemotherapy.
- Trial name
- NCT00394966
- Testing
- SCH 619734 Dose 1, SCH 619734 Dose 2, SCH 619734 Dose 3
- Volunteers
- 450 people
- Sponsor
- Schering-Plough
Lymphoma
Gene Therapy, Chemotherapy, and Peripheral Stem Cell Transplantation in Treating Patients With HIV-Related Non-Hodgkin's Lymphoma
RATIONALE: Inserting the gene for RevM10 into a person's peripheral stem cells may improve the body's ability to fight cancer or make the cancer more sensitive to chemotherapy.
- Trial name
- NCT00003942
- Testing
- RevM10 gene, RevM10/polAS gene, in vitro-treated peripheral blood stem cell transplantation
- Where
- 6 sites in United States
- Volunteers
- 15 people
- Sponsor
- Systemix
Leptomeningeal Metastasis, NSCLC
Firmonertinib Combined With Intrathecal Injection for the Treatment of EGFR Mutant NSCLC With Leptomeningeal Metastases
Leptomeningeal metastases (LM) are a relatively rare site of metastasis in advanced non-small cell lung cancer (NSCLC), and LM patients have a poor prognosis.
- Conditions
- Leptomeningeal Metastasis, NSCLC, Intrathecal Chemotherapy, Tyrosine Kinase Inhibitor
- Trial name
- NCT07092202
- Testing
- Firmonertinib, Intrathecal injection of pemetrexed
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Healthy Volunteers
A Study to Compare the Bioavailability (BA) of Dexlansoprazole Delayed-release Capsules
The purpose of this study is to assess the BA of 30 or 60 milligram (mg) dexlansoprazole capsule manufactured at TOB (Takeda GmbH Plant Oranienburg) to the corresponding 30 or 60 mg dexlansoprazole manufactured at TPC (Takeda…
- Trial name
- NCT03801148
- Testing
- 30 mg dexlansoprazole capsules manufactured at TOB, 30 mg dexlansoprazole capsules manufactured at TPC, 60 mg dexlansoprazole capsules manufactured at TOB
- Where
- United States
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Takeda
Breast Cancer
Standard Chemotherapy Compared With High-Dose Chemotherapy Plus Peripheral Stem Cell Transplant in Treating Women With Advanced or Inflammatory Breast Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy with peripheral stem cell transplantation may allow the doctor to give higher doses of…
- Trial name
- NCT00003680
- Testing
- CMF regimen, cyclophosphamide, fluorouracil
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- Scottish Cancer Therapy Network
Locally Advanced Pancreatic Adenocarcinoma
A Study of High Dose Radiation Therapy for Locally Advanced Pancreatic Cancer That Responded to Initial Chemotherapy Treatment
The goal of this clinical trial is to test the effect of high-dose radiation therapy after initial chemotherapy in patients with locally advanced pancreatic cancer.
- Trial name
- ABLATE (NCT06453486)
- Testing
- High dose radiation therapy
- Where
- 2 sites in Canada
- Volunteers
- 43 people
- Sponsor
- University Health Network, Toronto
Acute Myeloid Leukemia
Safety and Efficacy Study of Nilotinib Combined With Mitoxantrone, Etoposide, and High-dose Cytarabine Induction Chemotherapy Followed by Consolidation for Patients With C-kit Positive Acute Myeloid Leukemia
This is a phase I/II open-label study that is evaluating the toxicity and efficacy of nilotinib combined with mitoxantrone, etoposide, and high-dose cytarabine (NOVE-HiDAC) chemotherapy for patients with poor-risk acute myeloid…
- Trial name
- NCT01222143
- Testing
- NOVE-HiDAC, Nilotinib
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- University Health Network, Toronto
Anemia
High Dose IV Iron Plus ESA in Chemotherapy-induced Anemia
This study is a multicenter, prospective, randomized phase 3 clinical study comparing the efficacy and safety of the combination treatment of ESA and high-dose IV iron (darbepoietin alfa + ferric derisomaltose/iron isomaltoside)…
- Trial name
- NCT05768997
- Testing
- Ferric Derisomaltose Injection, Darbepoetin Alfa Injection
- Where
- South Korea
- Volunteers
- 312 people
- Sponsor
- Hallym University Medical Center