Clinical trials: High-risk Medications
HIV-1 Infection
A Study Evaluating the Safety of Cal-1 (LVsh5/C46) Drug Product in HIV-1 Infected Patient With High Risk Lymphoma
The purpose of this study is to evaluate the safety and the feasibility, and the success of engraftment of the introduction of Cal-1 gene-transduced haematopoietic cell populations (Ttn and HSPCtn) in patients with HIV-1-related…
- Trial name
- GENHIV (NCT03593187)
- Testing
- Cal-1 (LVsh5/C46) drug product
- Where
- France
- Volunteers
- 2 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Atherosclerosis, Cardiovascular Disease
A Study of VERVE-102 (LY4636581) in Adults With or at High Risk for Cardiovascular Disease
The purpose of this study is to measure the change in bad cholesterol (LDL-C) with VERVE-102 compared to placebo in adults who have plaque buildup in their arteries or are at high risk of developing it.
- Conditions
- Atherosclerosis, Cardiovascular Disease, Hypercholesterolemia
- Trial name
- HEART-3 (NCT07839936)
- Testing
- VERVE-102
- Where
- United States
- Volunteers
- 175 people
- Sponsor
- Verve Therapeutics, Inc.
Coronary Disease, Heart Diseases
Single vs. Dual Antiplatelet Therapy in Elderly or HBR Patients Undergoing Percutaneous Intervention With DCB (PICCOLETO IV-EPIC 38)
This international, multicenter, open-label, randomized clinical trial evaluates the safety and efficacy of single antiplatelet therapy (SAPT) compared to dual antiplatelet therapy (DAPT) in elderly or high bleeding risk patients…
- Conditions
- Coronary Disease, Heart Diseases, Cardiovascular Diseases, Myocardial Ischemia
- Trial name
- PIV-EPIC (NCT06535568)
- Testing
- Drug-coated balloon, Single antiplatelet therapy (SAPT), Dual antiplatelet therapy (DAPT)
- Where
- Italy
- Volunteers
- 576 people
- Sponsor
- Fondazione Ricerca e Innovazione Cardiovascolare ETS
Glioma
Study of Intraparenchymal Therapy With Irinotecan Drug Eluting Beads as Adjunct to Recurrent Surgically Resectable High Grade Glioma
A study to demonstrate safety, and feasibility for intraparenchymal injection of irinotecan hydrochloride drug-eluting beads in the treatment of recurrent high grade glioma (HGG).
- Trial name
- IDEB-glioma (NCT02481960)
- Testing
- CM-BC2 Irinotecan drug-eluting bead
- Where
- 2 sites in France, Germany
- Volunteers
- 5 people
- Sponsor
- Boston Scientific Corporation
Appendiceal Cancer, Colorectal Adenocarcinoma
A Feasibility Study of Mass-Based Response Drug Screening to Guide Personalized Hyperthermic Intraperitoneal Chemotherapy for High-Grade Appendiceal and Colorectal Adenocarcinoma With Peritoneal Metastasis
This study will evaluate the role of mass-based response testing (MRT) to select and deliver personalized hyperthermic intraperitoneal chemotherapy (HIPEC) regimens to patients with peritoneal metastasis (PM) from high-grade…
- Conditions
- Appendiceal Cancer, Colorectal Adenocarcinoma, Peritoneal Metastases
- Trial name
- NCT07291180
- Testing
- Mass-based response testing (MRT)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Yale University
Diffuse Large B-Cell Lymphoma, Not Otherwise Specified, High Grade B-Cell Lymphoma
Testing the Combination of Anti-cancer Drugs Mosunetuzumab, Polatuzumab Vedotin, and Lenalidomide for the Treatment of Relapsed/Refractory Diffuse Large B-Cell Lymphoma
This phase I trial studies the side effects and best dose of mosunetuzumab when given together with polatuzumab vedotin and lenalidomide in treating patients with diffuse large B-cell lymphoma (DLBCL) that has come back after a…
- Conditions
- Diffuse Large B-Cell Lymphoma, Not Otherwise Specified, High Grade B-Cell Lymphoma, Transformed Indolent B-Cell Non-Hodgkin Lymphoma to Diffuse Large B-Cell Lymphoma
- Trial name
- NCT06015880
- Testing
- Biospecimen Collection, Computed Tomography, Lenalidomide
- Where
- 8 sites in United States
- Volunteers
- 30 people
- Sponsor
- National Cancer Institute (NCI)
Coronary Artery Disease, Myocardial Infarction
Aspirin Response in High Risk Patients With Coronary Artery Disease
Previous studies indicate that patients with cardiovascular disease have a variable response to aspirin. Despite treatment with aspirin a large number of patients suffer a myocardial infarction.
- Conditions
- Coronary Artery Disease, Myocardial Infarction, Diabetes Mellitus, Renal Insufficiency, Chronic
- Trial name
- NCT01383304
- Where
- Denmark
- Volunteers
- 906 people
- Sponsor
- University of Aarhus
Hypotension Drug-Induced, Spinal Aneshtesia
Effect of Lateral Decubitus Position After Spinal Anesthesia on Hemodynamic Stability in High-Risk Geriatric Patients
Spinal anesthesia is a common and preferred anesthetic technique for lower extremity orthopedic surgery in elderly patients. However, it can cause a significant drop in blood pressure (hypotension), especially in high-risk older…
- Conditions
- Hypotension Drug-Induced, Spinal Aneshtesia, Geriatric, Orthopedic Surgery Patients
- Trial name
- NCT07597148
- Testing
- Lateral Decubitus Positioning, Immediate Supine Positioning
- Volunteers
- 70 people
- Sponsor
- University of Health Sciences Balikesir Hospital Eduation and Research
Advanced Cancer, Opioid Use, Unspecified
Paracetamol for Cancer Pain
Randomised, double-blind placebo controlled cross-over trial Main goal: Optimize the medical pain treatment for patients with advanced cancer disease Study goal: Measure paracetamol's additional analgesic effect in a situation…
- Trial name
- NCT01313247
- Testing
- paracetamol
- Where
- Norway
- Volunteers
- 50 people
- Sponsor
- Haraldsplass Deaconess Hospital
Hypertension
Virtual Lifestyle Medicine Group Visits for High Blood Pressure
The purpose of this study is to learn whether virtual Lifestyle medicine shared medical appointments (LMSMAs) can help people better manage their blood pressure and improve their overall health.
- Trial name
- NCT07698509
- Testing
- Lifestyle Medicine Virtual group, Usual Care Group
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- The University of Texas Health Science Center, Houston
Reintegration Difficulties, Suicidal Ideation and Behaviors
Expanding Veteran Sponsorship Initiative+ to Support High-Risk Transitioning Servicemembers and Veterans: A Precision Medicine Approach
Background Young Veterans in the U.S. face a heightened risk of suicide, particularly during the first year after leaving military service-a period often referred to as the "deadly gap." Suicide rates among Veterans aged 18 to 34…
- Conditions
- Reintegration Difficulties, Suicidal Ideation and Behaviors, Health, Connectedness
- Trial name
- NCT07356492
- Testing
- Onward Ops- receive peer sponsor and community support, VA stepped care services
- Where
- United States
- Volunteers
- 2,700 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Glioblastoma Multiforme
Vacuolar ATPase and Drug Resistance of High Grade Gliomas
GBMs are still considered tumors with few available treatment options that are able only to achieve a temporary local control of the disease.
- Trial name
- GLIODRUG-V (NCT05328089)
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- University of Milano Bicocca
Body Weight, Obesity
Meta-analyses of Food Sources of Fructose-Containing Sugars and Obesity
Sugars have been implicated in the epidemics of overweight and obesity. This view is supported by lower quality evidence from ecological observations, animal models, and select human trials.
- Conditions
- Body Weight, Obesity, Overweight, Adiposity
- Trial name
- NCT02558920
- Testing
- Fructose-containing Sugars
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- John Sievenpiper
High-risk Medications
Testing a Medication Risk Communication and Surveillance Strategy: The EMC2 Trial
This study evaluates the effectiveness of an electronic health record based educational intervention (the EMC2 strategy) to improve patient understanding and use of higher-risk medications.
- Trial name
- NCT02785458
- Testing
- EMC2 Strategy
- Where
- United States
- Volunteers
- 1,005 people
- Sponsor
- Northwestern University
Healthy Volunteers
A Study to Evaluate the Effect of High-Fat Meal on TAK-788 Pharmacokinetics (PK) in Healthy Adult Participants
The purpose of this study is to characterize the effect of a high-fat meal on the PK of TAK-788 administered in healthy participants.
- Trial name
- NCT04441255
- Testing
- TAK-788
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Takeda
Ovarian Cancer, Peritoneal Cancer
Mirvetuximab Soravtansine With Bevacizumab Versus Bevacizumab as Maintenance in Platinum-sensitive Epithelial Ovarian, Fallopian Tube, or Peritoneal Cancer
GLORIOSA is a Phase 3 multicenter, open label study designed to evaluate the safety and efficacy of mirvetuximab Soravtansine + Bevacizumab as maintenance therapy in participants with platinum-sensitive ovarian, primary…
- Conditions
- Ovarian Cancer, Peritoneal Cancer, Fallopian Tube Cancer
- Trial name
- GLORIOSA (NCT05445778)
- Testing
- Mirvetuximab soravtansine plus Bevacizumab, Bevacizumab
- Where
- 264 sites in United States, Argentina and 20 more
- Volunteers
- 520 people
- Sponsor
- AbbVie
Altitude, Ultraviolet Rays
Ultraviolet Exposure, Antioxidant Use and Skin Erythema at Extreme High Altitude
With the increasing tourism and adventure travel into extreme environments comes the need to reassess the required protection against ultraviolet (UV) radiation and possible other oxidative stresses.
- Conditions
- Altitude, Ultraviolet Rays, Antioxidants, Oxidative Stress
- Trial name
- NCT00685438
- Where
- Nepal
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre