Clinical trials: High-risk Medications
Osteosarcoma
A Clinical Research on the Relation of Blood Drug Concentration and Calcium Folinate Rescued in High-dose MTX Therapy
At present, the most effective drugs to osteosarcoma include ADM,DDP,,HD-MTX,IFO and so on.The effective rate of single drug was about 30%, and if the chemotherapy contains HD-MTX, the survival rate can reach about 60%, so the…
- Trial name
- NCT01758666
- Testing
- Methotrexate,Calcium folinate
- Volunteers
- 40 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Coronary Artery Disease
COmparison and Modification in Neointimal Pattern Assessed by Optical Coherence Tomography With High Versus Moderate Efficacy Statin Treatment After Drug Eluting Stent Implantation: COMPASS Trial
This study is a prospective randomized trial to evaluate and compare the quantitative and qualitative characteristics of neointimal formation between high and low efficacy statin treatment after drug eluting stent (DES)…
- Trial name
- NCT02155530
- Testing
- Atorvastatin 40mg, pravastatin 20 mg
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Yonsei University
Breast Cancer, Cardiotoxicity
Exercise Prescription Guided by Heart Rate Variability in Breast Cancer Patients
Breast cancer is a chronic disease that has seen a boom in research into its treatments, improvements and effects in recent decades.
- Conditions
- Breast Cancer, Cardiotoxicity, Autonomic Imbalance
- Trial name
- NCT05040867
- Testing
- Physical exercise program
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- GO fit Lab- Ingesport
HIV-1-infection
Administration of High Doses of Antiretroviral Drugs to Eliminate the Latent HIV-1 Reservoir
The HIV epidemic represents one of the greatest health challenges worldwide, with important social and economic implications for public health.
- Trial name
- NCT06640192
- Testing
- Standardised triple antiretroviral therapy, High doses Triple therapy antiretroviral drugs
- Where
- 2 sites in Spain
- Volunteers
- 18 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Anterior Cruciate Ligament
Efficacy of the SurgiStim3 Electrical Stimulation Device in Persons Undergoing Anterior Cruciate Ligament Repair
The purpose of this study is to determine whether a functional electrical stimulation device, the SurgiStim3, decreases pain, pain medications and/or edema in patients undergoing anterior cruciate ligament repair.
- Trial name
- NCT00717171
- Testing
- SurgiStim3
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- VQ OrthoCare
High Grade Ovarian Serous Adenocarcinoma, High Grade Serous Carcinoma
Multi-layer Data to Improve Diagnosis, Predict Therapy Resistance and Suggest Targeted Therapies in HGSOC
Chemotherapy resistance is the greatest contributor to mortality in advanced cancers and severe challenges remain in finding effective treatment modalities to cancer patients with metastasized and relapsed disease.
- Trial name
- DECIDER (NCT04846933)
- Testing
- WGS and RNA sequencing, circulating tumor DNA (ctDNA), FDG PET/CT imaging
- Where
- Finland
- Volunteers
- 200 people
- Sponsor
- Turku University Hospital
Organoids, HNSCC
Selecting Chemotherapy With High-throughput Drug Screen Assay Using Patient Derived Organoids in Patients With Refractory Solid Tumours (SCORE)
This is a single-centre study based on the Simon 2-stage optimax design: 12 patients will be enrolled initially (Stage I), which will then be expanded to a further 13 patients (Stage II) if 3 or more patients enrolled in stage I…
- Conditions
- Organoids, HNSCC, Epithelial Ovarian Cancer, Colorectal Cancer
- Trial name
- NCT04279509
- Testing
- Tumor Core Biopsy, Blood sampling
- Where
- Singapore
- Volunteers
- 35 people
- Sponsor
- National University Hospital, Singapore
Dialysis; Complications, Central Vein Obstruction
APERTO CVS PMCF Study
Prospective Observational Single Arm study aimed to assess safety and effectiveness of APERTO OTW DCB in treating stenosis and restenosis of central veins in dialysis patients
- Conditions
- Dialysis; Complications, Central Vein Obstruction, Stenosis, Restenosis
- Trial name
- APERTO CVS (NCT04514406)
- Testing
- APERTO OTW DCB
- Where
- 2 sites in Germany
- Volunteers
- 6 people
- Sponsor
- Cardionovum GmbH
Prostatic Neoplasms
Vitamin C as an Anti-cancer Drug
Can high dose, intravenous Vitamin C prolong life for patients with metastatic prostate cancer? Prostate cancer is the most common cancer (excluding skin cancer) in men in Denmark and the Unites States.
- Trial name
- NCT01080352
- Testing
- Ascorbic Acid (Vitamin C)
- Where
- Denmark
- Volunteers
- 31 people
- Sponsor
- Copenhagen University Hospital at Herlev
Ultrasonography, Breast Neoplasm Female
Intelligent Remote Intervention for High-risk Breast Cancer Populations
The goal of this clinical trial is to compare the effects of modern remote health intervention regime with traditional in-person intervention strategies for high-risk breast cancer groups that with BI-RADS 3 or higher nodules.
- Conditions
- Ultrasonography, Breast Neoplasm Female, Breast Carcinoma, Health Education
- Trial name
- NCT06193707
- Testing
- the Remote Intervention, the Traditional Intervention
- Volunteers
- 1,250 people
- Sponsor
- Qianfoshan Hospital
Colon Cancer Stage II, Colon Cancer Stage III
The Sagittarius Trial
Background \& Rationale: Colon cancer is a leading cause of cancer deaths, with a high recurrence rate in stage II high-risk and stage III patients due to undetectable micro-metastases.
- Trial name
- NCT06490536
- Testing
- Oxaliplatin, Capecitabine, Folinic acid
- Where
- 26 sites in Germany, Italy and 1 more
- Volunteers
- 700 people
- Sponsor
- IFOM ETS - The AIRC Institute of Molecular Oncology
Respiratory Depression, Hypoxemia
Dexmedetomidine vs Propofol in High-Risk ERCP Patients
ERCP requires deep sedation due to pain and discomfort, but propofol-commonly used with opioids-often causes respiratory and cardiovascular complications, especially in elderly or high-risk patients.
- Conditions
- Respiratory Depression, Hypoxemia, Hypotension Drug-Induced, Bradycardia
- Trial name
- NCT07166614
- Testing
- dexmedetomidin, Propofol
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Pain, Chronic, Prescription Drug Abuse (Not Dependent)
Linking Epigenomics With Prescription Opioid Abuse and High Impact Musculoskeletal Pain
Genetic variability from epigenetic modification of genes related to pain physiology and opioid pharmacodynamics may influence susceptibility to high-impact chronic musculoskeletal pain, opioid efficacy, and vulnerability to…
- Trial name
- LEAP (NCT03947749)
- Where
- 2 sites in United States
- Volunteers
- 275 people, healthy volunteers welcome
- Sponsor
- University of Florida
Smoking, Marijuana
Laboratory Study of Cannabidiol on the Effects of Smoked Marijuana
The objective of this study is to assess the effects of oral cannabidiol (CBD; 0, 200, 400, 800 mg) on smoked marijuana's (0, 5.6% THC) subjective, reinforcing, cognitive, and cardiovascular effects.
- Trial name
- NCT01844687
- Testing
- CBD
- Where
- 3 sites in United States
- Volunteers
- 50 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Coronary Heart Disease
Ticagrelor Single Antiplatelet Therapy in Patients With High Risk of Bleeding After DCB for Coronary Small Vessel Disease
The present study is aimed to determine the safety and efficacy of Ticagrelor single antiplatelet therapy (SAPT) in patients with primary coronary small vessel disease at high risk of bleeding after drug coated balloon (DCB)…
- Trial name
- NCT06088433
- Testing
- Ticagrelor, Clopidogrel, Aspirin
- Where
- China
- Volunteers
- 292 people
- Sponsor
- Fu Wai Hospital, Beijing, China
Fallopian Tube Endometrioid Tumor, Fallopian Tube High Grade Serous Adenocarcinoma
Testing the Addition of an Immunotherapy Drug, Tremelimumab, to the PARP Inhibition Drug, Olaparib, for Recurrent Ovarian, Fallopian Tube or Peritoneal Cancer
This phase II trial studies how well olaparib with or without tremelimumab works in treating patients with ovarian, fallopian tube, or peritoneal cancer that has come back (recurrent).
- Conditions
- Fallopian Tube Endometrioid Tumor, Fallopian Tube High Grade Serous Adenocarcinoma, Malignant Ovarian Endometrioid Tumor, Ovarian High Grade Serous Adenocarcinoma
- Trial name
- NCT04034927
- Testing
- Biospecimen Collection, Computed Tomography, Magnetic Resonance Imaging
- Where
- 20 sites in United States
- Volunteers
- 61 people
- Sponsor
- National Cancer Institute (NCI)
Acute Coronary Syndrome
Comparison of High and Moderate Intensity Statins in Achieving the Target LDL-C Level After Acute Coronary Syndrome
This study evaluates the effectiveness of high- and moderate-intensity statins in achieving target low-density lipoprotein cholesterol (LDL-C) levels in patients with acute coronary syndrome (ACS).
- Trial name
- NCT06782243
- Testing
- Moderate-Intensity Statins, High-Intensity Statins
- Where
- Pakistan
- Volunteers
- 190 people
- Sponsor
- Khyber Medical University Peshawar
Triple Negative Breast Cancer
Pilot Study of Glembatumumab Vedotin Following Doxorubicin and Cytoxan as Neo-adjuvant Therapy in Gp-NMB-expressing High Risk Triple Negative Breast Cancer
This is a single arm, pilot study assessing safety/feasibility and efficacy of neo-adjuvant glembatumumab vedotin (GV) in patients with high risk triple negative breast cancer (TNBC) with glycoprotein-NMB (gpNMB) expression ≥…
- Trial name
- Breast50 (NCT03473691)
- Testing
- Glembatumumab Vedotin
- Sponsor
- University of Virginia
Primary Immune Thrombocytopenia (ITP)
rhTPO Dose Escalation vs Eltrombopag Switch in ITP
This study is a prospective, multicenter, randomized controlled study, planning to enroll 110 ITP patients who failed to respond to conventional-dose rhTPO (300 IU/kg/d) after 14 days of treatment (PLT < 30×10⁹/L).
- Trial name
- NCT07476846
- Testing
- Recombinant Human Thrombopoietin（rhTPO）, Eltrombopag PfOS
- Volunteers
- 112 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Coronary Artery Disease (CAD)
BASel Kosten-Effektivitäts-Trial: Drug-coated BALLoon (DCB) vs. Drug-eluting Stent (DES) Strategy in High-risk Patients With Coronary Artery Disease (CAD)
The main objective of this randomized, multicenter, international, open-label clinical trial is to demonstrate that, in the context of percutaneous coronary intervention for complex coronary artery disease, a SeQuent® SCB…
- Trial name
- BASKET BALL (NCT07363161)
- Testing
- PCI
- Where
- 3 sites in Germany, Switzerland
- Volunteers
- 2,184 people
- Sponsor
- B. Braun Melsungen AG