Clinical trials: High-risk Medications
Multi Drug Resistant Infections
Clinical Effectiveness of a Once-daily Regimen of Tigecycline Compared to the Standard Regimen
To compare the clinical response (efficacy) and the safety of the tigecycline once daily regimen versus the standard regimen (twice daily regimen).
- Trial name
- NCT07258225
- Testing
- Tigecycline once daily regimen, Usual doses of tigecycline
- Where
- Egypt
- Volunteers
- 86 people
- Sponsor
- Air Force Specialized Hospital, Cairo, Egypt
Glaucoma Medication Adherence, Glaucoma Patients
Eye Patient Adherence and Compliance Study
This study looks at ways to help people with glaucoma take their eye drops regularly and attend their clinic appointments. Each participant will be asked about the main challenges they face, such as forgetfulness, difficulty…
- Trial name
- EYE-PACIP (NCT07793474)
- Testing
- Eye Droppers, Eye Educate, Eye Coordinate
- Where
- Canada
- Volunteers
- 189 people
- Sponsor
- St. Joseph's Healthcare Hamilton
Glioma
Study of Intraparenchymal Therapy With Irinotecan Drug Eluting Beads as Adjunct to Recurrent Surgically Resectable High Grade Glioma
A study to demonstrate safety, and feasibility for intraparenchymal injection of irinotecan hydrochloride drug-eluting beads in the treatment of recurrent high grade glioma (HGG).
- Trial name
- IDEB-glioma (NCT02481960)
- Testing
- CM-BC2 Irinotecan drug-eluting bead
- Where
- 2 sites in France, Germany
- Volunteers
- 5 people
- Sponsor
- Boston Scientific Corporation
Germ Cell Tumor
High-dose Chemotherapy as Second-line Drug Therapy for Relapsed Germ Cell Tumors
This is a prospective, single-center, non-randomized phase II study. Patients with germ cell tumors of gonadal and extragonadal localization who have progressed after prior platinum-containing first-line chemotherapy will receive…
- Trial name
- GERMAN (NCT06418789)
- Testing
- High-dose chemotherapy (TI- 2 cycles, CE- 3 cycles )
- Where
- Russia
- Volunteers
- 25 people
- Sponsor
- N.N. Petrov National Medical Research Center of Oncology
Hypertension
A Comparative Single-Dose Pharmacokinetic (PK) and Safety Study of Azilsartan Medoxomil in Children With Hypertension and in Healthy Adults
The purpose of this study was to assess the pharmacokinetics (PK) and safety of a single dose of azilsartan medoxomil in children with hypertension, and comparative PK in healthy adults.
- Trial name
- NCT01078376
- Testing
- Azilsartan medoxomil (TAK-491)
- Where
- 8 sites in United States, United Kingdom
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Takeda
Potentially Inappropriate Medications
An Intuitive, Non-intrusive, Approach to Reduce Patient Harm From Inappropriate Dosing of High-risk Drugs in Older Adult Patients Across an Urban Safety Net Hospital System
This study will assess whether a modification in the default dose and frequency (the first option a provider sees) during electronic prescribing of a high-risk drug can impact prescribing behavior and subsequent changes in…
- Trial name
- NCT05218343
- Testing
- EHR-based "nudge" interventions
- Where
- 2 sites in United States
- Volunteers
- 8,640 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Low Cardiac Output Syndrome
Levosimendan in High Risk Patients Undergoing Cardiac Surgery
Low cardiac output syndrome (LCOs) is a serious complication in critically ill patients or those undergoing major surgery, resulting in multiple organ damage with significant in-hospital and long-term morbidity and mortality, as…
- Trial name
- CHEETAH (NCT00994825)
- Testing
- Levosimendan
- Where
- 18 sites in Brazil, Italy and 1 more
- Volunteers
- 1,000 people
- Sponsor
- Università Vita-Salute San Raffaele
Advance Care Planning
Quality Improvement Project for Advance Care Planning Tool in Hospital Medicine
Hospitalized patients and their families are often unprepared regarding end-of-life care. Even patients with high risk of mortality within the index admission or 30 days after admission often do not have clearly defined goals of…
- Trial name
- NCT04296136
- Testing
- Advance Care Planning Discussion
- Where
- United States
- Volunteers
- 743 people
- Sponsor
- Duke University
Colorectal Cancer
Systemic Neoadjuvant and Adjuvant Control by Precision Medicine in Rectal Cancer
Rectal cancer represents the most complex area of multidisciplinary treatment in bowel surgery. In 2017, there were 1221 new rectal cancers in Finland.
- Trial name
- SYNCOPE (NCT04842006)
- Testing
- Total neoadjuvant therapy (TNT), Minimal residual disease (MRD), Long radiation therapy
- Where
- 2 sites in Finland
- Volunteers
- 93 people
- Sponsor
- Helsinki University Central Hospital
Refractive Error - Myopia Axial
Axis Length and Its Relationship With Refractive Error in Chinese University Students
To investigate the relationship between axis length (AL) and refractive error. eyes of low hyperopia to emmetropia subjects, comprising eyes with moderate to high myopia (-11.00D ≤ SE ≤ -4.00D) were analyzed in this…
- Trial name
- NCT04666870
- Testing
- myopia or not myopia
- Where
- China
- Volunteers
- 1,901 people
- Sponsor
- Wang Hongxia
Drug Use, Hepatitis
Low Dead-space Injecting Equipment Distribution Program for People Who Inject Drugs in Low- and Middle-income Countries
Implementation and evaluation of a distribution program for low dead-space syringes/needles (LDSS/N) in Armenia, Georgia, and Tanzania, Egypt, Nigeria, Vietnam, India, Ukraine, and South Africa.
- Conditions
- Drug Use, Hepatitis, Hiv
- Trial name
- NCT06395129
- Testing
- Low dead-space syringes/needles, Hepatitis C Antibody Rapid Diagnostic Test, HIV rapid Diagnostic Test
- Where
- 9 sites in Armenia, Georgia and 1 more
- Volunteers
- 2,400 people, healthy volunteers welcome
- Sponsor
- Médecins du Monde
Breast Cancer Metastatic, Breast Cancer Stage IV
Detecting Tumor DNA in the Blood of HR+/HER2-low Metastatic Breast Cancer Patients to Find Candidates for T-DXd Therapy
After an initial screening phase to identify patients with persistent blood circulating DNA tumors, patients will be enrolled in the treatment phase that was designed as an open-label, multicentre, phase II study, to test the…
- Trial name
- SAFIR3LibHERty (NCT06680596)
- Testing
- trastuzumab derxutecan
- Where
- 40 sites in France
- Volunteers
- 80 people
- Sponsor
- UNICANCER
Medication Safety
Improving Safety After Hospitalization in Older Persons on High-Risk Medications
This study evaluates an intervention to reduce medication errors and adverse drug events in older adults who have recently been discharged from the hospital and prescribed anticoagulants, diabetes agents, or opioids.
- Trial name
- NCT02781662
- Testing
- Pharmacist Home-Visit
- Volunteers
- 361 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
Breast Neoplasms, Neoplasm Metastasis
Study of High-dose Chemotherapy (HDC) Combined With Adoptive Cellular Therapy With DC-CIK Cells in Triple Negative Breast Cancer Patients
To access the effectiveness of High-dose Cyclophosphamide Combined Chemotherapy combined with adoptive cellular therapy with dentritic and cytokine-induced killer cells in triple negative metastatic breast cancer patients
- Trial name
- DC-CIK (NCT01232062)
- Where
- China
- Volunteers
- 46 people
- Sponsor
- Peking University Cancer Hospital & Institute
Neoplasms, Ovarian
A Study of MORAb-202 Versus Investigator's Choice Chemotherapy in Female Participants With Platinum-resistant High-grade Serous (HGS) Ovarian, Primary Peritoneal, or Fallopian Tube Cancer
The purpose of the study is to assess the safety, tolerability, and efficacy of farletuzumab ecteribulin (MORAb-202) and compare it to Investigator's choice (IC) chemotherapy in female participants with platinum-resistant HGS…
- Trial name
- NCT05613088
- Testing
- MORAb-202, Paclitaxel, Pegylated Liposomal Doxorubicin (PLD)
- Where
- 50 sites in United States, Australia and 7 more
- Volunteers
- 106 people
- Sponsor
- Bristol-Myers Squibb
Hypertension, Cardiovascular Disease
Combination of OLMesartan and CCB or Low Dose Diuretics in High Risk Elderly Hypertensive Patients Study (COLM-Study)
The purpose of this study is to investigate which combination therapy is more effective in reducing the incidence of cardiovascular events in Japanese elderly high-risk hypertensive patients: AT1 subtype angiotensin II receptor…
- Conditions
- Hypertension, Cardiovascular Disease, Diabetes
- Trial name
- NCT00454662
- Testing
- olmesartan medoxomil / amlodipine or azelnidipine, olmesartan medoxomil / low dose thiazide type drug
- Where
- Japan
- Volunteers
- 5,141 people
- Sponsor
- COLM Study Research Organization
Feeding Intolerance
Efficacy of Itopride Versus Metoclopramide in Hospitalized Medicine Patients With High Gastric Residual Volume
A prospective randomized controlled trial included 86 patients in medicine ward who were diagnosed with feeding intolerance, defined as having a gastric residual volume greater than 200 ml.
- Trial name
- GRV (NCT07031479)
- Testing
- Itopride HCI 50 mg, Metoclopramide 10 mg ampoule
- Volunteers
- 86 people
- Sponsor
- Chulalongkorn University
Addiction, Risk Reduction Behaviour
The Effectiveness of Skill-Based HIV Psychoeducation in IV-Drug Abuser for Reducing High-risk Behavior
The Effectiveness of Skill-Based HIV Psychoeducation in IV-Drug abuser for reducing high-risk behavior
- Trial name
- NCT00935103
- Testing
- Psychoeducation
- Volunteers
- 120 people
- Sponsor
- Iran University of Medical Sciences
Medication Adherence, Medication Safety
Evaluation of Medication Management Service
Medication management services (MMS) is a pharmacist-led service of optimizing the medication use and health outcomes, by promoting medication safety and enhancing the ability in self-management of health and diseases of patients…
- Conditions
- Medication Adherence, Medication Safety, Diabetes Mellitus, Type 2, Hypertension
- Trial name
- NCT06273761
- Testing
- Medication Management Service (MMS)
- Where
- 8 sites in Hong Kong
- Volunteers
- 640 people
- Sponsor
- The University of Hong Kong
Metastatic Breast Cancer, Breast Cancer
Image-guided Targeted Doxorubicin Delivery With Hyperthermia to Optimize Loco-regional Control in Breast Cancer
In this phase I feasibility study, the investigators evaluate the combination of lyso-thermosensitive liposomal doxorubicin (LTLD, ThermoDox) with local hyperthermia and cyclophosphamide (C), for the local treatment of the…
- Conditions
- Metastatic Breast Cancer, Breast Cancer, Breast Neoplasms, Stage IV Breast Cancer
- Trial name
- i-GO (NCT03749850)
- Testing
- LTLD, MR-HIFU induced hyperthermia, Cyclophosphamide
- Where
- Netherlands
- Volunteers
- 12 people
- Sponsor
- UMC Utrecht